| Assay ID | Title | Year | Journal | Article |
|---|
| AID267955 | Cmax in Sprague-Dawley rat at 1.89 mg/kg, po | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID267952 | Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID267951 | Reduction in plasma insulin level in po dosed Zucker obese rat after 2 hrs | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID267959 | Half life in Sprague-Dawley rat at 1.89 mg/kg, po | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID267944 | Repolarization of beta-TC3 cells | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID248509 | inhibitory concentration required for repolarization of beta cell membrane potential in presence of 10 mM glucose | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
| 2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels. |
| AID286542 | Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currents | 2007 | Journal of medicinal chemistry, May-03, Volume: 50, Issue:9
| Virtual screening for novel openers of pancreatic K(ATP) channels. |
| AID267949 | Inhibition of glucose-stimulated insulin release in Wistar rat islets | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID208996 | Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without ATP | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID267947 | Relaxation of precontracted Wistar rat aorta rings | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID267957 | Oral bioavailability in Sprague-Dawley rat at 1.89 mg/kg, po | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID286541 | Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization | 2007 | Journal of medicinal chemistry, May-03, Volume: 50, Issue:9
| Virtual screening for novel openers of pancreatic K(ATP) channels. |
| AID189385 | Reduction in plasma insulin in 30 min post-injection in rat | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID267958 | Clearance in Sprague-Dawley rat at 1.89 mg/kg, po or 0.89 mg/kg, iv | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID172703 | Maximum change in MAP in rat | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID175326 | Ability to relax phenylephrine-contracted rat aorta rings | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID267953 | Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID188883 | Maximum reduction in plasma insulin in rat | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID248136 | Concentration required for inhibition of glucose stimulated insulin release from beta TC6 cells | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
| 2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels. |
| AID267946 | Inhibition of glucose-stimulated insulin release in beta-TC6 cells at 10 uM | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID267956 | Tmax in Sprague-Dawley rat at 1.89 mg/kg, po or 0.89 mg/kg, iv | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID267945 | Inhibition of glucose-stimulated insulin release in betaTC6 cells | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID179966 | Inhibition of glucose-stimulated insulin release from Wistar rat islets | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID286543 | Repolarization of tolbutamide-depolarized beta-TC3 cells | 2007 | Journal of medicinal chemistry, May-03, Volume: 50, Issue:9
| Virtual screening for novel openers of pancreatic K(ATP) channels. |
| AID44708 | Ability to inhibit the release of insulin from the mouse beta-TC6 cell line | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID267948 | Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID14000 | Oral bioavailability in rat (Sprague-Dawley) | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID10710 | Area under the MAP curve measured over 5 min. | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID251164 | Percent efficacy for inhibition of glucose stimulated insulin release from beta TC6 cells | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
| 2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels. |
| AID24886 | Half life after oral administration to Sprague-Dawley rats | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID286544 | Inhibition of insulin release from rat INS-1E cells | 2007 | Journal of medicinal chemistry, May-03, Volume: 50, Issue:9
| Virtual screening for novel openers of pancreatic K(ATP) channels. |
| AID267950 | Reduction in plasma insulin level in anaesthetized Sprague-Dawley rat at 3 mg/kg, iv | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells. |
| AID208994 | Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high affinity state with 2 mM MgATP | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID176043 | Vasodilation effects on Wistar rat mesenteric arteries precontracted with phenylephrine | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID42092 | Changes in potassium fluxes assessed in the glucose responsive insulin-producing murine cell line beta-TC3 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID208995 | Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low affinity state with 2 mM MgATP | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| AID44707 | Percentage insulin release in vitro in beta-TC6 cells | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
| 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |