| Assay ID | Title | Year | Journal | Article |
|---|
| AID1436340 | Drug uptake in mouse plasma at 30 mg/kg, administered as single dose via oral gavage after 120 hrs by HPLC-ESI-MS/MS analysis | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| AID1436335 | Half-life in mouse liver microsomes at 1 uM in presence of NADPH by HPLC-ESI-MS/MS analysis | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| AID1260978 | n-octanol-water distribution coefficient, log D of the compound at pH 7.4 after 4 hrs by shake-flask method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1260976 | AUC (0 to t) in mouse at 30 mg/kg, po administered as single dose by HPLC-MS analysis | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1260979 | Metabolic stability in mouse liver S9 fractions assessed as compound remaining at 1 uM after 1 hr by HPLC-ESI-MS/MS analysis in presence of NADPH regenerating system | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1260975 | Cmax in mouse at 30 mg/kg, po administered as single dose by HPLC-MS analysis | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1436332 | n-Octanol-buffer partition co-efficient, log D of the compound at pH 7.4 incubated overnight by shake-flask method | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| AID1424429 | Cmax in mouse at 30 mg/kg, po | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | Targeting Eph/ephrin system in cancer therapy. |
| AID1436334 | Stability in mouse plasma assessed as compound remaining at 1 uM after 24 hrs by HPLC-ESI-MS/MS analysis | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| AID1436330 | Displacement of biotinylated ephrin-A1-Fc from recombinant mouse EphA2 receptor preincubated for 1 hr followed by biotinylated ephrin-A1-Fc addition measured after 4 hrs by ELISA method | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| AID1260977 | Metabolic stability in mouse plasma assessed as compound remaining at 1 uM after 24 hrs by HPLC-ESI-MS/MS analysis | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1436336 | Cmax in mouse at 30 mg/kg, administered as single dose via oral gavage by HPLC-ESI-MS/MS analysis | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| AID1260980 | Kinetic solubility of the compound in NaCl solution at 25 deg C after 2 hrs by HPLC-ESI-MS/MS analysis | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1436329 | Drug metabolism in mouse liver microsomes assessed as (S)-3-((S)-4-((5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-4-(1H-indol-3-yl)butanoic acid formation by HPLC-ESI-MS/MS analysis | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| AID1424430 | Kinetic solubility of the compound | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | Targeting Eph/ephrin system in cancer therapy. |
| AID1260972 | Agonist activity at TGR5 (unknown origin) assessed as cAMP level | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1689866 | Competitive inhibition of biotinylated ephrin-A1-Fc binding to EphA2 (unknown origin) | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties. |
| AID1260973 | Activation of human recombinant PXR up to 10 uM by alphascreen method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. |
| AID1436333 | Kinetic solubility in MOPS buffer at pH 7.4 measured after 4 hrs by HPLC-ESI-MS/MS analysis | 2017 | Journal of medicinal chemistry, 01-26, Volume: 60, Issue:2
| Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |