| Assay ID | Title | Year | Journal | Article |
|---|
| AID156064 | Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT) | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT. |
| AID155146 | Inhibition of PNMT (Phenylethanolamine N-Methyltransferase) in vitro | 1999 | Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
| Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID257556 | Displacement of [3H]clonidine from Adrenergic alpha-2 receptor | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
| Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. |
| AID155137 | Affinity for bovine Phenylethanolamine N-Methyltransferase (PNMT) | 1999 | Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18
| Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID257555 | Inhibitory activity against human PNMT | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
| Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. |
| AID35335 | Selectivity determined by Ki of alpha 2 receptor / Ki of PNMT | 1999 | Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
| Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID37366 | Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor | 1999 | Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18
| Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID239340 | Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4
| Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. |
| AID239958 | Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]clonidine as radioligand | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4
| Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. |
| AID35194 | The compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]clonidine, A precipitate was noted at 1000 uM | 1999 | Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
| Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID257557 | Selectivity of Adrenergic alpha-2 receptor over human PNMT | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
| Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. |
| AID313557 | Inhibition of human PNMT by radiochemical assay | 2008 | Bioorganic & medicinal chemistry, Jan-01, Volume: 16, Issue:1
| Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. |
| AID35216 | Ratio for binding affinity towards alpha-2 adrenoceptor to PNMT | 1999 | Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18
| Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID234315 | Relative affinity for alpha-2-adrenoceptor and phenylethanolamine N-methyl-transferase (PNMT) | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT. |
| AID35395 | Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptor | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
| Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |