You're asking about **1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine**, a complex organic compound with a fascinating structure.
**What it is:**
* **Structure:** This molecule is a fused ring system containing both indole and quinolizine moieties. Octahydro indicates the presence of eight hydrogen atoms, meaning the ring system is partially saturated.
* **Appearance:** It is likely a solid with a specific melting point and potential solubility in organic solvents.
**Why it's important for research:**
While the specific compound you mentioned might not have a vast literature, compounds with similar structures are often studied due to their potential applications in various fields:
* **Pharmacology:** Many natural and synthetic alkaloids with fused ring systems like this exhibit biological activity. They may act as:
* **Antidepressants:** Affecting neurotransmitters like serotonin and dopamine.
* **Anti-cancer agents:** Targeting specific cellular pathways involved in tumor growth.
* **Analgesics:** Reducing pain by interacting with pain receptors.
* **Medicinal Chemistry:** Researchers are constantly exploring new compounds with these structural features to develop novel drugs with improved efficacy and reduced side effects.
* **Organic Synthesis:** These complex structures serve as challenging targets for synthetic chemists, pushing the boundaries of synthetic methods and understanding how to control complex reactions.
**Key Considerations:**
* **Specificity:** To understand the true significance of this specific compound, more information is needed. For instance:
* **Natural Source:** Is it found in a particular plant or organism?
* **Biological Activity:** Has it been tested for any specific biological activity?
* **Research Focus:** The specific research area related to this compound (pharmacology, medicinal chemistry, etc.) will determine its importance.
**To learn more:**
* **Search for related structures:** Search scientific databases like PubChem, SciFinder, or Google Scholar using terms like indoloquinolizine, fused ring systems, and alkaloids.
* **Consult specialized journals:** Look for articles in journals focused on organic chemistry, medicinal chemistry, or natural products chemistry.
Remember, scientific research is an ongoing process. New discoveries and applications are constantly being made, so the importance of a specific compound can evolve over time.
1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 98358 |
CHEMBL ID | 345349 |
SCHEMBL ID | 5269957 |
MeSH ID | M0140762 |
Synonym |
---|
1,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine |
indolo[2,3-a]quinolizidine |
4802-79-3 |
nsc-112669 |
indoloquinolizidine |
nsc112669 |
indolo[2, 1,2,3,4,6,7,12,12b-octahydro- |
inchi=1/c15h18n2/c1-2-6-13-11(5-1)12-8-10-17-9-4-3-7-14(17)15(12)16-13/h1-2,5-6,14,16h,3-4,7-10h |
1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine |
1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine |
CHEMBL345349 , |
bdbm50018737 |
2,3,4,5,6,7,12,12b-octahydro-1h-pyrido[2,1-a]beta-carboline |
indolo(2,3-a)quinolizine, 1,2,3,4,6,7,12,12b-octahydro- |
indolo(2,3-a)quinolizidine |
1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine |
octahydroindolo(2,3-a)quinolizine |
nsc 112669 |
SCHEMBL5269957 |
OURDZMSSMGUMKR-UHFFFAOYSA-N |
indolo[2,3-a]quinolizine, 1,2,3,4,6,7,12,12b-octahydro- |
indolo[a]quinolizidine |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
D(2) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.6518 | 10.0000 | AID257772 |
Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0380 | 0.0000 | 0.5072 | 3.7020 | AID35974 |
D(1A) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0001 | 0.8363 | 10.0000 | AID257771 |
D(1B) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0003 | 0.4017 | 7.9000 | AID257773 |
Alpha-2A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0603 | 0.0015 | 0.1019 | 0.2200 | AID35913 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 3 (60.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 1 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.53) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |