secramine a

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Description

secramine A: inhibits VSVG transport from the Golgi to the plasma membrane; also inhibits Cdc42-dependent cell functions; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10372387
CHEMBL ID	1222038
MeSH ID	M0496369

Synonyms (7)

Synonym
secramine
CHEMBL1222038 ,
secramine a
PROBES2_000397
PROBES1_000057
bdbm50324672
[(1r,3s,12r,14e,16r)-9-bromo-8-(cyclopropylmethoxy)-16-[(4-methoxyphenyl)methylsulfanyl]-14-phenylmethoxyimino-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6,8,10(17)-trien-3-yl]methanol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cell division control protein 42 homolog	Homo sapiens (human)	IC50 (µMol)	9.0000	2.0000	5.5000	9.0000	AID502930
Cell division control protein 42 homolog	Xenopus laevis (African clawed frog)	IC50 (µMol)	1.0000	1.0000	1.0000	1.0000	AID502922
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (59)

Process	via Protein(s)	Taxonomy
sprouting angiogenesis	Cell division control protein 42 homolog	Homo sapiens (human)
cardiac conduction system development	Cell division control protein 42 homolog	Homo sapiens (human)
cardiac neural crest cell migration involved in outflow tract morphogenesis	Cell division control protein 42 homolog	Homo sapiens (human)
phagocytosis, engulfment	Cell division control protein 42 homolog	Homo sapiens (human)
actin filament organization	Cell division control protein 42 homolog	Homo sapiens (human)
Golgi organization	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of mitotic nuclear division	Cell division control protein 42 homolog	Homo sapiens (human)
nuclear migration	Cell division control protein 42 homolog	Homo sapiens (human)
establishment or maintenance of cell polarity	Cell division control protein 42 homolog	Homo sapiens (human)
integrin-mediated signaling pathway	Cell division control protein 42 homolog	Homo sapiens (human)
protein localization	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of lamellipodium assembly	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of lamellipodium assembly	Cell division control protein 42 homolog	Homo sapiens (human)
substantia nigra development	Cell division control protein 42 homolog	Homo sapiens (human)
actin cytoskeleton organization	Cell division control protein 42 homolog	Homo sapiens (human)
macrophage differentiation	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of cell growth	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of cell migration	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of pseudopodium assembly	Cell division control protein 42 homolog	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of cytokinesis	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of actin cytoskeleton organization	Cell division control protein 42 homolog	Homo sapiens (human)
cell junction assembly	Cell division control protein 42 homolog	Homo sapiens (human)
adherens junction organization	Cell division control protein 42 homolog	Homo sapiens (human)
embryonic heart tube development	Cell division control protein 42 homolog	Homo sapiens (human)
dendritic cell migration	Cell division control protein 42 homolog	Homo sapiens (human)
neuropilin signaling pathway	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of neuron apoptotic process	Cell division control protein 42 homolog	Homo sapiens (human)
modulation by host of viral process	Cell division control protein 42 homolog	Homo sapiens (human)
establishment of epithelial cell apical/basal polarity	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of DNA replication	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of JNK cascade	Cell division control protein 42 homolog	Homo sapiens (human)
filopodium assembly	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of pinocytosis	Cell division control protein 42 homolog	Homo sapiens (human)
neuron fate determination	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of filopodium assembly	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of filopodium assembly	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of stress fiber assembly	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of stress fiber assembly	Cell division control protein 42 homolog	Homo sapiens (human)
establishment of Golgi localization	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of synapse structural plasticity	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of attachment of spindle microtubules to kinetochore	Cell division control protein 42 homolog	Homo sapiens (human)
heart contraction	Cell division control protein 42 homolog	Homo sapiens (human)
Wnt signaling pathway, planar cell polarity pathway	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of epithelial cell proliferation involved in lung morphogenesis	Cell division control protein 42 homolog	Homo sapiens (human)
submandibular salivary gland formation	Cell division control protein 42 homolog	Homo sapiens (human)
dendritic spine morphogenesis	Cell division control protein 42 homolog	Homo sapiens (human)
cellular response to type II interferon	Cell division control protein 42 homolog	Homo sapiens (human)
organelle transport along microtubule	Cell division control protein 42 homolog	Homo sapiens (human)
endothelin receptor signaling pathway involved in heart process	Cell division control protein 42 homolog	Homo sapiens (human)
actin filament branching	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of intracellular protein transport	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of modification of postsynaptic structure	Cell division control protein 42 homolog	Homo sapiens (human)
regulation of postsynapse organization	Cell division control protein 42 homolog	Homo sapiens (human)
modification of synaptic structure	Cell division control protein 42 homolog	Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreading	Cell division control protein 42 homolog	Homo sapiens (human)
endocytosis	Cell division control protein 42 homolog	Homo sapiens (human)
Cdc42 protein signal transduction	Cell division control protein 42 homolog	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Process	via Protein(s)	Taxonomy
GTPase activity	Cell division control protein 42 homolog	Homo sapiens (human)
G protein activity	Cell division control protein 42 homolog	Homo sapiens (human)
protein binding	Cell division control protein 42 homolog	Homo sapiens (human)
GTP binding	Cell division control protein 42 homolog	Homo sapiens (human)
protein kinase binding	Cell division control protein 42 homolog	Homo sapiens (human)
GTP-dependent protein binding	Cell division control protein 42 homolog	Homo sapiens (human)
mitogen-activated protein kinase kinase kinase binding	Cell division control protein 42 homolog	Homo sapiens (human)
thioesterase binding	Cell division control protein 42 homolog	Homo sapiens (human)
GBD domain binding	Cell division control protein 42 homolog	Homo sapiens (human)
apolipoprotein A-I receptor binding	Cell division control protein 42 homolog	Homo sapiens (human)
identical protein binding	Cell division control protein 42 homolog	Homo sapiens (human)
ubiquitin protein ligase activity	Cell division control protein 42 homolog	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Process	via Protein(s)	Taxonomy
centrosome	Cell division control protein 42 homolog	Homo sapiens (human)
Golgi membrane	Cell division control protein 42 homolog	Homo sapiens (human)
storage vacuole	Cell division control protein 42 homolog	Homo sapiens (human)
cytoplasm	Cell division control protein 42 homolog	Homo sapiens (human)
endoplasmic reticulum membrane	Cell division control protein 42 homolog	Homo sapiens (human)
cytosol	Cell division control protein 42 homolog	Homo sapiens (human)
plasma membrane	Cell division control protein 42 homolog	Homo sapiens (human)
cell-cell junction	Cell division control protein 42 homolog	Homo sapiens (human)
focal adhesion	Cell division control protein 42 homolog	Homo sapiens (human)
membrane	Cell division control protein 42 homolog	Homo sapiens (human)
secretory granule	Cell division control protein 42 homolog	Homo sapiens (human)
filopodium	Cell division control protein 42 homolog	Homo sapiens (human)
midbody	Cell division control protein 42 homolog	Homo sapiens (human)
leading edge membrane	Cell division control protein 42 homolog	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Cell division control protein 42 homolog	Homo sapiens (human)
neuron projection	Cell division control protein 42 homolog	Homo sapiens (human)
neuronal cell body	Cell division control protein 42 homolog	Homo sapiens (human)
dendritic spine	Cell division control protein 42 homolog	Homo sapiens (human)
apical part of cell	Cell division control protein 42 homolog	Homo sapiens (human)
phagocytic vesicle	Cell division control protein 42 homolog	Homo sapiens (human)
spindle midzone	Cell division control protein 42 homolog	Homo sapiens (human)
extracellular exosome	Cell division control protein 42 homolog	Homo sapiens (human)
mitotic spindle	Cell division control protein 42 homolog	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Cell division control protein 42 homolog	Homo sapiens (human)
glutamatergic synapse	Cell division control protein 42 homolog	Homo sapiens (human)
Golgi transport complex	Cell division control protein 42 homolog	Homo sapiens (human)
protein-containing complex	Cell division control protein 42 homolog	Homo sapiens (human)
dendritic spine	Cell division control protein 42 homolog	Homo sapiens (human)
plasma membrane	Cell division control protein 42 homolog	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay ID	Title	Year	Journal	Article
AID502946	Inhibition of GEF-independent nucleotide exchange activity of prenylated Cdc42 assessed as protein dissociation from RhoGD11 complex at 100 uM after 3 mins in presence of 4 mM Mg2+ chelator EDTA	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502947	Binding affinity to phosphatidylinositol 4,5-bisphosphate liposome at 50 uM by electron microscopy	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502930	Inhibition of GEF-independent nucleotide exchange activity of prenylated Cdc42 after 3 mins in presence of 4 mM Mg2+ chelator EDTA	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502922	Inhibition of CDC42-mediated actin polymerization in PIP2-stimulated Xenopus laevis egg extract after 6 mins by fluorescence assay	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502940	Inhibition of CDC42-mediated actin polymerization in PIP2-stimulated Xenopus laevis egg extract at 0.1 to 100 uM by fluorescence assay	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502927	Inhibition of Cdc42 binding to PIP2 liposomes at 100 uM after 10 mins	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502931	Inhibition of GEF-independent nucleotide exchange activity of nonprenylated Cdc42 at 100 uM after 10 mins in presence of 4 mM EDTA	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502932	Effect on Cdc42-mediated cellular response in human U373MG cells assessed as reorientation of golgi complex 15 uM after 6 hrs by epifluorescence assay	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502938	Effect on transferrin translocation from golgi complex to endoplasmic reticulum of african green monkey BSC1 cells at 12.5 uM after 2.5 hrs by epifluorescence microscopy	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502929	Increase in p75-GFP transport from golgi complex of MDCK cells at 10 uM after 20 mins by fluorescence assay	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502945	Effect on nucleotide binding activity of PIP2-stimulated Cdc42 at 25 uM by liquid scintillation counting	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502933	Inhibition of Cdc42 binding to rat liver golgi membrane at 10 to 150 uM by Western blot analysis	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502934	Inhibition of VSVG-EGFP anterograde transport from endoplasmic reticulum to golgi complex of african green monkey BSC1 cells at 12.5 uM after 3 hrs by epifluorescence microscopy	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502925	Effect on GST-PBD binding to recombinant nonprenylated Cdc42 in PIP2 liposome-stimulated Xenopus laevis egg extract at 50 uM by Western blot analysis	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502941	Inhibition of actin polymerization in N-WASP VCA-stimulated Xenopus laevis egg extract at 20 uM after 1.5 mins by fluorescence assay	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502921	Inhibition of VSVG-EGFP anterograde transport from endoplasmic reticulum to plasma membrane of african green monkey BSC1 cells after 3 hrs by epifluorescence microscopy	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502944	Effect on GEF interaction with PIP2-stimulated Cdc42 at 25 uM by liquid scintillation counting	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502936	Inhibition of GST-PBD binding to Cdc42 in Xenopus laevis egg extract assessed as Cdc42(GTPgammasS) activation at 50 uM treated before addition of GST-PBD by Western blot analysis	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502924	Inhibition of PIP2 liposome-stimulated Cdc42 activation in Xenopus laevis egg extract assessed as inhibition of association of Cdc42(GTPgammaS) with GST-PBD at 1 to 25 uM by Western blot analysis	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502948	Binding affinity to phosphatidylinositol 4,5-bisphosphate liposome assessed as dynamin2-stimulated GTP hydrolysis at 25 uM by scintillation counting	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502937	Effect on perinuclear localization of trans-Golgi network in african green monkey BSC1 cells at 12.5 uM after 2.5 hrs by epifluorescence microscopy	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502935	Inhibition of GST-PBD binding to Cdc42 in Xenopus laevis egg extract assessed as Cdc42(GTPgammasS) activation at 50 uM treated after addition of GST-PBD by Western blot analysis	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502928	Decrease in NCAM-GFP transport from golgi complex of MDCK cells at 10 uM after 20 mins by fluorescence assay	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502939	Effect on transferrin endocytosis in african green monkey BSC1 cells at 12.5 uM after 2.5 hrs by epifluorescence microscopy	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502943	Inhibition of nucleotide exchange activity of PIP2-stimulated Cdc42 at 25 uM by liquid scintillation counting	2006	Nature chemical biology, Jan, Volume: 2, Issue:1	Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (62.50)	29.6817
2010's	2 (25.00)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.33 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.52 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.33)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (12.50%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (87.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
framycetin Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.	2.03	1	aminoglycoside	allergen; antibacterial drug; Escherichia coli metabolite
galantamine Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.	2.03	1	benzazepine alkaloid fundamental parent; benzazepine alkaloid; organic heterotetracyclic compound; tertiary amino compound	antidote to curare poisoning; cholinergic drug; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; plant metabolite
thiazolidines Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.	2.06	1	thiazolidine
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	2.04	1	iditol	fungal metabolite
latrunculin a latrunculin A: 16-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica; see also latrunculin B; structure given in first source. latrunculin A : A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.	2.06	1	cyclic hemiketal; macrolide; oxabicycloalkane; thiazolidinone	actin polymerisation inhibitor; metabolite; toxin
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	3.41	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
latrunculin b latrunculin B: 14-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica; see also latrunculin A; structure given in first source. latrunculin B : A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.	2.03	1	cyclic hemiketal; macrolide; oxabicycloalkane; thiazolidinone	actin polymerisation inhibitor; metabolite; toxin
nsc 23766 NSC 23766 trihydrochloride : A hydrochloride resulting from the formal reaction of NSC 23766 with 3 mol eq. of hydrogen chloride. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).. Rac1 inhibitor : Any inhibitor of Rac1.	3.63	2	hydrochloride	antiviral agent; apoptosis inducer; EC 3.6.5.2 (small monomeric GTPase) inhibitor; muscarinic antagonist
cytochalasin d Cytochalasin D: A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.. cytochalasin D : An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.	2.04	1

Condition	Indicated	Relationship Strength	Studies	Trials
Benign Neoplasms [description not available]	0	3.23	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	0	3.23	1	0

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