| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID685468 | Cytotoxicity against CHO cells at 200 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685474 | Volume of distribution at steady state in Wistar rat at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685461 | Inhibition of p38alpha | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685472 | AUC in Wistar rat at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685477 | Oral bioavailability in Wistar rat at 10 mg/kg | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685489 | Inhibition of CYP2C19 at < 25 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685486 | Inhibition of CYP1A2 at < 25 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685478 | AUC in beagle dog at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685475 | Cmax in Wistar rat at 10 mg/kg, po | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685464 | Stability in human hepatic microsomes assessed as compound turnover at 5 uM incubated for 30 mins in presence of NADPH | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685466 | Passive permeability from basolateral to apical side in human Caco2 cells at 12.5 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685469 | Protein binding in rat plasma | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685483 | Oral bioavailability in beagle dog at 1 mg/kg | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685479 | Clearance in beagle dog at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685462 | Inhibition of LPS-induced TNFalpha production in human whole blood | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685476 | AUC in Wistar rat at 10 mg/kg, po | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685471 | Half life in Wistar rat at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685480 | Volume of distribution at steady state in beagle dog at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685465 | Passive permeability from apical to basolateral side in human Caco2 cells at 12.5 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685487 | Inhibition of CYP3A4 at < 25 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685481 | Cmax in beagle dog at 1 mg/kg, po | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685496 | Antiarthritic effect in rat adjuvant-induced arthritis model assessed as inhibition of right paw edema at 3 mg/kg, po dosed daily during last 10 days of test | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685482 | AUC in beagle dog at 1 mg/kg, po | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685490 | Inhibition of CYP2D6 at < 25 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685485 | Toxicity against CHO cells | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685484 | Half life in beagle dog at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685470 | Protein binding in human plasma | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685492 | Inhibition of RET | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685473 | Clearance in Wistar rat at 1 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685495 | Inhibition of TNFalpha release in rat LPS-induced endotoxemia model dosed orally 1 hr prior to LPS challenge and measured 1.5 hrs post LPS challenge | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685463 | Stability in rat hepatic microsomes assessed as compound turnover at 5 uM incubated for 30 mins in presence of NADPH | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| AID685488 | Inhibition of CYP2C9 at < 25 uM | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |