Page last updated: 2024-12-08

sch 45752

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Cross-References

ID Source	ID
PubMed CID	160115
CHEMBL ID	463175
CHEBI ID	181037
SCHEMBL ID	1111561
MeSH ID	M0057717

Synonyms (31)

Synonym
CHEBI:181037
25908-26-3
nsc-627953
nsc-201419
nsc201419
cephalochromin
MEGXM0_000312
ACON0_000585
NCGC00180856-01
5,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-one
nsc627953
5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-2,2',3,3'-tetrahydro-4h,4'h-9,9'-bibenzo[g]chromene-4,4'-dione
ACON1_000126
MLS000876993 ,
smr000440611
cid_160115
bdbm50269745
CHEMBL463175 ,
SR-01000758207-2
sr-01000758207
sch 45752
2,2',3,3'-tetrahydro-5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-9,9'-bi-4h-naphtho(2,3-b)pyran-4,4'-dione
sch-45752
HMS2270H11
SCHEMBL1111561
HB3825
2,2',3,3'-tetrahydro-5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-9,9'-bi[4h-naphtho[2,3-b]pyran]-4,4'-dione
5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-2h,2'h-[9,9'-bibenzo[g]chromene]-4,4'(3h,3'h)-dione
DTXSID60948813
compound np-004604
AKOS040739787

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
organooxygen compound	An organochalcogen compound containing at least one carbon-oxygen bond.
organic heterotricyclic compound	An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (80)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	11.2323	0.0032	45.4673	12,589.2998	AID2517; AID2572
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	44.6684	0.6310	35.7641	100.0000	AID504339
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	8.9125	0.1778	14.3909	39.8107	AID2147
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	17.7828	0.1259	19.1169	125.8920	AID2549
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	15.8489	5.6234	17.2929	31.6228	AID485281
endonuclease IV	Escherichia coli	Potency	10.0000	0.7079	12.4324	31.6228	AID2565
glp-1 receptor, partial	Homo sapiens (human)	Potency	11.2202	0.0184	6.8060	14.1254	AID624417
WRN	Homo sapiens (human)	Potency	89.1251	0.1683	31.2583	100.0000	AID651768
ATAD5 protein, partial	Homo sapiens (human)	Potency	8.1961	0.0041	10.8903	31.5287	AID504467
USP1 protein, partial	Homo sapiens (human)	Potency	31.6228	0.0316	37.5844	354.8130	AID743255
GLS protein	Homo sapiens (human)	Potency	2.8184	0.3548	7.9355	39.8107	AID624170
TDP1 protein	Homo sapiens (human)	Potency	1.1659	0.0008	11.3822	44.6684	AID686978; AID686979
Microtubule-associated protein tau	Homo sapiens (human)	Potency	12.3129	0.1800	13.5574	39.8107	AID1460; AID1468
Smad3	Homo sapiens (human)	Potency	19.9526	0.0052	7.8098	29.0929	AID588855
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	7.0795	0.7079	12.1943	39.8107	AID720542
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	44.6684	0.0112	12.4002	100.0000	AID1030
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	56.2341	0.5318	15.4358	37.6858	AID504845
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	15.8489	0.2818	9.7212	35.4813	AID2326
67.9K protein	Vaccinia virus	Potency	12.0627	0.0001	8.4406	100.0000	AID720579; AID720580
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	39.8107	0.7079	36.9043	89.1251	AID504333
IDH1	Homo sapiens (human)	Potency	4.6109	0.0052	10.8652	35.4813	AID686970
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	2.5119	0.0355	20.9770	89.1251	AID504332
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	25.1189	0.0165	25.3078	41.3999	AID602332
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	35.4813	0.0366	19.6376	50.1187	AID2100
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	1.5849	0.0126	2.4518	25.0177	AID485313
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	79.4328	0.3548	28.0659	89.1251	AID504847
chromobox protein homolog 1	Homo sapiens (human)	Potency	28.1838	0.0060	26.1688	89.1251	AID540317
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	44.6684	0.0100	39.5371	1,122.0200	AID1479
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	11.5821	0.0041	9.9848	25.9290	AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	12.5893	3.5481	19.5427	44.6684	AID743266
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	39.8107	5.8048	36.1306	65.1308	AID540253
DNA polymerase beta	Homo sapiens (human)	Potency	17.7828	0.0224	21.0102	89.1251	AID485314
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	5.6234	0.0398	16.7842	39.8107	AID1454
flap endonuclease 1	Homo sapiens (human)	Potency	14.1254	0.1337	25.4129	89.1251	AID588795
ras-related protein Rab-9A	Homo sapiens (human)	Potency	2.5119	0.0002	2.6215	31.4954	AID485297
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	26.6795	0.1683	16.4040	67.0158	AID720504
snurportin-1	Homo sapiens (human)	Potency	39.8107	5.8048	36.1306	65.1308	AID540253
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	4.4668	0.4256	12.0591	28.1838	AID504891
tumor susceptibility gene 101 protein	Homo sapiens (human)	Potency	79.4328	0.1298	10.8331	32.6090	AID493005
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	39.8107	5.8048	16.9962	25.9290	AID540253
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	10.0000	0.1000	28.9256	213.3130	AID588591
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	1.1220	0.0501	27.0736	89.1251	AID588590
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	10.0000	0.1585	5.2879	12.5893	AID540303
plasminogen precursor	Mus musculus (house mouse)	Potency	10.0000	0.1585	5.2879	12.5893	AID540303
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	10.0000	0.1585	5.2879	12.5893	AID540303
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	8.8006	0.0079	8.2332	1,122.0200	AID2546; AID2551
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	0.6310	0.0752	15.2253	39.8107	AID485360
geminin	Homo sapiens (human)	Potency	9.7542	0.0046	11.3741	33.4983	AID624296; AID624297
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	14.1254	0.0316	22.3146	100.0000	AID588579
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	39.8107	0.0041	9.9625	28.1838	AID2675
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	35.4813	0.2512	15.8432	39.8107	AID504327
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	10.0000	0.0158	12.3113	615.5000	AID1461
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	10.0000	6.3096	60.2008	112.2020	AID720709
Glycoprotein hormones alpha chain	Homo sapiens (human)	Potency	28.1838	4.4668	8.3448	10.0000	AID624291
Glutamate receptor 1	Rattus norvegicus (Norway rat)	Potency	19.9526	0.0141	8.6024	39.8107	AID2572
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	19.9526	0.0015	51.7393	15,848.9004	AID2572
Glutamate receptor 3	Rattus norvegicus (Norway rat)	Potency	19.9526	0.0141	8.6024	39.8107	AID2572
Glutamate receptor 4	Rattus norvegicus (Norway rat)	Potency	19.9526	0.0141	8.6024	39.8107	AID2572
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	28.1838	1.9953	25.5327	50.1187	AID624288
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	35.4813	1.7783	16.2081	35.4813	AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
glutathione-S-transferase	Schistosoma japonicum	IC50 (µMol)	100.0000	0.8500	52.5540	100.0000	AID1117362
Mcl-1	Homo sapiens (human)	IC50 (µMol)	1.4919	0.4000	7.1344	54.0000	AID1417
Valosin-containing protein	Homo sapiens (human)	IC50 (µMol)	46.9300	0.1100	6.0187	28.0000	AID1534; AID1544
Vif	Human immunodeficiency virus 1	IC50 (µMol)	0.4100	0.2700	34.0015	100.0000	AID1117319
Tat	Human immunodeficiency virus 1	IC50 (µMol)	7.6180	0.9960	39.8009	100.0000	AID1117361
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	IC50 (µMol)	0.4100	0.2700	26.3638	100.0000	AID1117319
Botulinum neurotoxin type A	Clostridium botulinum A str. Hall	IC50 (µMol)	29.2000	2.1000	2.1000	2.1000	AID673914
Glucagon receptor	Homo sapiens (human)	IC50 (µMol)	20.0000	0.0066	0.4017	2.6000	AID333259
M1-family alanyl aminopeptidase	Plasmodium falciparum 3D7	IC50 (µMol)	64.8900	2.6000	48.1803	128.9800	AID1445
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
alkaline phosphatase, intestinal	Homo sapiens (human)	EC50 (µMol)	21.7000	0.2570	26.8395	81.0000	AID488873
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	Homo sapiens (human)	EC50 (µMol)	26.7000	0.2270	25.0904	86.8000	AID488880
intestinal alkaline phosphatase precursor	Mus musculus (house mouse)	EC50 (µMol)	19.1000	0.3820	42.4691	75.0000	AID488783
alkaline phosphatase, germ cell type preproprotein	Homo sapiens (human)	EC50 (µMol)	21.1000	0.5500	33.7339	74.0000	AID488878
recombinase A	Mycobacterium tuberculosis H37Rv	EC50 (µMol)	2.0345	0.0180	23.2882	287.6000	AID434968; AID435010
streptokinase A precursor	Streptococcus pyogenes M1 GAS	EC50 (µMol)	75.2505	0.0600	8.9128	130.5170	AID1902; AID1914
Estrogen receptor	Rattus norvegicus (Norway rat)	EC50 (µMol)	150.0000	0.0060	22.3670	130.5170	AID1914
Estrogen receptor beta	Rattus norvegicus (Norway rat)	EC50 (µMol)	150.0000	0.0060	22.3670	130.5170	AID1914
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
replicative DNA helicase	Mycobacterium tuberculosis H37Rv	AC50	2.2460	0.0570	30.7482	325.3000	AID449749; AID449750
POsterior Segregation	Caenorhabditis elegans	AC50	8.2920	3.2980	12.4649	24.6150	AID493130
Zinc finger protein mex-5	Caenorhabditis elegans	AC50	2.0690	0.3000	31.0987	106.7000	AID449745
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (66)

Process	via Protein(s)	Taxonomy
angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
adaptive immune response	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
associative learning	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
Rap protein signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of actin cytoskeleton organization	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
intracellular signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of GTPase activity	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of protein export from nucleus	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of stress fiber assembly	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
establishment of endothelial barrier	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cellular response to cAMP	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
Ras protein signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of insulin secretion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of cell population proliferation	Glycoprotein hormones alpha chain	Homo sapiens (human)
hormone-mediated signaling pathway	Glycoprotein hormones alpha chain	Homo sapiens (human)
regulation of signaling receptor activity	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of steroid biosynthetic process	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of cell migration	Glycoprotein hormones alpha chain	Homo sapiens (human)
thyroid gland development	Glycoprotein hormones alpha chain	Homo sapiens (human)
luteinizing hormone secretion	Glycoprotein hormones alpha chain	Homo sapiens (human)
organ growth	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone signaling pathway	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Glycoprotein hormones alpha chain	Homo sapiens (human)
negative regulation of organ growth	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone secretion	Glycoprotein hormones alpha chain	Homo sapiens (human)
thyroid hormone generation	Glycoprotein hormones alpha chain	Homo sapiens (human)
cellular response to starvation	Glucagon receptor	Homo sapiens (human)
positive regulation of gene expression	Glucagon receptor	Homo sapiens (human)
generation of precursor metabolites and energy	Glucagon receptor	Homo sapiens (human)
exocytosis	Glucagon receptor	Homo sapiens (human)
cell surface receptor signaling pathway	Glucagon receptor	Homo sapiens (human)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Glucagon receptor	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Glucagon receptor	Homo sapiens (human)
response to nutrient	Glucagon receptor	Homo sapiens (human)
regulation of blood pressure	Glucagon receptor	Homo sapiens (human)
hormone-mediated signaling pathway	Glucagon receptor	Homo sapiens (human)
glucose homeostasis	Glucagon receptor	Homo sapiens (human)
response to starvation	Glucagon receptor	Homo sapiens (human)
regulation of glycogen metabolic process	Glucagon receptor	Homo sapiens (human)
cellular response to glucagon stimulus	Glucagon receptor	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
renal water homeostasis	Guanine nucleotide-binding protein G	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G	Homo sapiens (human)
regulation of insulin secretion	Guanine nucleotide-binding protein G	Homo sapiens (human)
cellular response to glucagon stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
negative regulation of protein phosphorylation	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA processing	TAR DNA-binding protein 43	Homo sapiens (human)
RNA splicing	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of protein stability	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of insulin secretion	TAR DNA-binding protein 43	Homo sapiens (human)
response to endoplasmic reticulum stress	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of protein import into nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of circadian rhythm	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of apoptotic process	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation by host of viral transcription	TAR DNA-binding protein 43	Homo sapiens (human)
rhythmic process	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of cell cycle	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA destabilization	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear inner membrane organization	TAR DNA-binding protein 43	Homo sapiens (human)
amyloid fibril formation	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (19)

Process	via Protein(s)	Taxonomy
guanyl-nucleotide exchange factor activity	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
protein binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
protein domain specific binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cAMP binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
hormone activity	Glycoprotein hormones alpha chain	Homo sapiens (human)
protein binding	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone activity	Glycoprotein hormones alpha chain	Homo sapiens (human)
glucagon receptor activity	Glucagon receptor	Homo sapiens (human)
guanyl-nucleotide exchange factor activity	Glucagon receptor	Homo sapiens (human)
peptide hormone binding	Glucagon receptor	Homo sapiens (human)
G protein activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
adenylate cyclase activator activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
double-stranded DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
RNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA 3'-UTR binding	TAR DNA-binding protein 43	Homo sapiens (human)
protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
lipid binding	TAR DNA-binding protein 43	Homo sapiens (human)
identical protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
pre-mRNA intronic binding	TAR DNA-binding protein 43	Homo sapiens (human)
molecular condensate scaffold activity	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (23)

Process	via Protein(s)	Taxonomy
plasma membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cortical actin cytoskeleton	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
plasma membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
microvillus	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
endomembrane system	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
lamellipodium	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
filopodium	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
extracellular exosome	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
extracellular region	Glycoprotein hormones alpha chain	Homo sapiens (human)
extracellular space	Glycoprotein hormones alpha chain	Homo sapiens (human)
Golgi lumen	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone complex	Glycoprotein hormones alpha chain	Homo sapiens (human)
pituitary gonadotropin complex	Glycoprotein hormones alpha chain	Homo sapiens (human)
extracellular space	Glycoprotein hormones alpha chain	Homo sapiens (human)
plasma membrane	Glutamate receptor 1	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor 2	Rattus norvegicus (Norway rat)
endosome	Glucagon receptor	Homo sapiens (human)
plasma membrane	Glucagon receptor	Homo sapiens (human)
membrane	Glucagon receptor	Homo sapiens (human)
plasma membrane	Glucagon receptor	Homo sapiens (human)
plasma membrane	Guanine nucleotide-binding protein G	Homo sapiens (human)
intracellular non-membrane-bounded organelle	TAR DNA-binding protein 43	Homo sapiens (human)
nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
perichromatin fibrils	TAR DNA-binding protein 43	Homo sapiens (human)
mitochondrion	TAR DNA-binding protein 43	Homo sapiens (human)
cytoplasmic stress granule	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear speck	TAR DNA-binding protein 43	Homo sapiens (human)
interchromatin granule	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
chromatin	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (59)

Assay ID	Title	Year	Journal	Article
AID1138475	Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 51 +/- 1.1%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138498	Induction of apoptosis in human A549 cells assessed as induction of ROS production at 3 uM after 12 hrs using DCF-DA staining by flow cytometry analysis relative to control	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138472	Cell cycle arrest in human A549 cells assessed as accumulation at sub-G1 phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 2 +/- 0.3%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138465	Cytotoxicity against human A549 cells after 48 hrs by SRB assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138479	Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 10 uM after 36 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 9.6 +/- 0.9%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138499	Induction of apoptosis in human A549 cells assessed as induction of ROS production at 10 uM after 12 hrs using DCF-DA staining by flow cytometry analysis relative to control	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138489	Induction of apoptosis in human A549 cells assessed as induction of cleaved PARP protein expression at 10 uM after 26 to 36 hrs by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138480	Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 10 uM after 48 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 9.5 +/- 0.7%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138471	Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138484	Induction of apoptosis in human A549 cells assessed as DNA level after 24 to 48 hrs using propidium iodide staining by flow cytometry analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138503	Induction of apoptosis in human A549 cells assessed as induction of ROS production at 10 uM after 5 hrs using DCF-DA staining by flow cytometry analysis in presence of Tiron	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138477	Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 10 uM after 48 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 57.3 +/- 0.9%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138466	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138467	Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID673913	Inhibition of Clostridium botulinum Hall BoNT/A protease activity using Ac-SNKTRIDEANQRATKML-NH2 as substrate at 20 uM after 5 mins by RP-HPLC analysis	2012	ACS medicinal chemistry letters, May-10, Volume: 3, Issue:5	Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.
AID1138478	Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 12 +/- 1.4%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138470	Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138488	Induction of apoptosis in human A549 cells assessed as proteolytic cleavage of inactive procaspase-8, 9, and 3 into active caspase-8, 9, and 3 at 10 uM by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138504	Induction of apoptosis in human A549 cells assessed as increase in expression of LC3-II at 10 uM by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138490	Induction of apoptosis in human A549 cells assessed as reduction of survivin expression at 10 uM by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138493	Induction of apoptosis in human A549 cells assessed as hypodiploid DNA content at 10 to 20 uM after 48 hrs by flow cytometry analysis in presence of Z-VAD-fmk	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138487	Induction of apoptosis in human A549 cells assessed as downregulation of cyclin D1, cyclin E, Cdk 2, and Cdk 4 protein levels after 24 hrs by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID333259	Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA	2004	Journal of natural products, Sep, Volume: 67, Issue:9	BI-32169, a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp.
AID1138486	Induction of apoptosis in human A549 cells assessed as downregulation of cyclin D1, cyclin E, Cdk 2, and Cdk 4 protein levels at 10 uM after 6 to 36 hrs by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138496	Induction of apoptosis in human A549 cells assessed as induction of ROS production after 12 hrs using DCF-DA staining by flow cytometry analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138502	Induction of apoptosis in human A549 cells assessed as induction of ROS production at 10 uM using DCF-DA staining by flow cytometry analysis relative to control	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138494	Induction of apoptosis in human A549 cells assessed as loss of mitochondrial membrane potential at 10 to 30 uM after 12 to 24 hrs by flow cytometry analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138501	Induction of apoptosis in human A549 cells assessed as induction of ROS production at 5 mM after 12 hrs using DCF-DA staining by flow cytometry analysis relative to control	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138483	Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 10 uM after 48 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 31.9 +/- 1.4%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID673915	Inhibition of Clostridium botulinum Hall BoNT/A-mediated paralysis in CD1 mouse phrenic nerve hemidiaphragm assessed as time required to 50% loss of twitch tension at 20 uM measured upto 5 hrs (Rvb = 62 mins)	2012	ACS medicinal chemistry letters, May-10, Volume: 3, Issue:5	Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.
AID673912	Inhibition of Clostridium botulinum Hall BoNT/A protease activity using Ac-SNKTRIDEANQRATKML-NH2 as substrate at 100 uM after 5 mins by RP-HPLC analysis	2012	ACS medicinal chemistry letters, May-10, Volume: 3, Issue:5	Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.
AID1138481	Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 35.2 +/- 2.3%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138476	Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 10 uM after 36 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 53.1 +/- 1.2%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138469	Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138468	Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138474	Cell cycle arrest in human A549 cells assessed as accumulation at sub-G1 phase at 10 uM after 48 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 1.5 +/- 0.1%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138492	Induction of apoptosis in human A549 cells assessed as reduction of Bad proteins expression at 10 uM after 6 to 36 hrs by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138473	Cell cycle arrest in human A549 cells assessed as accumulation at sub-G1 phase at 10 uM after 36 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 1.7 +/- 0.4%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138500	Induction of apoptosis in human A549 cells assessed as induction of ROS production at 30 uM after 12 hrs using DCF-DA staining by flow cytometry analysis relative to control	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID673914	Inhibition of Clostridium botulinum Hall BoNT/A protease activity using Ac-SNKTRIDEANQRATKML-NH2 as substrate after 5 mins by RP-HPLC analysis	2012	ACS medicinal chemistry letters, May-10, Volume: 3, Issue:5	Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.
AID1138497	Induction of apoptosis in human A549 cells assessed as induction of ROS production at 1 uM after 12 hrs using DCF-DA staining by flow cytometry analysis relative to control	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID673916	Inhibition of Clostridium botulinum Hall BoNT/A-mediated paralysis in CD1 mouse phrenic nerve hemidiaphragm assessed as time required to 50% loss of twitch tension at 2 uM measured upto 5 hrs (Rvb = 62 mins)	2012	ACS medicinal chemistry letters, May-10, Volume: 3, Issue:5	Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.
AID1138491	Induction of apoptosis in human A549 cells assessed as reduction of Bcl-xL expression at 10 uM after 6 to 36 hrs by Western blot analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138482	Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 10 uM after 36 hrs using propidium iodide staining by flow cytometry analysis (Rvb = 35.8 +/- 1.8%)	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138485	Induction of apoptosis in human A549 cells assessed as DNA level at 3 to 30 uM using propidium iodide staining by flow cytometry analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID1138495	Induction of apoptosis in human A549 cells assessed as loss of mitochondrial membrane potential at 50 uM after 12 to 24 hrs by flow cytometry analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (7.69)	18.7374
1990's	1 (7.69)	18.2507
2000's	4 (30.77)	29.6817
2010's	5 (38.46)	24.3611
2020's	2 (15.38)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.56 (24.57)
Research Supply Index	2.64 (2.92)
Research Growth Index	5.20 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chaetochromin chaetochromin: from Chaetomium spp.; RN given refers to chaetochromin A	1.97	1
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	3.28	6	cephalosporin	fungal metabolite
skyrin skyrin: main pigment of toxin rice fungus Penicillium islandicum; RN given refers to parent cpd; structure	2.07	1	biaryl; trihydroxyanthraquinone
cb 7969312 [no description available]	2.07	1	organochlorine compound; quinolines
bi-32169 BI-32169: a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp.; structure in first source	2.02	1
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor	2.1	1

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Carcinoma, Non-Small Cell Lung [description not available]	2.1	1
Cancer of Lung [description not available]	2.1	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.1	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.1	1

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