Compounds > 6-amino-5,7,7-tricyano-8-pyridin-4-yl-1,3,8,8a-tetrahydroisoquinoline-2-carboxylic acid (phenylmethyl) ester
Page last updated: 2024-07-31 21:48:18

6-amino-5,7,7-tricyano-8-pyridin-4-yl-1,3,8,8a-tetrahydroisoquinoline-2-carboxylic acid (phenylmethyl) ester

Description

6-amino-5,7,7-tricyano-8-pyridin-4-yl-1,3,8,8a-tetrahydroisoquinoline-2-carboxylic acid (phenylmethyl) ester : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID3156405
CHEMBL ID1603667
CHEBI ID117052

Synonyms (15)

Synonym
smr000120384
6-amino-5,7,7-tricyano-8-pyridin-4-yl-3,7,8,8a-tetrahydro-1h-isoquinoline-2-carboxylic acid benzyl ester
MLS000527810 ,
MLS002539067
CHEBI:117052
AKOS000667568
benzyl 6-amino-5,7,7-tricyano-8-pyridin-4-yl-1,3,8,8a-tetrahydroisoquinoline-2-carboxylate
HMS2165K17
HMS3322F09
AKOS024306295
CHEMBL1603667
sr-01000364656
SR-01000364656-1
6-amino-5,7,7-tricyano-8-pyridin-4-yl-1,3,8,8a-tetrahydroisoquinoline-2-carboxylic acid (phenylmethyl) ester
Q27203675

Drug Classes (1)

ClassDescription
carboxylic esterAn ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.

Protein Targets (28)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency35.4813AID2147
Chain A, CruzipainTrypanosoma cruziPotency39.8107AID1476
acid sphingomyelinaseHomo sapiens (human)Potency25.1189AID504937
Nrf2Homo sapiens (human)Potency35.4813AID624171
glp-1 receptor, partialHomo sapiens (human)Potency28.1838AID624417
TDP1 proteinHomo sapiens (human)Potency18.4782AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency25.1189AID1460; AID1468
thioredoxin glutathione reductaseSchistosoma mansoniPotency31.6228AID485364
Smad3Homo sapiens (human)Potency15.8489AID588855
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency17.7828AID1030
isocitrate dehydrogenase 1, partialHomo sapiens (human)Potency47.0795AID602179; AID623995; AID624002
P53Homo sapiens (human)Potency50.1187AID504706
IDH1Homo sapiens (human)Potency20.5962AID686970
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency15.8489AID504332
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency12.5893AID504847
chromobox protein homolog 1Homo sapiens (human)Potency79.4328AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.1093AID504444
importin subunit beta-1 isoform 1Homo sapiens (human)Potency65.8114AID540253; AID540263
snurportin-1Homo sapiens (human)Potency65.8114AID540253; AID540263
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency84.9214AID504891
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency31.6228AID540253
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency12.5893AID588590
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency0.1122AID2551
gemininHomo sapiens (human)Potency26.9188AID624296; AID624297
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency17.7828AID602310
neuropeptide S receptor isoform AHomo sapiens (human)Potency3.9811AID1461
Glycoprotein hormones alpha chainHomo sapiens (human)Potency15.8489AID624291
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency35.4813AID901

Bioassays (7)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
acemetacin
0
carboxylic ester;
indol-3-yl carboxylic acid;
monocarboxylic acid;
monochlorobenzenes;
N-acylindole		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug		00low000000
camostat
0
benzoate ester;
carboxylic ester;
diester;
guanidines;
tertiary carboxamide		anti-inflammatory agent;
anticoronaviral agent;
antifibrinolytic drug;
antihypertensive agent;
antineoplastic agent;
antiviral agent;
serine protease inhibitor		00low000000
cyclandelate
0
carboxylic ester;
secondary alcohol		vasodilator agent00low000000
cyclopentolate
0
carboxylic ester;
tertiary alcohol;
tertiary amino compound		diagnostic agent;
muscarinic antagonist;
mydriatic agent;
parasympatholytic		00low000000
dicyclomine
0
carboxylic ester;
tertiary amine		antispasmodic drug;
muscarinic antagonist;
parasympatholytic		00low000000
fenvalerate
0
aromatic ether;
carboxylic ester;
monochlorobenzenes		pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
flavoxate
0
carboxylic ester;
flavones;
piperidines;
tertiary amino compound		antispasmodic drug;
muscarinic antagonist;
parasympatholytic		00low000000
fpl 64176
0
carboxylic ester;
pyrroles		calcium channel agonist00low000000
glafenine
0
aminoquinoline;
carboxylic ester;
glycol;
organochlorine compound;
secondary amino compound		inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
oxybutynin
0
acetylenic compound;
carboxylic ester;
racemate;
tertiary alcohol;
tertiary amino compound		antispasmodic drug;
calcium channel blocker;
local anaesthetic;
muscarinic antagonist;
muscle relaxant;
parasympatholytic		00low000000
proglumetacin
0
aromatic ether;
benzamides;
carboxylic ester;
monochlorobenzenes;
N-acylindole;
N-alkylpiperazine		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
lipoxygenase inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug		00low000000
diethylhexyladipate
0
carboxylic ester;
dicarboxylic acids and O-substituted derivatives;
diester		plasticiser00low000000
citronellyl formate
0
carboxylic ester00low000000
lauryl acetate
0
carboxylic ester00low000000
n-butyl lactate
0
carboxylic ester00low000000
triflusal
0
benzoic acids;
carboxylic ester;
salicylates		00low000000
nitrosomethylurethane
0
carboxylic ester00low000000
diloxanide furoate
0
carboxylic ester;
furans;
organochlorine compound;
tertiary carboxamide		antiamoebic agent;
prodrug		00low000000
tocamphyl
0
carboxylic ester00low000000
dioctyl adipate
0
carboxylic ester00low000000
bitolterol
0
carboxylic ester;
diester;
ethanolamines;
secondary alcohol;
secondary amino compound		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
prodrug		00low000000
nitazoxanide
0
benzamides;
carboxylic ester		00low000000
fluazifop-butyl
0
aromatic ether;
carboxylic ester;
organofluorine compound;
pyridines		00low000000
pravastatin
0
3-hydroxy carboxylic acid;
carbobicyclic compound;
carboxylic ester;
hydroxy monocarboxylic acid;
secondary alcohol;
statin (semi-synthetic)		anticholesteremic drug;
environmental contaminant;
metabolite;
xenobiotic		00low000000
Phenylmethyl benzeneacetate
0
carboxylic ester00low000000
methylphenylcarbinyl acetate
0
carboxylic ester00low000000
mevastatin
0
2-pyranones;
carboxylic ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		antifungal agent;
apoptosis inducer;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
fungal metabolite;
Penicillium metabolite		00low000000
xanthoxyline
0
carboxylic ester00low000000
tosiben
0
benzoic acids;
carboxylic ester;
salicylates		00low000000
2,4,6-trihydroxybenzaldehyde
0
carboxylic ester00low000000
aceclofenac
0
amino acid;
carboxylic ester;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
serpentine (alkaloid)
0
carboxylic ester;
iminium betaine;
indole alkaloid;
quinolizines;
zwitterion		00low000000
indicine
0
carboxylic ester;
pyrrolizines		00low000000
clodinafop-propargyl
0
aromatic ether;
carboxylic ester;
organochlorine compound;
organofluorine compound;
propyzamide;
pyridines		agrochemical;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
herbicide		00low000000
cloquintocet-mexyl
0
aromatic ether;
carboxylic ester;
organochlorine compound;
quinolines		00low000000
methyl 5-nitro-2-furoate
0
carboxylic ester00low000000
efonidipine
0
C-nitro compound;
carboxylic ester;
dihydropyridine;
tertiary amino compound		00low000000
nitroflurbiprofen
0
biphenyls;
carboxylic ester;
nitrate ester;
organofluorine compound		cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector;
non-steroidal anti-inflammatory drug;
vasodilator agent		00low000000
benzyloxycarbonylphenylalanylphenylalanine diazomethyl ketone
0
carboxylic ester;
diazo compound;
L-phenylalanine derivative;
secondary carboxamide		cathepsin L (EC 3.4.22.15) inhibitor00low000000
cefotiam hexetil
0
carboxylic esterprodrug00low000000
celastrol methyl ester
0
carboxylic ester00low000000
sulochrin
0
benzophenones;
carboxylic ester;
phenols		metabolite00low000000
asperphenamate
0
benzamides;
carboxylic ester;
L-phenylalanine derivative		antineoplastic agent00low000000
bifenazate
0
carboxylic esteracaricide00low000000
dabigatran etexilate
0
aromatic amide;
benzimidazoles;
beta-alanine derivative;
carboxamidine;
carboxylic ester;
pyridines		anticoagulant;
EC 3.4.21.5 (thrombin) inhibitor;
prodrug		00low000000
Tautomycin
0
carboxylic ester00low000000
glaucarubinone
0
carboxylic ester;
organic heteropentacyclic compound;
quassinoid;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone;
tetrol		antimalarial;
antineoplastic agent;
geroprotector;
plant metabolite		00low000000
glaucolide b
0
carboxylic ester;
ketone		00low000000
agrimophol
0
carboxylic ester00low000000
[(1S,2R,3S,4S,6R,7R,8R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetate
0
carbotricyclic compound;
carboxylic ester;
cyclic ketone		00low000000
valnemulin
0
carbotricyclic compound;
carboxylic ester;
cyclic ketone		00low000000
colforsin daropate
0
acetate ester;
carboxylic ester;
cyclic ketone;
diol;
organic heterotricyclic compound;
tertiary amino compound		adenylate cyclase agonist;
antihypertensive agent;
cardiotonic drug;
vasodilator agent		00low000000
kt 5720
0
carboxylic ester;
gamma-lactam;
hemiaminal;
indolocarbazole;
organic heterooctacyclic compound;
semisynthetic derivative;
tertiary alcohol		EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor00low000000
azaserine
0
carboxylic ester;
diazo compound;
L-serine derivative;
non-proteinogenic L-alpha-amino acid		antifungal agent;
antimetabolite;
antimicrobial agent;
antineoplastic agent;
glutamine antagonist;
immunosuppressive agent;
metabolite		00low000000
5-[[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]methyl]-2-furancarboxylic acid ethyl ester
0
carboxylic ester00low000000
transfluthrin
0
carboxylic ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester insecticide00low000000
tiamulin
0
carbotricyclic compound;
carboxylic ester;
cyclic ketone;
organic sulfide;
secondary alcohol;
semisynthetic derivative;
tertiary amino compound;
tetracyclic diterpenoid		antibacterial drug00low000000
2-furancarboxylic acid (2-acetyl-1-benzothiophen-3-yl) ester
0
carboxylic ester00low000000
2,4-dimethyl-6-oxo-3-pyrancarboxylic acid (3-nitrophenyl)methyl ester
0
carboxylic ester00low000000
2-(4-methylsulfonyl-2-nitrophenyl)sulfinylacetic acid (phenylmethyl) ester
0
carboxylic ester00low000000
4-(3-methylanilino)-4-oxobutanoic acid (4-bromophenyl)methyl ester
0
carboxylic ester00low000000
N-[1-methyl-3-(trifluoromethyl)-5-thieno[2,3-c]pyrazolyl]carbamic acid (4-fluorophenyl)methyl ester
0
carboxylic ester00low000000
4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (5-methoxycarbonyl-2-furanyl)methyl ester
0
carboxylic ester00low000000
N-[[(cyclohexylamino)-sulfanylidenemethyl]amino]carbamic acid tert-butyl ester
0
carboxylic ester00low000000
3-oxo-2,4-dihydroquinoxaline-1-carboxylic acid (phenylmethyl) ester
0
carboxylic ester00low000000
5-bromo-2-furancarboxylic acid [2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester
0
carboxylic ester00low000000
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid O4-ethyl ester O2-[(2-fluorophenyl)methyl] ester
0
carboxylic ester00low000000
5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester
0
carboxylic ester00low000000
5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester
0
carboxylic ester00low000000
4-[2-(difluoromethoxy)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (phenylmethyl) ester
0
carboxylic ester00low000000
2-[2-[5-[(3,4-dimethylanilino)-oxomethyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin-4-yl]phenoxy]propanoic acid ethyl ester
0
carboxylic ester00low000000
2-(6-imidazo[2,1-b]thiazolyl)acetic acid (phenylmethyl) ester
0
carboxylic ester00low000000
orlistat
0
beta-lactone;
carboxylic ester;
formamides;
L-leucine derivative		anti-obesity agent;
bacterial metabolite;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor		00low000000
2-furancarboxylic acid [2-(cyclohexylamino)-2-oxo-1-phenylethyl] ester
0
carboxylic ester00low000000
N-[(S)-[(1S,2R)-1-methyl-2-[(2R)-1-[(5-methyl-2-furanyl)methylamino]-1-oxopropan-2-yl]cyclopropyl]-phenylmethyl]carbamic acid (phenylmethyl) ester
0
carboxylic ester00low000000
N-[(S)-[(1S,2R)-1-methyl-2-[(2R)-1-oxo-1-[(phenylmethyl)amino]propan-2-yl]cyclopropyl]-phenylmethyl]carbamic acid (phenylmethyl) ester
0
carboxylic ester00low000000
2,5-dimethyl-3-furancarboxylic acid [2-(2-ethoxyanilino)-2-oxo-1-phenylethyl] ester
0
carboxylic ester00low000000
mycophenolate mofetil
0
carboxylic ester;
ether;
gamma-lactone;
phenols;
tertiary amino compound		anticoronaviral agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
immunosuppressive agent;
prodrug		00low000000
5-o-caffeoylshikimic acid
0
alpha,beta-unsaturated monocarboxylic acid;
carboxylic ester;
catechols;
cyclohexenecarboxylic acid		plant metabolite00low000000
metofluthrin
0
carboxylic ester00low000000
n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester
0
carboxylic ester;
difluorobenzene;
dipeptide;
tert-butyl ester		EC 3.4.23.46 (memapsin 2) inhibitor00low000000
rosmarinic acid
0
carboxylic ester;
monocarboxylic acid;
phenylpropanoid;
polyphenol		antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite;
serine proteinase inhibitor		00low000000
3-hexenylacetate
0
carboxylic ester00low000000
11-tetradecenyl acetate
0
carboxylic ester00low000000
crotoxyphos
0
carboxylic ester00low000000
4-[6-(2,4-dichlorophenyl)-4-methyl-2-oxo-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl]butanoic acid
0
carboxylic ester00low000000
6-[4-methyl-6-(4-nitrophenyl)-2-oxo-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl]hexanoic acid
0
carboxylic ester00low000000
resiniferatoxin
0
carboxylic ester;
diterpenoid;
enone;
monomethoxybenzene;
organic heteropentacyclic compound;
ortho ester;
phenols;
tertiary alpha-hydroxy ketone		analgesic;
neurotoxin;
plant metabolite;
TRPV1 agonist		00low000000
bifenthrin
0
carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
cefpodoxime proxetil
0
carboxylic acid;
carboxylic ester;
cephalosporin		antibacterial drug;
prodrug		00low000000
fumagillin
0
antibiotic antifungal drug;
carboxylic ester;
dicarboxylic acid monoester;
meroterpenoid;
organooxygen heterocyclic antibiotic;
spiro-epoxide		angiogenesis inhibitor;
antibacterial drug;
antimicrobial agent;
antiprotozoal drug;
fungal metabolite;
methionine aminopeptidase 2 inhibitor		00low000000
laulimalide
0
carboxylic ester;
epoxide;
macrolide;
secondary alcohol;
secondary allylic alcohol		animal metabolite;
antimitotic;
antineoplastic agent;
marine metabolite;
microtubule-stabilising agent		00low000000
retapamulin
0
carbotricyclic compound;
carboxylic ester;
cyclic ketone		00low000000
5-Chloro-3-pyridinyl 2-furoate
0
carboxylic esteranticoronaviral agent00low000000
capsiate
0
carboxylic ester;
monomethoxybenzene;
phenols		angiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antioxidant;
capsaicin receptor agonist;
hypoglycemic agent;
plant metabolite		00low000000
naproxen-n-butyl nitrate
0
carboxylic ester;
methoxynaphthalene;
nitrate ester		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
nitric oxide donor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug		00low000000
tiamulin fumarate (1:1), (3as-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10s*))-isomer
0
carbotricyclic compound;
carboxylic ester;
cyclic ketone		00low000000
elloramycin
0
alpha-L-rhamnoside;
carboxylic ester;
enol ether;
enone;
methyl ester;
monosaccharide derivative;
phenols;
tertiary alpha-hydroxy ketone;
tetracenomycin		antimicrobial agent;
bacterial metabolite		00low000000
vibrioferrin
0
carboxylic ester;
N-acyl hemiaminal;
pyrrolidin-2-ones;
tertiary alcohol;
tricarboxylic acid		marine metabolite;
siderophore		00low000000
kalopanax saponin b
0
carboxylic ester;
pentacyclic triterpenoid;
triterpenoid saponin		anti-inflammatory agent;
plant metabolite		00low000000
batzelladine a
0
alkaloid;
carboxylic ester;
guanidines;
organic heterotricyclic compound;
pyrrolopyrimidine;
triazaacenaphthylene		anti-HIV-1 agent;
metabolite		00low000000
tosedostat
0
carboxylic ester;
hydroxamic acid;
secondary carboxamide		00low000000
5-Bromopyridin-3-yl furan-2-carboxylate
0
carboxylic esteranticoronaviral agent00low000000
5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate
0
carboxylic esteranticoronaviral agent00low000000
cauloside D
0
carboxylic ester;
pentacyclic triterpenoid;
triterpenoid saponin		anti-inflammatory agent;
plant metabolite		00low000000
n(alpha)-acetylfusarinines
0
2,5-diketopiperazines;
acetamides;
carboxylic ester;
homoallylic alcohol;
hydroxamic acid;
primary alcohol		siderophore00low000000
madecassoside
0
carboxylic ester;
pentacyclic triterpenoid;
trisaccharide derivative;
triterpenoid saponin		anti-inflammatory agent;
antioxidant;
antirheumatic drug;
plant metabolite;
vulnerary		00low000000
N-[[1H-benzimidazol-2-yl(oxo)methyl]amino]carbamic acid (phenylmethyl) ester
0
carboxylic ester00low000000
3-[[2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-1-oxoethyl]hydrazo]-3-oxo-2-phenylpropanoic acid (phenylmethyl) ester
0
carboxylic ester00low000000
integric acid
0
carboxylic ester;
cyclic ketone;
dioxo monocarboxylic acid;
enal;
enone;
eremophilane sesquiterpenoid		HIV-1 integrase inhibitor;
metabolite		00low000000
jq1 compound
0
carboxylic ester;
organochlorine compound;
tert-butyl ester;
thienotriazolodiazepine		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
bromodomain-containing protein 4 inhibitor;
cardioprotective agent;
ferroptosis inducer		00low000000
crambescidin 800
0
alkaloid;
carboxylic ester;
guanidines;
monocarboxylic acid amide;
organic heteropentacyclic compound;
primary amino compound;
secondary alcohol;
spiro compound		anti-HIV-1 agent;
anti-HSV-1 agent;
antimalarial;
marine metabolite		00low000000
opt 80
0
carboxylic ester;
glycoside;
macrolide antibiotic;
organochlorine compound;
phenols		antibacterial drug;
bacterial metabolite;
EC 2.7.7.6 (RNA polymerase) inhibitor		00low000000
ap20187
0
aromatic ether;
carboxylic ester;
N-acylpiperidine;
tertiary amino compound		ligand00low000000
s 8932
0
aromatic amine;
C-nucleoside;
carboxylic ester;
nitrile;
phosphoramidate ester;
pyrrolotriazine		anticoronaviral agent;
antiviral drug;
prodrug		00low000000
tak 491
0
1,2,4-oxadiazole;
aromatic ether;
benzimidazoles;
carboxylic ester;
cyclic carbonate ester;
dioxolane		angiotensin receptor antagonist;
antihypertensive agent;
prodrug		00low000000
dabigatran etexilate
0
aromatic amide;
benzimidazoles;
beta-alanine derivative;
carboxamidine;
carboxylic ester;
pyridines		anticoagulant;
EC 3.4.21.5 (thrombin) inhibitor;
prodrug		00low000000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100