Assay ID | Title | Year | Journal | Article |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID351368 | Intrinsic clearance in human liver microsomes | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks. |
AID371521 | Volume of distribution in iv dosed dog | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID351361 | Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR relative to phenylephrine | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks. |
AID352019 | Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID352015 | Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID351360 | Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks. |
AID352023 | Apparent permeability from apical to basolateral side of MDCK cells expressing MDR1 | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID371523 | Ratio of drug level in iv dosed rat free plasma to cerebral spinal fluid | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371275 | Inhibition of CYP2C9 at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371268 | Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371270 | Metabolic stability in human liver microsomes assessed as intrinsic clearance | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371525 | Apparent permeability from apical to basolateral side of MDCK cells expressing MDR1 | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID352022 | Intrinsic clearance in human liver microsomes | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID351371 | Permeability from basolateral to apical side of MDCK2 cells expressing MDR1 | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks. |
AID371271 | Distribution coefficient, log D at pH 7.4 | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371276 | Inhibition of CYP3A4 at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371273 | Metabolic stability in dog liver microsomes assessed as intrinsic clearance | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371522 | Half life in iv dosed dog | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371277 | Inhibition of CYP2C19 | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID352017 | Agonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID371278 | Inhibition of CYP2D6 | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID351370 | Permeability from apical to basolateral side of MDCK2 cells expressing MDR1 | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks. |
AID352024 | Apparent permeability from basolateral to apical side of MDCK cells expressing MDR1 | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID371524 | Bioavailability in human | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371272 | Binding affinity to adrenergic alpha1A receptor | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371269 | Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay relative to phenylephrine | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID371526 | Apparent permeability from basolateral to apical side of MDCK cells expressing MDR1 | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID352016 | Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR relative to 10 uM phenylephrine | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID352025 | Lipophilicity, log D at pH 7.4 | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID371274 | Activity at human ERG | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
AID352021 | Inhibition of adrenergic alpha2A receptor | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
AID371520 | Clearance in iv dosed dog | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
| Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |