| Assay ID | Title | Year | Journal | Article |
|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1231825 | Induction of DNA intercalation using 5'-d(CGATCG)2-3' by NMR analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID247461 | Concentration required to inhibit the growth of human colon cancer HCT116 cell line by 50% to initial after 120 hours; determined using MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID1231818 | Induction of DNA intercalation using 5'-d(GTAATATTAC)2-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1667372 | Anticancer activity against human HepG2 cells xenografted in mouse assessed as tumor inhibition rate at 5 mg/kg measured at day 14 relative to control | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID1452941 | Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1727974 | Antiproliferative activity against human SK-OV-3 cells by MTT assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. |
| AID442948 | Displacement of ethidium bromide from calf thymus DNA by fluorescence assay | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID249160 | Concentration required to cause lethality in human small cell lung cancer A549 cell line by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID442967 | Cytotoxicity against human SH-SY5Y assessed as decrease in ERK1 phosphorylation at 5 uM after 20 hrs by Western blotting | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID1231826 | Induction of DNA intercalation using 5'-d(GTCCGCGGAC)2-3' at 1:0, 1:0.5, 1:1, 1:1.5, 1:2 DNA to compound molar ratio by CD spectroscopic analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID273560 | Cytotoxicity against PC3 cells by SRB assay after 48 hrs | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24
| Synthesis and biological evaluation of new asymmetrical bisintercalators as potential antitumor drugs. |
| AID1452950 | Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1667368 | Antiproliferative activity against human SMMC7721 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID1452942 | Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID442968 | Cytotoxicity against human SH-SY5Y assessed as decrease in ERK2 phosphorylation at 5 uM after 20 hrs by Western blotting | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID442966 | Cytotoxicity against human SH-SY5Y assessed as decrease in ERK2 protein level at 5 uM after 20 hrs by Western blotting | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID1667366 | Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID247457 | Concentration required to inhibit the growth of human leukemia cancer HL-60 cell line by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID1667365 | Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID1231834 | Binding affinity to 5'-r(GCGCGCGC)2-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1667369 | Cytotoxicity against human HL7702 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID442945 | Cytotoxicity against human HL60 cells after 24 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID249159 | Concentration required to cause lethality in human malenoma cancer SK-MEL-2 cell line by 50% after 120 hrs; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID249157 | Concentration required to cause lethality in human colon cancer HCT116 cell line by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID1231830 | Binding affinity to 5'-d(GTAATATTAC)2-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID247459 | Concentration required to inhibit human small cell lung cancer A549 cell growth by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID1231823 | Induction of DNA intercalation using 5'-r(GUCCGCGGAC)2-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1452948 | Antiproliferative activity against human A375M cells harboring BRAF V600E mutant after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1727976 | Antiproliferative activity against human MGC-803 cells by MTT assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. |
| AID1667370 | Anticancer activity against human HepG2 cells xenografted in mouse assessed as tumor growth inhibition by measuring T/C ratio at 5 mg/kg measured at day 14 relative to control | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID1231821 | Induction of DNA intercalation using 5'-d(GTCCGTCGGAC)-3'/5'-(GTCCGACGGAC)-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID83616 | In vitro cytotoxicity against HT-29 (human colon adenocarcinoma) cell line. | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
| Chromophore-modified bis-naphthalimides: synthesis and antitumor activity of bis-dibenz[de,h]isoquinoline-1,3-diones. |
| AID442963 | Cytotoxicity against human SH-SY5Y assessed as p53 protein accumulation at 5 uM after 20 hrs by Western blotting | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID1231827 | Binding affinity to 5'-d(ATATATATATAT)2-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1231815 | Induction of DNA intercalation using 5'-d(ATATATATATAT)2-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1452946 | Antiproliferative activity against human 1205 Lu cells harboring BRAF V600E mutant after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1231829 | Binding affinity to 5'-d(ATATAGTATATA)-3'/5'-(TATATACTATAT)-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID442952 | Induction of apoptosis in human HL60 cells assessed as caspase 3 activation at 5 uM after 24 hrs by DEVDase activity assay | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID247458 | Concentration required to inhibit the growth of human malenoma cancer SK-MEL-2 cell line by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID442951 | Induction of apoptosis in human HL60 cells assessed as caspase 3 activation at 5 uM after 4 hrs by DEVDase activity assay | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID1727975 | Antiproliferative activity against human A549 cells by MTT assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. |
| AID1452953 | Cytotoxicity against human NHDF cells assessed as reduction in cell viability at 2.5 uM after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1231822 | Induction of DNA intercalation using 5'-r(GCGCGCGC)2-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1667376 | Anticancer activity against human T24 cells xenografted in mouse assessed as tumor growth inhibition by measuring T/C ratio at 5 mg/kg measured at day 14 relative to control | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID297007 | Antiproliferative activity against U373MG cells after 72 hrs by MTT assay | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. |
| AID1452943 | Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID235923 | Concentration required to cause lethality in human leukemia cancer HL-60 cell line by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID294813 | Cytotoxicity against V79 cells in hypoxic condition after 24 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: synthesis and biological evaluation. |
| AID297006 | Antiproliferative activity against Hs683 cells after 72 hrs by MTT assay | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. |
| AID1231831 | Binding affinity to 5'-d(GCGCGCGC)2-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1667364 | Antiproliferative activity against human SKOV3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID297009 | Antiproliferative activity against LoVo cells after 72 hrs by MTT assay | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. |
| AID297008 | Antiproliferative activity against HCT15 cells after 72 hrs by MTT assay | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. |
| AID1231832 | Binding affinity to 5'-d(GTCCGCGGAC)2-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1452945 | Antiproliferative activity against human 1205 Lu cells harboring BRAF V600E mutant after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID387556 | Displacement of ethidium bromide from calf thymus DNA assessed as ratio of concentration of ethidium in ethidium DNA complex to drug concentration by fluorometric assay | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
| Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs. |
| AID1452947 | Antiproliferative activity against human A375M cells harboring BRAF V600E mutant after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID26756 | DNA binding dissociation constant as KD | 1984 | Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
| Interactions of antitumor drugs with natural DNA: 1H NMR study of binding mode and kinetics. |
| AID1727973 | Antiproliferative activity against human T-24 cells by MTT assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. |
| AID249156 | Concentration required to cause lethality in human breast cancer MCF-7 cell line by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID297010 | Antiproliferative activity against A549 cells after 72 hrs by MTT assay | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. |
| AID1231817 | Induction of DNA intercalation using 5'-d(ATATAGTATATA)-3'/5'-(TATATACTATAT)-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID442964 | Cytotoxicity against human SH-SY5Y assessed as cell viability at 5 uM after 20 hrs by trypan blue exclusion assay | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID442965 | Cytotoxicity against human SH-SY5Y assessed as decrease in ERK1 protein level at 5 uM after 20 hrs by Western blotting | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
| Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. |
| AID1452949 | Antiproliferative activity against human A375M cells harboring BRAF V600E mutant after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1452955 | Inhibition of human DNA topoisomerase 2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA at 0.5 to 5 uM after 1 hr by ethidium bromide staining-based agarose gel electrophoresis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID297015 | Antitumor activity in L1210 cells xenografted B6D2F1 mouse at 20 mg/kg, ip relative to control | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. |
| AID1231833 | Binding affinity to 5'-d(GTCCGTCGGAC)-3'/5'-(GTCCGACGGAC)-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID297012 | Toxicity in ip dosed B6D2F1 mouse | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. |
| AID1231820 | Induction of DNA intercalation using 5'-d(GTCCGCGGAC)2-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1231819 | Induction of DNA intercalation using 5'-d(GCGCGCGC)2-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1667367 | Antiproliferative activity against human T24 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID247456 | Concentration required to inhibit the growth of human breast cancer MCF-7 cell line by 50% after 120 hours; determined by MTT assay | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| A new synthetic agent with potent but selective cytotoxic activity against cancer. |
| AID1727972 | Antiproliferative activity against human SMMC-7721 cells by MTT assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. |
| AID294811 | Cytotoxicity against human A375 cells in hypoxic condition after 24 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: synthesis and biological evaluation. |
| AID1452952 | Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1452951 | Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID1452944 | Antiproliferative activity against human 1205 Lu cells harboring BRAF V600E mutant after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| AID387557 | Cytotoxicity against human HT-29 cells after 144 hrs | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
| Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs. |
| AID273556 | Displacement of ethidium from Calf thymus DNA by fluorescent displacement assay | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24
| Synthesis and biological evaluation of new asymmetrical bisintercalators as potential antitumor drugs. |
| AID1667378 | Anticancer activity against human T24 cells xenografted in mouse assessed as tumor inhibition rate at 5 mg/kg measured at day 14 relative to control | 2020 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
| Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. |
| AID1231835 | Binding affinity to 5'-r(GUCCGCGGAC)2-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1231828 | Binding affinity to 5'-d(ATATATGATATA)-3'/5'-(TATATCATATAT)-3' DNA assessed as change in melting temperature at 1:1 DNA to compound molar ratio by spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1231816 | Induction of DNA intercalation using 5'-d(ATATATGATATA)-3'/5'-(TATATCATATAT)-3' at 250 uM by UV-vis spectrophotometric analysis | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
| Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. |
| AID1452954 | Cytotoxicity against human NHDF cells assessed as reduction in cell viability at 5 uM after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |