fipamezole: an alpha2 adrenergic antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 213041 |
| CHEMBL ID | 1255582 |
| SCHEMBL ID | 935549 |
| SCHEMBL ID | 18826053 |
| MeSH ID | M0459669 |
| Synonym |
|---|
| 5-(2-ethyl-5-fluoro-2,3-dihydro-1h-inden-2-yl)-1h-imidazole |
| jp-1730 , |
| fipamezole |
| L001472 |
| 150586-58-6 |
| 5-(2-ethyl-5-fluoro-1,3-dihydroinden-2-yl)-1h-imidazole |
| CHEMBL1255582 |
| 4-((2rs)-2-ethyl-5-fluoroindan-2-yl)-1h-imidazole |
| t5rck09khv , |
| unii-t5rck09khv |
| fipamezole [inn] |
| bdbm50417007 |
| KXSUAWAUCNFBQJ-UHFFFAOYSA-N |
| 4-(2-ethyl-5-fluoro-indan-2-yl)-1h-imidazole |
| SCHEMBL935549 |
| SCHEMBL18826053 |
| DB06585 |
| mpv 1730 |
| SB17014 |
| Q27289711 |
| 4-(2-ethyl-5-fluoro-2,3-dihydro-1h-inden-2-yl)-1h-imidazole |
| 1h-imidazole, 5-(2-ethyl-5-fluoro-2,3-dihydro-1h-inden-2-yl)- |
| DTXSID00869997 |
| AKOS040745794 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0072 | 0.0001 | 0.8074 | 10.0000 | AID516907 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0068 | 0.0002 | 0.7257 | 10.0000 | AID516908 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0138 | 0.0003 | 0.4834 | 10.0000 | AID516909 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 2.0893 | 0.0000 | 0.4713 | 10.0000 | AID516906 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID516910 | Antihypothermic activity in ip dosed NMRI mouse assessed as inhibition of guanabenz-induced hypothermia administered 5 mins before guanabenz challenge measured after 25 mins | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516915 | Increase of normetanephrine level in NMRI mouse cortex at 10 mg/kg, ip after 1 hr microwave irradiation | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516912 | Ratio of ED50 for santihypothermic activity in po dosed NMRI mouse to ED50 for antihypothermic activity in ip dosed NMRI mouse | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516907 | Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516911 | Antihypothermic activity in po dosed NMRI mouse assessed as inhibition of guanabenz-induced hypothermia administered 35 mins before guanabenz challenge measured after 25 mins | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516908 | Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516906 | Displacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation counting | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516905 | Antagonist activity at human adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of adrenaline-induced [35S]GTPgammaS binding after 30 mins by scintillation counting | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| AID516909 | Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting | 2010 | Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19 | Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.98) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (20.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||