Platelet-derived growth factor subunit A

A platelet-derived growth factor subunit A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04085]

Synonyms

PDGF subunit A;
PDGF-1;
Platelet-derived growth factor A chain;
Platelet-derived growth factor alpha polypeptide

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tak-632	Homo sapiens (human)	IC50	0.6100	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
platelet-derived growth factor receptor binding	molecular function	Binding to a platelet-derived growth factor receptor. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
collagen binding	molecular function	Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732]
growth factor activity	molecular function	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]
platelet-derived growth factor binding	molecular function	Binding to platelet-derived growth factor. [GOC:dgh]

Located In

This protein is located in 8 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
Golgi lumen	cellular component	The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah]
microvillus	cellular component	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. [ISBN:0815316194]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
platelet alpha granule lumen	cellular component	The volume enclosed by the membrane of the platelet alpha granule. [GOC:mah, PMID:8467233]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
platelet-derived growth factor complex	cellular component	A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). [GOC:bhm, PMID:11331882]

Involved In

This protein is involved in 32 target(s):

Target	Category	Definition
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
cell activation	biological process	A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell. [GOC:mgi_curators]
hair follicle development	biological process	The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. [GOC:dph, UBERON:0002073]
positive regulation of mesenchymal cell proliferation	biological process	The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. [GOC:dph]
cell-cell signaling	biological process	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
response to wounding	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators]
animal organ morphogenesis	biological process	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
negative regulation of phosphatidylinositol biosynthetic process	biological process	Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. [GOC:dph, GOC:tb, GOC:vw]
negative regulation of platelet activation	biological process	Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:BHF, GOC:dph, GOC:tb]
regulation of smooth muscle cell migration	biological process	Any process that modulates the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]
cell projection assembly	biological process	Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
actin cytoskeleton organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
positive regulation of protein autophosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]
regulation of actin cytoskeleton organization	biological process	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:mah]
platelet-derived growth factor receptor-alpha signaling pathway	biological process	The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:yaf, PMID:10372961]
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	biological process	Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration resulting from the platelet-derived growth factor receptor-beta signaling pathway. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101]
wound healing	biological process	The series of events that restore integrity to a damaged tissue, following an injury. [GOC:bf, PMID:15269788]
positive regulation of MAP kinase activity	biological process	Any process that activates or increases the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]
positive regulation of MAPK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
skin development	biological process	The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. [GOC:jl, UBERON:0002097]
platelet-derived growth factor receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
positive regulation of fibroblast proliferation	biological process	Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]
lung alveolus development	biological process	The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]
regulation of peptidyl-tyrosine phosphorylation	biological process	Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]
negative chemotaxis	biological process	The directed movement of a motile cell or organism towards a lower concentration of a chemical. [GOC:ai, GOC:bf, GOC:isa_complete]
positive regulation of cell division	biological process	Any process that activates or increases the frequency, rate or extent of cell division. [GOC:ai]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	biological process	Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland. [GOC:dph, PMID:18559345]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
embryonic lung development	biological process	The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure. [PMID:24785085]