dihydroisosteviol: isolated from Stevia rebaudiana; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Stevia | genus | A plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 21578548 |
| CHEMBL ID | 471642 |
| MeSH ID | M0588102 |
| Synonym |
|---|
| CHEMBL471642 , |
| dihydroisosteviol |
| bdbm50504373 |
| (1r,4s,5r,9s,10r,13s,14r)-14-hydroxy-5,9,13-trimethyltetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Coagulation factor X | Homo sapiens (human) | Ki | 27.5580 | 0.0000 | 0.4708 | 9.0000 | AID1517792 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| proteolysis | Coagulation factor X | Homo sapiens (human) |
| blood coagulation | Coagulation factor X | Homo sapiens (human) |
| positive regulation of cell migration | Coagulation factor X | Homo sapiens (human) |
| positive regulation of TOR signaling | Coagulation factor X | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| serine-type endopeptidase activity | Coagulation factor X | Homo sapiens (human) |
| calcium ion binding | Coagulation factor X | Homo sapiens (human) |
| protein binding | Coagulation factor X | Homo sapiens (human) |
| phospholipid binding | Coagulation factor X | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| extracellular region | Coagulation factor X | Homo sapiens (human) |
| endoplasmic reticulum lumen | Coagulation factor X | Homo sapiens (human) |
| Golgi lumen | Coagulation factor X | Homo sapiens (human) |
| plasma membrane | Coagulation factor X | Homo sapiens (human) |
| external side of plasma membrane | Coagulation factor X | Homo sapiens (human) |
| extracellular space | Coagulation factor X | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID392928 | Inhibition of yeast alpha glucosidase after 30 mins | 2009 | Bioorganic & medicinal chemistry, Feb-15, Volume: 17, Issue:4 | Stereoselective synthesis of bioactive isosteviol derivatives as alpha-glucosidase inhibitors. |
| AID1517792 | Inhibition of human activated Factor X using S-2765 as substrate incubated for 15 mins followed by substrate addition and measured after 1 hr by chromogenic assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Discovery of novel, potent, isosteviol-based antithrombotic agents. |
| AID1517827 | Antithrombotic activity in Wistar rat plasma assessed as thrombus formation time at 22 umol/kg, po measured after 1 hr (Rvb = 9.4 +/- 8.9 mins) | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Discovery of novel, potent, isosteviol-based antithrombotic agents. |
| AID414285 | Cytotoxicity against mouse B16F10 cells at 100 uM after 48 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities. |
| AID730810 | Vasorelaxant activity in Sprague-Dawley rat aorta assessed as reduction of phenylephrine-induced contraction | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Potent vasorelaxant analogs from chemical modification and biotransformation of isosteviol. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.51) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||