1-(phenylmethyl)benzimidazole profile

1-(Phenylmethyl)benzimidazole, also known as **benzyl benzimidazole**, is a heterocyclic organic compound with the formula C14H12N2.

**Structure:**

It consists of a benzimidazole ring (a fused benzene and imidazole ring system) with a benzyl group (phenylmethyl) attached at the nitrogen atom in position 1.

**Importance in Research:**

1-(Phenylmethyl)benzimidazole has shown potential in various areas of research, including:

* **Anti-cancer Activity:** Studies have indicated that this compound exhibits anti-proliferative effects against various cancer cell lines, potentially by inhibiting cell cycle progression and inducing apoptosis.

* **Anti-inflammatory Activity:** Some research suggests that 1-(phenylmethyl)benzimidazole possesses anti-inflammatory properties, possibly by modulating the activity of inflammatory mediators.

* **Antimicrobial Activity:** This compound has been found to exhibit antimicrobial activity against bacteria and fungi, potentially by interfering with their growth and development.

* **Neuroprotective Activity:** Studies have shown that 1-(phenylmethyl)benzimidazole may offer neuroprotective effects, possibly by reducing oxidative stress and protecting neurons from damage.

* **Drug Delivery:** Benzyl benzimidazole derivatives have been explored for their potential as drug delivery carriers, enhancing the efficacy and bioavailability of drugs.

**Note:** While the research on 1-(phenylmethyl)benzimidazole and its derivatives is promising, it's essential to remember that further investigation is needed to fully understand its therapeutic potential and safety profile.

**Currently, this compound is not a commercially available drug, and its use in clinical settings is not yet established.**

ID Source	ID
PubMed CID	563347
CHEMBL ID	347547
CHEBI ID	109701
SCHEMBL ID	230002

Synonym
MLS000526503
smr000116977
1-phenylbenzimidazole deriv. 4
bdbm3787
1-benzyl-1h-1,3-benzodiazole
IFLAB1_003893
1-benzyl-1h-benzoimidazole
AE-907/30533008
1-benzyl-1h-benzimidazole ,
CHEBI:109701
STK804589
CHEMBL347547
AKOS000283139
HMS1423A21
1-benzylbenzimidazole
HMS2493C03
1-benzylbenzoimidazole
4981-92-4
CCG-17389
1h-benzimidazole, 1-(phenylmethyl)-
F0852-0025
1-benzyl-1h-benzo[d]imidazole
(phenylmethyl)-1h-benzimidazole
1-(phenylmethyl)benzimidazole
n-(phenylmethyl)-1h-benzimidazole
SCHEMBL230002
n-benzyl-1h-benzimidazole
1-benzyl-1h-benzimidazole #
Q27188896
1-(benzyl)benzimidazole
mfcd00458798
SR-01000446470-1
sr-01000446470
DTXSID60340297
CS-0206121
Z26333438
AS-10099
UTS ,
EN300-183328

Class	Description
benzimidazoles	An organic heterocyclic compound containing a benzene ring fused to an imidazole ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (12)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	50.1187	0.0447	17.8581	100.0000	AID485294
glp-1 receptor, partial	Homo sapiens (human)	Potency	1.9953	0.0184	6.8060	14.1254	AID624417
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	10.3225	0.0041	9.9848	25.9290	AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	44.6684	3.5481	19.5427	44.6684	AID743266
geminin	Homo sapiens (human)	Potency	23.1093	0.0046	11.3741	33.4983	AID624296
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	0.8913	1.9953	25.5327	50.1187	AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Tumor necrosis factor	Homo sapiens (human)	IC50 (µMol)	204.0000	0.2000	0.6791	1.3000	AID1744292
Platelet-derived growth factor receptor beta	Mus musculus (house mouse)	IC50 (µMol)	50.0000	0.0018	0.7552	9.5000	AID161099
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50 (µMol)	50.0000	0.0006	0.8007	8.5000	AID1795561
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50 (µMol)	50.0000	0.0002	0.9420	10.0000	AID1795561; AID73439
Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)	IC50 (µMol)	0.2460	0.0005	0.2902	2.7800	AID553065
Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)	IC50 (µMol)	0.8650	0.0001	0.2738	3.5000	AID553066
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Tumor necrosis factor	Homo sapiens (human)	Kd	300.0000	0.0027	4.2926	9.7700	AID1744286
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (289)

Process	via Protein(s)	Taxonomy
positive regulation of gene expression	Tumor necrosis factor	Homo sapiens (human)
negative regulation of gene expression	Tumor necrosis factor	Homo sapiens (human)
positive regulation of MAP kinase activity	Tumor necrosis factor	Homo sapiens (human)
positive regulation of MAPK cascade	Tumor necrosis factor	Homo sapiens (human)
positive regulation of interleukin-33 production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of cytokine production involved in inflammatory response	Tumor necrosis factor	Homo sapiens (human)
negative regulation of miRNA transcription	Tumor necrosis factor	Homo sapiens (human)
positive regulation of miRNA transcription	Tumor necrosis factor	Homo sapiens (human)
negative regulation of signaling receptor activity	Tumor necrosis factor	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Tumor necrosis factor	Homo sapiens (human)
positive regulation of gene expression	Tumor necrosis factor	Homo sapiens (human)
negative regulation of gene expression	Tumor necrosis factor	Homo sapiens (human)
positive regulation of interleukin-8 production	Tumor necrosis factor	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Tumor necrosis factor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Tumor necrosis factor	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Tumor necrosis factor	Homo sapiens (human)
positive regulation of calcineurin-NFAT signaling cascade	Tumor necrosis factor	Homo sapiens (human)
positive regulation of cytokine production involved in inflammatory response	Tumor necrosis factor	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Tumor necrosis factor	Homo sapiens (human)
positive regulation of synoviocyte proliferation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of I-kappaB phosphorylation	Tumor necrosis factor	Homo sapiens (human)
negative regulation of apoptotic signaling pathway	Tumor necrosis factor	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Tumor necrosis factor	Homo sapiens (human)
response to hypoxia	Tumor necrosis factor	Homo sapiens (human)
microglial cell activation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of cytokine production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of protein phosphorylation	Tumor necrosis factor	Homo sapiens (human)
negative regulation of endothelial cell proliferation	Tumor necrosis factor	Homo sapiens (human)
negative regulation of L-glutamate import across plasma membrane	Tumor necrosis factor	Homo sapiens (human)
macrophage activation involved in immune response	Tumor necrosis factor	Homo sapiens (human)
chronic inflammatory response to antigenic stimulus	Tumor necrosis factor	Homo sapiens (human)
leukocyte migration involved in inflammatory response	Tumor necrosis factor	Homo sapiens (human)
regulation of immunoglobulin production	Tumor necrosis factor	Homo sapiens (human)
negative regulation of cytokine production involved in immune response	Tumor necrosis factor	Homo sapiens (human)
positive regulation of chronic inflammatory response to antigenic stimulus	Tumor necrosis factor	Homo sapiens (human)
positive regulation of humoral immune response mediated by circulating immunoglobulin	Tumor necrosis factor	Homo sapiens (human)
skeletal muscle contraction	Tumor necrosis factor	Homo sapiens (human)
negative regulation of systemic arterial blood pressure	Tumor necrosis factor	Homo sapiens (human)
glucose metabolic process	Tumor necrosis factor	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Tumor necrosis factor	Homo sapiens (human)
inflammatory response	Tumor necrosis factor	Homo sapiens (human)
humoral immune response	Tumor necrosis factor	Homo sapiens (human)
JNK cascade	Tumor necrosis factor	Homo sapiens (human)
circadian rhythm	Tumor necrosis factor	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Tumor necrosis factor	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Tumor necrosis factor	Homo sapiens (human)
response to xenobiotic stimulus	Tumor necrosis factor	Homo sapiens (human)
response to virus	Tumor necrosis factor	Homo sapiens (human)
response to salt stress	Tumor necrosis factor	Homo sapiens (human)
response to fructose	Tumor necrosis factor	Homo sapiens (human)
negative regulation of heart rate	Tumor necrosis factor	Homo sapiens (human)
vascular endothelial growth factor production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of gene expression	Tumor necrosis factor	Homo sapiens (human)
negative regulation of gene expression	Tumor necrosis factor	Homo sapiens (human)
negative regulation of lipid storage	Tumor necrosis factor	Homo sapiens (human)
response to activity	Tumor necrosis factor	Homo sapiens (human)
regulation of metabolic process	Tumor necrosis factor	Homo sapiens (human)
calcium-mediated signaling	Tumor necrosis factor	Homo sapiens (human)
extracellular matrix organization	Tumor necrosis factor	Homo sapiens (human)
osteoclast differentiation	Tumor necrosis factor	Homo sapiens (human)
sequestering of triglyceride	Tumor necrosis factor	Homo sapiens (human)
cortical actin cytoskeleton organization	Tumor necrosis factor	Homo sapiens (human)
positive regulation of protein-containing complex assembly	Tumor necrosis factor	Homo sapiens (human)
positive regulation of fever generation	Tumor necrosis factor	Homo sapiens (human)
negative regulation of myelination	Tumor necrosis factor	Homo sapiens (human)
response to nutrient levels	Tumor necrosis factor	Homo sapiens (human)
negative regulation of interleukin-6 production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of chemokine production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of fractalkine production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of type II interferon production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of interleukin-18 production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of interleukin-6 production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of interleukin-8 production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Tumor necrosis factor	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Tumor necrosis factor	Homo sapiens (human)
positive regulation of heterotypic cell-cell adhesion	Tumor necrosis factor	Homo sapiens (human)
toll-like receptor 3 signaling pathway	Tumor necrosis factor	Homo sapiens (human)
negative regulation of myosin-light-chain-phosphatase activity	Tumor necrosis factor	Homo sapiens (human)
response to isolation stress	Tumor necrosis factor	Homo sapiens (human)
response to macrophage colony-stimulating factor	Tumor necrosis factor	Homo sapiens (human)
vasodilation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Tumor necrosis factor	Homo sapiens (human)
positive regulation of apoptotic process	Tumor necrosis factor	Homo sapiens (human)
positive regulation of programmed cell death	Tumor necrosis factor	Homo sapiens (human)
regulation of canonical NF-kappaB signal transduction	Tumor necrosis factor	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Tumor necrosis factor	Homo sapiens (human)
negative regulation of protein-containing complex disassembly	Tumor necrosis factor	Homo sapiens (human)
positive regulation of protein-containing complex disassembly	Tumor necrosis factor	Homo sapiens (human)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Tumor necrosis factor	Homo sapiens (human)
positive regulation of MAP kinase activity	Tumor necrosis factor	Homo sapiens (human)
positive regulation of MAPK cascade	Tumor necrosis factor	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Tumor necrosis factor	Homo sapiens (human)
positive regulation of JUN kinase activity	Tumor necrosis factor	Homo sapiens (human)
positive regulation of neuron apoptotic process	Tumor necrosis factor	Homo sapiens (human)
negative regulation of blood vessel endothelial cell migration	Tumor necrosis factor	Homo sapiens (human)
negative regulation of viral genome replication	Tumor necrosis factor	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Tumor necrosis factor	Homo sapiens (human)
response to ethanol	Tumor necrosis factor	Homo sapiens (human)
regulation of fat cell differentiation	Tumor necrosis factor	Homo sapiens (human)
negative regulation of fat cell differentiation	Tumor necrosis factor	Homo sapiens (human)
negative regulation of myoblast differentiation	Tumor necrosis factor	Homo sapiens (human)
negative regulation of osteoblast differentiation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of osteoclast differentiation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of protein catabolic process	Tumor necrosis factor	Homo sapiens (human)
positive regulation of action potential	Tumor necrosis factor	Homo sapiens (human)
positive regulation of cell adhesion	Tumor necrosis factor	Homo sapiens (human)
positive regulation of mitotic nuclear division	Tumor necrosis factor	Homo sapiens (human)
negative regulation of DNA-templated transcription	Tumor necrosis factor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Tumor necrosis factor	Homo sapiens (human)
negative regulation of mitotic cell cycle	Tumor necrosis factor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Tumor necrosis factor	Homo sapiens (human)
positive regulation of translational initiation by iron	Tumor necrosis factor	Homo sapiens (human)
negative regulation of glucose import	Tumor necrosis factor	Homo sapiens (human)
positive regulation of JNK cascade	Tumor necrosis factor	Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STAT	Tumor necrosis factor	Homo sapiens (human)
astrocyte activation	Tumor necrosis factor	Homo sapiens (human)
embryonic digestive tract development	Tumor necrosis factor	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of inflammatory response	Tumor necrosis factor	Homo sapiens (human)
negative regulation of neurogenesis	Tumor necrosis factor	Homo sapiens (human)
regulation of insulin secretion	Tumor necrosis factor	Homo sapiens (human)
positive regulation of synaptic transmission	Tumor necrosis factor	Homo sapiens (human)
regulation of synapse organization	Tumor necrosis factor	Homo sapiens (human)
defense response to Gram-positive bacterium	Tumor necrosis factor	Homo sapiens (human)
cognition	Tumor necrosis factor	Homo sapiens (human)
leukocyte tethering or rolling	Tumor necrosis factor	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Tumor necrosis factor	Homo sapiens (human)
negative regulation of lipid catabolic process	Tumor necrosis factor	Homo sapiens (human)
positive regulation of membrane protein ectodomain proteolysis	Tumor necrosis factor	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Tumor necrosis factor	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Tumor necrosis factor	Homo sapiens (human)
positive regulation of protein transport	Tumor necrosis factor	Homo sapiens (human)
response to glucocorticoid	Tumor necrosis factor	Homo sapiens (human)
positive regulation of hair follicle development	Tumor necrosis factor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Tumor necrosis factor	Homo sapiens (human)
regulation of synaptic transmission, glutamatergic	Tumor necrosis factor	Homo sapiens (human)
positive regulation of glial cell proliferation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of vitamin D biosynthetic process	Tumor necrosis factor	Homo sapiens (human)
positive regulation of calcidiol 1-monooxygenase activity	Tumor necrosis factor	Homo sapiens (human)
epithelial cell proliferation involved in salivary gland morphogenesis	Tumor necrosis factor	Homo sapiens (human)
regulation of branching involved in salivary gland morphogenesis	Tumor necrosis factor	Homo sapiens (human)
negative regulation of vascular wound healing	Tumor necrosis factor	Homo sapiens (human)
negative regulation of branching involved in lung morphogenesis	Tumor necrosis factor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Tumor necrosis factor	Homo sapiens (human)
cellular response to lipopolysaccharide	Tumor necrosis factor	Homo sapiens (human)
cellular response to amino acid stimulus	Tumor necrosis factor	Homo sapiens (human)
cellular response to retinoic acid	Tumor necrosis factor	Homo sapiens (human)
cellular response to nicotine	Tumor necrosis factor	Homo sapiens (human)
cellular response to type II interferon	Tumor necrosis factor	Homo sapiens (human)
cellular response to ionizing radiation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of mononuclear cell migration	Tumor necrosis factor	Homo sapiens (human)
positive regulation of podosome assembly	Tumor necrosis factor	Homo sapiens (human)
endothelial cell apoptotic process	Tumor necrosis factor	Homo sapiens (human)
protein localization to plasma membrane	Tumor necrosis factor	Homo sapiens (human)
negative regulation of oxidative phosphorylation	Tumor necrosis factor	Homo sapiens (human)
inflammatory response to wounding	Tumor necrosis factor	Homo sapiens (human)
extrinsic apoptotic signaling pathway	Tumor necrosis factor	Homo sapiens (human)
cellular response to toxic substance	Tumor necrosis factor	Homo sapiens (human)
liver regeneration	Tumor necrosis factor	Homo sapiens (human)
necroptotic signaling pathway	Tumor necrosis factor	Homo sapiens (human)
negative regulation of bile acid secretion	Tumor necrosis factor	Homo sapiens (human)
antiviral innate immune response	Tumor necrosis factor	Homo sapiens (human)
response to Gram-negative bacterium	Tumor necrosis factor	Homo sapiens (human)
positive regulation of neuroinflammatory response	Tumor necrosis factor	Homo sapiens (human)
negative regulation of amyloid-beta clearance	Tumor necrosis factor	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Tumor necrosis factor	Homo sapiens (human)
positive regulation of amyloid-beta formation	Tumor necrosis factor	Homo sapiens (human)
response to L-glutamate	Tumor necrosis factor	Homo sapiens (human)
positive regulation of neutrophil activation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Tumor necrosis factor	Homo sapiens (human)
regulation of establishment of endothelial barrier	Tumor necrosis factor	Homo sapiens (human)
negative regulation of bicellular tight junction assembly	Tumor necrosis factor	Homo sapiens (human)
cellular response to amyloid-beta	Tumor necrosis factor	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of leukocyte adhesion to vascular endothelial cell	Tumor necrosis factor	Homo sapiens (human)
positive regulation of leukocyte adhesion to arterial endothelial cell	Tumor necrosis factor	Homo sapiens (human)
regulation of membrane lipid metabolic process	Tumor necrosis factor	Homo sapiens (human)
response to 3,3',5-triiodo-L-thyronine	Tumor necrosis factor	Homo sapiens (human)
response to gold nanoparticle	Tumor necrosis factor	Homo sapiens (human)
positive regulation of protein localization to cell surface	Tumor necrosis factor	Homo sapiens (human)
positive regulation of blood microparticle formation	Tumor necrosis factor	Homo sapiens (human)
positive regulation of chemokine (C-X-C motif) ligand 2 production	Tumor necrosis factor	Homo sapiens (human)
positive regulation of hepatocyte proliferation	Tumor necrosis factor	Homo sapiens (human)
regulation of endothelial cell apoptotic process	Tumor necrosis factor	Homo sapiens (human)
regulation of reactive oxygen species metabolic process	Tumor necrosis factor	Homo sapiens (human)
positive regulation of DNA biosynthetic process	Tumor necrosis factor	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Tumor necrosis factor	Homo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathway	Tumor necrosis factor	Homo sapiens (human)
signal transduction	Platelet-derived growth factor receptor beta	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell population proliferation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phospholipase C activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of smooth muscle cell migration	Platelet-derived growth factor receptor beta	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell migration	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
regulation of actin cytoskeleton organization	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell migration involved in vasculogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
aorta morphogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of MAP kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of mitotic nuclear division	Platelet-derived growth factor receptor beta	Homo sapiens (human)
phosphatidylinositol metabolic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein autophosphorylation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cardiac myofibril assembly	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell migration involved in coronary angiogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
retina vasculature development in camera-type eye	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Platelet-derived growth factor receptor beta	Homo sapiens (human)
smooth muscle cell chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
metanephric glomerular mesangial cell proliferation involved in metanephros development	Platelet-derived growth factor receptor beta	Homo sapiens (human)
metanephric glomerular capillary formation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of calcium ion import	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of DNA biosynthetic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
angiogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
multicellular organism development	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell population proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Fibroblast growth factor receptor 1	Homo sapiens (human)
MAPK cascade	Fibroblast growth factor receptor 1	Homo sapiens (human)
skeletal system development	Fibroblast growth factor receptor 1	Homo sapiens (human)
angiogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
ureteric bud development	Fibroblast growth factor receptor 1	Homo sapiens (human)
in utero embryonic development	Fibroblast growth factor receptor 1	Homo sapiens (human)
organ induction	Fibroblast growth factor receptor 1	Homo sapiens (human)
neuron migration	Fibroblast growth factor receptor 1	Homo sapiens (human)
epithelial to mesenchymal transition	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of mesenchymal cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
chondrocyte differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein phosphorylation	Fibroblast growth factor receptor 1	Homo sapiens (human)
sensory perception of sound	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of cell population proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
mesenchymal cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
gene expression	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of phospholipase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of phospholipase C activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of phosphate transport	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of neuron projection development	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell migration	Fibroblast growth factor receptor 1	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Fibroblast growth factor receptor 1	Homo sapiens (human)
ventricular zone neuroblast division	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell projection assembly	Fibroblast growth factor receptor 1	Homo sapiens (human)
embryonic limb morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
midbrain development	Fibroblast growth factor receptor 1	Homo sapiens (human)
neuron projection development	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	Fibroblast growth factor receptor 1	Homo sapiens (human)
inner ear morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
outer ear morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
middle ear morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
chordate embryonic development	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of MAP kinase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of MAPK cascade	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Fibroblast growth factor receptor 1	Homo sapiens (human)
cellular response to fibroblast growth factor stimulus	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of cell differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of neuron differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein autophosphorylation	Fibroblast growth factor receptor 1	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Fibroblast growth factor receptor 1	Homo sapiens (human)
paraxial mesoderm development	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of lateral mesodermal cell fate specification	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell maturation	Fibroblast growth factor receptor 1	Homo sapiens (human)
skeletal system morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
stem cell differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Fibroblast growth factor receptor 1	Homo sapiens (human)
calcium ion homeostasis	Fibroblast growth factor receptor 1	Homo sapiens (human)
cardiac muscle cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
auditory receptor cell development	Fibroblast growth factor receptor 1	Homo sapiens (human)
branching involved in salivary gland morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
lung-associated mesenchyme development	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	Fibroblast growth factor receptor 1	Homo sapiens (human)
vitamin D3 metabolic process	Fibroblast growth factor receptor 1	Homo sapiens (human)
diphosphate metabolic process	Fibroblast growth factor receptor 1	Homo sapiens (human)
cementum mineralization	Fibroblast growth factor receptor 1	Homo sapiens (human)
stem cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
negative regulation of fibroblast growth factor production	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of mitotic cell cycle DNA replication	Fibroblast growth factor receptor 1	Homo sapiens (human)
response to sodium phosphate	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of vascular endothelial cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of stem cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of parathyroid hormone secretion	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of extrinsic apoptotic signaling pathway in absence of ligand	Fibroblast growth factor receptor 1	Homo sapiens (human)
multicellular organism development	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of cell differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of kinase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
C21-steroid hormone biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
glucocorticoid biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
immune response	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
regulation of blood pressure	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
sterol metabolic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
aldosterone biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cellular response to hormone stimulus	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cortisol biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cellular response to potassium ion	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
glucose homeostasis	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cortisol metabolic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cellular response to peptide hormone stimulus	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cortisol biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
regulation of blood volume by renal aldosterone	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
renal water homeostasis	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
C21-steroid hormone biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
mineralocorticoid biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
sterol metabolic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
aldosterone biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cellular response to hormone stimulus	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cortisol biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cellular response to potassium ion	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
potassium ion homeostasis	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
sodium ion homeostasis	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
glucocorticoid biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cortisol metabolic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cellular response to peptide hormone stimulus	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
renal water homeostasis	Guanine nucleotide-binding protein G	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G	Homo sapiens (human)
regulation of insulin secretion	Guanine nucleotide-binding protein G	Homo sapiens (human)
cellular response to glucagon stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (32)

Process	via Protein(s)	Taxonomy
transcription cis-regulatory region binding	Tumor necrosis factor	Homo sapiens (human)
protease binding	Tumor necrosis factor	Homo sapiens (human)
cytokine activity	Tumor necrosis factor	Homo sapiens (human)
tumor necrosis factor receptor binding	Tumor necrosis factor	Homo sapiens (human)
protein binding	Tumor necrosis factor	Homo sapiens (human)
death receptor agonist activity	Tumor necrosis factor	Homo sapiens (human)
identical protein binding	Tumor necrosis factor	Homo sapiens (human)
protein kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein tyrosine kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet activating factor receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor beta-receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
signaling receptor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
ATP binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
enzyme binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein kinase binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
vascular endothelial growth factor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein tyrosine kinase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
ATP binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
heparin binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
SH2 domain binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
identical protein binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein homodimerization activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
receptor-receptor interaction	Fibroblast growth factor receptor 1	Homo sapiens (human)
steroid 11-beta-monooxygenase activity	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
iron ion binding	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
heme binding	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
corticosterone 18-monooxygenase activity	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
steroid 11-beta-monooxygenase activity	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
iron ion binding	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
steroid hydroxylase activity	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
heme binding	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
corticosterone 18-monooxygenase activity	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
G protein activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
adenylate cyclase activator activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (22)

Process	via Protein(s)	Taxonomy
extracellular space	Tumor necrosis factor	Homo sapiens (human)
phagocytic cup	Tumor necrosis factor	Homo sapiens (human)
extracellular region	Tumor necrosis factor	Homo sapiens (human)
extracellular space	Tumor necrosis factor	Homo sapiens (human)
plasma membrane	Tumor necrosis factor	Homo sapiens (human)
external side of plasma membrane	Tumor necrosis factor	Homo sapiens (human)
cell surface	Tumor necrosis factor	Homo sapiens (human)
neuronal cell body	Tumor necrosis factor	Homo sapiens (human)
membrane raft	Tumor necrosis factor	Homo sapiens (human)
recycling endosome	Tumor necrosis factor	Homo sapiens (human)
cell surface	Tumor necrosis factor	Homo sapiens (human)
nucleus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cytoplasm	Platelet-derived growth factor receptor beta	Homo sapiens (human)
Golgi apparatus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
focal adhesion	Platelet-derived growth factor receptor beta	Homo sapiens (human)
membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
apical plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cytoplasmic vesicle	Platelet-derived growth factor receptor beta	Homo sapiens (human)
lysosomal lumen	Platelet-derived growth factor receptor beta	Homo sapiens (human)
intracellular membrane-bounded organelle	Platelet-derived growth factor receptor beta	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
receptor complex	Platelet-derived growth factor receptor beta	Homo sapiens (human)
extracellular region	Fibroblast growth factor receptor 1	Homo sapiens (human)
nucleus	Fibroblast growth factor receptor 1	Homo sapiens (human)
cytosol	Fibroblast growth factor receptor 1	Homo sapiens (human)
plasma membrane	Fibroblast growth factor receptor 1	Homo sapiens (human)
membrane	Fibroblast growth factor receptor 1	Homo sapiens (human)
cytoplasmic vesicle	Fibroblast growth factor receptor 1	Homo sapiens (human)
receptor complex	Fibroblast growth factor receptor 1	Homo sapiens (human)
plasma membrane	Fibroblast growth factor receptor 1	Homo sapiens (human)
mitochondrion	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
mitochondrion	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
plasma membrane	Guanine nucleotide-binding protein G	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (31)

Assay ID	Title	Year	Journal	Article
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID18990	Partition coefficient (logD7.4) measured using octanol and PBS at pH7.4	2003	Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4	A structure-permeability study of small drug-like molecules.
AID553066	Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate	2011	ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1	First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
AID1744288	Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) assessed as binding constant (Koff) by SPR analysis	2021	Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1	Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
AID7817	Permeability coefficient (Papp) (Caco-2 cell monolayer)	2003	Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4	A structure-permeability study of small drug-like molecules.
AID73439	Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing human fibroblast growth factor receptor 1	1998	Journal of medicinal chemistry, Dec-31, Volume: 41, Issue:27	Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.
AID553068	Inhibition of human recombinant CYP17 expressed in Escherichia coli at 2 uM using progesterone substrate	2011	ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1	First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
AID433906	Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 5 days by microplate alamar blue assay	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and antitubercular screening of imidazole derivatives.
AID161099	Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing mouse platelet-derived growth factor receptor beta	1998	Journal of medicinal chemistry, Dec-31, Volume: 41, Issue:27	Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.
AID1744292	Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assay	2021	Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1	Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
AID553067	Selectivity index, ratio of IC50 for human CYP11B2 to IC50 for human CYP11B1	2011	ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1	First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
AID1744287	Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) assessed as binding constant (Kon) by SPR analysis	2021	Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1	Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
AID643269	Inhibition of N-terminus His-tagged Francisella tularensis subsp. Tularensis Schu4 Fab1 expressed in Escherichia coli DL21 (DE3) cells assessed as conversion of crotonyl-CoA and NADH to butyryl-CoA and NAD+ preincubated for 30 mins by measured fluorescenc	2012	Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1	Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching.
AID1744286	Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis	2021	Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1	Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
AID553065	Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate	2011	ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1	First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
AID433905	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar microdilution assay	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and antitubercular screening of imidazole derivatives.
AID553069	Inhibition of human placental microsomes CYP19 at 500 nM using androstenedione substrate	2011	ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1	First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
AID1744298	Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assay	2021	Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1	Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
AID1795561	Kinase Inhibition Assay from Article 10.1021/jm9804681: \\Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.\\	1998	Journal of medicinal chemistry, Dec-31, Volume: 41, Issue:27	Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (9.09)	18.2507
2000's	3 (27.27)	29.6817
2010's	5 (45.45)	24.3611
2020's	2 (18.18)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	2.05	1	carbohydrazide	antitubercular agent; drug allergen
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.06	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
metyrapone Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.. metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.	2.06	1	aromatic ketone	antimetabolite; diagnostic agent; EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor
2-phenylbenzimidazole 2-phenylbenzimidazole: structure in first source	1.99	1
ethambutol Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.	2.05	1	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic
1-benzylimidazole 1-benzylimidazole: inhibits human thromboxane synthetase	2.44	2
etomidate Etomidate: Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.. etomidate : The ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity.	2.06	1	ethyl ester; imidazoles	intravenous anaesthetic; sedative
1-[(3-methylphenyl)methyl]benzimidazole [no description available]	2.06	1	benzimidazoles

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Rheumatoid Arthritis [description not available]	2.31	1
Autoimmune Disease [description not available]	2.31	1
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	2.31	1
Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	2.31	1

1-(phenylmethyl)benzimidazole

Cross-References

Synonyms (39)

Drug Classes (1)

Protein Targets (12)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (289)

Molecular Functions (32)

Ceullar Components (22)

Bioassays (31)

Research

Studies (11)

Market Indicators

Research Demand Index: 12.64

Study Types

1-(phenylmethyl)benzimidazole

Cross-References

Synonyms (39)

Drug Classes (1)

Protein Targets (12)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (289)

Molecular Functions (32)

Ceullar Components (22)

Bioassays (31)

Research

Studies (11)

Market Indicators

Research Demand Index: 12.64

Study Types

Related Drugs (8)

Related Conditions (6)