Page last updated: 2024-11-12
dysinosin a
Description
dysinosin A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
Synonyms (5)
| Synonym |
|---|
| bdbm50269776 |
| CHEMBL502639 , |
| dysinosin a |
| [(2r)-3-[[(2r)-1-[(2s,3ar,5s,6s,7as)-2-[2-[1-(diaminomethylidene)-2,5-dihydropyrrol-1-ium-3-yl]ethylcarbamoyl]-5,6-dihydroxy-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-2-methoxy-3-oxopropyl] sulfate |
| DTXSID001047314 |
Research Excerpts
Overview
Dysinosin A is a potent inhibitor of the blood coagulation cascade factor VIIa. It is also an inhibitors of the serine protease thrombin.
| Excerpt | Reference | Relevance |
|---|
| "Dysinosin A is a potent inhibitor of the blood coagulation cascade factor VIIa and an inhibitor of the serine protease thrombin." | ( Dysinosin A: a novel inhibitor of Factor VIIa and thrombin from a new genus and species of Australian sponge of the family Dysideidae.
Boström, SL; Carroll, AR; De Almeida Leone, P; Fechner, G; Hooper, JN; Hyde, E; Musil, D; Ngo, A; Pierens, GK; Quinn, RJ; Simpson, M, 2002) | 2.48 |
Protein Targets (3)
Inhibition Measurements
Biological Processes (54)
Molecular Functions (9)
Ceullar Components (11)
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID333058 | Inhibition of factor 7a by spectrophotometric assay | 2004 | Journal of natural products, Aug, Volume: 67, Issue:8
| Dysinosins B-D, inhibitors of factor VIIa and thrombin from the Australian sponge Lamellodysidea chlorea. |
| AID425654 | Inhibition of thrombin | 2009 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
| Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety. |
| AID333059 | Inhibition of thrombin by spectrophotometric assay | 2004 | Journal of natural products, Aug, Volume: 67, Issue:8
| Dysinosins B-D, inhibitors of factor VIIa and thrombin from the Australian sponge Lamellodysidea chlorea. |
| AID449340 | Inhibition of human thrombin | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
| From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. |
| AID425656 | Inhibition of factor7a | 2009 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
| Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.19
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.19 (24.57) | | Research Supply Index | 2.08 (2.92) | | Research Growth Index | 4.27 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |