ID Source | ID |
---|---|
PubMed CID | 72813 |
CHEMBL ID | 610198 |
SCHEMBL ID | 1461789 |
MeSH ID | M0074200 |
Synonym |
---|
HMS2612K09 |
1-fenyl-4,5-dichlor-6-pyridazinon |
wln: t6nnvj br& dg eg |
nsc-224369 |
NCI60_014437 |
NCI60_001850 |
nsc-642642 |
3(2h)-pyridazinone,5-dichloro-2-phenyl- |
4,5-dichloro-2-phenyl-2h-pyridazin-3-one |
MLS000332063 |
smr000221555 |
4,5-dichloro-2,3-dihydro-2-phenylpyridazin-3-one |
einecs 216-917-6 |
nsc 642642 |
3(2h)-pyridazinone, 4,5-dichloro-2-phenyl- |
nsc 224369 |
4,5-dichloro-2-phenyl-3(2h)-pyridazinone |
ai3-18651 |
brn 0175852 |
2-phenyl-4,5-dichloro-3-pyridazinone |
1-fenyl-4,5-dichlor-6-pyridazinon [czech] |
nsc224369 |
1698-53-9 |
nsc642642 |
4,5-dichloro-2-phenyl-pyridazin-3-one |
4,5-dichloro-2-phenylpyridazin-3-one |
2(2h)-pyridazinone, 4,5-dichloro-2-phenyl- |
CHEMDIV2_002909 , |
STK350677 |
4,5-dichloro-2-phenylpyridazin-3(2h)-one , |
1-phenyl-4,5-dichloro-6-pyridazone, >=99% |
pyridazinone, 2-42 |
bdbm33355 |
cid_72813 |
AKOS000313144 |
HMS1377E05 |
CHEMBL610198 |
AC-907/34127045 |
4,5-dichloro-2-cyclohexa-1,3-dien-1-yl-pyridazin-3-one;4,5-dichloro-2-phenylpyridazin-3(2h)-one |
A811147 |
4,5-dichloro-2-phenyl-2,3-dihydropyridazin-3-one |
NCGC00246299-01 |
1-phenyl-4,5-dichloro-6-pyridazone |
SCHEMBL1461789 |
CCG-129262 |
5-24-02-00024 (beilstein handbook reference) |
unii-n78ah78wrv |
n78ah78wrv , |
3(2h)-pyridazinone,4,5-dichloro-2-phenyl- |
FT-0617168 |
5M-603S |
4,5-dichlor-2-phenyl-3(2h)-pyridazinon |
4,5-dichloro-1-phenylpyridaz-6-one |
2-phenyl-4,5-dichloro-3(2h)-pyridazinone |
1-phenyl-4,5-dichloropyridazin-6-one |
4,5-dichloro-2-phenyl-pyridazinone |
4,5-dichloro-2-phenyl-3(2h)-pyridazinone # |
J-640178 |
1-phenyl-4,5-dichloro-5-pyridazone |
W-109120 |
AC-27715 |
HMS3438D08 |
DTXSID60168751 |
J-800179 |
SR-01000403864-1 |
sr-01000403864 |
mfcd00006470 |
CS-0128769 |
D71015 |
SY101526 |
EN300-02004 |
D5325 |
Z56851285 |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0032 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
Nrf2 | Homo sapiens (human) | Potency | 3.1623 | 0.0920 | 8.2222 | 23.1093 | AID624171 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 0.1000 | 20.8793 | 79.4328 | AID588453 |
ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.3564 | 0.0041 | 10.8903 | 31.5287 | AID504467 |
TDP1 protein | Homo sapiens (human) | Potency | 3.0868 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
Microtubule-associated protein tau | Homo sapiens (human) | Potency | 31.6228 | 0.1800 | 13.5574 | 39.8107 | AID1460 |
thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 0.1000 | 22.9075 | 100.0000 | AID485364 |
Smad3 | Homo sapiens (human) | Potency | 35.4813 | 0.0052 | 7.8098 | 29.0929 | AID588855 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 12.5893 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
P53 | Homo sapiens (human) | Potency | 3.1623 | 0.0731 | 9.6858 | 31.6228 | AID504706 |
IDH1 | Homo sapiens (human) | Potency | 4.1095 | 0.0052 | 10.8652 | 35.4813 | AID686970 |
NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 3.1623 | 0.0126 | 2.4518 | 25.0177 | AID485313 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 5.6234 | 0.0100 | 39.5371 | 1,122.0200 | AID1479 |
nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 18.3564 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 70.7946 | 3.5481 | 19.5427 | 44.6684 | AID743266 |
huntingtin isoform 2 | Homo sapiens (human) | Potency | 8.9125 | 0.0006 | 18.4198 | 1,122.0200 | AID1688 |
ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.7079 | 0.0002 | 2.6215 | 31.4954 | AID485297 |
urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 3.5481 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
plasminogen precursor | Mus musculus (house mouse) | Potency | 3.5481 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 3.5481 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 10.6101 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
geminin | Homo sapiens (human) | Potency | 3.8860 | 0.0046 | 11.3741 | 33.4983 | AID624296; AID624297 |
survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 0.1259 | 12.2344 | 35.4813 | AID1458 |
muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 0.0041 | 9.9625 | 28.1838 | AID2675 |
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 0.0580 | 10.6949 | 26.6086 | AID602310 |
Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 2.5119 | 4.4668 | 8.3448 | 10.0000 | AID624291 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Sphingosine-1-phosphate receptor 4 | Homo sapiens (human) | IC50 (µMol) | 1.8600 | 0.0890 | 0.7015 | 2.0290 | AID1692 |
XBP1 | Homo sapiens (human) | IC50 (µMol) | 5.2300 | 0.1600 | 5.4049 | 10.0000 | AID504313 |
caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 (µMol) | 49.7470 | 0.6215 | 4.0504 | 6.6330 | AID651553 |
sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | IC50 (µMol) | 8.7060 | 1.4180 | 4.6494 | 8.7060 | AID1821 |
receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 (µMol) | 49.7470 | 0.6215 | 4.0504 | 6.6330 | AID651553 |
DNA damage-inducible transcript 3 protein | Mus musculus (house mouse) | IC50 (µMol) | 9.4500 | 0.1600 | 3.9959 | 10.0000 | AID504322 |
Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 (µMol) | 49.7470 | 0.7091 | 5.0549 | 7.7510 | AID651552 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Hsf1 protein | Mus musculus (house mouse) | EC50 (µMol) | 5.4480 | 0.1600 | 24.4900 | 236.5000 | AID2382 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
PAX8 | Homo sapiens (human) | AC50 | 6.1000 | 0.0488 | 5.4354 | 69.1700 | AID687027 |
MSH | Drosophila melanogaster (fruit fly) | AC50 | 16.3100 | 0.2090 | 9.5788 | 48.6900 | AID743444 |
Microphthalmia-associated transcription factor | Homo sapiens (human) | AC50 | 11.6556 | 0.0150 | 10.9049 | 46.0480 | AID493073; AID493102; AID493177; AID493191; AID540346 |
Hsf1 protein | Mus musculus (house mouse) | AC50 | 14.4030 | 0.1710 | 30.8718 | 167.9780 | AID493085 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
hormone activity | Glycoprotein hormones alpha chain | Homo sapiens (human) |
protein binding | Glycoprotein hormones alpha chain | Homo sapiens (human) |
follicle-stimulating hormone activity | Glycoprotein hormones alpha chain | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
extracellular region | Glycoprotein hormones alpha chain | Homo sapiens (human) |
extracellular space | Glycoprotein hormones alpha chain | Homo sapiens (human) |
Golgi lumen | Glycoprotein hormones alpha chain | Homo sapiens (human) |
follicle-stimulating hormone complex | Glycoprotein hormones alpha chain | Homo sapiens (human) |
pituitary gonadotropin complex | Glycoprotein hormones alpha chain | Homo sapiens (human) |
extracellular space | Glycoprotein hormones alpha chain | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
AID1640019 | Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent | 2018 | Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419 | Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. |
AID1640018 | Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent | 2018 | Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419 | Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. |
AID453287 | Inhibition of Staphylococcus aureus sortase A deltaN59 mutant assessed as Dap(Dnp) hydrolysis by FRET assay | 2009 | Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20 | Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. |
AID1799237 | Fluorescence Resonance Energy Transfer (FRET) Assay from Article 10.1016/j.bmc.2009.08.067: \\Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.\\ | 2009 | Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20 | Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (10.00) | 18.7374 |
1990's | 1 (10.00) | 18.2507 |
2000's | 2 (20.00) | 29.6817 |
2010's | 5 (50.00) | 24.3611 |
2020's | 1 (10.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 10 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |