tyrphostin AG 1112: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 135402851 |
| CHEMBL ID | 65827 |
| SCHEMBL ID | 18045510 |
| SCHEMBL ID | 6055081 |
| MeSH ID | M0225525 |
| Synonym |
|---|
| indole-containing inhibitor 11 |
| 3-amino-5-[(1z)-1-cyano-2-(1h-indol-3-yl)eth-1-en-1-yl]-1h-pyrazole-4-carbonitrile |
| bdbm5177 |
| tyrphostin ag 1112 |
| AKOS000112967 |
| CHEMBL65827 |
| ag-1112 |
| 1h-pyrazole-3-acetonitrile, 5-amino-4-cyano-alpha-(1h-indol-3-ylmethylene), (z)- |
| 153150-84-6 |
| ag 1112 |
| SCHEMBL18045510 |
| SCHEMBL6055081 |
| tyrphostin ag 1112, >=98%, solid |
| 5-azanyl-3-[(~{z})-1-cyano-2-(1~{h}-indol-3-yl)ethenyl]-1~{h}-pyrazole-4-carbonitrile |
| 3-amino-5-[(z)-1-cyano-2-(1h-indol-3-yl)ethenyl]-1h-pyrazole-4-carbonitrile |
| tyrphostin ag-1112 |
| tyrphostin ag1112 |
| HY-120036 |
| CS-0069341 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0000 | 0.5369 | 10.0000 | AID1795753 |
| Platelet-derived growth factor receptor beta | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0006 | 0.8007 | 8.5000 | AID1795753 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1795753 | Membrane Autophosphorylation Assay. from Article 10.1021/jm950727b: \\Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins.\\ | 1996 | Journal of medicinal chemistry, May-24, Volume: 39, Issue:11 | Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||