| Assay ID | Title | Year | Journal | Article |
|---|
| AID605662 | Displacement of biotinylated-TN14003 from CXCL12 binding site of CXCR4 in human MDA-MB-231 cells assessed as concentration required to inhibit >50% using rhodamine staining | 2010 | Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
| Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
| AID605664 | Antagonist activity at CXCR4 in human MDA-MB-231 cells assessed as inhibition of CXCL12-mediated cell invasion at 10 nM by madrigal cell invasion assay | 2010 | Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
| Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
| AID1564384 | Toxicity in C57BL/6J mouse at 10 mg/kg, ip | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | Synthesis and evaluation of 2,5-furan, 2,5-thiophene and 3,4-thiophene-based derivatives as CXCR4 inhibitors. |
| AID1574050 | Inhibition of CXCR4-mediated chemotaxis in human MDA-MB-231 cells assessed as reduction in CXCL12alpha-induced cell invasion at 100 nM after 22 hrs by hematoxylin/eosin dye-based matrigel assay relative to control | 2019 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2
| Synthesis and evaluation of 2,5-diamino and 2,5-dianilinomethyl pyridine analogues as potential CXCR4 antagonists. |
| AID303357 | Displacement of biotinylated TN14003 from CXCR4 in MDA-MB-231 cells | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of small molecule CXCR4 antagonists. |
| AID604429 | Antagonist activity at human CCR5 expressed in human U87 cells expressing CD4 assessed as inhibition of CCL5-induced cAMP production pretreated for 15 mins before forskolin challenge by TR-FRET analysis | 2010 | Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
| Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
| AID605663 | Antagonist activity at CXCR4 in human MDA-MB-231 cells assessed as inhibition of CXCL12-mediated cell invasion at 100 nM by madrigal cell invasion assay | 2010 | Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
| Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
| AID604428 | Antagonist activity at human CCR3 expressed in human U87 cells expressing CD4 assessed as inhibition of CCL5-induced cAMP production pretreated for 15 mins before forskolin challenge by TR-FRET analysis | 2010 | Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
| Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
| AID1574049 | Inhibition of biotinylated TN14003 binding to CXCR4 in human MDA-MB-231 cells preincubated for 10 mins followed by biotinylated-TN14003 addition measured after 30 mins by streptavidin-rhodamine staining based fluorescence microscopic analysis | 2019 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2
| Synthesis and evaluation of 2,5-diamino and 2,5-dianilinomethyl pyridine analogues as potential CXCR4 antagonists. |
| AID1564383 | Antiinflammatory activity in C57BL/6J mouse assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg, ip daily dosed 30 mins after carrageenan challenge and measured after 74 hrs carrageenan challenge and 2 hrs post last dose by caliper method | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | Synthesis and evaluation of 2,5-furan, 2,5-thiophene and 3,4-thiophene-based derivatives as CXCR4 inhibitors. |
| AID303358 | Antagonist activity at CXCR4 in human U87 cells assessed as inhibition of SDF1-induced modulation of cAMP production by TR-FRET assay | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of small molecule CXCR4 antagonists. |
| AID604427 | Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated for 15 mins before forskolin challenge by TR-FRET analysis | 2010 | Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
| Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
| AID1501134 | Binding affinity to CXCR4 in human MDA-MB-231 cells preincubated for 15 mins followed by biotinylated TN41003 addition measured after 30 mins by rhodamine staining-based assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics. |
| AID604430 | Antiinflammatory activity in C57BL/6L mouse assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg, ip administered 30 mins before carrageenan challenge measured after 76 hrs | 2010 | Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
| Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
| AID303359 | Inhibition of SDF1-mediated invasion of human MDA-MB-231 cells | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of small molecule CXCR4 antagonists. |
| AID1574051 | Antiinflammatory activity in C57Bl/6J mouse assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg, ip treated for 2 days measured 2 hrs post last dose by caliper method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2
| Synthesis and evaluation of 2,5-diamino and 2,5-dianilinomethyl pyridine analogues as potential CXCR4 antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |