Page last updated: 2024-10-21

hydroxyindoleacetic acid and Gastrinoma

hydroxyindoleacetic acid has been researched along with Gastrinoma in 8 studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Gastrinoma: A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).

Research Excerpts

ExcerptRelevanceReference
"To assess whether serum histamine, chromogranin A or serotonin and urinary N-methylimidazoleacetic acid or 5-hydroxyindoleacetic acid correlate with advanced enterochromaffin cell changes or gastric carcinoids in patients with gastrinomas."7.71Prospective study of the ability of histamine, serotonin or serum chromogranin A levels to identify gastric carcinoids in patients with gastrinomas. ( Asgharian, B; Bashir, S; Bordi, C; Crafa, P; Entsuah, LK; Ferraro, G; Gibril, F; Jensen, RT; Ojeaburu, JV, 2002)
"To assess whether serum histamine, chromogranin A or serotonin and urinary N-methylimidazoleacetic acid or 5-hydroxyindoleacetic acid correlate with advanced enterochromaffin cell changes or gastric carcinoids in patients with gastrinomas."3.71Prospective study of the ability of histamine, serotonin or serum chromogranin A levels to identify gastric carcinoids in patients with gastrinomas. ( Asgharian, B; Bashir, S; Bordi, C; Crafa, P; Entsuah, LK; Ferraro, G; Gibril, F; Jensen, RT; Ojeaburu, JV, 2002)
" In this study we examined the effects of two agents that promote cellular differentiation, sodium butyrate and hexamethylene bisacetamide, on the in vitro growth and secretory responses of a human pancreatic carcinoid (BON) and human gastrinoma (PT-2 and PT-SM) cell lines that have been established in our laboratory."3.68Differential effects of sodium butyrate and hexamethylene bisacetamide on growth and secretion of cultured human endocrine tumor cells. ( Beauchamp, RD; Haber, BE; Hsieh, J; Ishizuka, J; Karp, G; Parekh, D; Rajaraman, S; Thompson, JC; Townsend, CM, 1991)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (75.00)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
O'Toole, D1
Grossman, A1
Gross, D1
Delle Fave, G1
Barkmanova, J1
O'Connor, J1
Pape, UF1
Plöckinger, U1
Bashir, S1
Gibril, F1
Ojeaburu, JV1
Asgharian, B1
Entsuah, LK1
Ferraro, G1
Crafa, P1
Bordi, C1
Jensen, RT1
Nold, R1
Frank, M1
Kajdan, U1
Trost, U1
Klose, KJ1
Arnold, R1
Eriksson, B1
Janson, ET1
Bax, ND1
Mignon, M1
Morant, R1
Opolon, P1
Rougier, P1
Oberg, KE1
Nobels, FR1
Kwekkeboom, DJ1
Coopmans, W1
Schoenmakers, CH1
Lindemans, J1
De Herder, WW1
Krenning, EP1
Bouillon, R1
Lamberts, SW1
Blanchin, M1
James-Deidier, A1
Chaumet-Riffaud, PD1
Chayvialle, JA1
Parekh, D1
Ishizuka, J1
Townsend, CM1
Haber, BE1
Beauchamp, RD1
Rajaraman, S1
Karp, G1
Hsieh, J1
Thompson, JC1
Creutzfeldt, W1
Bartsch, HH1
Jacubaschke, U1
Stöckmann, F1

Trials

3 trials available for hydroxyindoleacetic acid and Gastrinoma

ArticleYear
The use of new somatostatin analogues, lanreotide and octastatin, in neuroendocrine gastro-intestinal tumours.
    Digestion, 1996, Volume: 57 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Biomarkers,

1996
[Use of octreotide in the treatment of digestive endocrine tumors. A French multicenter study].
    Presse medicale (Paris, France : 1983), 1992, Apr-18, Volume: 21, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Female; France; Gastrinoma; Glucagonoma; Humans; Hydroxyindoleacetic

1992
Treatment of gastrointestinal endocrine tumours with interferon-alpha and octreotide.
    Acta oncologica (Stockholm, Sweden), 1991, Volume: 30, Issue:4

    Topics: Aged; Carcinoid Tumor; Drug Evaluation; Female; Gastrinoma; Gastrointestinal Neoplasms; Humans; Hydr

1991

Other Studies

5 other studies available for hydroxyindoleacetic acid and Gastrinoma

ArticleYear
ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: biochemical markers.
    Neuroendocrinology, 2009, Volume: 90, Issue:2

    Topics: Biomarkers; Chromogranin A; Fasting; Gastrinoma; Humans; Hydroxyindoleacetic Acid; Hypoglycemia; Ins

2009
Prospective study of the ability of histamine, serotonin or serum chromogranin A levels to identify gastric carcinoids in patients with gastrinomas.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Biopsy; Carcinoid Tumor; Chromogranin A; Chromogr

2002
[Combined treatment of metastatic endocrine tumors of the gastrointestinal tract with octreotide and interferon-alpha].
    Zeitschrift fur Gastroenterologie, 1994, Volume: 32, Issue:4

    Topics: Biomarkers, Tumor; Combined Modality Therapy; Female; Gastrinoma; Gastrins; Gastrointestinal Neoplas

1994
Chromogranin A as serum marker for neuroendocrine neoplasia: comparison with neuron-specific enolase and the alpha-subunit of glycoprotein hormones.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:8

    Topics: Adult; Aged; Biomarkers, Tumor; Carcinoid Tumor; Carcinoma, Medullary; Carcinoma, Small Cell; Chromo

1997
Differential effects of sodium butyrate and hexamethylene bisacetamide on growth and secretion of cultured human endocrine tumor cells.
    Archives of surgery (Chicago, Ill. : 1960), 1991, Volume: 126, Issue:4

    Topics: 5-Hydroxytryptophan; Acetamides; Analysis of Variance; Butyrates; Butyric Acid; Carcinoid Tumor; Cel

1991