| Assay ID | Title | Year | Journal | Article |
|---|
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID589398 | Induction of NQO1 activity in in mouse Hepa-1c1c7 cells after 48 hrs | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. |
| AID281329 | Induction of HO1 in CD1 mouse liver at at 1 umol, po after 6 hrs | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents. |
| AID589397 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. |
| AID281330 | Induction of HO1 in CD1 mouse stomach at 1 umol, po after 6 hrs | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents. |
| AID1357234 | Inhibition of Keap1/Nrf2 interaction in human HaCaT cells assessed as increase in NQO1 protein expression at 10 uM incubated for 6 hrs by immunoblot assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. |
| AID281328 | Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after 24 hrs | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents. |
| AID589477 | Toxicity in F344 rat assessed as effect on body weight at 0.3 to 60 umol administered via gavage | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. |
| AID1228975 | Antiproliferative activity against human WPMY-1 cells after 72 hrs by CCK8 assay | 2015 | Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11
| Synthesis and Biological Evaluation of Novel Olean-28,13β-lactams as Potential Antiprostate Cancer Agents. |
| AID1357236 | Inhibition of Keap1/Nrf2 interaction in human HaCaT cells assessed as increase in NRF2 protein expression at 10 uM incubated for 24 hrs by immunoblot assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. |
| AID1228973 | Antiproliferative activity against human BxPC3 cells after 72 hrs by CCK8 assay | 2015 | Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11
| Synthesis and Biological Evaluation of Novel Olean-28,13β-lactams as Potential Antiprostate Cancer Agents. |
| AID1228972 | Antiproliferative activity against human H460 cells after 72 hrs by CCK8 assay | 2015 | Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11
| Synthesis and Biological Evaluation of Novel Olean-28,13β-lactams as Potential Antiprostate Cancer Agents. |
| AID589416 | Toxicity in F344 rat assessed as growth rate at 0.3 to 60 umol administered via gavage | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. |
| AID140447 | Inhibitory activity against production of nitric oxide induced by interferon gamma in mouse macrophages | 2002 | Bioorganic & medicinal chemistry letters, Apr-08, Volume: 12, Issue:7
| A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production. |
| AID589405 | Induction of HO-1 expression in CD-1 mouse liver at 1 umol administered via gavage measured after 6 hrs by Western blotting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. |
| AID1228971 | Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay | 2015 | Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11
| Synthesis and Biological Evaluation of Novel Olean-28,13β-lactams as Potential Antiprostate Cancer Agents. |
| AID591192 | Inhibition of NO production in INFgamma-stimulated mouse RAW264.7 cells measured after 24 hrs by Griess reaction method | 2011 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8
| Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent. |
| AID591195 | Stability of the compound at 4 degC | 2011 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8
| Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent. |
| AID1357235 | Inhibition of Keap1/Nrf2 interaction in human HaCaT cells assessed as increase in NQO1 protein expression at 10 uM incubated for 24 hrs by immunoblot assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. |
| AID1357237 | Inhibition of Keap1/Nrf2 interaction in human HaCaT cells assessed as increase in GCLM protein expression at 10 uM incubated for 24 hrs by immunoblot assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. |
| AID589410 | Antitumor activity against aflatoxin B1-induced tumorigenesis in F344 rat liver assessed as reduction in tumor burden at 10 umol/kg administered via gavage relative to control | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. |
| AID589406 | Induction of HO-1 expression in CD-1 mouse stomach at 1 umol administered via gavage measured after 6 hrs by Western blotting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. |
| AID1728767 | Anti-necroptotic activity in mouse L929 cells assessed as inhibition of TNFalpha/Z-VAD-fmk (TZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay | 2021 | European journal of medicinal chemistry, Feb-15, Volume: 212 | Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. |
| AID591194 | Induction of HO1 activity in mouse RAW264.7 cells at 30 to 100 nM after 16 hrs | 2011 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8
| Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent. |
| AID1228974 | Antiproliferative activity against human Bel7404 cells after 72 hrs by CCK8 assay | 2015 | Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11
| Synthesis and Biological Evaluation of Novel Olean-28,13β-lactams as Potential Antiprostate Cancer Agents. |
| AID1728762 | Anti-necroptotic activity in human HT-29 cells assessed as inhibition of TNFalpha/SM-164/Z-VAD-fmk (TSZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay | 2021 | European journal of medicinal chemistry, Feb-15, Volume: 212 | Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. |
| AID591193 | Induction of NQO1 activity in mouse Hepa-1c1c7 cells assessed as concentration require to double the specific enzyme activity after 48 hrs | 2011 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8
| Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent. |
| AID1357233 | Inhibition of Keap1/Nrf2 interaction in human HaCaT cells assessed as increase in NRF2 protein expression at 10 uM incubated for 6 hrs by immunoblot assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. |
| AID1424315 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of nitric oxide production | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment. |
| AID1802486 | GOAT Activity Assay from Article 10.1021/acs.biochem.6b01008: \\Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation.\\ | 2017 | Biochemistry, 02-21, Volume: 56, Issue:7
| Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |