valproic acid has been researched along with De Lange Syndrome in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
De Lange Syndrome: A syndrome characterized by growth retardation, severe MENTAL RETARDATION, short stature, a low-pitched growling cry, brachycephaly, low-set ears, webbed neck, carp mouth, depressed nasal bridge, bushy eyebrows meeting at the midline, hirsutism, and malformations of the hands. The condition may occur sporadically or be associated with an autosomal dominant pattern of inheritance or duplication of the long arm of chromosome 3. (Menkes, Textbook of Child Neurology, 5th ed, p231)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Partial epilepsy is the most common type of epilepsy in CdLS patients." | 1.39 | Epilepsy in patients with Cornelia de Lange syndrome: a clinical series. ( Agostinelli, S; Capovilla, G; Chiarelli, F; Coppola, G; Curatolo, P; Foiadelli, T; Grosso, S; Parisi, P; Prezioso, G; Romeo, A; Savasta, S; Spalice, A; Striano, P; Verrotti, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verrotti, A | 1 |
| Agostinelli, S | 1 |
| Prezioso, G | 1 |
| Coppola, G | 1 |
| Capovilla, G | 1 |
| Romeo, A | 1 |
| Striano, P | 1 |
| Parisi, P | 1 |
| Grosso, S | 1 |
| Spalice, A | 1 |
| Foiadelli, T | 1 |
| Curatolo, P | 1 |
| Chiarelli, F | 1 |
| Savasta, S | 1 |
1 other study available for valproic acid and De Lange Syndrome
| Article | Year |
|---|---|
Epilepsy in patients with Cornelia de Lange syndrome: a clinical series.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; De Lange Syndrome; Electroencephalography; Epile | 2013 |