| Assay ID | Title | Year | Journal | Article |
|---|
| AID569580 | Ratio of product of IC50 for rabbit bone resorption and IC50 for humanized rabbit cathepsin K to IC50 for rabbit cathepsin K | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
| Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. |
| AID262988 | Potency against Cathepsin L in HepG2 cells by whole cell enzyme occupancy assay | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID308694 | Inhibition of human cathepsin L | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID314229 | Inhibition of rabbit cathepsin K | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID263000 | Cmax in rat at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID263007 | Volume of distribution in dog at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID308699 | Inhibition of rat liver lysosomal cathepsin B | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID262996 | Decrease in urinary uNTx/Cr in ovariectomized rhesus monkey after 6 days at 3 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID314220 | Inhibition of cathepsin B | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID263004 | Half life in dog at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID314221 | Inhibition of cathepsin L | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID262991 | Inhibition of Cathepsin B | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID263008 | Volume of distribution in rhesus monkey at 5 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID314228 | Inhibition of human cathepsin K | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID308721 | Inhibition of antigen presentation in mouse B cells | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID262994 | Inhibition of humanized rabbit Cathepsin K | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID569577 | Selectivity ratio of IC50 for human cathepsin F to IC50 for human cathepsin K | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
| Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. |
| AID262998 | Oral bioavailability in dog at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID262993 | Inhibition of Cathepsin S | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID342300 | Inhibition of cathepsin K | 2008 | Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
| The many roles for fluorine in medicinal chemistry. |
| AID569576 | Selectivity ratio of IC50 for human cathepsin B to IC50 for human cathepsin K | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
| Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. |
| AID308697 | Inhibition of mouse recombinant cathepsin B | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID569575 | Inhibition of humanized rabbit cathepsin K | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
| Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. |
| AID263003 | Half life in rat at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID308691 | Inhibition of human cathepsin S | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID262999 | Oral bioavailability in rhesus monkey at 5 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID569578 | Selectivity ratio of IC50 for human cathepsin L to IC50 for human cathepsin K | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
| Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. |
| AID262989 | Potency against Cathepsin S in Ramos cells by whole cell enzyme occupancy assay | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID262992 | Inhibition of Cathepsin L | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID308693 | Inhibition of human cathepsin B | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID308695 | Inhibition of mouse recombinant cathepsin S | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID314230 | Inhibition of bone resorption in rabbit osteoclast | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID314232 | Inhibition of cathepsin L in human HepG2 cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID314233 | Inhibition of cathepsin S in human ramos cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID308692 | Inhibition of human cathepsin K | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID308310 | Inhibition of humanized rabbit cathepsin K | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
| Primary amides as selective inhibitors of cathepsin K. |
| AID262997 | Oral bioavailability in rat at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID308700 | Inhibition of mouse recombinant cathepsin L | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID314219 | Inhibition of humanized rabbit cathepsin K | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID314215 | Clearance in monkey | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID308696 | Inhibition of mouse recombinant cathepsin K | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID263006 | Volume of distribution in rat at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID263002 | Cmax in rhesus monkey at 5 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID262990 | Potency against Cathepsin K in rabbit osteoclasts by bone resorption assay | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID314231 | Inhibition of cathepsin B in human HepG2 cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID308698 | Inhibition of rat spleen cathepsin S | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID569579 | Selectivity ratio of IC50 for human cathepsin S to IC50 for human cathepsin K | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
| Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. |
| AID314214 | Half life in monkey | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID262987 | Potency against Cathepsin B in HepG2 cells by whole cell enzyme occupancy assay | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID314222 | Inhibition of cathepsin S | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
| AID263005 | Half life in rhesus monkey at 5 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID263001 | Cmax in dog at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID262995 | Activity in rabbit osteoclasts by bone resorption assay | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| AID308701 | Inhibition of rat liver lysosomal cathepsin L | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID1345903 | Human cathepsin K (C1: Papain) | 2009 | Biological chemistry, Sep, Volume: 390, Issue:9
| Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools. |
| AID1797859 | Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2007.06.023: \\The identification of potent, selective, and bioavailable cathepsin S inhibitors.\\ | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| The identification of potent, selective, and bioavailable cathepsin S inhibitors. |
| AID1797866 | Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2005.12.071: \\Identification of a potent and selective non-basic cathepsin K inhibitor.\\ | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7
| Identification of a potent and selective non-basic cathepsin K inhibitor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |