| Assay ID | Title | Year | Journal | Article |
|---|
| AID196019 | In vivo number of rotations at a dose of 2 mg/kg administered subcutaneously to Sprague-Dawley rats | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| (+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist. |
| AID63066 | Binding affinity to human Dopamine receptor D2 by using radioligand [3H]spiperone in LTK cells | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID62918 | Binding affinity against cloned human Dopamine receptor D2 using [3H]spiperone as radioligand transfected in HEK cells | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID37373 | In vitro binding affinity against adrenergic Alpha-2 adrenergic receptor from rat cortical membrane using [3H]rauwolscine as radioligand | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID62748 | Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D2 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID61862 | In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID229081 | Ratio of ED50(seizures) to that of ED50(rotation) | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID230016 | Ratio of Ki for human dopamine-2(D-2) and dopamine-1(D-1) receptors | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID176653 | Subcutaneous dose at which one half of the test animals (rats) exhibit at least 50 net contralateral rotations in 30 min in vivo | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID63341 | Intrinsic activity relative against Dopamine receptor D1. | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID63348 | Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID114379 | Subcutaneous dose at which one half of the test animals (mice) display seizure-like behaviors in vivo | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID64301 | In vitro binding affinity against Dopamine receptor D2 like from rat caudate membrane using [3H]-spiperone as radioligand | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID61858 | Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID63338 | Intrinsic activity relative to dopamine for human Dopamine receptor D1 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID196018 | In vivo number of rotations at a dose of 0.2 mg/kg administered subcutaneously to Sprague-Dawley rats | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| (+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist. |
| AID63211 | Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID63212 | Potency in adenylate cyclase functional assay against Dopamine receptor D1 | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID232939 | Binding selectivity against D2/D1 receptor. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID63344 | Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID62764 | Intrinsic activity relative to dopamine for human Dopamine receptor D2 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID232940 | Binding selectivity against alpha-2/D1 receptor. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID176654 | Subcutaneous dose required to induce seizures in rats | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID61859 | Intrinsic activity is the magnitude of response for stimulation of Dopamine receptor D1 like expressed as percent relative to the dopamine | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |