robustaflavone profile

robustaflavone: bis-apigenin coupled at 6 and 3' positions; a potential non-nucleoside anti-hepatitis B agent; [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

robustaflavone : A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-6 of the chromene ring. Isolated from Thuja orientalis and Rhus succedanea it exhibits antioxidant, cytotoxic and anti-hepatitis B activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Rhus	genus	A plant genus of the family Anacardiaceae, order Sapindales, subclass Rosidae. It is a source of gallotannin (TANNIC ACID) and of somewhat edible fruit. Do not confuse with TOXICODENDRON which used to be part of this genus.[MeSH]	Anacardiaceae	The sumac plant family in the order Sapindales, subclass Rosidae, class Magnoliopsida. They are tropical and subtropical trees, shrubs, and woody vines that have resin ducts in the bark. The sap of many of the species is irritating to the skin.[MeSH]
Thuja	genus	A plant genus of the family CUPRESSACEAE.[MeSH]	Cupressaceae	A plant family of the order Pinales, class Pinopsida, division Tracheophyta. They are mainly resinous, aromatic evergreen trees.[MeSH]
Thuja orientalis	species	Formerly called Biota orientalis.[MeSH]	Cupressaceae	A plant family of the order Pinales, class Pinopsida, division Tracheophyta. They are mainly resinous, aromatic evergreen trees.[MeSH]

ID Source	ID
PubMed CID	5281694
CHEBI ID	8881
SCHEMBL ID	561807
MeSH ID	M0299116

Synonym
6-(5-(5,7-dihydroxy-4-oxo-4h-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
6-[5-(5,7-dihydroxy-4-oxo-4h-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-chromen-4-one
robustaflavone
3',6''-biapigenin
49620-13-5
4h-1-benzopyran-4-one, 6-[5-(5,7-dihydroxy-4-oxo-4h-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl-
6-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
LMPK12040005
chebi:8881 ,
4h-1-benzopyran-4-one, 6-(5-(5,7-dihydroxy-4-oxo-4h-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)
6-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
SCHEMBL561807
DTXSID30197937
6-(5-(5,7-dihydroxy-4-oxo-4h-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-chromen-4-one
BORWSEZUWHQTOK-UHFFFAOYSA-N
Q27089374
FT-0776777
AKOS040747412

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antioxidant	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
anti-HBV agent	An antiviral agent that destroys or inhibits the replication of the hepatitis B virus.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
biflavonoid	A flavonoid oligomer that is obtained by the oxidative coupling of at least two units of aryl-substituted benzopyran rings or its substituted derivatives, resulting in the two ring systems being joined together by a single atom or bond.
hydroxyflavone	Any flavone in which one or more ring hydrogens are replaced by hydroxy groups.
ring assembly	Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Neutrophil elastase	Homo sapiens (human)	IC50 (µMol)	1.3300	0.0063	2.0734	22.3780	AID1349968
72 kDa type IV collagenase	Homo sapiens (human)	IC50 (µMol)	10.2200	0.0000	1.2848	10.0000	AID1381208
Matrix metalloproteinase-9	Homo sapiens (human)	IC50 (µMol)	11.8500	0.0000	0.7053	10.0000	AID1381215
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50 (µMol)	6.2000	0.0005	3.4984	9.7600	AID1231481
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	Ki	6.8000	0.1900	4.8327	9.6000	AID1231482
Beta-secretase 1	Homo sapiens (human)	IC50 (µMol)	10.0000	0.0006	1.6194	10.0000	AID493814
Reverse transcriptase/RNaseH	Human immunodeficiency virus 1	IC50 (µMol)	65.0000	0.0001	1.0768	10.0000	AID355251
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
proteolysis	Neutrophil elastase	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Neutrophil elastase	Homo sapiens (human)
response to yeast	Neutrophil elastase	Homo sapiens (human)
leukocyte migration involved in inflammatory response	Neutrophil elastase	Homo sapiens (human)
biosynthetic process of antibacterial peptides active against Gram-negative bacteria	Neutrophil elastase	Homo sapiens (human)
proteolysis	Neutrophil elastase	Homo sapiens (human)
intracellular calcium ion homeostasis	Neutrophil elastase	Homo sapiens (human)
response to UV	Neutrophil elastase	Homo sapiens (human)
extracellular matrix disassembly	Neutrophil elastase	Homo sapiens (human)
protein catabolic process	Neutrophil elastase	Homo sapiens (human)
response to lipopolysaccharide	Neutrophil elastase	Homo sapiens (human)
negative regulation of chemokine production	Neutrophil elastase	Homo sapiens (human)
negative regulation of interleukin-8 production	Neutrophil elastase	Homo sapiens (human)
positive regulation of interleukin-8 production	Neutrophil elastase	Homo sapiens (human)
defense response to bacterium	Neutrophil elastase	Homo sapiens (human)
positive regulation of MAP kinase activity	Neutrophil elastase	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Neutrophil elastase	Homo sapiens (human)
negative regulation of inflammatory response	Neutrophil elastase	Homo sapiens (human)
positive regulation of immune response	Neutrophil elastase	Homo sapiens (human)
negative regulation of chemotaxis	Neutrophil elastase	Homo sapiens (human)
pyroptosis	Neutrophil elastase	Homo sapiens (human)
neutrophil-mediated killing of gram-negative bacterium	Neutrophil elastase	Homo sapiens (human)
neutrophil-mediated killing of fungus	Neutrophil elastase	Homo sapiens (human)
positive regulation of leukocyte tethering or rolling	Neutrophil elastase	Homo sapiens (human)
phagocytosis	Neutrophil elastase	Homo sapiens (human)
acute inflammatory response to antigenic stimulus	Neutrophil elastase	Homo sapiens (human)
angiogenesis	72 kDa type IV collagenase	Homo sapiens (human)
ovarian follicle development	72 kDa type IV collagenase	Homo sapiens (human)
ovulation from ovarian follicle	72 kDa type IV collagenase	Homo sapiens (human)
luteinization	72 kDa type IV collagenase	Homo sapiens (human)
blood vessel maturation	72 kDa type IV collagenase	Homo sapiens (human)
intramembranous ossification	72 kDa type IV collagenase	Homo sapiens (human)
proteolysis	72 kDa type IV collagenase	Homo sapiens (human)
negative regulation of cell adhesion	72 kDa type IV collagenase	Homo sapiens (human)
heart development	72 kDa type IV collagenase	Homo sapiens (human)
embryo implantation	72 kDa type IV collagenase	Homo sapiens (human)
parturition	72 kDa type IV collagenase	Homo sapiens (human)
response to xenobiotic stimulus	72 kDa type IV collagenase	Homo sapiens (human)
response to mechanical stimulus	72 kDa type IV collagenase	Homo sapiens (human)
peripheral nervous system axon regeneration	72 kDa type IV collagenase	Homo sapiens (human)
response to activity	72 kDa type IV collagenase	Homo sapiens (human)
protein metabolic process	72 kDa type IV collagenase	Homo sapiens (human)
extracellular matrix disassembly	72 kDa type IV collagenase	Homo sapiens (human)
protein catabolic process	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of cell migration	72 kDa type IV collagenase	Homo sapiens (human)
collagen catabolic process	72 kDa type IV collagenase	Homo sapiens (human)
response to retinoic acid	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to reactive oxygen species	72 kDa type IV collagenase	Homo sapiens (human)
response to nicotine	72 kDa type IV collagenase	Homo sapiens (human)
endodermal cell differentiation	72 kDa type IV collagenase	Homo sapiens (human)
response to hydrogen peroxide	72 kDa type IV collagenase	Homo sapiens (human)
response to estrogen	72 kDa type IV collagenase	Homo sapiens (human)
negative regulation of vasoconstriction	72 kDa type IV collagenase	Homo sapiens (human)
ephrin receptor signaling pathway	72 kDa type IV collagenase	Homo sapiens (human)
macrophage chemotaxis	72 kDa type IV collagenase	Homo sapiens (human)
response to electrical stimulus	72 kDa type IV collagenase	Homo sapiens (human)
response to hyperoxia	72 kDa type IV collagenase	Homo sapiens (human)
face morphogenesis	72 kDa type IV collagenase	Homo sapiens (human)
bone trabecula formation	72 kDa type IV collagenase	Homo sapiens (human)
prostate gland epithelium morphogenesis	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to amino acid stimulus	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to interleukin-1	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to estradiol stimulus	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to UV-A	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to fluid shear stress	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	72 kDa type IV collagenase	Homo sapiens (human)
response to amyloid-beta	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	72 kDa type IV collagenase	Homo sapiens (human)
extracellular matrix organization	72 kDa type IV collagenase	Homo sapiens (human)
response to hypoxia	72 kDa type IV collagenase	Homo sapiens (human)
tissue remodeling	72 kDa type IV collagenase	Homo sapiens (human)
skeletal system development	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of protein phosphorylation	Matrix metalloproteinase-9	Homo sapiens (human)
proteolysis	Matrix metalloproteinase-9	Homo sapiens (human)
apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
embryo implantation	Matrix metalloproteinase-9	Homo sapiens (human)
cell migration	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix disassembly	Matrix metalloproteinase-9	Homo sapiens (human)
macrophage differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
collagen catabolic process	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to reactive oxygen species	Matrix metalloproteinase-9	Homo sapiens (human)
endodermal cell differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of DNA binding	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
ephrin receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of keratinocyte migration	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to lipopolysaccharide	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to cadmium ion	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to UV-A	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Matrix metalloproteinase-9	Homo sapiens (human)
regulation of neuroinflammatory response	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of receptor binding	Matrix metalloproteinase-9	Homo sapiens (human)
response to amyloid-beta	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of epithelial cell differentiation involved in kidney development	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cation channel activity	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix organization	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of JUN kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein dephosphorylation	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of signal transduction	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of signal transduction	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
actin cytoskeleton organization	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of endocytosis	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of intracellular protein transport	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cellular response to unfolded protein	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
peptidyl-tyrosine dephosphorylation	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
IRE1-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor recycling	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of MAP kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of type I interferon-mediated signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STAT	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of protein tyrosine kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of receptor catabolic process	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
proteolysis	Beta-secretase 1	Homo sapiens (human)
membrane protein ectodomain proteolysis	Beta-secretase 1	Homo sapiens (human)
response to lead ion	Beta-secretase 1	Homo sapiens (human)
protein processing	Beta-secretase 1	Homo sapiens (human)
amyloid-beta formation	Beta-secretase 1	Homo sapiens (human)
amyloid precursor protein catabolic process	Beta-secretase 1	Homo sapiens (human)
positive regulation of neuron apoptotic process	Beta-secretase 1	Homo sapiens (human)
amyloid-beta metabolic process	Beta-secretase 1	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Beta-secretase 1	Homo sapiens (human)
prepulse inhibition	Beta-secretase 1	Homo sapiens (human)
cellular response to copper ion	Beta-secretase 1	Homo sapiens (human)
cellular response to manganese ion	Beta-secretase 1	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Beta-secretase 1	Homo sapiens (human)
signaling receptor ligand precursor processing	Beta-secretase 1	Homo sapiens (human)
cellular response to amyloid-beta	Beta-secretase 1	Homo sapiens (human)
amyloid fibril formation	Beta-secretase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protease binding	Neutrophil elastase	Homo sapiens (human)
transcription corepressor activity	Neutrophil elastase	Homo sapiens (human)
endopeptidase activity	Neutrophil elastase	Homo sapiens (human)
serine-type endopeptidase activity	Neutrophil elastase	Homo sapiens (human)
protein binding	Neutrophil elastase	Homo sapiens (human)
heparin binding	Neutrophil elastase	Homo sapiens (human)
peptidase activity	Neutrophil elastase	Homo sapiens (human)
cytokine binding	Neutrophil elastase	Homo sapiens (human)
fibronectin binding	72 kDa type IV collagenase	Homo sapiens (human)
endopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
metalloendopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
serine-type endopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
protein binding	72 kDa type IV collagenase	Homo sapiens (human)
metallopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
zinc ion binding	72 kDa type IV collagenase	Homo sapiens (human)
endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metalloendopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
serine-type endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
collagen binding	Matrix metalloproteinase-9	Homo sapiens (human)
peptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metallopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
zinc ion binding	Matrix metalloproteinase-9	Homo sapiens (human)
identical protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
RNA binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein tyrosine phosphatase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
zinc ion binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
enzyme binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein kinase binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
receptor tyrosine kinase binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cadherin binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
ephrin receptor binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein phosphatase 2A binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
amyloid-beta binding	Beta-secretase 1	Homo sapiens (human)
endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
aspartic-type endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
protein binding	Beta-secretase 1	Homo sapiens (human)
peptidase activity	Beta-secretase 1	Homo sapiens (human)
beta-aspartyl-peptidase activity	Beta-secretase 1	Homo sapiens (human)
enzyme binding	Beta-secretase 1	Homo sapiens (human)
protein serine/threonine kinase binding	Beta-secretase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Neutrophil elastase	Homo sapiens (human)
extracellular space	Neutrophil elastase	Homo sapiens (human)
cytoplasm	Neutrophil elastase	Homo sapiens (human)
cytosol	Neutrophil elastase	Homo sapiens (human)
cell surface	Neutrophil elastase	Homo sapiens (human)
secretory granule	Neutrophil elastase	Homo sapiens (human)
azurophil granule lumen	Neutrophil elastase	Homo sapiens (human)
specific granule lumen	Neutrophil elastase	Homo sapiens (human)
phagocytic vesicle	Neutrophil elastase	Homo sapiens (human)
collagen-containing extracellular matrix	Neutrophil elastase	Homo sapiens (human)
extracellular exosome	Neutrophil elastase	Homo sapiens (human)
transcription repressor complex	Neutrophil elastase	Homo sapiens (human)
extracellular space	Neutrophil elastase	Homo sapiens (human)
collagen-containing extracellular matrix	72 kDa type IV collagenase	Homo sapiens (human)
extracellular region	72 kDa type IV collagenase	Homo sapiens (human)
extracellular space	72 kDa type IV collagenase	Homo sapiens (human)
nucleus	72 kDa type IV collagenase	Homo sapiens (human)
mitochondrion	72 kDa type IV collagenase	Homo sapiens (human)
plasma membrane	72 kDa type IV collagenase	Homo sapiens (human)
sarcomere	72 kDa type IV collagenase	Homo sapiens (human)
collagen-containing extracellular matrix	72 kDa type IV collagenase	Homo sapiens (human)
extracellular space	72 kDa type IV collagenase	Homo sapiens (human)
extracellular region	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
collagen-containing extracellular matrix	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular exosome	Matrix metalloproteinase-9	Homo sapiens (human)
tertiary granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
ficolin-1-rich granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
plasma membrane	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasm	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
mitochondrial matrix	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
early endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytosol	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
mitochondrial crista	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endosome lumen	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
sorting endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membrane	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein-containing complex	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasm	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
early endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
lysosome	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
early endosome	Beta-secretase 1	Homo sapiens (human)
late endosome	Beta-secretase 1	Homo sapiens (human)
multivesicular body	Beta-secretase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Beta-secretase 1	Homo sapiens (human)
Golgi apparatus	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
synaptic vesicle	Beta-secretase 1	Homo sapiens (human)
cell surface	Beta-secretase 1	Homo sapiens (human)
endosome membrane	Beta-secretase 1	Homo sapiens (human)
membrane	Beta-secretase 1	Homo sapiens (human)
axon	Beta-secretase 1	Homo sapiens (human)
dendrite	Beta-secretase 1	Homo sapiens (human)
neuronal cell body	Beta-secretase 1	Homo sapiens (human)
membrane raft	Beta-secretase 1	Homo sapiens (human)
recycling endosome	Beta-secretase 1	Homo sapiens (human)
Golgi-associated vesicle lumen	Beta-secretase 1	Homo sapiens (human)
hippocampal mossy fiber to CA3 synapse	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (67)

Assay ID	Title	Year	Journal	Article
AID1349950	Cytotoxicity against rat RBL2H3 cells assessed as cell viability at 400 uM after 24 hrs by MTT assay relative to control	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1091419	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from H2O to DCPIP at 300 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1381214	Inhibition of recombinant human MMP3 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluorescence assay	2018	Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14	Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
AID380050	Cytotoxicity against human Wish cells after 3 days	2000	Journal of natural products, May, Volume: 63, Issue:5	Cytotoxic biflavonoids from Selaginella delicatula.
AID1091411	Inhibition of photosystem I in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from DCPIP to MV at 100 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1381211	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2018	Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14	Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
AID1091412	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from DPC to DCPIP at 300 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID355255	Selectivity index, ratio of IC50 for human PBMC to EC50 for HIV1 LAV-1	1997	Journal of natural products, Sep, Volume: 60, Issue:9	In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
AID1091415	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from H2O to SiMo at 200 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1444846	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral DNA level	2017	Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15	Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.
AID1381208	Inhibition of recombinant human MMP2 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluorescence assay	2018	Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14	Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
AID1349954	Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 200 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1349958	Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 100 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measur	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1091416	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from H2O to SiMo at 100 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1231481	Inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microplate reader analysis	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
AID317377	Inhibition of UVB irradiation-induced MMP1 production in human dermal fibroblasts at 1.25 uM after 48 hrs	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts.
AID1349951	Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 1 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID380046	Cytotoxicity against human Raji cells after 3 days	2000	Journal of natural products, May, Volume: 63, Issue:5	Cytotoxic biflavonoids from Selaginella delicatula.
AID380051	Cytotoxicity against human HeLa cells after 3 days	2000	Journal of natural products, May, Volume: 63, Issue:5	Cytotoxic biflavonoids from Selaginella delicatula.
AID1349955	Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 400 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1231482	Mixed-competitive inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by Lineweaver-Burk/Dixon plot analysis	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
AID1349957	Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 10 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measure	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1091406	Inhibition of photosystem I in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from TMQH2 to MV at 200 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1349960	Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 400 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measur	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1091390	Inhibition of photosystem II in freshly lysed Spinacia oleracea (spinach) leaves chloroplasts assessed as induction of loss of reactions centers capacity to capture excitons at 300 to 900 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID493814	Inhibition of BACE1 after 60 mins by FRET assay	2010	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15	beta-Secretase (BACE-1) inhibitory effect of biflavonoids.
AID1091397	Inhibition of uncoupled electron transport flow in Spinacia oleracea (spinach) leaves intact chloroplasts	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091405	Inhibition of photosystem I in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from TMQH2 to MV at 300 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1381215	Inhibition of recombinant human MMP9 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluorescence assay	2018	Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14	Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
AID1349968	Inhibition of human neutrophil elastase using N-Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilid as substrate measured after 1 hr	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID380048	Cytotoxicity against human K562 cells after 3 days	2000	Journal of natural products, May, Volume: 63, Issue:5	Cytotoxic biflavonoids from Selaginella delicatula.
AID1091396	Inhibition of basal electron transport flow in Spinacia oleracea (spinach) leaves intact chloroplasts at 88 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID355254	Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method	1997	Journal of natural products, Sep, Volume: 60, Issue:9	In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
AID1091403	Inhibition of thylakoid membrane bound Magnesium-transporting Mg2+ ATPase in Spinacia oleracea (spinach) leaves chloroplasts assessed as enzyme activity at 100 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1349964	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation at 10 uM pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide d	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1091410	Inhibition of photosystem I in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from DCPIP to MV at 200 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091418	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from H2O to DCPIP at 200 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091421	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from H2O to DCPIP at 100 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID355252	Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coli at 200 ug/mL	1997	Journal of natural products, Sep, Volume: 60, Issue:9	In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
AID1091409	Inhibition of photosystem I in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from DCPIP to MV at 300 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091413	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from DPC to DCPIP at 100 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091401	Inhibition of thylakoid membrane bound Magnesium-transporting Mg2+ ATPase in Spinacia oleracea (spinach) leaves chloroplasts assessed as enzyme activity at 300 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1231480	Cytotoxicity against mouse 3T3L1 cells assessed as inhibition of cell viability at 5 to 10 uM after 48 hrs by MTT assay	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
AID1349963	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1381212	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2018	Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14	Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
AID317375	Inhibition of UVB irradiation-induced MMP1 production in human dermal fibroblasts at 5 uM after 48 hrs	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts.
AID1349953	Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 100 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID317378	Inhibition of UVB irradiation-induced MMP1 production in human dermal fibroblasts at 2.5 uM after 48 hrs	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts.
AID144729	Antituberculosis activity against Mycobacterium tuberculosis at a concentration of 12.5 ug/mL	2001	Bioorganic & medicinal chemistry letters, Aug-20, Volume: 11, Issue:16	Biflavonoids as novel antituberculosis agents.
AID1349959	Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 200 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measur	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1231478	Inhibition of PTP1B in mouse 3T3L1 cells assessed as stimulation of 2-NBDG uptake preincubated for 24 hrs followed by 2-NBDG addition measured after 30 mins by fluorescence reader analysis	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
AID1091407	Inhibition of photosystem I in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from TMQH2 to MV at 100 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091402	Inhibition of thylakoid membrane bound Magnesium-transporting Mg2+ ATPase in Spinacia oleracea (spinach) leaves chloroplasts assessed as enzyme activity at 200 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091414	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from H2O to SiMo at 300 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID355251	Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coli	1997	Journal of natural products, Sep, Volume: 60, Issue:9	In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
AID1349966	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release at 10 uM pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate relative to control	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1349956	Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 1 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measured	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1349965	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID380047	Cytotoxicity against human Calu1 cells after 3 days	2000	Journal of natural products, May, Volume: 63, Issue:5	Cytotoxic biflavonoids from Selaginella delicatula.
AID355253	Antiviral activity against HIV1 LAV-1 in PHA-stimulated human PBMC after 6 days	1997	Journal of natural products, Sep, Volume: 60, Issue:9	In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
AID1091420	Inhibition of photosystem II in Spinacia oleracea (spinach) leaves intact chloroplasts assessed as electron transport flow from DPC to DCPIP at 200 uM	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1091422	Inhibition of ATP synthesis in Spinacia oleracea (spinach) leaves intact chloroplasts	2008	Journal of agricultural and food chemistry, Aug-27, Volume: 56, Issue:16	Biflavonoids isolated from Selaginella lepidophylla inhibit photosynthesis in spinach chloroplasts.
AID1349952	Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 10 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
AID1381210	Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2018	Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14	Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
AID1381213	Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2018	Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14	Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
AID317387	Inhibition of MMP2 in UVB irradiated human dermal fibroblasts at <5 uM by zymography	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts.
AID380049	Cytotoxicity against african green monkey Vero cells after 3 days	2000	Journal of natural products, May, Volume: 63, Issue:5	Cytotoxic biflavonoids from Selaginella delicatula.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (11.11)	18.2507
2000's	7 (38.89)	29.6817
2010's	7 (38.89)	24.3611
2020's	2 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.56%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (94.44%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
diuron Diuron: A pre-emergent herbicide.. diuron : A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.	2.04	1	3-(3,4-substituted-phenyl)-1,1-dimethylurea; dichlorobenzene	environmental contaminant; mitochondrial respiratory-chain inhibitor; photosystem-II inhibitor; urea herbicide; xenobiotic
avapro Irbesartan: A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.. irbesartan : A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.	3.25	1	azaspiro compound; biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source	2.17	1	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	1.99	1	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
tromethamine Tromethamine: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)	2.04	1	primary amino compound; triol	buffer
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	1.99	1	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	1.99	1	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
nitazoxanide nitazoxanide: a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug	3.25	1	benzamides; carboxylic ester
lamivudine [no description available]	1.99	1	monothioacetal; nucleoside analogue; oxacycle; primary alcohol	allergen; anti-HBV agent; antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor; HIV-1 reverse transcriptase inhibitor; prodrug
ursolic acid [no description available]	2.11	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
betulinic acid [no description available]	2.25	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	3.25	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
10-hydroxycamptothecin [no description available]	2.17	1	pyranoindolizinoquinoline
helioxanthin helioxanthin: structure in first source. helioxanthin : A furonaphthodioxole that is furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one substituted by a 1,3-benzodioxol-5-yl group at posiiton 10. It is a inhibitor of HBV, HCV and HSV-1 viruses.	3.25	1	benzodioxoles; furonaphthodioxole; lignan	anti-HBV agent; antineoplastic agent; plant metabolite
lupeol [no description available]	2.25	1	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
tizoxanide tizoxanide: major metabolite of nitazoxanide; structure in first source	3.25	1	salicylamides
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	1.99	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
eriodictyol eriodictyol: structure. eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.	2.05	1	3'-hydroxyflavanones; tetrahydroxyflavanone
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	2.04	1	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
cgs 27023a CGS 27023A: a matrix metalloproteinase inhibitor	2.17	1
gamma-sitosterol clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.	2.61	2	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols	marine metabolite; plant metabolite
bay 41-4109 BAY 41-4109: structure in first source	3.25	1
glycosides [no description available]	2.48	2
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	2.61	2
ginkgetin ginkgetin: from Cephalotaxus drupacea; biflavone; active against HSV-1; structure given in first source. ginkgetin : A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2.	2.05	1	biflavonoid; hydroxyflavone; methoxyflavone; ring assembly	anti-HSV-1 agent; antineoplastic agent; cyclooxygenase 2 inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; metabolite
acacetin 5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.	2.02	1	dihydroxyflavone; monomethoxyflavone	anticonvulsant; plant metabolite
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	1.99	1	trihydroxyflavone	antineoplastic agent; metabolite
stigmasterol stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.	2.25	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols; stigmastane sterol	plant metabolite
agathisflavone agathisflavone: bis-apigenin coupled at 6 and 8 positions; isolated from the plant Canarium manii; has hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity. agathisflavone : A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-6 and C-8 of the two chromene rings.	2.4	2	biaryl; biflavonoid; hydroxyflavone	antineoplastic agent; antiviral agent; hepatoprotective agent; metabolite
amentoflavone [no description available]	3.92	12	biflavonoid; hydroxyflavone; ring assembly	angiogenesis inhibitor; antiviral agent; cathepsin B inhibitor; P450 inhibitor; plant metabolite
cupressuflavone cupressuflavone: from Cupressus macrocarpa; structure in first source. cupressuflavone : A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-8 of the two chromene rings respectively. Isolated from Cupressus sempervirens and Juniperus occidentalis, it exhibits free radical scavenging and antielastase activities.	2.48	2	biflavonoid; hydroxyflavone; ring assembly	EC 3.4.21.37 (leukocyte elastase) inhibitor; metabolite; radical scavenger
diosmin [no description available]	2.02	1	dihydroxyflavanone; disaccharide derivative; glycosyloxyflavone; monomethoxyflavone; rutinoside	anti-inflammatory agent; antioxidant
hinokiflavone hinokiflavone: from Rhus succedanea; structure given in first source. hinokiflavone : A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic potential.	2.7	3	aromatic ether; biflavonoid; hydroxyflavone	antineoplastic agent; metabolite; neuroprotective agent
sciadopitysin sciadopitysin: biflavonoid from Taxus celebica & Ginkgo biloba. sciadopitysin : A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.	2.05	1	biflavonoid; hydroxyflavone; methoxyflavone; ring assembly	bone density conservation agent; platelet aggregation inhibitor
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	3.25	1	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
bilobetin bilobetin: a phospholipase A2 antagonist	2.5	2	flavonoid oligomer
linarin linarin: flavone glycoside isolated from leaves of Linaria japonica MIQ	2.02	1
isoginkgetin isoginkgetin: Isolated from Ginkgo biloba; structure in first source. isoginkgetin : A biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4'-methoxyflavone and the 3' position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metalloproteinase 9 (MMP-9).	2.05	1	aromatic ether; biflavonoid	antineoplastic agent; EC 3.4.24.35 (gelatinase B) inhibitor; plant metabolite
podocarpusflavone a podocarpusflavone A: isolated from Podocarpus imbricatus	2.05	1	flavonoid oligomer
sequoiaflavone sequoiaflavone: Isolated from Ginkgo biloba; structure in first source	2.05	1
w-13 [no description available]	2.05	1
helioxanthin 8-1 helioxanthin 8-1: an antiviral agent; structure in first source	3.25	1
biapigenin biapigenin: bis-apigenin coupled at 3' & 3' positions; inhibits various cytochrome P450 enzymes; isolated from St. John's Wort	2.11	1	flavonoid oligomer
caudatin caudatin: antineoplastic from Cynanchum; structure in first source	3.25	1
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.21	1
taiwaniaflavone taiwaniaflavone: inhibits induction of iNOS and COX-2 genes	2.47	2
rk 682 [no description available]	2.11	1
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	1.99	1	2-aminopurines; oxopurine	antimetabolite; antiviral drug
guanine [no description available]	1.99	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
penciclovir penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.	1.99	1	2-aminopurines; propane-1,3-diols	antiviral drug
allopurinol Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.	2.05	1	nucleobase analogue; organic heterobicyclic compound	antimetabolite; EC 1.17.3.2 (xanthine oxidase) inhibitor; gout suppressant; radical scavenger

Condition	Relationship Strength	Studies
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.04	1
Chronic Hepatitis B [description not available]	3.06	1
Hepatitis B, Chronic INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	3.06	1
Cancer of Colon [description not available]	2.25	1
Angiogenesis, Pathologic [description not available]	2.25	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.25	1
Leishmaniasis, American [description not available]	2.1	1
Leishmaniasis, Cutaneous An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.	2.1	1

robustaflavone

Description

Cross-References

Synonyms (18)

Roles (4)

Drug Classes (3)

Protein Targets (6)

Inhibition Measurements

Biological Processes (128)

Molecular Functions (28)

Ceullar Components (43)

Bioassays (67)

Research

Studies (18)

Market Indicators

Research Demand Index: 21.09

Study Types

robustaflavone

Description

Related Flora

Cross-References

Synonyms (18)

Roles (4)

Drug Classes (3)

Protein Targets (6)

Inhibition Measurements

Biological Processes (128)

Molecular Functions (28)

Ceullar Components (43)

Bioassays (67)

Research

Studies (18)

Market Indicators

Research Demand Index: 21.09

Study Types

Related Drugs (51)

Related Conditions (8)