Page last updated: 2024-11-13

dcc-2701

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Description

DCC-2701: inhibits c-Met protein, TIE-2 protein, and vascular endothelial growth factor receptor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	54576299
CHEMBL ID	3545365
SCHEMBL ID	139906
MeSH ID	M000605057

Synonyms (47)

Synonym
GNNDEPIMDAZHRQ-UHFFFAOYSA-N
n-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
S6412
SCHEMBL139906
CS-3944
n-(4-((2-((cyclopropylcarbonyl)amino)pyridin-4-yl)oxy)-2,5-difluorophenyi)-n-(4- fluorophenyl)cyclopropane-1,1-dicarboxamide
altiratinib [usan]
dp-5164
unii-t678746713
dcc-2701
altiratinib
t678746713 ,
1,1-cyclopropanedicarboxamide, n-(4-((2-((cyclopropylcarbonyl)amino)-4-pyridinyl)oxy)-2,5-difluorophenyl)-n'-(4-fluorophenyl)-
1345847-93-9
AC-35383
dcc2701
HY-B0791
altiratinib [inn]
altiratinib [who-dd]
CHEMBL3545365
1-n'-[4-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
gtpl9174
dcc-270
J-690136
4-{5-[(e)-2-{4-(2-chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4h-1,2,4-triazol-3-yl}vinyl]-1,3,4-oxadiazol-2-yl}benzonitrile
AKOS026750329
altiratinib;dcc2701
EX-A902
mfcd28900672
n-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-2,5-difluorophenyl]-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
D10862
altiratinib (usan)
bdbm50193395
1,1-cyclopropanedicarboxamide, n-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-2,5-difluorophenyl]-n'-(4-fluorophenyl)-
altiratinib(dcc-2701)
FT-0700171
BCP15682
n-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide.
F11464
Q27074416
SB18876
NCGC00480913-04
A887875
MS-29472
nsc-784590
nsc784590
A9I ,

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (11)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
PPM1D protein	Homo sapiens (human)	Potency	18.5569	0.0052	9.4661	32.9993	AID1347411
Interferon beta	Homo sapiens (human)	Potency	18.5569	0.0033	9.1582	39.8107	AID1347411
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
High affinity nerve growth factor receptor	Homo sapiens (human)	IC50 (µMol)	0.0009	0.0002	0.5436	10.0000	AID1318751; AID1533332
Acyl-CoA desaturase 1	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.0027	0.0004	0.1594	1.7100	AID1421976
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50 (µMol)	0.0027	0.0004	0.3722	10.0000	AID1318734; AID1421976; AID1533349
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50 (µMol)	0.0092	0.0000	0.4830	8.8000	AID1421977; AID1533346
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.0009	0.0009	0.2094	9.0300	AID1318751
Angiopoietin-1 receptor	Homo sapiens (human)	IC50 (µMol)	0.0080	0.0004	0.5553	9.0700	AID1318740; AID1533350
NT-3 growth factor receptor	Homo sapiens (human)	IC50 (µMol)	0.0046	0.0001	0.1336	1.1150	AID1318753; AID1533334
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	IC50 (µMol)	0.0046	0.0001	0.3352	2.9620	AID1318752; AID1533333
Cysteinyl leukotriene receptor 1	Cavia porcellus (domestic guinea pig)	IC50 (µMol)	0.0009	0.0009	0.0880	0.5000	AID1318751
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (197)

Process	via Protein(s)	Taxonomy
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell activation involved in immune response	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to virus	Interferon beta	Homo sapiens (human)
positive regulation of autophagy	Interferon beta	Homo sapiens (human)
cytokine-mediated signaling pathway	Interferon beta	Homo sapiens (human)
natural killer cell activation	Interferon beta	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Interferon beta	Homo sapiens (human)
cellular response to interferon-beta	Interferon beta	Homo sapiens (human)
B cell proliferation	Interferon beta	Homo sapiens (human)
negative regulation of viral genome replication	Interferon beta	Homo sapiens (human)
innate immune response	Interferon beta	Homo sapiens (human)
positive regulation of innate immune response	Interferon beta	Homo sapiens (human)
regulation of MHC class I biosynthetic process	Interferon beta	Homo sapiens (human)
negative regulation of T cell differentiation	Interferon beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Interferon beta	Homo sapiens (human)
defense response to virus	Interferon beta	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interferon beta	Homo sapiens (human)
neuron cellular homeostasis	Interferon beta	Homo sapiens (human)
cellular response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
cellular response to virus	Interferon beta	Homo sapiens (human)
negative regulation of Lewy body formation	Interferon beta	Homo sapiens (human)
negative regulation of T-helper 2 cell cytokine production	Interferon beta	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell differentiation	Interferon beta	Homo sapiens (human)
natural killer cell activation involved in immune response	Interferon beta	Homo sapiens (human)
adaptive immune response	Interferon beta	Homo sapiens (human)
T cell activation involved in immune response	Interferon beta	Homo sapiens (human)
humoral immune response	Interferon beta	Homo sapiens (human)
cellular response to amyloid-beta	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
protein phosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
axon guidance	High affinity nerve growth factor receptor	Homo sapiens (human)
learning or memory	High affinity nerve growth factor receptor	Homo sapiens (human)
circadian rhythm	High affinity nerve growth factor receptor	Homo sapiens (human)
negative regulation of cell population proliferation	High affinity nerve growth factor receptor	Homo sapiens (human)
response to xenobiotic stimulus	High affinity nerve growth factor receptor	Homo sapiens (human)
programmed cell death involved in cell development	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of neuron projection development	High affinity nerve growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
olfactory nerve development	High affinity nerve growth factor receptor	Homo sapiens (human)
B cell differentiation	High affinity nerve growth factor receptor	Homo sapiens (human)
response to nutrient levels	High affinity nerve growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
nerve growth factor signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
mechanoreceptor differentiation	High affinity nerve growth factor receptor	Homo sapiens (human)
negative regulation of apoptotic process	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of programmed cell death	High affinity nerve growth factor receptor	Homo sapiens (human)
negative regulation of neuron apoptotic process	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of GTPase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of Ras protein signal transduction	High affinity nerve growth factor receptor	Homo sapiens (human)
protein autophosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin TRK receptor signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
ephrin receptor signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
sympathetic nervous system development	High affinity nerve growth factor receptor	Homo sapiens (human)
response to axon injury	High affinity nerve growth factor receptor	Homo sapiens (human)
detection of temperature stimulus involved in sensory perception of pain	High affinity nerve growth factor receptor	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
neuron apoptotic process	High affinity nerve growth factor receptor	Homo sapiens (human)
response to hydrostatic pressure	High affinity nerve growth factor receptor	Homo sapiens (human)
response to electrical stimulus	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of synapse assembly	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	High affinity nerve growth factor receptor	Homo sapiens (human)
Sertoli cell development	High affinity nerve growth factor receptor	Homo sapiens (human)
axonogenesis involved in innervation	High affinity nerve growth factor receptor	Homo sapiens (human)
behavioral response to formalin induced pain	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	High affinity nerve growth factor receptor	Homo sapiens (human)
cellular response to nicotine	High affinity nerve growth factor receptor	Homo sapiens (human)
cellular response to nerve growth factor stimulus	High affinity nerve growth factor receptor	Homo sapiens (human)
multicellular organism development	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	High affinity nerve growth factor receptor	Homo sapiens (human)
endothelial cell morphogenesis	Hepatocyte growth factor receptor	Homo sapiens (human)
signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of autophagy	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of microtubule polymerization	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of Rho protein signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
branching morphogenesis of an epithelial tube	Hepatocyte growth factor receptor	Homo sapiens (human)
positive chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of stress fiber assembly	Hepatocyte growth factor receptor	Homo sapiens (human)
excitatory postsynaptic potential	Hepatocyte growth factor receptor	Homo sapiens (human)
establishment of skin barrier	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin-plexin signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of hydrogen peroxide-mediated programmed cell death	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of guanyl-nucleotide exchange factor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
liver development	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
phagocytosis	Hepatocyte growth factor receptor	Homo sapiens (human)
multicellular organism development	Hepatocyte growth factor receptor	Homo sapiens (human)
neuron differentiation	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
cell migration	Hepatocyte growth factor receptor	Homo sapiens (human)
pancreas development	Hepatocyte growth factor receptor	Homo sapiens (human)
nervous system development	Hepatocyte growth factor receptor	Homo sapiens (human)
branching involved in blood vessel morphogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of macroautophagy	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mitochondrial depolarization	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mitochondrial fission	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
ovarian follicle development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vasculogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of protein phosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
lymph vessel development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell migration involved in sprouting angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mesenchymal cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
epithelial cell maturation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endocardium development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endothelium development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell population proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of cell shape	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
mesenchymal cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of gene expression	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of BMP signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
embryonic hemopoiesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor-2 signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
surfactant homeostasis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of MAPK cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of neuron apoptotic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell fate commitment	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein autophosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
lung alveolus development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
post-embryonic camera-type eye morphogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
epithelial cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of positive chemotaxis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of focal adhesion assembly	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
calcium ion homeostasis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
blood vessel endothelial cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular wound healing	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
semaphorin-plexin signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
stem cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of hematopoietic progenitor cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of bone development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cellular response to hydrogen sulfide	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of stem cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of vasculogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of MAPK cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
multicellular organism development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endothelial cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Angiopoietin-1 receptor	Homo sapiens (human)
angiogenesis	Angiopoietin-1 receptor	Homo sapiens (human)
response to hypoxia	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	Angiopoietin-1 receptor	Homo sapiens (human)
endothelial cell proliferation	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Angiopoietin-1 receptor	Homo sapiens (human)
endochondral ossification	Angiopoietin-1 receptor	Homo sapiens (human)
sprouting angiogenesis	Angiopoietin-1 receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Angiopoietin-1 receptor	Homo sapiens (human)
cell-cell signaling	Angiopoietin-1 receptor	Homo sapiens (human)
heart development	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of endothelial cell migration	Angiopoietin-1 receptor	Homo sapiens (human)
negative regulation of angiogenesis	Angiopoietin-1 receptor	Homo sapiens (human)
regulation of establishment or maintenance of cell polarity	Angiopoietin-1 receptor	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of Rac protein signal transduction	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of Rho protein signal transduction	Angiopoietin-1 receptor	Homo sapiens (human)
negative regulation of apoptotic process	Angiopoietin-1 receptor	Homo sapiens (human)
regulation of vascular permeability	Angiopoietin-1 receptor	Homo sapiens (human)
response to peptide hormone	Angiopoietin-1 receptor	Homo sapiens (human)
response to estrogen	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of angiogenesis	Angiopoietin-1 receptor	Homo sapiens (human)
Tie signaling pathway	Angiopoietin-1 receptor	Homo sapiens (human)
negative regulation of inflammatory response	Angiopoietin-1 receptor	Homo sapiens (human)
response to cAMP	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of focal adhesion assembly	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Angiopoietin-1 receptor	Homo sapiens (human)
definitive hemopoiesis	Angiopoietin-1 receptor	Homo sapiens (human)
heart trabecula formation	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Angiopoietin-1 receptor	Homo sapiens (human)
glomerulus vasculature development	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of intracellular signal transduction	Angiopoietin-1 receptor	Homo sapiens (human)
regulation of endothelial cell apoptotic process	Angiopoietin-1 receptor	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of MAPK cascade	Angiopoietin-1 receptor	Homo sapiens (human)
positive regulation of kinase activity	Angiopoietin-1 receptor	Homo sapiens (human)
multicellular organism development	Angiopoietin-1 receptor	Homo sapiens (human)
activation of protein kinase B activity	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of MAP kinase activity	NT-3 growth factor receptor	Homo sapiens (human)
negative regulation of protein phosphorylation	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	NT-3 growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	NT-3 growth factor receptor	Homo sapiens (human)
nervous system development	NT-3 growth factor receptor	Homo sapiens (human)
heart development	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of cell population proliferation	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of gene expression	NT-3 growth factor receptor	Homo sapiens (human)
cell differentiation	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of cell migration	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	NT-3 growth factor receptor	Homo sapiens (human)
neurotrophin signaling pathway	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of positive chemotaxis	NT-3 growth factor receptor	Homo sapiens (human)
activation of GTPase activity	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of neuron projection development	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	NT-3 growth factor receptor	Homo sapiens (human)
cellular response to nerve growth factor stimulus	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	NT-3 growth factor receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	NT-3 growth factor receptor	Homo sapiens (human)
multicellular organism development	NT-3 growth factor receptor	Homo sapiens (human)
negative regulation of amyloid-beta formation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
vasculogenesis	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
neuron migration	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
learning	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
circadian rhythm	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
feeding behavior	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of cell population proliferation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of gene expression	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of neuron projection development	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
glutamate secretion	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
neuronal action potential propagation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
central nervous system neuron development	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
cerebral cortex development	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
myelination in peripheral nervous system	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
neuron differentiation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
brain-derived neurotrophic factor receptor signaling pathway	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
neurotrophin signaling pathway	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
mechanoreceptor differentiation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
regulation of GTPase activity	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of MAPK cascade	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
negative regulation of neuron apoptotic process	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
retinal rod cell development	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
protein autophosphorylation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
oligodendrocyte differentiation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
peripheral nervous system neuron development	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of axonogenesis	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of synapse assembly	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
long-term synaptic potentiation	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
cellular response to amino acid stimulus	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
trans-synaptic signaling by BDNF, modulating synaptic transmission	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
negative regulation of anoikis	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of kinase activity	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
multicellular organism development	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
cellular response to brain-derived neurotrophic factor stimulus	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
trans-synaptic signaling by neuropeptide, modulating synaptic transmission	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (34)

Process	via Protein(s)	Taxonomy
cytokine activity	Interferon beta	Homo sapiens (human)
cytokine receptor binding	Interferon beta	Homo sapiens (human)
type I interferon receptor binding	Interferon beta	Homo sapiens (human)
protein binding	Interferon beta	Homo sapiens (human)
chloramphenicol O-acetyltransferase activity	Interferon beta	Homo sapiens (human)
protein tyrosine kinase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
GPI-linked ephrin receptor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin p75 receptor binding	High affinity nerve growth factor receptor	Homo sapiens (human)
protein binding	High affinity nerve growth factor receptor	Homo sapiens (human)
ATP binding	High affinity nerve growth factor receptor	Homo sapiens (human)
nerve growth factor receptor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
kinase binding	High affinity nerve growth factor receptor	Homo sapiens (human)
identical protein binding	High affinity nerve growth factor receptor	Homo sapiens (human)
protein homodimerization activity	High affinity nerve growth factor receptor	Homo sapiens (human)
nerve growth factor binding	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin binding	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin receptor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
ATP binding	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein phosphatase binding	Hepatocyte growth factor receptor	Homo sapiens (human)
identical protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
molecular function activator activity	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
integrin binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
ATP binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
coreceptor activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
growth factor binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
identical protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cadherin binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
Hsp90 protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein kinase activity	Angiopoietin-1 receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Angiopoietin-1 receptor	Homo sapiens (human)
protein binding	Angiopoietin-1 receptor	Homo sapiens (human)
ATP binding	Angiopoietin-1 receptor	Homo sapiens (human)
growth factor binding	Angiopoietin-1 receptor	Homo sapiens (human)
signaling receptor activity	Angiopoietin-1 receptor	Homo sapiens (human)
identical protein binding	Angiopoietin-1 receptor	Homo sapiens (human)
p53 binding	NT-3 growth factor receptor	Homo sapiens (human)
neurotrophin receptor activity	NT-3 growth factor receptor	Homo sapiens (human)
protein binding	NT-3 growth factor receptor	Homo sapiens (human)
ATP binding	NT-3 growth factor receptor	Homo sapiens (human)
neurotrophin binding	NT-3 growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	NT-3 growth factor receptor	Homo sapiens (human)
protease binding	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
protein binding	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
ATP binding	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
protein homodimerization activity	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
neurotrophin binding	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
brain-derived neurotrophic factor binding	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
brain-derived neurotrophic factor receptor activity	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (42)

Process	via Protein(s)	Taxonomy
extracellular space	Interferon beta	Homo sapiens (human)
extracellular region	Interferon beta	Homo sapiens (human)
early endosome	High affinity nerve growth factor receptor	Homo sapiens (human)
late endosome	High affinity nerve growth factor receptor	Homo sapiens (human)
plasma membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
cell surface	High affinity nerve growth factor receptor	Homo sapiens (human)
endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
dendrite	High affinity nerve growth factor receptor	Homo sapiens (human)
early endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
late endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
neuronal cell body	High affinity nerve growth factor receptor	Homo sapiens (human)
recycling endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
protein-containing complex	High affinity nerve growth factor receptor	Homo sapiens (human)
receptor complex	High affinity nerve growth factor receptor	Homo sapiens (human)
axon	High affinity nerve growth factor receptor	Homo sapiens (human)
plasma membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
extracellular region	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface	Hepatocyte growth factor receptor	Homo sapiens (human)
membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
postsynapse	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
receptor complex	Hepatocyte growth factor receptor	Homo sapiens (human)
extracellular region	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
nucleus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
early endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endoplasmic reticulum	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
Golgi apparatus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
external side of plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell junction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
membrane raft	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
anchoring junction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
sorting endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
receptor complex	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
stress fiber	Angiopoietin-1 receptor	Homo sapiens (human)
actin filament	Angiopoietin-1 receptor	Homo sapiens (human)
extracellular region	Angiopoietin-1 receptor	Homo sapiens (human)
cytoplasm	Angiopoietin-1 receptor	Homo sapiens (human)
plasma membrane	Angiopoietin-1 receptor	Homo sapiens (human)
microvillus	Angiopoietin-1 receptor	Homo sapiens (human)
cell-cell junction	Angiopoietin-1 receptor	Homo sapiens (human)
focal adhesion	Angiopoietin-1 receptor	Homo sapiens (human)
basal plasma membrane	Angiopoietin-1 receptor	Homo sapiens (human)
cell surface	Angiopoietin-1 receptor	Homo sapiens (human)
basolateral plasma membrane	Angiopoietin-1 receptor	Homo sapiens (human)
apical plasma membrane	Angiopoietin-1 receptor	Homo sapiens (human)
centriolar satellite	Angiopoietin-1 receptor	Homo sapiens (human)
membrane raft	Angiopoietin-1 receptor	Homo sapiens (human)
plasma membrane	Angiopoietin-1 receptor	Homo sapiens (human)
receptor complex	Angiopoietin-1 receptor	Homo sapiens (human)
plasma membrane	NT-3 growth factor receptor	Homo sapiens (human)
receptor complex	NT-3 growth factor receptor	Homo sapiens (human)
plasma membrane	NT-3 growth factor receptor	Homo sapiens (human)
axon	NT-3 growth factor receptor	Homo sapiens (human)
early endosome	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
cytosol	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
plasma membrane	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
postsynaptic density	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
axon	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
dendrite	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
early endosome membrane	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
terminal bouton	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
perinuclear region of cytoplasm	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
receptor complex	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
axon terminus	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
plasma membrane	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
postsynaptic density	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
axon	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
dendritic spine	BDNF/NT-3 growth factors receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID1533333	Inhibition of TRKB (unknown origin)	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1533349	Inhibition of cMET (unknown origin)	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1318751	Inhibition of TrkA (unknown origin)	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
AID1533351	Antiproliferative activity against human K562 cells	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1318734	Inhibition of MET (unknown origin)	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
AID1533334	Inhibition of TRKC (unknown origin)	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1533352	Antiproliferative activity against human SK-N-SH cells	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1533332	Inhibition of TRKA (unknown origin)	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1318740	Inhibition of TIE-2 (unknown origin)	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
AID1533353	Antiproliferative activity against human KM12 cells	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1318752	Inhibition of TrkB (unknown origin)	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
AID1318753	Inhibition of TrkC (unknown origin)	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
AID1533346	Inhibition of VEGFR2 (unknown origin)	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1421976	Inhibition of c-MET (unknown origin)	2018	European journal of medicinal chemistry, Oct-05, Volume: 158	Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2.
AID1318775	Inhibition of VEGFR (unknown origin)	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
AID1421977	Inhibition of VEGFR2 (unknown origin)	2018	European journal of medicinal chemistry, Oct-05, Volume: 158	Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2.
AID1533350	Inhibition of TIE2 (unknown origin)	2019	Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4	Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347411	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (85.71)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.61 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.61)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
betaxolol [no description available]	2.13	1	propanolamine	antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent
metoprolol Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.. metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.	2.13	1	aromatic ether; propanolamine; secondary alcohol; secondary amino compound	antihypertensive agent; beta-adrenergic antagonist; environmental contaminant; geroprotector; xenobiotic
alpha-aminopyridine alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.	2.52	2
a 75925 A 75925: has HIV antiviral & HIV type 1 protease inhibitory activity	2.13	1
roflumilast [no description available]	2.13	1	aromatic ether; benzamides; chloropyridine; cyclopropanes; organofluorine compound	anti-asthmatic drug; phosphodiesterase IV inhibitor
ly335979 [no description available]	2.13	1	carbopolycyclic compound
montelukast montelukast: a leukotriene D4 receptor antagonist	2.13	1	aliphatic sulfide; monocarboxylic acid; quinolines	anti-arrhythmia drug; anti-asthmatic drug; leukotriene antagonist
pitavastatin pitavastatin : A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.	2.13	1	cyclopropanes; dihydroxy monocarboxylic acid; monofluorobenzenes; quinolines; statin (synthetic)	antioxidant
nalmefene nalmefene: RN given refers to 5-alpha isomer	2.13	1	morphinane alkaloid
verlukast verlukast: LTD4 receptor antagonist	2.13	1
volasertib BI 6727: a polo-like kinase inhibitor with broad antitumor activity; structure in first source	2.13	1
gw 2580 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine: a cFMS kinase inhibitor; structure in first source	2.21	1
e 7050 [no description available]	2.13	1	aromatic ether
bms 754807 BMS 754807: an IGR-1R kinase inhibitor; structure in first source	2.21	1	pyrazoles; pyridines; pyrrolidines; pyrrolotriazine	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
cabozantinib cabozantinib: a multikinase inhibitor. cabozantinib : A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.	2.55	2	aromatic ether; dicarboxylic acid diamide; organofluorine compound; quinolines	antineoplastic agent; tyrosine kinase inhibitor
entrectinib entrectinib: inhibits TRK, ROS1, and ALK receptor tyrosine kinases; structure in first source. entrectinib : A member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours.	2.21	1	benzamides; difluorobenzene; indazoles; N-methylpiperazine; oxanes; secondary amino compound; secondary carboxamide	antibacterial agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
gsk 1363089 GSK 1363089: a multikinase inhibitor that acts on Met, RON, Axl, and VEGFR; structure in first source	2.55	2	aromatic ether
n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide merestinib: in phase I clinical trials (2013); structure in first source	2.21	1

Condition	Indicated	Relationship Strength	Studies
Benign Neoplasms [description not available]	0	2.59	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	1	4.59	2
Disease Exacerbation [description not available]	0	2.11	1
Cancer of Ovary [description not available]	0	2.11	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	0	2.11	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	2.11	1
B16 Melanoma [description not available]	0	2.11	1
Angiogenesis, Pathologic [description not available]	0	2.11	1

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