| Assay ID | Title | Year | Journal | Article |
|---|
| AID1063748 | Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898769 | Inhibition of recombinant human Cathepsin B in African green monkey Vero E6 using Z-Phe-Arg-AMC as substrate for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1405437 | Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1063734 | Irreversible inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate assessed as residual activity at 10 fold IC50 preincubated for 30 mins followed by 100 fold dilution measured for 2 hrs by fluorescence assay | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1063749 | Inhibition of recombinant human Cathepsin L assessed as inhibition of activity-based probe DCG-04 labelling preincubated for 30 mins followed by DCG-04 addition measured after 30 mins | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898770 | Inhibition of recombinant human Cathepsin B expressed in African green monkey Vero E6 using Z-Phe-Arg-AMC as substrate followed by CA-074 addition incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID423033 | Cytotoxicity against human NCI-H460 cells at 16.9 uM | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1
| Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. |
| AID1405436 | Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1898752 | Inhibition of human recombinant Cathepsin S assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1063743 | Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898758 | Inhibition of human recombinant Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1405434 | Antiproliferative activity against mouse 4T1 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1526363 | Inhibition of human cathepsin L assessed as Kinact /Ki ratio using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometry | | | |
| AID1171534 | Inhibition of FP1 in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysis | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. |
| AID1526369 | Cytotoxicity in mouse C2C12 cells assessed as reduction in cell viability incubated for 3 days | | | |
| AID1898751 | Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898761 | Inhibition of human recombinant Cathepsin L assessed as ratio of Kinact/Kiapp using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID423031 | Antileishmanial activity against Leishmania donovani | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1
| Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. |
| AID1063740 | Selectivity index, ratio of IC50 for human Cathepsin V to IC50 for recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898768 | Inhibition of SARS-CoV-2 PLpro at 10 uM assessed as remaining activity using Z-RLRGG-AMC as substrate at 10 uM incubated for 15 mins followed by substrate addition by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898764 | Cytotoxicity against cells African green monkey Vero E6 cells incubated for 24 to 72 hrs by alamar blue assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1902912 | Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysis | 2022 | Journal of medicinal chemistry, 03-10, Volume: 65, Issue:5
| Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against |
| AID1526367 | Antitrypanosomal activity against Trypanosoma cruzi amastigote stage forms infected in mouse C2C12 cells incubated for 3 days by 4',6-diamidino-2-phenylindole staining based microscopy | | | |
| AID1405430 | Antiproliferative activity against human HeLa cells | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1898759 | Inhibition of human recombinant Cathepsin B assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898781 | Inhibition of recombinant human Cathepsin L in African green monkey Vero E6 at 20 uM using Z-Phe-Arg-AMC as substrate for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898763 | Inhibition of mouse Cathepsin L assessed as ratio of Kinact/Kiapp using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1405431 | Antiproliferative activity against human HT-29 cells | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1063739 | Selectivity index, ratio of IC50 for human Cathepsin V to IC50 for recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898777 | Inhibition of recombinant human furin assessed as remaining activity at 50 uM using pERTKR-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1171537 | Inhibition of FP3 in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysis | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. |
| AID1898750 | Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898754 | Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre incubated for 30 minutes followed by viral infection and measured after 72 hrs by Nucblue dye based fluorometric analysis | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1063742 | Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrate | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1405433 | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1898748 | Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral entry at 0.5 uM for >= 60 mins post infection by Alexa Fluor 488 and Hoechst dye based fluorescence microscopy | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898767 | Inhibition of SARS-CoV-2 main protease assessed as remaining activity using Mu-HSSKLQ-AMC as substrate at 10 uM incubated for 15 mins followed by substrate addition by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID423029 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1
| Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. |
| AID1526365 | Irreversible inhibition of human cathepsin L assessed as residual enzyme activity using fluorogenic substrate cbz-FR-AMC incubated for 30 mins followed by 100 fold dilution and measured after 1 hrs by spectrophotometry | | | |
| AID1898765 | Anti viral activity against SARS-CoV-2 infected in African green monkey veroE6 assessed as reduction in viral load | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID423030 | Cytotoxicity against african green monkey Vero cells | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1
| Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. |
| AID1898780 | Inhibition of recombinant human TMPRSS2 assessed as remaining activity at 50 uM using Boc-QAR-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID423034 | Cytotoxicity against mouse Neuro2a cells at 16.9 uM | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1
| Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. |
| AID1898762 | Inhibition of human recombinant Cathepsin B assessed as ratio of Kinact/Kiapp using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1063741 | Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1902914 | Cytotoxicity against mouse C2C12 cells assessed as lethal dose | 2022 | Journal of medicinal chemistry, 03-10, Volume: 65, Issue:5
| Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against |
| AID1063737 | Selectivity index, ratio of IC50 for human Cathepsin B to IC50 for recombinant human Cathepsin L after 30 mins using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898766 | Antiviral activity against SARS-CoV-2 infected in human A549 cells overexpressing ACE2 assessed as reduction in virus-induced cytopathic effect at 625 nM incubated for 1 hr followed by viral infection measured after 96 hrs by inverted microscopy | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898779 | Antiviral activity against SARS-CoV-2 infected in human MRC5 cells expressing ACE2/TMPRSS2 assessed as inhibition of viral entry at 32 uM | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1063738 | Selectivity index, ratio of IC50 for human Cathepsin B to IC50 for recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898776 | Binding affinity to Cathepsin L in African green monkey VeroE6 cell lysates assessed as covalent adducts by quantitative mass spectrometry | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1526368 | Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence based assay | | | |
| AID1526364 | Irreversible inhibition of human cathepsin L assessed as residual enzyme activity using fluorogenic substrate cbz-FR-AMC incubated for 30 mins followed by 100 fold dilution and measured after 2 hrs by spectrophotometry | | | |
| AID1063744 | Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrate | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1405435 | Antiproliferative activity against human A375 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1898755 | Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898756 | Inhibition of human recombinant Cathepsin B assessed as Kinact using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1526361 | Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometry | | | |
| AID1526360 | Inhibition of human cathepsin L | | | |
| AID1898783 | Synergistic antiviral activity against SARS-CoV-2 infected in human HEK293 cells expressing TMPRSS2 as inhibition of viral entry in presence of Na-famostat mesylate | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1171533 | Antiplasmodial activity against Plasmodium falciparum 3D7 | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. |
| AID1063735 | Irreversible inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate assessed as residual activity at 10 fold IC50 preincubated for 30 mins followed by 100 fold dilution measured immediately after dilution by fluoresce | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1063746 | Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1171535 | Inhibition of FP2 in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysis | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. |
| AID1898775 | Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral entry at 0.5 uM pretreated for 30 mins with cells followed by viral infection and measured after 24 hrs post infection by Alexa Fluor 488 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898782 | Antiviral activity against SARS-CoV-2 infected in Vero E6 cells assessed as inhibition of viral entry at 0.5 uM and measured after 24 hrs post infection by Alexa Fluor 488 and Hoechst dye based fluorescence microscopy | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898774 | Antiviral activity against SARS-CoV-2 infected in human HEK293 cells expressing TMPRSS2 as inhibition of viral entry | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898749 | Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898757 | Inhibition of mouse Cathepsin L assessed as Kinact using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1405432 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1063745 | Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1171536 | Inhibition of FP2' in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysis | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. |
| AID1063747 | Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID423032 | Antitrypanosomal activity against Trypanosoma cruzi at 16.9 uM | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1
| Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. |
| AID1898771 | Inhibition of recombinant human Cathepsin B expressed in huamn A549 using Z-Phe-Arg-AMC as substrate incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898753 | Inhibition of human recombinant Cathepsin K assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1405438 | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. |
| AID1898773 | Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero E6 cells expressing TMPRSS2 as inhibition of viral entry | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1898760 | Inhibition of mouse Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| AID1063736 | Irreversible inhibition of recombinant human cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1
| The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. |
| AID1898772 | Inhibition of recombinant human Cathepsin B expressed in human A549 using Z-Phe-Arg-AMC as substrate followed by CA-074 addition incubated for 30 mins by fluorometric assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |