| ID Source | ID |
|---|---|
| PubMed CID | 10047585 |
| CHEMBL ID | 279078 |
| MeSH ID | M0382968 |
| Synonym |
|---|
| CHEMBL279078 , |
| kb r8301 |
| kb 8301 |
| (2r,3s)-n*4*-hydroxy-2-isobutyl-3-methyl-n*1*-[(s)-1-methylcarbamoyl-2-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethyl]-succinamide |
| bdbm50063915 |
| 190383-65-4 |
| osu 8-1 |
| (2s,3r)-n-hydroxy-2-methyl-n'-[(2s)-1-(methylamino)-1-oxo-3-(5,6,7,8-tetrahydronaphthalen-1-yl)propan-2-yl]-3-(2-methylpropyl)butanediamide |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Interstitial collagenase | Homo sapiens (human) | IC50 (µMol) | 0.0003 | 0.0002 | 0.8502 | 10.0000 | AID108731 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 (µMol) | 0.0003 | 0.0000 | 1.2848 | 10.0000 | AID109580 |
| Stromelysin-1 | Homo sapiens (human) | IC50 (µMol) | 0.0006 | 0.0000 | 1.1484 | 10.0000 | AID107358 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 (µMol) | 0.0003 | 0.0000 | 0.7053 | 10.0000 | AID108007 |
| Matrix metalloproteinase-14 | Homo sapiens (human) | IC50 (µMol) | 0.0021 | 0.0003 | 0.7182 | 10.0000 | AID220527 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID108731 | Activity against Matrix metalloprotease-1 (MMP-1). | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8 | Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. |
| AID220527 | Activity against deletion mutant of MT1-MMP lacking the transmembrane domain (deltaMT1) | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8 | Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. |
| AID109580 | Activity against Matrix metalloprotease-2 (MMP-2). | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8 | Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. |
| AID107358 | Activity against Matrix metalloprotease-3 (MMP-3). | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8 | Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. |
| AID108007 | Activity against Matrix metalloprotease-9 (MMP-9). | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8 | Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.91) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||