| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID660666 | Drug metabolism in po dosed monkey plasma assessed as formation of 4-phenoxy benzoic acid | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648581 | Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648603 | Drug metabolism in po dosed rat plasma assessed as 4-PBA level | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648598 | AUC (0 to 72 hrs) in Lewis rat at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648599 | Cmax in C57BL/6J mouse at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID660661 | Stability of the compound in presence of enterobacteria from monkey feces contents under anaerobic condition at 3 to 30 uM after 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648595 | Cmax in Lewis rat at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648591 | Cmax in Lewis rat at 0.1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID660662 | Stability of the compound in presence of enterobacteria from rat cecal contents under anaerobic condition at 3 to 30 uM after 48 hrs | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648601 | Terminal half life in C57BL/6J mouse at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648593 | Terminal half life in Lewis rat at 0.1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID660665 | Drug metabolism in po dosed rat plasma assessed as formation of 4-phenoxy benzoic acid | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID660639 | Immunosuppressive activity in po dosed LEW rat transplanted with spleen cells of WKAH rat assessed as inhibition of enlargement of draining popliteal lymph node administered qd for 4 days | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648590 | Antimultiple sclerosis activity in C57BL/6J mouse assessed as reduction of experimental autoimmune encephalomyelitis score at 1 mg/kg, po qd for 23 days | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648589 | Antimultiple sclerosis activity in C57BL/6J mouse assessed as reduction of experimental autoimmune encephalomyelitis score at 0.3 mg/kg, po qd for 23 days | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648582 | Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID645222 | Selectivity ratio of EC50 for human S1P3 receptor to EC50 for human S1P1 receptor | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. |
| AID648608 | Agonist activity at human S1P5 receptor | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID660636 | Agonist activity at human S1P1 receptor by [S35]GTPgammaS binding assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648596 | Tmax in Lewis rat at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648588 | Antiarthritic activity in po dosed Lewis rat assessed as reduction of adjuvant-induced right hind foot volume administered as qd for 18 days | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648580 | Agonist activity at rat S1P3 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID660663 | Stability of the compound in presence of enterobacteria from monkey feces contents under anaerobic condition at 3 to 30 uM after 48 hrs | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648592 | Tmax in Lewis rat at 0.1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648583 | Selectivity ratio of EC50 for human S1P3 receptor to EC50 for human S1P1 receptor | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID660660 | Stability of the compound in presence of enterobacteria from rat cecal contents under anaerobic condition at 3 to 30 uM after 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648602 | AUC (0 to 72 hrs) in C57BL/6J mouse at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648579 | Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID645223 | Immunosuppressive activity in po dosed LEW rat model assessed as inhibition of WKAH rat spleen cells-induced popliteal lymph node swelling administered qd for 4 days measured at day 4 by host versus graft reaction analysis | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. |
| AID648604 | Drug metabolism in po dosed monkey plasma assessed as 4-PBA level | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648607 | Agonist activity at human S1P4 receptor | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648585 | Immunomodulatory activity in Lewis rat assessed as decrease in peripheral blood lymphocyte numbers at 0.1 mg/kg, po after 8 hrs relative to control | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648600 | Tmax in C57BL/6J mouse at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648605 | Metabolic stability in liver microsomes assessed as 4-PBA level | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648587 | Immunomodulatory activity in Lewis rat assessed as decrease in peripheral blood lymphocyte numbers at 0.1 to 1 mg/kg, po after 24 to 48 hrs | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID660637 | Agonist activity at human S1P3 receptor by [S35]GTPgammaS binding assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
| Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists. |
| AID648606 | Metabolic stability in liver microsomes assessed as degradation of 1,2,4-oxadiazole ring | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID645221 | Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgamma binding | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. |
| AID648594 | AUC (0 to 72 hrs) in Lewis rat at 0.1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID648586 | Immunomodulatory activity in Lewis rat assessed as decrease in peripheral blood lymphocyte numbers at 1 mg/kg, po after 8 hrs relative to control | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| AID645220 | Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgamma binding | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. |
| AID648597 | Terminal half life in Lewis rat at 1 mg/kg, po | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |