**1-(1-Pyrrolidinyl)-2-(8-quinolinylthio)ethanone** is a chemical compound with the following structure:
![Structure of 1-(1-Pyrrolidinyl)-2-(8-quinolinylthio)ethanone](https://pubchem.ncbi.nlm.nih.gov/image/image/215358107/2D)
**Importance for research:**
1-(1-Pyrrolidinyl)-2-(8-quinolinylthio)ethanone has shown promising potential in various research areas, including:
* **Anti-cancer activity:** Studies have demonstrated its cytotoxic effects against various cancer cell lines, suggesting its potential as a novel anti-cancer drug.
* **Anti-microbial activity:** The compound has exhibited antibacterial and antifungal properties, indicating its possible application in the development of new antibiotics.
* **Anti-inflammatory activity:** Research suggests that it possesses anti-inflammatory effects, potentially making it a therapeutic candidate for inflammatory conditions.
* **Neuroprotective activity:** Studies have shown neuroprotective effects against oxidative stress and neuronal damage, suggesting its potential for treating neurodegenerative diseases.
* **Chemical probe:** Due to its unique structure and reactivity, it can be utilized as a chemical probe for studying cellular processes and drug target identification.
**Mechanism of action:**
The exact mechanism of action of 1-(1-Pyrrolidinyl)-2-(8-quinolinylthio)ethanone is not fully understood, but it is believed to involve multiple pathways, including:
* **Induction of apoptosis:** The compound can trigger programmed cell death in cancer cells.
* **Inhibition of enzyme activity:** It may interfere with the activity of certain enzymes involved in cell signaling and metabolism.
* **Antioxidant effects:** It can act as an antioxidant, protecting cells from oxidative damage.
**Current research status:**
While the compound has shown promising results in preclinical studies, further research is needed to evaluate its safety, efficacy, and optimal dosage for therapeutic applications. Clinical trials are ongoing to explore its potential in treating various diseases.
**Conclusion:**
1-(1-Pyrrolidinyl)-2-(8-quinolinylthio)ethanone is a promising chemical compound with potential applications in various research areas, including anti-cancer, anti-microbial, anti-inflammatory, and neuroprotective activities. Further investigations are underway to fully understand its mechanism of action and explore its potential as a therapeutic agent.
ID Source | ID |
---|---|
PubMed CID | 975656 |
CHEMBL ID | 1412548 |
CHEBI ID | 92646 |
Synonym |
---|
OPREA1_282239 |
SDCCGMLS-0039547.P002 |
8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline |
MLS000063258 , |
smr000074849 |
NCGC00059731-02 |
1-pyrrolidin-1-yl-2-quinolin-8-ylsulfanylethanone |
HMS2283B05 |
CHEMBL1412548 |
sr-01000270116 |
SR-01000270116-1 |
CHEBI:92646 |
1-(1-pyrrolidinyl)-2-(8-quinolinylthio)ethanone |
Q27164357 |
ml065 |
Class | Description |
---|---|
quinolines | A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, HADH2 protein | Homo sapiens (human) | Potency | 20.4839 | 0.0251 | 20.2376 | 39.8107 | AID886; AID893 |
Chain B, HADH2 protein | Homo sapiens (human) | Potency | 20.4839 | 0.0251 | 20.2376 | 39.8107 | AID886; AID893 |
Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 3.1623 | 0.6310 | 35.7641 | 100.0000 | AID504339 |
Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 32.0043 | 0.1778 | 14.3909 | 39.8107 | AID2147; AID2677 |
Nrf2 | Homo sapiens (human) | Potency | 3.5481 | 0.0920 | 8.2222 | 23.1093 | AID624171 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 3.7904 | 0.0184 | 6.8060 | 14.1254 | AID624172; AID624417 |
thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 16.0824 | 0.1000 | 20.8793 | 79.4328 | AID588453; AID588456 |
ClpP | Bacillus subtilis | Potency | 31.6228 | 1.9953 | 22.6730 | 39.8107 | AID651965 |
phosphopantetheinyl transferase | Bacillus subtilis | Potency | 56.2341 | 0.1413 | 37.9142 | 100.0000 | AID1490 |
ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0929 | 0.0041 | 10.8903 | 31.5287 | AID504467 |
GLS protein | Homo sapiens (human) | Potency | 35.4813 | 0.3548 | 7.9355 | 39.8107 | AID624170 |
TDP1 protein | Homo sapiens (human) | Potency | 4.6415 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
Smad3 | Homo sapiens (human) | Potency | 3.5481 | 0.0052 | 7.8098 | 29.0929 | AID588855 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 22.3872 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 25.1189 | 0.0013 | 18.0743 | 39.8107 | AID926 |
hypothetical protein, conserved | Trypanosoma brucei | Potency | 33.0488 | 0.2239 | 11.2451 | 35.4813 | AID624173; AID720569; AID720584 |
nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.9433 | 0.2818 | 9.7212 | 35.4813 | AID2326 |
67.9K protein | Vaccinia virus | Potency | 11.2202 | 0.0001 | 8.4406 | 100.0000 | AID720579; AID720580 |
formaldehyde dehydrogenase | Pseudomonas putida | Potency | 11.4909 | 0.2818 | 3.2451 | 11.4909 | AID2680 |
IDH1 | Homo sapiens (human) | Potency | 7.3078 | 0.0052 | 10.8652 | 35.4813 | AID686970 |
euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.1254 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 6.5131 | 0.0058 | 6.0263 | 32.6427 | AID492947 |
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 0.0018 | 15.6638 | 39.8107 | AID894 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 7.9433 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 2.9935 | 0.1683 | 16.4040 | 67.0158 | AID720504 |
lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 39.8107 | 0.0752 | 15.2253 | 39.8107 | AID485360 |
geminin | Homo sapiens (human) | Potency | 8.0965 | 0.0046 | 11.3741 | 33.4983 | AID624296; AID624297 |
Vpr | Human immunodeficiency virus 1 | Potency | 44.6684 | 1.5849 | 19.6264 | 63.0957 | AID651644 |
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 0.0580 | 10.6949 | 26.6086 | AID602310 |
Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 3.9811 | 4.4668 | 8.3448 | 10.0000 | AID624291 |
TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1.7783 | 16.2081 | 35.4813 | AID652104 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
aryl hydrocarbon receptor nuclear translocator | Homo sapiens (human) | AC50 | 3.2800 | 0.1900 | 23.3694 | 115.5100 | AID651703 |
transforming acidic coiled-coil-containing protein 3 | Homo sapiens (human) | AC50 | 3.2800 | 0.1900 | 24.2333 | 115.5100 | AID651703 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |