Page last updated: 2024-11-13
dihydroisosteviol
Description
dihydroisosteviol: isolated from Stevia rebaudiana; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Flora | Rank | Flora Definition | Family | Family Definition |
Stevia | genus | A plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
Cross-References
Synonyms (4)
Synonym |
CHEMBL471642 , |
dihydroisosteviol |
bdbm50504373 |
(1r,4s,5r,9s,10r,13s,14r)-14-hydroxy-5,9,13-trimethyltetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid |
Protein Targets (1)
Inhibition Measurements
Biological Processes (4)
Molecular Functions (4)
Ceullar Components (6)
Bioassays (5)
Assay ID | Title | Year | Journal | Article |
AID392928 | Inhibition of yeast alpha glucosidase after 30 mins | 2009 | Bioorganic & medicinal chemistry, Feb-15, Volume: 17, Issue:4
| Stereoselective synthesis of bioactive isosteviol derivatives as alpha-glucosidase inhibitors. |
AID1517792 | Inhibition of human activated Factor X using S-2765 as substrate incubated for 15 mins followed by substrate addition and measured after 1 hr by chromogenic assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Discovery of novel, potent, isosteviol-based antithrombotic agents. |
AID1517827 | Antithrombotic activity in Wistar rat plasma assessed as thrombus formation time at 22 umol/kg, po measured after 1 hr (Rvb = 9.4 +/- 8.9 mins) | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Discovery of novel, potent, isosteviol-based antithrombotic agents. |
AID414285 | Cytotoxicity against mouse B16F10 cells at 100 uM after 48 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities. |
AID730810 | Vasorelaxant activity in Sprague-Dawley rat aorta assessed as reduction of phenylephrine-induced contraction | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Potent vasorelaxant analogs from chemical modification and biotransformation of isosteviol. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (7)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 1 (14.29) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (28.57) | 29.6817 |
2010's | 4 (57.14) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.51
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 12.51 (24.57) | Research Supply Index | 2.08 (2.92) | Research Growth Index | 4.59 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |