Compounds > cur 61414
Page last updated: 2024-11-12

cur 61414

Description

CUR 61414: inhibits the hedehog signaling pathway; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10392802
CHEMBL ID480889
SCHEMBL ID8256419
MeSH IDM0449944

Synonyms (22)

Synonym
n-((3s,5s)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl)-n-(3-methoxybenzyl)-3,3-dimethylbutanamide
bdbm50249519
CHEMBL480889 ,
cur 61414
334998-36-6
SCHEMBL8256419
cur61414
n-[(3s,5s)-1-(1,3-benzodioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl]-n-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
DTXSID00439139
g-856
cur-61414
AKOS030242346
809u4o7oqo ,
unii-809u4o7oqo
g-024586
CS-0064795
HY-113965
butanamide, n-((3s,5s)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl)-n-((3-methoxyphenyl)methyl)-3,3-dimethyl-
n-((3s,5s)-1-(1,3-benzodioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl)-n-((3-methoxyphenyl)methyl)-3,3-dimethyl-butanamide
g-024856
n-((3s,5s)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl)-n-((3-methoxyphenyl)methyl)-3,3-dimethylbutanamide
MS-30081
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sonic hedgehog proteinHomo sapiens (human)IC50 (µMol)0.10000.01500.59301.7500AID351762
Sonic hedgehog proteinMus musculus (house mouse)IC50 (µMol)0.20000.00301.19115.0000AID606346; AID606347
Smoothened homologHomo sapiens (human)IC50 (µMol)0.14000.00040.16401.5000AID661553
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (197)

Processvia Protein(s)Taxonomy
positive regulation of transcription by RNA polymerase IISonic hedgehog proteinHomo sapiens (human)
epithelial-mesenchymal cell signalingSonic hedgehog proteinHomo sapiens (human)
negative regulation of transcription by RNA polymerase IISonic hedgehog proteinHomo sapiens (human)
branching involved in blood vessel morphogenesisSonic hedgehog proteinHomo sapiens (human)
vasculogenesisSonic hedgehog proteinHomo sapiens (human)
metanephros developmentSonic hedgehog proteinHomo sapiens (human)
branching involved in ureteric bud morphogenesisSonic hedgehog proteinHomo sapiens (human)
cell fate specificationSonic hedgehog proteinHomo sapiens (human)
neural crest cell migrationSonic hedgehog proteinHomo sapiens (human)
heart loopingSonic hedgehog proteinHomo sapiens (human)
positive regulation of neuroblast proliferationSonic hedgehog proteinHomo sapiens (human)
osteoblast developmentSonic hedgehog proteinHomo sapiens (human)
lymphoid progenitor cell differentiationSonic hedgehog proteinHomo sapiens (human)
determination of left/right asymmetry in lateral mesodermSonic hedgehog proteinHomo sapiens (human)
protein import into nucleusSonic hedgehog proteinHomo sapiens (human)
endocytosisSonic hedgehog proteinHomo sapiens (human)
smoothened signaling pathwaySonic hedgehog proteinHomo sapiens (human)
cell-cell signalingSonic hedgehog proteinHomo sapiens (human)
pattern specification processSonic hedgehog proteinHomo sapiens (human)
ectoderm developmentSonic hedgehog proteinHomo sapiens (human)
neuroblast proliferationSonic hedgehog proteinHomo sapiens (human)
axon guidanceSonic hedgehog proteinHomo sapiens (human)
central nervous system developmentSonic hedgehog proteinHomo sapiens (human)
ventral midline developmentSonic hedgehog proteinHomo sapiens (human)
hindgut morphogenesisSonic hedgehog proteinHomo sapiens (human)
heart developmentSonic hedgehog proteinHomo sapiens (human)
blood coagulationSonic hedgehog proteinHomo sapiens (human)
androgen metabolic processSonic hedgehog proteinHomo sapiens (human)
positive regulation of cell population proliferationSonic hedgehog proteinHomo sapiens (human)
embryonic pattern specificationSonic hedgehog proteinHomo sapiens (human)
polarity specification of anterior/posterior axisSonic hedgehog proteinHomo sapiens (human)
dorsal/ventral pattern formationSonic hedgehog proteinHomo sapiens (human)
positive regulation of gene expressionSonic hedgehog proteinHomo sapiens (human)
negative regulation of gene expressionSonic hedgehog proteinHomo sapiens (human)
oligodendrocyte developmentSonic hedgehog proteinHomo sapiens (human)
striated muscle tissue developmentSonic hedgehog proteinHomo sapiens (human)
skeletal muscle cell proliferationSonic hedgehog proteinHomo sapiens (human)
positive regulation of skeletal muscle cell proliferationSonic hedgehog proteinHomo sapiens (human)
intein-mediated protein splicingSonic hedgehog proteinHomo sapiens (human)
protein autoprocessingSonic hedgehog proteinHomo sapiens (human)
spinal cord dorsal/ventral patterningSonic hedgehog proteinHomo sapiens (human)
spinal cord motor neuron differentiationSonic hedgehog proteinHomo sapiens (human)
thalamus developmentSonic hedgehog proteinHomo sapiens (human)
dorsal/ventral neural tube patterningSonic hedgehog proteinHomo sapiens (human)
cerebellar granule cell precursor proliferationSonic hedgehog proteinHomo sapiens (human)
positive regulation of cerebellar granule cell precursor proliferationSonic hedgehog proteinHomo sapiens (human)
telencephalon regionalizationSonic hedgehog proteinHomo sapiens (human)
regulation of proteolysisSonic hedgehog proteinHomo sapiens (human)
positive regulation of Wnt signaling pathwaySonic hedgehog proteinHomo sapiens (human)
lung developmentSonic hedgehog proteinHomo sapiens (human)
embryonic limb morphogenesisSonic hedgehog proteinHomo sapiens (human)
negative regulation of cell migrationSonic hedgehog proteinHomo sapiens (human)
male genitalia developmentSonic hedgehog proteinHomo sapiens (human)
prostate gland developmentSonic hedgehog proteinHomo sapiens (human)
thyroid gland developmentSonic hedgehog proteinHomo sapiens (human)
forebrain developmentSonic hedgehog proteinHomo sapiens (human)
midbrain developmentSonic hedgehog proteinHomo sapiens (human)
hindbrain developmentSonic hedgehog proteinHomo sapiens (human)
pancreas developmentSonic hedgehog proteinHomo sapiens (human)
hair follicle morphogenesisSonic hedgehog proteinHomo sapiens (human)
negative regulation of proteasomal ubiquitin-dependent protein catabolic processSonic hedgehog proteinHomo sapiens (human)
T cell differentiation in thymusSonic hedgehog proteinHomo sapiens (human)
negative regulation of T cell differentiation in thymusSonic hedgehog proteinHomo sapiens (human)
positive regulation of T cell differentiation in thymusSonic hedgehog proteinHomo sapiens (human)
positive regulation of immature T cell proliferation in thymusSonic hedgehog proteinHomo sapiens (human)
negative regulation of transcription elongation by RNA polymerase IISonic hedgehog proteinHomo sapiens (human)
embryonic forelimb morphogenesisSonic hedgehog proteinHomo sapiens (human)
embryonic hindlimb morphogenesisSonic hedgehog proteinHomo sapiens (human)
trunk neural crest cell migrationSonic hedgehog proteinHomo sapiens (human)
T cell proliferationSonic hedgehog proteinHomo sapiens (human)
regulation of cell population proliferationSonic hedgehog proteinHomo sapiens (human)
negative regulation of T cell proliferationSonic hedgehog proteinHomo sapiens (human)
positive regulation of protein import into nucleusSonic hedgehog proteinHomo sapiens (human)
odontogenesis of dentin-containing toothSonic hedgehog proteinHomo sapiens (human)
regulation of odontogenesisSonic hedgehog proteinHomo sapiens (human)
embryonic digit morphogenesisSonic hedgehog proteinHomo sapiens (human)
camera-type eye developmentSonic hedgehog proteinHomo sapiens (human)
negative regulation of apoptotic processSonic hedgehog proteinHomo sapiens (human)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitmentSonic hedgehog proteinHomo sapiens (human)
positive thymic T cell selectionSonic hedgehog proteinHomo sapiens (human)
negative thymic T cell selectionSonic hedgehog proteinHomo sapiens (human)
intermediate filament organizationSonic hedgehog proteinHomo sapiens (human)
myoblast differentiationSonic hedgehog proteinHomo sapiens (human)
negative regulation of cell differentiationSonic hedgehog proteinHomo sapiens (human)
positive regulation of smoothened signaling pathwaySonic hedgehog proteinHomo sapiens (human)
positive regulation of DNA-templated transcriptionSonic hedgehog proteinHomo sapiens (human)
positive regulation of transcription by RNA polymerase IISonic hedgehog proteinHomo sapiens (human)
alpha-beta T cell differentiationSonic hedgehog proteinHomo sapiens (human)
positive regulation of alpha-beta T cell differentiationSonic hedgehog proteinHomo sapiens (human)
negative regulation of alpha-beta T cell differentiationSonic hedgehog proteinHomo sapiens (human)
cell developmentSonic hedgehog proteinHomo sapiens (human)
thymus developmentSonic hedgehog proteinHomo sapiens (human)
embryonic digestive tract morphogenesisSonic hedgehog proteinHomo sapiens (human)
embryonic foregut morphogenesisSonic hedgehog proteinHomo sapiens (human)
positive regulation of skeletal muscle tissue developmentSonic hedgehog proteinHomo sapiens (human)
animal organ formationSonic hedgehog proteinHomo sapiens (human)
neuron fate commitmentSonic hedgehog proteinHomo sapiens (human)
embryonic skeletal system developmentSonic hedgehog proteinHomo sapiens (human)
positive regulation of astrocyte differentiationSonic hedgehog proteinHomo sapiens (human)
positive regulation of oligodendrocyte differentiationSonic hedgehog proteinHomo sapiens (human)
smooth muscle tissue developmentSonic hedgehog proteinHomo sapiens (human)
branching morphogenesis of an epithelial tubeSonic hedgehog proteinHomo sapiens (human)
inner ear developmentSonic hedgehog proteinHomo sapiens (human)
formation of anatomical boundarySonic hedgehog proteinHomo sapiens (human)
stem cell developmentSonic hedgehog proteinHomo sapiens (human)
positive regulation of striated muscle cell differentiationSonic hedgehog proteinHomo sapiens (human)
positive regulation of cell divisionSonic hedgehog proteinHomo sapiens (human)
Bergmann glial cell differentiationSonic hedgehog proteinHomo sapiens (human)
roof of mouth developmentSonic hedgehog proteinHomo sapiens (human)
canonical Wnt signaling pathwaySonic hedgehog proteinHomo sapiens (human)
limb bud formationSonic hedgehog proteinHomo sapiens (human)
regulation of glial cell proliferationSonic hedgehog proteinHomo sapiens (human)
lung epithelium developmentSonic hedgehog proteinHomo sapiens (human)
trachea morphogenesisSonic hedgehog proteinHomo sapiens (human)
branching involved in salivary gland morphogenesisSonic hedgehog proteinHomo sapiens (human)
bud outgrowth involved in lung branchingSonic hedgehog proteinHomo sapiens (human)
right lung developmentSonic hedgehog proteinHomo sapiens (human)
left lung developmentSonic hedgehog proteinHomo sapiens (human)
lung lobe morphogenesisSonic hedgehog proteinHomo sapiens (human)
lung-associated mesenchyme developmentSonic hedgehog proteinHomo sapiens (human)
primary prostatic bud elongationSonic hedgehog proteinHomo sapiens (human)
prostate epithelial cord elongationSonic hedgehog proteinHomo sapiens (human)
salivary gland cavitationSonic hedgehog proteinHomo sapiens (human)
epithelial cell proliferation involved in salivary gland morphogenesisSonic hedgehog proteinHomo sapiens (human)
regulation of prostatic bud formationSonic hedgehog proteinHomo sapiens (human)
epithelial cell proliferation involved in prostate gland developmentSonic hedgehog proteinHomo sapiens (human)
positive regulation of epithelial cell proliferation involved in prostate gland developmentSonic hedgehog proteinHomo sapiens (human)
regulation of mesenchymal cell proliferation involved in prostate gland developmentSonic hedgehog proteinHomo sapiens (human)
mesenchymal smoothened signaling pathway involved in prostate gland developmentSonic hedgehog proteinHomo sapiens (human)
artery developmentSonic hedgehog proteinHomo sapiens (human)
mesenchymal cell proliferation involved in lung developmentSonic hedgehog proteinHomo sapiens (human)
somite developmentSonic hedgehog proteinHomo sapiens (human)
positive regulation of sclerotome developmentSonic hedgehog proteinHomo sapiens (human)
cellular response to lithium ionSonic hedgehog proteinHomo sapiens (human)
dopaminergic neuron differentiationSonic hedgehog proteinHomo sapiens (human)
stem cell proliferationSonic hedgehog proteinHomo sapiens (human)
regulation of stem cell proliferationSonic hedgehog proteinHomo sapiens (human)
metanephric mesenchymal cell proliferation involved in metanephros developmentSonic hedgehog proteinHomo sapiens (human)
metanephric collecting duct developmentSonic hedgehog proteinHomo sapiens (human)
negative regulation of canonical Wnt signaling pathwaySonic hedgehog proteinHomo sapiens (human)
establishment of epithelial cell polaritySonic hedgehog proteinHomo sapiens (human)
negative regulation of cholesterol effluxSonic hedgehog proteinHomo sapiens (human)
mesenchymal cell apoptotic processSonic hedgehog proteinHomo sapiens (human)
apoptotic signaling pathwaySonic hedgehog proteinHomo sapiens (human)
self proteolysisSonic hedgehog proteinHomo sapiens (human)
skeletal muscle fiber differentiationSonic hedgehog proteinHomo sapiens (human)
regulation of protein localization to nucleusSonic hedgehog proteinHomo sapiens (human)
negative regulation of dopaminergic neuron differentiationSonic hedgehog proteinHomo sapiens (human)
tracheoesophageal septum formationSonic hedgehog proteinHomo sapiens (human)
negative regulation of ureter smooth muscle cell differentiationSonic hedgehog proteinHomo sapiens (human)
positive regulation of ureter smooth muscle cell differentiationSonic hedgehog proteinHomo sapiens (human)
negative regulation of kidney smooth muscle cell differentiationSonic hedgehog proteinHomo sapiens (human)
positive regulation of kidney smooth muscle cell differentiationSonic hedgehog proteinHomo sapiens (human)
positive regulation of mesenchymal cell proliferation involved in ureter developmentSonic hedgehog proteinHomo sapiens (human)
negative regulation of mesenchymal cell apoptotic processSonic hedgehog proteinHomo sapiens (human)
oligodendrocyte differentiationSonic hedgehog proteinHomo sapiens (human)
regulation of gene expressionSonic hedgehog proteinHomo sapiens (human)
positive regulation of transcription by RNA polymerase IISmoothened homologHomo sapiens (human)
negative regulation of transcription by RNA polymerase IISmoothened homologHomo sapiens (human)
vasculogenesisSmoothened homologHomo sapiens (human)
osteoblast differentiationSmoothened homologHomo sapiens (human)
in utero embryonic developmentSmoothened homologHomo sapiens (human)
cell fate specificationSmoothened homologHomo sapiens (human)
neural crest cell migrationSmoothened homologHomo sapiens (human)
negative regulation of protein phosphorylationSmoothened homologHomo sapiens (human)
heart loopingSmoothened homologHomo sapiens (human)
positive regulation of neuroblast proliferationSmoothened homologHomo sapiens (human)
positive regulation of mesenchymal cell proliferationSmoothened homologHomo sapiens (human)
determination of left/right asymmetry in lateral mesodermSmoothened homologHomo sapiens (human)
type B pancreatic cell developmentSmoothened homologHomo sapiens (human)
protein import into nucleusSmoothened homologHomo sapiens (human)
apoptotic processSmoothened homologHomo sapiens (human)
G protein-coupled receptor signaling pathwaySmoothened homologHomo sapiens (human)
smoothened signaling pathwaySmoothened homologHomo sapiens (human)
ventral midline determinationSmoothened homologHomo sapiens (human)
neuroblast proliferationSmoothened homologHomo sapiens (human)
midgut developmentSmoothened homologHomo sapiens (human)
anterior/posterior pattern specificationSmoothened homologHomo sapiens (human)
gene expressionSmoothened homologHomo sapiens (human)
positive regulation of gene expressionSmoothened homologHomo sapiens (human)
negative regulation of gene expressionSmoothened homologHomo sapiens (human)
spinal cord dorsal/ventral patterningSmoothened homologHomo sapiens (human)
dentate gyrus developmentSmoothened homologHomo sapiens (human)
cerebellar cortex morphogenesisSmoothened homologHomo sapiens (human)
thalamus developmentSmoothened homologHomo sapiens (human)
dorsal/ventral neural tube patterningSmoothened homologHomo sapiens (human)
central nervous system neuron differentiationSmoothened homologHomo sapiens (human)
cerebral cortex developmentSmoothened homologHomo sapiens (human)
positive regulation of cell migrationSmoothened homologHomo sapiens (human)
negative regulation of epithelial cell differentiationSmoothened homologHomo sapiens (human)
hair follicle morphogenesisSmoothened homologHomo sapiens (human)
multicellular organism growthSmoothened homologHomo sapiens (human)
positive regulation of multicellular organism growthSmoothened homologHomo sapiens (human)
positive regulation of protein import into nucleusSmoothened homologHomo sapiens (human)
odontogenesis of dentin-containing toothSmoothened homologHomo sapiens (human)
negative regulation of apoptotic processSmoothened homologHomo sapiens (human)
negative regulation of DNA bindingSmoothened homologHomo sapiens (human)
positive regulation of smoothened signaling pathwaySmoothened homologHomo sapiens (human)
positive regulation of organ growthSmoothened homologHomo sapiens (human)
astrocyte activationSmoothened homologHomo sapiens (human)
skeletal muscle fiber developmentSmoothened homologHomo sapiens (human)
smooth muscle tissue developmentSmoothened homologHomo sapiens (human)
forebrain morphogenesisSmoothened homologHomo sapiens (human)
homeostasis of number of cells within a tissueSmoothened homologHomo sapiens (human)
epithelial cell proliferationSmoothened homologHomo sapiens (human)
positive regulation of epithelial cell proliferationSmoothened homologHomo sapiens (human)
protein stabilizationSmoothened homologHomo sapiens (human)
myoblast migrationSmoothened homologHomo sapiens (human)
negative regulation of hair follicle developmentSmoothened homologHomo sapiens (human)
contact inhibitionSmoothened homologHomo sapiens (human)
atrial septum morphogenesisSmoothened homologHomo sapiens (human)
mammary gland epithelial cell differentiationSmoothened homologHomo sapiens (human)
epithelial-mesenchymal cell signalingSmoothened homologHomo sapiens (human)
somite developmentSmoothened homologHomo sapiens (human)
pancreas morphogenesisSmoothened homologHomo sapiens (human)
left/right axis specificationSmoothened homologHomo sapiens (human)
cellular response to cholesterolSmoothened homologHomo sapiens (human)
dopaminergic neuron differentiationSmoothened homologHomo sapiens (human)
mesenchymal to epithelial transition involved in metanephric renal vesicle formationSmoothened homologHomo sapiens (human)
positive regulation of branching involved in ureteric bud morphogenesisSmoothened homologHomo sapiens (human)
regulation of somatic stem cell population maintenanceSmoothened homologHomo sapiens (human)
regulation of heart morphogenesisSmoothened homologHomo sapiens (human)
pattern specification processSmoothened homologHomo sapiens (human)
central nervous system developmentSmoothened homologHomo sapiens (human)
commissural neuron axon guidanceSmoothened homologHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (15)

Processvia Protein(s)Taxonomy
endopeptidase activitySonic hedgehog proteinHomo sapiens (human)
patched bindingSonic hedgehog proteinHomo sapiens (human)
calcium ion bindingSonic hedgehog proteinHomo sapiens (human)
protein bindingSonic hedgehog proteinHomo sapiens (human)
glycosaminoglycan bindingSonic hedgehog proteinHomo sapiens (human)
peptidase activitySonic hedgehog proteinHomo sapiens (human)
zinc ion bindingSonic hedgehog proteinHomo sapiens (human)
morphogen activitySonic hedgehog proteinHomo sapiens (human)
laminin-1 bindingSonic hedgehog proteinHomo sapiens (human)
cholesterol-protein transferase activitySonic hedgehog proteinHomo sapiens (human)
cAMP-dependent protein kinase inhibitor activitySmoothened homologHomo sapiens (human)
G protein-coupled receptor activitySmoothened homologHomo sapiens (human)
patched bindingSmoothened homologHomo sapiens (human)
protein bindingSmoothened homologHomo sapiens (human)
oxysterol bindingSmoothened homologHomo sapiens (human)
protein kinase A catalytic subunit bindingSmoothened homologHomo sapiens (human)
protein sequestering activitySmoothened homologHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (25)

Processvia Protein(s)Taxonomy
Golgi membraneSonic hedgehog proteinHomo sapiens (human)
extracellular regionSonic hedgehog proteinHomo sapiens (human)
extracellular spaceSonic hedgehog proteinHomo sapiens (human)
endoplasmic reticulumSonic hedgehog proteinHomo sapiens (human)
endoplasmic reticulum lumenSonic hedgehog proteinHomo sapiens (human)
endoplasmic reticulum membraneSonic hedgehog proteinHomo sapiens (human)
Golgi apparatusSonic hedgehog proteinHomo sapiens (human)
cytosolSonic hedgehog proteinHomo sapiens (human)
plasma membraneSonic hedgehog proteinHomo sapiens (human)
cell surfaceSonic hedgehog proteinHomo sapiens (human)
membrane raftSonic hedgehog proteinHomo sapiens (human)
collagen-containing extracellular matrixSonic hedgehog proteinHomo sapiens (human)
extracellular spaceSonic hedgehog proteinHomo sapiens (human)
extracellular regionSonic hedgehog proteinMus musculus (house mouse)
nucleoplasmSonic hedgehog proteinMus musculus (house mouse)
endoplasmic reticulum lumenSonic hedgehog proteinMus musculus (house mouse)
plasma membraneSonic hedgehog proteinMus musculus (house mouse)
Golgi apparatusSmoothened homologHomo sapiens (human)
caveolaSmoothened homologHomo sapiens (human)
late endosomeSmoothened homologHomo sapiens (human)
endoplasmic reticulumSmoothened homologHomo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentSmoothened homologHomo sapiens (human)
centrioleSmoothened homologHomo sapiens (human)
plasma membraneSmoothened homologHomo sapiens (human)
ciliumSmoothened homologHomo sapiens (human)
endocytic vesicle membraneSmoothened homologHomo sapiens (human)
intracellular membrane-bounded organelleSmoothened homologHomo sapiens (human)
ciliary membraneSmoothened homologHomo sapiens (human)
extracellular exosomeSmoothened homologHomo sapiens (human)
ciliary tipSmoothened homologHomo sapiens (human)
9+0 non-motile ciliumSmoothened homologHomo sapiens (human)
ciliumSmoothened homologHomo sapiens (human)
dendriteSmoothened homologHomo sapiens (human)
plasma membraneSmoothened homologHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID606350Inhibition of SHH pathway in mouse Shh Light2 cells at 0.3 uM after 40 hrs by Gli-dependent luciferase reporter gene assay2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
AID661558Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopy2012Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
AID606346Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assay2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
AID606347Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assay2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
AID606348Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation at 1 uM by alkaline phosphatase assay2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
AID606349Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation at 10 uM by alkaline phosphatase assay2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
AID661482Antiproliferative activity against SAG-induced rat cerebellar granule cell precursors by [3H]-thymidine incorporation assay2012Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
AID661553Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assay2012Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
AID606352Inhibition of SHH pathway in mouse Shh Light2 cells at 10 uM after 40 hrs by Gli-dependent luciferase reporter gene assay2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
AID606351Inhibition of SHH pathway in mouse Shh Light2 cells at 3 uM after 40 hrs by Gli-dependent luciferase reporter gene assay2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
AID661552Inhibition of SAG-induced differentiation of mouse mesenchymal pluripotent C3H10T1/2 cells to alkaline phosphatase positive oeseoblasts after 6 hrs2012Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
AID351762Inhibition of lipid-modified (octylated) form of SHH expressed in mouse s12 cells by luciferase reporter gene assay2009Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (46.15)29.6817
2010's6 (46.15)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (7.69%)5.53%
Reviews5 (38.46%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (53.85%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
staurosporine aglycone
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor		3.1410
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		3.1510mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
jervine
jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure		3.5320piperidines
itraconazole
Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.. itraconazole : An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.		3.5110aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles		EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor
betulinic acid
[no description available]		3.1410hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
tomatidine
tomatidine: RN given refers to (3beta,5alpha,22beta,25S)-isomer; structure. tomatidine : A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.		2.05103beta-hydroxy steroid;
azaspiro compound;
oxaspiro compound
gant58
GANT58: inhibits hedgehog signalling; structure in first source		4.0620pyridines
gant 61
GANT 61: a sonic hedgehog pathway inhibitor and Gli inhibitor; structure in first source. GANT61 : An aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor.		3.5520aminal;
dialkylarylamine;
pyridines;
substituted aniline;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
glioma-associated oncogene inhibitor;
Hedgehog signaling pathway inhibitor
cyclopamine
[no description available]		5.3870piperidinesglioma-associated oncogene inhibitor
jk184
JK184: structure in first source		3.1410
zerumbone
zerumbone: RN given for (E,E,E)-isomer; structure in first source. zerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.		3.1410cyclic ketone;
sesquiterpenoid		anti-inflammatory agent;
glioma-associated oncogene inhibitor;
plant metabolite
nsc-287088
[no description available]		3.1410
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid
alphitolic acid: from the aerial parts of Gouania longipetala; structure in first source. 2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid : A pentacyclic triterpenoid that is betulinic acid carrying an additional alpha-hydroxy group at position 2. It has been isolated from Breynia fruticosa.		3.1410dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
lde225
sonidegib: specific Smoothened/Smo antagonist. sonidegib : A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as its phosphate salt) for treatment of locally advanced basal cell carcinoma.		3.5110aminopyridine;
aromatic ether;
benzamides;
biphenyls;
morpholines;
organofluorine compound;
tertiary amino compound		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist
gdc 0449
HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity		4.3630benzamides;
monochlorobenzenes;
pyridines;
sulfone		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
ipi-926
IPI-926: a semisynthetic derivative of cyclopamine that is a smoothened inhibitor with antineoplastic activity; structure in first source		3.1510piperidines
robotnikinin
robotnikinin: binds sonic hedgehog protein to block its signaling pathway; structure in first source		3.1410
physalin f
physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source. physalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata.		3.1410enone;
epoxy steroid;
lactone;
physalin		antileishmanial agent;
antimalarial;
antineoplastic agent;
apoptosis inducer;
immunosuppressive agent
tomatine
Tomatine: An alkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. (From The Merck Index, 11th ed). tomatine : A steroid alkaloid that is tomatidine in which the hydroxy group at position 3 is linked to lycotetraose, a tetrasaccharide composed of two units of D-glucose, one unit of D-xylose, and one unit of D-galactose.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		04.1130
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		04.1130
Carcinoma, Basal Cell, Pigmented
[description not available]		08.2121
Cancer of Skin
[description not available]		08.2121
Carcinoma, Basal Cell
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)		08.2121
Skin Neoplasms
Tumors or cancer of the SKIN.		08.2121
Bladder Cancer
[description not available]		02.0510
Invasiveness, Neoplasm
[description not available]		02.0510
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		02.0510
Carcinoma, Transitional Cell
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.		02.0510
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0710
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