Page last updated: 2024-11-12

secramine a

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Description

secramine A: inhibits VSVG transport from the Golgi to the plasma membrane; also inhibits Cdc42-dependent cell functions; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10372387
CHEMBL ID1222038
MeSH IDM0496369

Synonyms (7)

Synonym
secramine
CHEMBL1222038 ,
secramine a
PROBES2_000397
PROBES1_000057
bdbm50324672
[(1r,3s,12r,14e,16r)-9-bromo-8-(cyclopropylmethoxy)-16-[(4-methoxyphenyl)methylsulfanyl]-14-phenylmethoxyimino-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6,8,10(17)-trien-3-yl]methanol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cell division control protein 42 homologHomo sapiens (human)IC50 (µMol)9.00002.00005.50009.0000AID502930
Cell division control protein 42 homolog Xenopus laevis (African clawed frog)IC50 (µMol)1.00001.00001.00001.0000AID502922
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (59)

Processvia Protein(s)Taxonomy
sprouting angiogenesisCell division control protein 42 homologHomo sapiens (human)
cardiac conduction system developmentCell division control protein 42 homologHomo sapiens (human)
cardiac neural crest cell migration involved in outflow tract morphogenesisCell division control protein 42 homologHomo sapiens (human)
phagocytosis, engulfmentCell division control protein 42 homologHomo sapiens (human)
actin filament organizationCell division control protein 42 homologHomo sapiens (human)
Golgi organizationCell division control protein 42 homologHomo sapiens (human)
regulation of mitotic nuclear divisionCell division control protein 42 homologHomo sapiens (human)
nuclear migrationCell division control protein 42 homologHomo sapiens (human)
establishment or maintenance of cell polarityCell division control protein 42 homologHomo sapiens (human)
integrin-mediated signaling pathwayCell division control protein 42 homologHomo sapiens (human)
protein localizationCell division control protein 42 homologHomo sapiens (human)
regulation of lamellipodium assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of lamellipodium assemblyCell division control protein 42 homologHomo sapiens (human)
substantia nigra developmentCell division control protein 42 homologHomo sapiens (human)
actin cytoskeleton organizationCell division control protein 42 homologHomo sapiens (human)
macrophage differentiationCell division control protein 42 homologHomo sapiens (human)
positive regulation of cell growthCell division control protein 42 homologHomo sapiens (human)
positive regulation of cell migrationCell division control protein 42 homologHomo sapiens (human)
positive regulation of pseudopodium assemblyCell division control protein 42 homologHomo sapiens (human)
negative regulation of protein-containing complex assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of cytokinesisCell division control protein 42 homologHomo sapiens (human)
regulation of actin cytoskeleton organizationCell division control protein 42 homologHomo sapiens (human)
cell junction assemblyCell division control protein 42 homologHomo sapiens (human)
adherens junction organizationCell division control protein 42 homologHomo sapiens (human)
embryonic heart tube developmentCell division control protein 42 homologHomo sapiens (human)
dendritic cell migrationCell division control protein 42 homologHomo sapiens (human)
neuropilin signaling pathwayCell division control protein 42 homologHomo sapiens (human)
positive regulation of neuron apoptotic processCell division control protein 42 homologHomo sapiens (human)
modulation by host of viral processCell division control protein 42 homologHomo sapiens (human)
establishment of epithelial cell apical/basal polarityCell division control protein 42 homologHomo sapiens (human)
positive regulation of DNA replicationCell division control protein 42 homologHomo sapiens (human)
positive regulation of JNK cascadeCell division control protein 42 homologHomo sapiens (human)
filopodium assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of pinocytosisCell division control protein 42 homologHomo sapiens (human)
neuron fate determinationCell division control protein 42 homologHomo sapiens (human)
regulation of filopodium assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of filopodium assemblyCell division control protein 42 homologHomo sapiens (human)
regulation of stress fiber assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of stress fiber assemblyCell division control protein 42 homologHomo sapiens (human)
establishment of Golgi localizationCell division control protein 42 homologHomo sapiens (human)
positive regulation of synapse structural plasticityCell division control protein 42 homologHomo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionCell division control protein 42 homologHomo sapiens (human)
regulation of attachment of spindle microtubules to kinetochoreCell division control protein 42 homologHomo sapiens (human)
heart contractionCell division control protein 42 homologHomo sapiens (human)
Wnt signaling pathway, planar cell polarity pathwayCell division control protein 42 homologHomo sapiens (human)
positive regulation of epithelial cell proliferation involved in lung morphogenesisCell division control protein 42 homologHomo sapiens (human)
submandibular salivary gland formationCell division control protein 42 homologHomo sapiens (human)
dendritic spine morphogenesisCell division control protein 42 homologHomo sapiens (human)
cellular response to type II interferonCell division control protein 42 homologHomo sapiens (human)
organelle transport along microtubuleCell division control protein 42 homologHomo sapiens (human)
endothelin receptor signaling pathway involved in heart processCell division control protein 42 homologHomo sapiens (human)
actin filament branchingCell division control protein 42 homologHomo sapiens (human)
positive regulation of intracellular protein transportCell division control protein 42 homologHomo sapiens (human)
regulation of modification of postsynaptic structureCell division control protein 42 homologHomo sapiens (human)
regulation of postsynapse organizationCell division control protein 42 homologHomo sapiens (human)
modification of synaptic structureCell division control protein 42 homologHomo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreadingCell division control protein 42 homologHomo sapiens (human)
endocytosisCell division control protein 42 homologHomo sapiens (human)
Cdc42 protein signal transductionCell division control protein 42 homologHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Processvia Protein(s)Taxonomy
GTPase activityCell division control protein 42 homologHomo sapiens (human)
G protein activityCell division control protein 42 homologHomo sapiens (human)
protein bindingCell division control protein 42 homologHomo sapiens (human)
GTP bindingCell division control protein 42 homologHomo sapiens (human)
protein kinase bindingCell division control protein 42 homologHomo sapiens (human)
GTP-dependent protein bindingCell division control protein 42 homologHomo sapiens (human)
mitogen-activated protein kinase kinase kinase bindingCell division control protein 42 homologHomo sapiens (human)
thioesterase bindingCell division control protein 42 homologHomo sapiens (human)
GBD domain bindingCell division control protein 42 homologHomo sapiens (human)
apolipoprotein A-I receptor bindingCell division control protein 42 homologHomo sapiens (human)
identical protein bindingCell division control protein 42 homologHomo sapiens (human)
ubiquitin protein ligase activityCell division control protein 42 homologHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Processvia Protein(s)Taxonomy
centrosomeCell division control protein 42 homologHomo sapiens (human)
Golgi membraneCell division control protein 42 homologHomo sapiens (human)
storage vacuoleCell division control protein 42 homologHomo sapiens (human)
cytoplasmCell division control protein 42 homologHomo sapiens (human)
endoplasmic reticulum membraneCell division control protein 42 homologHomo sapiens (human)
cytosolCell division control protein 42 homologHomo sapiens (human)
plasma membraneCell division control protein 42 homologHomo sapiens (human)
cell-cell junctionCell division control protein 42 homologHomo sapiens (human)
focal adhesionCell division control protein 42 homologHomo sapiens (human)
membraneCell division control protein 42 homologHomo sapiens (human)
secretory granuleCell division control protein 42 homologHomo sapiens (human)
filopodiumCell division control protein 42 homologHomo sapiens (human)
midbodyCell division control protein 42 homologHomo sapiens (human)
leading edge membraneCell division control protein 42 homologHomo sapiens (human)
cytoplasmic ribonucleoprotein granuleCell division control protein 42 homologHomo sapiens (human)
neuron projectionCell division control protein 42 homologHomo sapiens (human)
neuronal cell bodyCell division control protein 42 homologHomo sapiens (human)
dendritic spineCell division control protein 42 homologHomo sapiens (human)
apical part of cellCell division control protein 42 homologHomo sapiens (human)
phagocytic vesicleCell division control protein 42 homologHomo sapiens (human)
spindle midzoneCell division control protein 42 homologHomo sapiens (human)
extracellular exosomeCell division control protein 42 homologHomo sapiens (human)
mitotic spindleCell division control protein 42 homologHomo sapiens (human)
Schaffer collateral - CA1 synapseCell division control protein 42 homologHomo sapiens (human)
glutamatergic synapseCell division control protein 42 homologHomo sapiens (human)
Golgi transport complexCell division control protein 42 homologHomo sapiens (human)
protein-containing complexCell division control protein 42 homologHomo sapiens (human)
dendritic spineCell division control protein 42 homologHomo sapiens (human)
plasma membraneCell division control protein 42 homologHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID502946Inhibition of GEF-independent nucleotide exchange activity of prenylated Cdc42 assessed as protein dissociation from RhoGD11 complex at 100 uM after 3 mins in presence of 4 mM Mg2+ chelator EDTA2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502947Binding affinity to phosphatidylinositol 4,5-bisphosphate liposome at 50 uM by electron microscopy2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502930Inhibition of GEF-independent nucleotide exchange activity of prenylated Cdc42 after 3 mins in presence of 4 mM Mg2+ chelator EDTA2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502922Inhibition of CDC42-mediated actin polymerization in PIP2-stimulated Xenopus laevis egg extract after 6 mins by fluorescence assay2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502940Inhibition of CDC42-mediated actin polymerization in PIP2-stimulated Xenopus laevis egg extract at 0.1 to 100 uM by fluorescence assay2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502927Inhibition of Cdc42 binding to PIP2 liposomes at 100 uM after 10 mins2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502931Inhibition of GEF-independent nucleotide exchange activity of nonprenylated Cdc42 at 100 uM after 10 mins in presence of 4 mM EDTA2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502932Effect on Cdc42-mediated cellular response in human U373MG cells assessed as reorientation of golgi complex 15 uM after 6 hrs by epifluorescence assay2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502938Effect on transferrin translocation from golgi complex to endoplasmic reticulum of african green monkey BSC1 cells at 12.5 uM after 2.5 hrs by epifluorescence microscopy2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502929Increase in p75-GFP transport from golgi complex of MDCK cells at 10 uM after 20 mins by fluorescence assay2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502945Effect on nucleotide binding activity of PIP2-stimulated Cdc42 at 25 uM by liquid scintillation counting2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502933Inhibition of Cdc42 binding to rat liver golgi membrane at 10 to 150 uM by Western blot analysis2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502934Inhibition of VSVG-EGFP anterograde transport from endoplasmic reticulum to golgi complex of african green monkey BSC1 cells at 12.5 uM after 3 hrs by epifluorescence microscopy2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502925Effect on GST-PBD binding to recombinant nonprenylated Cdc42 in PIP2 liposome-stimulated Xenopus laevis egg extract at 50 uM by Western blot analysis2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502941Inhibition of actin polymerization in N-WASP VCA-stimulated Xenopus laevis egg extract at 20 uM after 1.5 mins by fluorescence assay2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502921Inhibition of VSVG-EGFP anterograde transport from endoplasmic reticulum to plasma membrane of african green monkey BSC1 cells after 3 hrs by epifluorescence microscopy2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502944Effect on GEF interaction with PIP2-stimulated Cdc42 at 25 uM by liquid scintillation counting2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502936Inhibition of GST-PBD binding to Cdc42 in Xenopus laevis egg extract assessed as Cdc42(GTPgammasS) activation at 50 uM treated before addition of GST-PBD by Western blot analysis2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502924Inhibition of PIP2 liposome-stimulated Cdc42 activation in Xenopus laevis egg extract assessed as inhibition of association of Cdc42(GTPgammaS) with GST-PBD at 1 to 25 uM by Western blot analysis2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502948Binding affinity to phosphatidylinositol 4,5-bisphosphate liposome assessed as dynamin2-stimulated GTP hydrolysis at 25 uM by scintillation counting2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502937Effect on perinuclear localization of trans-Golgi network in african green monkey BSC1 cells at 12.5 uM after 2.5 hrs by epifluorescence microscopy2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502935Inhibition of GST-PBD binding to Cdc42 in Xenopus laevis egg extract assessed as Cdc42(GTPgammasS) activation at 50 uM treated after addition of GST-PBD by Western blot analysis2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502928Decrease in NCAM-GFP transport from golgi complex of MDCK cells at 10 uM after 20 mins by fluorescence assay2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502939Effect on transferrin endocytosis in african green monkey BSC1 cells at 12.5 uM after 2.5 hrs by epifluorescence microscopy2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
AID502943Inhibition of nucleotide exchange activity of PIP2-stimulated Cdc42 at 25 uM by liquid scintillation counting2006Nature chemical biology, Jan, Volume: 2, Issue:1
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.33 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.52 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]