Page last updated: 2024-11-13

amg 511

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Description

AMG 511: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	56947516
CHEMBL ID	2170081
SCHEMBL ID	116429
MeSH ID	M000607845

Synonyms (24)

Synonym
14K ,
4-(2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-{(1r)-1-[4-(methylsulfonyl)piperazin-1-yl]ethyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
chembl2170081 ,
us8772480, 148
bdbm50396808
SCHEMBL116429
amg-511
1253573-53-3
amg511
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1r)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
NCGC00387802-01
BCP28993
amg 511; amg511
EX-A1575
amg 511
nsc782122
nsc-782122
Q27451683
CS-0006892
HY-13440
(r)-4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
(r)-4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
(r)-4-(2-(5-fluoro-6-methoxypyridin-3-ylamino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
AKOS040741104

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (7)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Ki	0.0020	0.0000	0.0081	0.0310	AID701205
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	Ki	0.0040	0.0001	0.0394	0.1700	AID1175279; AID701205; AID701207; AID701208
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Ki	0.0040	0.0000	0.2539	6.0000	AID1175279; AID701208
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Ki	0.0060	0.0001	0.1168	0.6310	AID701207
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50 (µMol)	12.4000	0.0000	0.8575	10.0000	AID1175280; AID701201
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Ki	0.0010	0.0001	0.0950	0.5012	AID701206
Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)	IC50 (µMol)	10.0000	0.0012	0.9137	7.0000	AID701199
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (236)

Process	via Protein(s)	Taxonomy
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of cytokine production	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
adaptive immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
respiratory burst involved in defense response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
protein phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
neutrophil chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of neutrophil apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell degranulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
innate immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
neutrophil extravasation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of epithelial tube formation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
intracellular glucose homeostasis	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of cell-matrix adhesion	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of leukocyte migration	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
transcription by RNA polymerase II	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein import into nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
immune response	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of lamellipodium assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytokine-mediated signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
B cell differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
T cell differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
osteoclast differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cellular response to insulin stimulus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of RNA splicing	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
regulation of toll-like receptor 4 signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cellular response to UV	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
response to endoplasmic reticulum stress	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
interleukin-18-mediated signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of protein import into nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of apoptotic process	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of osteoclast differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of glucose import	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein stabilization	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of filopodium assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of stress fiber assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
growth hormone receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
myeloid leukocyte migration	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of focal adhesion disassembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of endoplasmic reticulum unfolded protein response	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
liver development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of protein phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
vasculature development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
glucose metabolic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phagocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of lamellipodium assembly	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to muscle inactivity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of macroautophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
actin cytoskeleton organization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
platelet activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of actin filament depolymerization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
T cell costimulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of TOR signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to insulin stimulus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to muscle stretch	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of multicellular organism growth	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to L-leucine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
anoikis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of cellular respiration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of neuron apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
T cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
relaxation of cardiac muscle	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cardiac muscle contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
adipose tissue development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to glucose stimulus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to hydrostatic pressure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to dexamethasone	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cardiac muscle cell contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
energy homeostasis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of actin filament organization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
autosome genomic imprinting	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to butyrate	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of protein localization to membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of fibroblast apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of anoikis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of cell-matrix adhesion	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
endothelial cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
response to ischemia	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
intracellular calcium ion homeostasis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
autophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
homophilic cell adhesion via plasma membrane adhesion molecules	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of autophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
platelet activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of neutrophil apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of Rac protein signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
embryonic cleavage	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of MAPK cascade	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
angiogenesis involved in wound healing	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
platelet aggregation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of sprouting angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
regulation of clathrin-dependent endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
protein destabilization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cell growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
T-helper 1 cell lineage commitment	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
heart morphogenesis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
heart valve morphogenesis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
energy reserve metabolic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
'de novo' pyrimidine nucleobase biosynthetic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
inflammatory response	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoskeleton organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosome organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
germ cell development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to nutrient	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cell size	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to heat	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
post-embryonic development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of autophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of lamellipodium assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of gene expression	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of myotube differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
neuronal action potential	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein catabolic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of cell growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of actin filament polymerization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
T cell costimulation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ruffle organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of myelination	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to nutrient levels	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to nutrient levels	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to nutrient	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TOR signaling	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to insulin stimulus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of actin cytoskeleton organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
calcineurin-NFAT signaling cascade	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to amino acid starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
multicellular organism growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC1 signaling	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of circadian rhythm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of apoptotic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to amino acid	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
anoikis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of osteoclast differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of translation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of cell size	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of glycolytic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of transcription by RNA polymerase III	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of translational initiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of lipid biosynthetic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
behavioral response to pain	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
rhythmic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
oligodendrocyte differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of oligodendrocyte differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
voluntary musculoskeletal movement	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of stress fiber assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of keratinocyte migration	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleus localization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cardiac muscle cell development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cardiac muscle contraction	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to methionine	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of calcineurin-NFAT signaling cascade	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to amino acid stimulus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to L-leucine	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to hypoxia	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to osmotic stress	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of membrane permeability	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cellular response to heat	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of protein localization to nucleus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of wound healing, spreading of epidermal cells	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of locomotor rhythm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of cytoplasmic translational initiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of lysosome organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of pentose-phosphate shunt	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to leucine starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of autophagosome assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of cytokine production	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
adaptive immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
dendritic cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of acute inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
respiratory burst involved in defense response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of triglyceride catabolic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
neutrophil chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
secretory granule localization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of cell adhesion mediated by integrin	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of Rac protein signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
natural killer cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
mast cell degranulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of MAP kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
innate immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of cardiac muscle contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
platelet aggregation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cellular response to cAMP	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
neutrophil extravasation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
hepatocyte apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of calcium ion transmembrane transport	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of fibroblast apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein lipidation	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
autophagy	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
autophagosome assembly	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
protein targeting to lysosome	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
regulation of autophagy	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
macroautophagy	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
regulation of macroautophagy	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
regulation of cytokinesis	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
protein localization to phagophore assembly site	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
cellular response to glucose starvation	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
positive regulation by host of viral genome replication	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
early endosome to late endosome transport	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
cell division	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
autophagosome maturation	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
autophagy of peroxisome	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
endocytosis	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (36)

Process	via Protein(s)	Taxonomy
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphotyrosine residue binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase adaptor activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin-like growth factor receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
neurotrophin TRKA receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
kinase activator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein phosphatase binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase regulator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase regulatory subunit binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
ErbB-3 class receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein heterodimerization activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol kinase activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
enzyme-substrate adaptor activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase activator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
1-phosphatidylinositol-3-kinase regulator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein serine/threonine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein kinase activator activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
RNA polymerase III type 1 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
RNA polymerase III type 2 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
RNA polymerase III type 3 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TFIIIC-class transcription factor complex binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ribosome binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphoprotein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein serine/threonine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
identical protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
ephrin receptor binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein kinase activity	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
protein binding	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
ATP binding	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
kinase activity	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phosphatidylinositol kinase activity	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (41)

Process	via Protein(s)	Taxonomy
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cis-Golgi network	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytosol	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cell-cell junction	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
perinuclear region of cytoplasm	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
perinuclear endoplasmic reticulum membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
intercalated disc	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
lamellipodium	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
perinuclear region of cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
nucleus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
nucleoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
nucleolus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
midbody	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
intracellular membrane-bounded organelle	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
PML body	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosomal membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
Golgi membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
mitochondrial outer membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosome	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosomal membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
endoplasmic reticulum membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
endomembrane system	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
dendrite	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC1 complex	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC2 complex	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phagocytic vesicle	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nuclear envelope	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
late endosome	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
autophagosome	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
cytosol	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
axoneme	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
membrane	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
midbody	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phagocytic vesicle membrane	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class III	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
autolysosome	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
peroxisome	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class III, type II	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
endosome	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
membrane	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phagophore assembly site	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class III, type I	Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (44)

Assay ID	Title	Year	Journal	Article
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347157	Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347161	Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347169	Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID701197	Mean residence time in Sprague-Dawley rat at 1 mg/kg, iv	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175283	Intrinsic clearance in rat liver microsomes at 1 uM after 30 mins	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701193	Inhibition of PI3K in po dosed CD1 nude mouse assessed as plasma concentration for inhibition of HGF-induced AKT Ser473 phosphorylation administered 6 hrs prior to HGF-stimulation measured after 5 mins by electrochemiluminescence immunoassay	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701205	Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisphosphate as substrate after 20 mins by spectrophotometric analysis	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701191	Antitumor activity against human U87MG cells xenografted in CD1 nude mouse assessed as tumor stasis at 3 mg/kg, po administered QD for 12 days relative to vehicle-treated control	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175288	Fraction unbound in Sprague-Dawley rat plasma at 1 mg/kg, iv and 2 mg/kg, po	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID1175286	Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701201	Inhibition of mTOR	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175287	Oral bioavailability in Sprague-Dawley rat at 2 mg/kg	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701198	Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701202	Intrinsic clearance in human liver microsomes assessed per mg of protein at 1 uM after 30 mins	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701206	Inhibition of human N-terminal polyHis-tagged PI3K p110gamma expressed in baculovirus infected Hi5 cells using ATP as substrate after 20 mins by spectrophotometric analysis	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175284	Clearance in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701203	Intrinsic clearance in rat liver microsomes assessed per mg of protein at 1 uM after 30 mins	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701194	Inhibition of PI3K in po dosed CD1 nude mouse liver assessed as inhibition of HGF-induced AKT Ser473 phosphorylation administered 6 hrs prior to HGF-stimulation measured after 5 mins by electrochemiluminescence immunoassay	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701200	Clearance in Sprague-Dawley rat at 1 mg/kg, iv	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175279	Inhibition of human N-terminal poly-His tagged p110 alpha/ p85alpha expressed in Sf9 Baculovirus system after 20 mins by AlphaScreen assay	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701207	Inhibition of human N-terminal polyHis-tagged PI3K p110beta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisphosphate as substrate after 20 mins by spectrophotometric analysis	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175281	Inhibition of PI3K-mediated Akt S473 phosphorylation in human U87MG cells after 2 hrs by cell-based assay	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701187	Inhibition of human PI4K	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701195	AUC in Sprague-Dawley rat at 2 mg/kg, po	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175282	Intrinsic clearance in human liver microsomes at 1 uM after 30 mins	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID1175289	Efflux ratio of permeability across pig LLC-PK1 cells stably over-expressing rat P-gp at 5 uM	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701199	Inhibition of human VPS34	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175292	Inhibition of human N-terminal poly-His tagged p110beta/p85alpha expressed in Sf9 Baculovirus system after 20 mins by AlphaScreen assay	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID1175293	Inhibition of human N-terminal poly-His tagged p110delta/p85alpha expressed in Sf9 Baculovirus system after 20 mins by AlphaScreen assay	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701208	Inhibition of human N-terminal polyHis-tagged PI3K p110alpha/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisphosphate as substrate after 20 mins by spectrophotometric analysis	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701196	Oral bioavailability in Sprague-Dawley rat at 2 mg/kg	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175280	Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mins by TR-FRET assay	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701192	Antitumor activity against human U87MG cells xenografted in CD1 nude mouse assessed as tumor growth inhibition at 1 mg/kg, po administered QD for 12 days relative to vehicle-treated control	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701190	Antitumor activity against human U87MG cells xenografted in CD1 nude mouse assessed as tumor regression at 10 mg/kg, po administered QD for 12 days relative to vehicle-treated control	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID1175294	Inhibition of human N-terminal poly-His tagged p110gamma (114 to 1102 aa)/p85alpha expressed in Sf9 Baculovirus system after 20 mins by AlphaScreen assay	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID1175285	Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po	2014	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24	Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
AID701188	AUC in CD1 nude mouse xenografted with human U87MG cells at 0.6 mg/kg, po administered QD for 12 days	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701204	Inhibition of PI3K-mediated AKT Ser473 phosphorylation in human U87MG cells after 2 hrs	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
AID701189	Antitumor activity against human U87MG cells xenografted in po dosed CD1 nude mouse administered QD for 12 days	2012	Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17	Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	2 (40.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.90

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.90 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.90)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
piperazine [no description available]	7.1	1	0	azacycloalkane; piperazines; saturated organic heteromonocyclic parent	anthelminthic drug

Condition	Relationship Strength	Studies
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

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