| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
bu 224
BU 224: a selective imidazoline 2-receptor blocker | 2 | 1 | 0 | quinolines | |
cirazoline
cirazoline: posseses agonist properties at alpha-adrenoreceptor sites; RN given refers to parent cpd | 2 | 1 | 0 | aromatic ether | |
clonidine
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group. | 2.52 | 2 | 0 | clonidine;
imidazoline | |
nordefrin
Nordefrin: A norepinephrine derivative used as a vasoconstrictor agent. | 2.01 | 1 | 0 | catecholamine | |
4-iodoclonidine
4-iodoclonidine: structure given in first source | 2.13 | 1 | 0 | | |
moxonidine
moxonidine: structure given in first source | 2.52 | 2 | 0 | organohalogen compound;
pyrimidines | |
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen. | 2.01 | 1 | 0 | pyrrole;
secondary amine | |
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom. | 2.41 | 2 | 0 | 1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
2-phenyl-2-imidazoline
[no description available] | 2 | 1 | 0 | | |
lofexidine
lofexidine: reduces narcotic withdrawal symptoms; RN given refers to parent cpd without isomeric designation; structure in Negwer, 5th ed, #6247 | 2.13 | 1 | 0 | aromatic ether;
carboxamidine;
dichlorobenzene;
imidazoles | alpha-adrenergic agonist;
antihypertensive agent |
idazoxan
Idazoxan: A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.. idazoxan : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group. | 2.44 | 2 | 0 | benzodioxine;
imidazolines | alpha-adrenergic antagonist |
rilmenidine
Rilmenidine: Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION. | 2.76 | 3 | 0 | isourea | |
2-phenylimidazole
[no description available] | 2 | 1 | 0 | | |
atipamezole
[no description available] | 2.13 | 1 | 0 | | |
fenoxazoline
fenoxazoline: RN given refers to parent cpd | 2 | 1 | 0 | alkylbenzene | |
efaroxan
efaroxan: RN given refers to parent cpd | 2.13 | 1 | 0 | 1-benzofurans | |
4-chloro-2-(2-imidazolin-2-ylamino)isoindoline
4-chloro-2-(2-imidazolin-2-ylamino)isoindoline: acts as partial agonist at the postsynaptic alpha-adrenoreceptors of the rat anococcygeus muscle & as antagonist at the presynaptic alpha-adrenoreceptors of the rat vas deferens | 2.13 | 1 | 0 | | |
2-(2-benzofuranyl)-2-imidazoline
2-(2-benzofuranyl)-2-imidazoline: structure given in first source | 2 | 1 | 0 | benzofurans | |
dexmedetomidine
[no description available] | 2.13 | 1 | 0 | medetomidine | alpha-adrenergic agonist;
analgesic;
non-narcotic analgesic;
sedative |
tracizoline
tracizoline: RN given for (R-(R*,R*))-2,3-dihydroxybutanedionate (1:1); ligand for imidazoline receptor; structure in first source | 2.44 | 2 | 0 | | |
guanosine 5'-o-(3-thiotriphosphate)
Guanosine 5'-O-(3-Thiotriphosphate): Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. | 2.41 | 2 | 0 | nucleoside triphosphate analogue | |