fluorouracil has been researched along with Gastrinoma in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Gastrinoma: A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primary tumours were carcinoids in nine, gastrinomas in five, non-functioning pancreatic tumours in six and calcitonin-secreting tumours in two patients." | 1.29 | Liver metastases of digestive endocrine tumours: natural history and response to medical treatment. ( Bernades, P; Menu, Y; Ruszniewski, P; Skinazi, F; Zins, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eriksson, B | 1 |
| Oberg, K | 1 |
| Skinazi, F | 1 |
| Zins, M | 1 |
| Menu, Y | 1 |
| Bernades, P | 1 |
| Ruszniewski, P | 1 |
| Gottwald, T | 1 |
| Köveker, G | 1 |
| Büsing, M | 1 |
| Lauchart, W | 1 |
| Becker, HD | 1 |
| Brentjens, R | 1 |
| Saltz, L | 1 |
| Congy, F | 1 |
| Pelletier, S | 1 |
| Langlois, P | 1 |
| Khayat, D | 1 |
| Homsi, T | 1 |
| Emerit, J | 1 |
1 review available for fluorouracil and Gastrinoma
| Article | Year |
|---|---|
Islet cell tumors of the pancreas: the medical oncologist's perspective.
Topics: Adenoma, Islet Cell; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Ag | 2001 |
4 other studies available for fluorouracil and Gastrinoma
| Article | Year |
|---|---|
An update of the medical treatment of malignant endocrine pancreatic tumors.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherap | 1993 |
Liver metastases of digestive endocrine tumours: natural history and response to medical treatment.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Chemoemboliz | 1996 |
Diagnosis and management of metastatic gastrinoma by multimodality treatment including liver transplantation: report of a case.
Topics: Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Combined Modality Therapy; Fema | 1998 |
[Pancreatic endocrine tumor with metastases and increase of alpha-fetoprotein. A case report].
Topics: alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Fatal Outcome; Fluoroura | 1992 |