Page last updated: 2024-11-12

kb r8301

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	10047585
CHEMBL ID	279078
MeSH ID	M0382968

Synonyms (8)

Synonym
CHEMBL279078 ,
kb r8301
kb 8301
(2r,3s)-n4-hydroxy-2-isobutyl-3-methyl-n1-[(s)-1-methylcarbamoyl-2-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethyl]-succinamide
bdbm50063915
190383-65-4
osu 8-1
(2s,3r)-n-hydroxy-2-methyl-n'-[(2s)-1-(methylamino)-1-oxo-3-(5,6,7,8-tetrahydronaphthalen-1-yl)propan-2-yl]-3-(2-methylpropyl)butanediamide

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Interstitial collagenase	Homo sapiens (human)	IC50 (µMol)	0.0003	0.0002	0.8502	10.0000	AID108731
72 kDa type IV collagenase	Homo sapiens (human)	IC50 (µMol)	0.0003	0.0000	1.2848	10.0000	AID109580
Stromelysin-1	Homo sapiens (human)	IC50 (µMol)	0.0006	0.0000	1.1484	10.0000	AID107358
Matrix metalloproteinase-9	Homo sapiens (human)	IC50 (µMol)	0.0003	0.0000	0.7053	10.0000	AID108007
Matrix metalloproteinase-14	Homo sapiens (human)	IC50 (µMol)	0.0021	0.0003	0.7182	10.0000	AID220527
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (95)

Process	via Protein(s)	Taxonomy
proteolysis	Interstitial collagenase	Homo sapiens (human)
protein metabolic process	Interstitial collagenase	Homo sapiens (human)
extracellular matrix disassembly	Interstitial collagenase	Homo sapiens (human)
collagen catabolic process	Interstitial collagenase	Homo sapiens (human)
positive regulation of protein-containing complex assembly	Interstitial collagenase	Homo sapiens (human)
cellular response to UV-A	Interstitial collagenase	Homo sapiens (human)
extracellular matrix organization	Interstitial collagenase	Homo sapiens (human)
angiogenesis	72 kDa type IV collagenase	Homo sapiens (human)
ovarian follicle development	72 kDa type IV collagenase	Homo sapiens (human)
ovulation from ovarian follicle	72 kDa type IV collagenase	Homo sapiens (human)
luteinization	72 kDa type IV collagenase	Homo sapiens (human)
blood vessel maturation	72 kDa type IV collagenase	Homo sapiens (human)
intramembranous ossification	72 kDa type IV collagenase	Homo sapiens (human)
proteolysis	72 kDa type IV collagenase	Homo sapiens (human)
negative regulation of cell adhesion	72 kDa type IV collagenase	Homo sapiens (human)
heart development	72 kDa type IV collagenase	Homo sapiens (human)
embryo implantation	72 kDa type IV collagenase	Homo sapiens (human)
parturition	72 kDa type IV collagenase	Homo sapiens (human)
response to xenobiotic stimulus	72 kDa type IV collagenase	Homo sapiens (human)
response to mechanical stimulus	72 kDa type IV collagenase	Homo sapiens (human)
peripheral nervous system axon regeneration	72 kDa type IV collagenase	Homo sapiens (human)
response to activity	72 kDa type IV collagenase	Homo sapiens (human)
protein metabolic process	72 kDa type IV collagenase	Homo sapiens (human)
extracellular matrix disassembly	72 kDa type IV collagenase	Homo sapiens (human)
protein catabolic process	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of cell migration	72 kDa type IV collagenase	Homo sapiens (human)
collagen catabolic process	72 kDa type IV collagenase	Homo sapiens (human)
response to retinoic acid	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to reactive oxygen species	72 kDa type IV collagenase	Homo sapiens (human)
response to nicotine	72 kDa type IV collagenase	Homo sapiens (human)
endodermal cell differentiation	72 kDa type IV collagenase	Homo sapiens (human)
response to hydrogen peroxide	72 kDa type IV collagenase	Homo sapiens (human)
response to estrogen	72 kDa type IV collagenase	Homo sapiens (human)
negative regulation of vasoconstriction	72 kDa type IV collagenase	Homo sapiens (human)
ephrin receptor signaling pathway	72 kDa type IV collagenase	Homo sapiens (human)
macrophage chemotaxis	72 kDa type IV collagenase	Homo sapiens (human)
response to electrical stimulus	72 kDa type IV collagenase	Homo sapiens (human)
response to hyperoxia	72 kDa type IV collagenase	Homo sapiens (human)
face morphogenesis	72 kDa type IV collagenase	Homo sapiens (human)
bone trabecula formation	72 kDa type IV collagenase	Homo sapiens (human)
prostate gland epithelium morphogenesis	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to amino acid stimulus	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to interleukin-1	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to estradiol stimulus	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to UV-A	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to fluid shear stress	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	72 kDa type IV collagenase	Homo sapiens (human)
response to amyloid-beta	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	72 kDa type IV collagenase	Homo sapiens (human)
extracellular matrix organization	72 kDa type IV collagenase	Homo sapiens (human)
response to hypoxia	72 kDa type IV collagenase	Homo sapiens (human)
tissue remodeling	72 kDa type IV collagenase	Homo sapiens (human)
proteolysis	Stromelysin-1	Homo sapiens (human)
extracellular matrix disassembly	Stromelysin-1	Homo sapiens (human)
protein catabolic process	Stromelysin-1	Homo sapiens (human)
regulation of cell migration	Stromelysin-1	Homo sapiens (human)
collagen catabolic process	Stromelysin-1	Homo sapiens (human)
positive regulation of protein-containing complex assembly	Stromelysin-1	Homo sapiens (human)
cellular response to reactive oxygen species	Stromelysin-1	Homo sapiens (human)
innate immune response	Stromelysin-1	Homo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Stromelysin-1	Homo sapiens (human)
cellular response to lipopolysaccharide	Stromelysin-1	Homo sapiens (human)
cellular response to amino acid stimulus	Stromelysin-1	Homo sapiens (human)
cellular response to UV-A	Stromelysin-1	Homo sapiens (human)
cellular response to nitric oxide	Stromelysin-1	Homo sapiens (human)
regulation of neuroinflammatory response	Stromelysin-1	Homo sapiens (human)
response to amyloid-beta	Stromelysin-1	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Stromelysin-1	Homo sapiens (human)
extracellular matrix organization	Stromelysin-1	Homo sapiens (human)
skeletal system development	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of protein phosphorylation	Matrix metalloproteinase-9	Homo sapiens (human)
proteolysis	Matrix metalloproteinase-9	Homo sapiens (human)
apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
embryo implantation	Matrix metalloproteinase-9	Homo sapiens (human)
cell migration	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix disassembly	Matrix metalloproteinase-9	Homo sapiens (human)
macrophage differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
collagen catabolic process	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to reactive oxygen species	Matrix metalloproteinase-9	Homo sapiens (human)
endodermal cell differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of DNA binding	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
ephrin receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of keratinocyte migration	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to lipopolysaccharide	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to cadmium ion	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to UV-A	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Matrix metalloproteinase-9	Homo sapiens (human)
regulation of neuroinflammatory response	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of receptor binding	Matrix metalloproteinase-9	Homo sapiens (human)
response to amyloid-beta	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of epithelial cell differentiation involved in kidney development	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cation channel activity	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix organization	Matrix metalloproteinase-9	Homo sapiens (human)
angiogenesis	Matrix metalloproteinase-14	Homo sapiens (human)
ovarian follicle development	Matrix metalloproteinase-14	Homo sapiens (human)
response to hypoxia	Matrix metalloproteinase-14	Homo sapiens (human)
endothelial cell proliferation	Matrix metalloproteinase-14	Homo sapiens (human)
endochondral ossification	Matrix metalloproteinase-14	Homo sapiens (human)
proteolysis	Matrix metalloproteinase-14	Homo sapiens (human)
response to oxidative stress	Matrix metalloproteinase-14	Homo sapiens (human)
male gonad development	Matrix metalloproteinase-14	Homo sapiens (human)
response to mechanical stimulus	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of myotube differentiation	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of protein processing	Matrix metalloproteinase-14	Homo sapiens (human)
response to organic cyclic compound	Matrix metalloproteinase-14	Homo sapiens (human)
protein processing	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular matrix disassembly	Matrix metalloproteinase-14	Homo sapiens (human)
protein catabolic process	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of cell growth	Matrix metalloproteinase-14	Homo sapiens (human)
lung development	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of cell migration	Matrix metalloproteinase-14	Homo sapiens (human)
collagen catabolic process	Matrix metalloproteinase-14	Homo sapiens (human)
zymogen activation	Matrix metalloproteinase-14	Homo sapiens (human)
endodermal cell differentiation	Matrix metalloproteinase-14	Homo sapiens (human)
chondrocyte proliferation	Matrix metalloproteinase-14	Homo sapiens (human)
astrocyte cell migration	Matrix metalloproteinase-14	Homo sapiens (human)
response to estrogen	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of B cell differentiation	Matrix metalloproteinase-14	Homo sapiens (human)
negative regulation of Notch signaling pathway	Matrix metalloproteinase-14	Homo sapiens (human)
embryonic cranial skeleton morphogenesis	Matrix metalloproteinase-14	Homo sapiens (human)
branching morphogenesis of an epithelial tube	Matrix metalloproteinase-14	Homo sapiens (human)
tissue remodeling	Matrix metalloproteinase-14	Homo sapiens (human)
cell motility	Matrix metalloproteinase-14	Homo sapiens (human)
negative regulation of focal adhesion assembly	Matrix metalloproteinase-14	Homo sapiens (human)
head development	Matrix metalloproteinase-14	Homo sapiens (human)
craniofacial suture morphogenesis	Matrix metalloproteinase-14	Homo sapiens (human)
negative regulation of GDF15-GFRAL signaling pathway	Matrix metalloproteinase-14	Homo sapiens (human)
regulation of protein localization to plasma membrane	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of macrophage migration	Matrix metalloproteinase-14	Homo sapiens (human)
response to odorant	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular matrix organization	Matrix metalloproteinase-14	Homo sapiens (human)
skeletal system development	Matrix metalloproteinase-14	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Process	via Protein(s)	Taxonomy
endopeptidase activity	Interstitial collagenase	Homo sapiens (human)
metalloendopeptidase activity	Interstitial collagenase	Homo sapiens (human)
serine-type endopeptidase activity	Interstitial collagenase	Homo sapiens (human)
peptidase activity	Interstitial collagenase	Homo sapiens (human)
zinc ion binding	Interstitial collagenase	Homo sapiens (human)
fibronectin binding	72 kDa type IV collagenase	Homo sapiens (human)
endopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
metalloendopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
serine-type endopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
protein binding	72 kDa type IV collagenase	Homo sapiens (human)
metallopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
zinc ion binding	72 kDa type IV collagenase	Homo sapiens (human)
endopeptidase activity	Stromelysin-1	Homo sapiens (human)
metalloendopeptidase activity	Stromelysin-1	Homo sapiens (human)
serine-type endopeptidase activity	Stromelysin-1	Homo sapiens (human)
protein binding	Stromelysin-1	Homo sapiens (human)
peptidase activity	Stromelysin-1	Homo sapiens (human)
metallopeptidase activity	Stromelysin-1	Homo sapiens (human)
zinc ion binding	Stromelysin-1	Homo sapiens (human)
endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metalloendopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
serine-type endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
collagen binding	Matrix metalloproteinase-9	Homo sapiens (human)
peptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metallopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
zinc ion binding	Matrix metalloproteinase-9	Homo sapiens (human)
identical protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
endopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
metalloendopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
serine-type endopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
integrin binding	Matrix metalloproteinase-14	Homo sapiens (human)
protein binding	Matrix metalloproteinase-14	Homo sapiens (human)
zinc ion binding	Matrix metalloproteinase-14	Homo sapiens (human)
metalloaminopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (19)

Process	via Protein(s)	Taxonomy
extracellular region	Interstitial collagenase	Homo sapiens (human)
extracellular matrix	Interstitial collagenase	Homo sapiens (human)
extracellular space	Interstitial collagenase	Homo sapiens (human)
collagen-containing extracellular matrix	72 kDa type IV collagenase	Homo sapiens (human)
extracellular region	72 kDa type IV collagenase	Homo sapiens (human)
extracellular space	72 kDa type IV collagenase	Homo sapiens (human)
nucleus	72 kDa type IV collagenase	Homo sapiens (human)
mitochondrion	72 kDa type IV collagenase	Homo sapiens (human)
plasma membrane	72 kDa type IV collagenase	Homo sapiens (human)
sarcomere	72 kDa type IV collagenase	Homo sapiens (human)
collagen-containing extracellular matrix	72 kDa type IV collagenase	Homo sapiens (human)
extracellular space	72 kDa type IV collagenase	Homo sapiens (human)
extracellular region	Stromelysin-1	Homo sapiens (human)
nucleus	Stromelysin-1	Homo sapiens (human)
mitochondrion	Stromelysin-1	Homo sapiens (human)
cytosol	Stromelysin-1	Homo sapiens (human)
extracellular matrix	Stromelysin-1	Homo sapiens (human)
extracellular space	Stromelysin-1	Homo sapiens (human)
extracellular region	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
collagen-containing extracellular matrix	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular exosome	Matrix metalloproteinase-9	Homo sapiens (human)
tertiary granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
ficolin-1-rich granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
cytoplasm	Matrix metalloproteinase-14	Homo sapiens (human)
plasma membrane	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-14	Homo sapiens (human)
nucleus	Matrix metalloproteinase-14	Homo sapiens (human)
Golgi lumen	Matrix metalloproteinase-14	Homo sapiens (human)
cytosol	Matrix metalloproteinase-14	Homo sapiens (human)
plasma membrane	Matrix metalloproteinase-14	Homo sapiens (human)
focal adhesion	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular matrix	Matrix metalloproteinase-14	Homo sapiens (human)
cytoplasmic vesicle	Matrix metalloproteinase-14	Homo sapiens (human)
melanosome	Matrix metalloproteinase-14	Homo sapiens (human)
macropinosome	Matrix metalloproteinase-14	Homo sapiens (human)
intermediate filament cytoskeleton	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-14	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID108731	Activity against Matrix metalloprotease-1 (MMP-1).	1998	Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8	Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
AID220527	Activity against deletion mutant of MT1-MMP lacking the transmembrane domain (deltaMT1)	1998	Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8	Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
AID109580	Activity against Matrix metalloprotease-2 (MMP-2).	1998	Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8	Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
AID107358	Activity against Matrix metalloprotease-3 (MMP-3).	1998	Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8	Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
AID108007	Activity against Matrix metalloprotease-9 (MMP-9).	1998	Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8	Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (27.27)	18.2507
2000's	8 (72.73)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.91 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.39 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.91)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	2.41	2	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
pd 98059 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.	2	1	aromatic amine; monomethoxyflavone	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector
isoflurophate Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.	2.01	1	dialkyl phosphate
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.03	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.03	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.4	2	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
8-bromo cyclic adenosine monophosphate 8-Bromo Cyclic Adenosine Monophosphate: A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.. 8-Br-cAMP : A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.	2	1	3',5'-cyclic purine nucleotide; adenyl ribonucleotide; organobromine compound	antidepressant; protein kinase agonist
arginyl-glycyl-aspartic acid arginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition system	2	1	oligopeptide
marimastat marimastat: a matrix metalloproteinase inhibitor active in patients with advanced carcinoma of the pancreas, prostate, or ovary. marimastat : A secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide.	1.99	1	hydroxamic acid; secondary carboxamide	antineoplastic agent; matrix metalloproteinase inhibitor
ilomastat CS 610: matrix metalloproteinase inhibitor; structure in first source. ilomastat : An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor	1.99	1	hydroxamic acid; L-tryptophan derivative; N-acyl-amino acid	anti-inflammatory agent; antibacterial agent; antineoplastic agent; EC 3.4.24.24 (gelatinase A) inhibitor; neuroprotective agent
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2	1	oxygen hydride; oxygen radical; reactive oxygen species
n-formylmethionine leucyl-phenylalanine N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.. N-formyl-L-methionyl-L-leucyl-L-phenylalanine : A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.	2.01	1	tripeptide
batimastat batimastat: structure given in first source; a synthetic matrix metalloproteinase inhibitor. batimastat : A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S,3R)-5-methyl-3-{[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-2-[(thiophen-2-ylsulfanyl)methyl]hexanoic acid with the amino group of hydroxylamine. It a broad-spectrum matrix metalloprotease inhibitor.	2.42	2	hydroxamic acid; L-phenylalanine derivative; organic sulfide; secondary carboxamide; thiophenes; triamide	angiogenesis inhibitor; antineoplastic agent; matrix metalloproteinase inhibitor
ro 31-9790 Ro 31-9790: hydroxamic acid derivative	1.99	1
ucn 1028 c calphostin C: structure given in first source; isolated from Cladosporium cladosporioides	2	1
noc-5 1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene: a nitric oxide donor compound. NOC-5 : A nitroso compound that is triazane in which the nitrogen at position 1 is substituted by an isopropyl group and a 3-aminopropyl group, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group. It is a nitric oxide donor.	2	1

Condition	Relationship Strength	Studies
Hypergammaglobulinemia An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.	2	1
Symptom Cluster [description not available]	2	1
Syndrome A characteristic symptom complex.	2	1
B-Cell Chronic Lymphocytic Leukemia [description not available]	2.03	1
Leukemia, Lymphocytic, Chronic, B-Cell A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.	2.03	1
Benign Neoplasms [description not available]	2	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2	1

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