etp-46321 profile

ETP-46321: inhibits PI3K alpha and PI3K delta; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	46927938
CHEMBL ID	2087474
SCHEMBL ID	10100315
MeSH ID	M0576940

Synonym
CHEMBL2087474 ,
bdbm50420714
CS-3350
HY-12340
etp-46321
SCHEMBL10100315
EX-A1284
1252594-99-2
5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine
5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-yl-imidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
BCP19935
etp46321
5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
5-(2-((4-(methyl sulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine
F85058
MS-28782
A926380
CAC59499
AC-36139

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Ki	0.0142	0.0000	0.0081	0.0310	AID1365734; AID1450088; AID685271
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	IC50 (µMol)	0.0023	0.0000	0.6832	10.0000	AID1450083; AID685262
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	Ki	0.0622	0.0001	0.0394	0.1700	AID1365733; AID1365734; AID1365736; AID1450085; AID1450086; AID1450088; AID685262; AID685270; AID685271
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	IC50 (µMol)	0.0043	0.0000	0.7340	10.0000	AID1450083; AID685261; AID685262
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Ki	0.0022	0.0000	0.2539	6.0000	AID1365733; AID1450085; AID685262; AID685274; AID685275; AID685276
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Ki	0.1700	0.0001	0.1168	0.6310	AID1365736; AID1450086; AID685270
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50 (µMol)	4.8800	0.0000	0.8575	10.0000	AID685272
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Ki	4.8800	0.0002	0.4081	4.8800	AID1365739
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Ki	0.1790	0.0001	0.0950	0.5012	AID1365732; AID1450087; AID685273
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of cytokine production	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
adaptive immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
respiratory burst involved in defense response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
protein phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
neutrophil chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of neutrophil apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell degranulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
innate immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
neutrophil extravasation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of epithelial tube formation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
intracellular glucose homeostasis	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of cell-matrix adhesion	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of leukocyte migration	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
transcription by RNA polymerase II	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein import into nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
immune response	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of lamellipodium assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytokine-mediated signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
B cell differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
T cell differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
osteoclast differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cellular response to insulin stimulus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of RNA splicing	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
regulation of toll-like receptor 4 signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cellular response to UV	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
response to endoplasmic reticulum stress	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
interleukin-18-mediated signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of protein import into nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of apoptotic process	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of osteoclast differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of glucose import	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein stabilization	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of filopodium assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of stress fiber assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
growth hormone receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
myeloid leukocyte migration	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of focal adhesion disassembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of endoplasmic reticulum unfolded protein response	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
liver development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of protein phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
vasculature development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
glucose metabolic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phagocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of lamellipodium assembly	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to muscle inactivity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of macroautophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
actin cytoskeleton organization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
platelet activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of actin filament depolymerization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
T cell costimulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of TOR signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to insulin stimulus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to muscle stretch	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of multicellular organism growth	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to L-leucine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
anoikis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of cellular respiration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of neuron apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
T cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
relaxation of cardiac muscle	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cardiac muscle contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
adipose tissue development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to glucose stimulus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to hydrostatic pressure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to dexamethasone	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cardiac muscle cell contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
energy homeostasis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of actin filament organization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
autosome genomic imprinting	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to butyrate	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of protein localization to membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of fibroblast apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of anoikis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of cell-matrix adhesion	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
endothelial cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
response to ischemia	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
intracellular calcium ion homeostasis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
autophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
homophilic cell adhesion via plasma membrane adhesion molecules	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of autophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
platelet activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of neutrophil apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of Rac protein signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
embryonic cleavage	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of MAPK cascade	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
angiogenesis involved in wound healing	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
platelet aggregation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of sprouting angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
regulation of clathrin-dependent endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
protein destabilization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cell growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
T-helper 1 cell lineage commitment	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
heart morphogenesis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
heart valve morphogenesis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
energy reserve metabolic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
'de novo' pyrimidine nucleobase biosynthetic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
inflammatory response	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoskeleton organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosome organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
germ cell development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to nutrient	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cell size	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to heat	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
post-embryonic development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of autophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of lamellipodium assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of gene expression	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of myotube differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
neuronal action potential	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein catabolic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of cell growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of actin filament polymerization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
T cell costimulation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ruffle organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of myelination	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to nutrient levels	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to nutrient levels	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to nutrient	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TOR signaling	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to insulin stimulus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of actin cytoskeleton organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
calcineurin-NFAT signaling cascade	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to amino acid starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
multicellular organism growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC1 signaling	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of circadian rhythm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of apoptotic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to amino acid	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
anoikis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of osteoclast differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of translation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of cell size	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of glycolytic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of transcription by RNA polymerase III	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of translational initiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of lipid biosynthetic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
behavioral response to pain	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
rhythmic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
oligodendrocyte differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of oligodendrocyte differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
voluntary musculoskeletal movement	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of stress fiber assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of keratinocyte migration	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleus localization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cardiac muscle cell development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cardiac muscle contraction	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to methionine	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of calcineurin-NFAT signaling cascade	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to amino acid stimulus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to L-leucine	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to hypoxia	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to osmotic stress	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of membrane permeability	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cellular response to heat	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of protein localization to nucleus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of wound healing, spreading of epidermal cells	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of locomotor rhythm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of cytoplasmic translational initiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of lysosome organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of pentose-phosphate shunt	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to leucine starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of autophagosome assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of cytokine production	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
adaptive immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
dendritic cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of acute inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
respiratory burst involved in defense response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of triglyceride catabolic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
neutrophil chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
secretory granule localization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of cell adhesion mediated by integrin	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of Rac protein signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
natural killer cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
mast cell degranulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of MAP kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
innate immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of cardiac muscle contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
platelet aggregation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cellular response to cAMP	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
neutrophil extravasation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
hepatocyte apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of calcium ion transmembrane transport	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of fibroblast apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphotyrosine residue binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase adaptor activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin-like growth factor receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
neurotrophin TRKA receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
kinase activator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein phosphatase binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase regulator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase regulatory subunit binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
ErbB-3 class receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein heterodimerization activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol kinase activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
enzyme-substrate adaptor activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase activator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
1-phosphatidylinositol-3-kinase regulator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein serine/threonine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein kinase activator activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
RNA polymerase III type 1 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
RNA polymerase III type 2 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
RNA polymerase III type 3 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TFIIIC-class transcription factor complex binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ribosome binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphoprotein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein serine/threonine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
identical protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
ephrin receptor binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cis-Golgi network	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytosol	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cell-cell junction	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
perinuclear region of cytoplasm	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
perinuclear endoplasmic reticulum membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
intercalated disc	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
lamellipodium	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
perinuclear region of cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
nucleus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
nucleoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
nucleolus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
midbody	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
intracellular membrane-bounded organelle	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
PML body	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosomal membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
Golgi membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
mitochondrial outer membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosome	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosomal membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
endoplasmic reticulum membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
endomembrane system	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
dendrite	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC1 complex	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC2 complex	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phagocytic vesicle	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nuclear envelope	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (139)

Assay ID	Title	Year	Journal	Article
AID1365771	Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685268	Inhibition of CYP2D6 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685269	Inhibition of CYP3A4 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685441	Inhibition of JAK2 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365773	Permeability of the compound at 300 uL after 5 hrs by PAMPA	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685447	Inhibition of PAK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450119	Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685436	Inhibition of FGFR1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685429	Inhibition of AKT1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450092	Inhibition of human AKT1 at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685288	Inhibition of INSR at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450103	Inhibition of wild-type human MEK1 (M1 to V393 residues) expressed in Sf9 insect cells at 1 uM using ERK2-K54R as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450100	Inhibition of recombinant human N-terminal GST-tagged INSR (G989 to S1382 residues) expressed in baculovirus infected Sf9 cells at 1 uM using Poly(Ala,Glu,Lys,Tyr)6:2:5:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685450	Inhibition of PIM2 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450104	Inhibition of recombinant human N-terminal GST/His6-tagged PLK1 (M1 to S603 residues) expressed in Sf9 insect cells at 1 uM using RBER-CDC25tide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685457	Antitumor activity in tamoxifen-induced mouse tumor model assessed as reduction in lung [18F]FDG uptake at 50 mg/kg/day, po for 3 weeks by PET-CT method	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450097	Inhibition of DYRK1A (unknown origin) at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685278	Inhibition of ARK5 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685275	Inhibition of human PI3Kalpha E545K mutant by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685426	Inhibition of PIM2 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450111	Inhibition of human SRC at 1 uM using poly(Glu,Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685439	Inhibition of IKKbeta at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450114	Stability in human liver microsomes assessed as compound remaining at 1 uM measured after 15 mins	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685427	Inhibition of RPS6KA1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365769	Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365776	Clearance in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365811	Clearance in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis relative to hepatic blood flow	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450080	Inhibition of human FAK at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685290	Inhibition of JNK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450081	Inhibition of recombinant human N-terminal GST/His6-tagged FGFR1 (G400 to R820 residues) expressed in Sf9 insect cells at 1 uM using poly(Glu,Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450087	Inhibition of PI3K p110gamma (unknown origin) using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450105	Inhibition of recombinant human N-terminal His6-tagged PDK1 (M1 to M460 residues) expressed in Sf9 insect cells at 1 uM using LRRWSLG as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685442	Inhibition of JNK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450102	Inhibition of recombinant human N-terminal GST/His6-tagged KIT (T544 to V976 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450109	Inhibition of RPS6KA1 (unknown origin) at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685444	Inhibition of MEK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450093	Inhibition of recombinant human N-terminal GST/His6-tagged B-RAF V600E mutant (Q417 to H766 residues) expressed in baculovirus infected Sf9 cells at 1 uM using MEK1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685282	Inhibition of EGFR at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685453	Clearance in BALB-C mouse	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685291	Inhibition of KIT at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685264	Stability in mouse liver microsomes at 1 uM incubated for 15 mins	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450121	Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365777	Volume of distribution in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685455	In-vivo inhibition of PI3Kalpha-mediated AKT Ser 473 phosphorylation in lung of tamoxifen-induced mouse tumor model at 50 mg/kg, po measured 2 to 4 hrs post dose	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450115	Stability in mouse liver microsomes assessed as compound remaining at 1 uM measured after 15 mins	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685423	Inhibition of PAK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685459	Selectivity ratio of Kiapp for human PI3Kbeta to Kiapp for human PI3Kalpha (p110alpha/p85alpha)	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685277	Inhibition of AKT1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365734	Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human full-length p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685428	Inhibition of SGK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685267	Inhibition of CYP2C19 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450083	Inhibition of full-length human p110alpha (1 to 1068 end residues)/N-terminal GST-tagged p85alpha (1 to 724 end residues) expressed in baculovirus expression system	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365765	Stability in human liver microsomes assessed as parent compound remaining at 0.5 uM after 30 mins by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685456	Antitumor activity in tamoxifen-induced mouse tumor model assessed as tumor growth inhibition at 50 mg/kg/day, po for 3 weeks by computed tomography	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685280	Inhibition of CK1alpha1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365791	Oral bioavailability in BALB-C mouse at 8 mg/kg by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685285	Inhibition of FLT3 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685287	Inhibition of IKKbeta at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685432	Inhibition of CK1alpha1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685284	Inhibition of FGFR1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365775	Half-life in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365741	Inhibition of PI3K in serum-stimulated human U2OS cells assessed as decrease in AKT1 phosphorylation at S473 by C-ELISA	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685445	Inhibition of MET at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365739	Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system by AlexaFluor647-labeled kinase tracer 314 based LanthaScreen assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365770	Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365737	Selectivity ratio of Ki(app) for p110beta/85alpha (unknown origin) to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724 residues) expressed in baculovirus expression system	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685435	Inhibition of FAK at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450095	Inhibition of full length N-terminal GST/His6-tagged human CDK8 (M1 to Y463 residues)/N-terminal His6-tagged Cyc C (M1 to S283 residues) expressed in Sf9 insect cells at 1 uM using RBER-IRStide as substrate by filter binding assay relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365732	Inhibition of recombinant full-length human N-terminal His6-tagged p110gamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450108	Inhibition of recombinant human N-terminal GST/His6-tagged PDGFRalpha (Q551 to L1089 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685262	Inhibition of human PI3Kalpha (p110alpha/p85alpha) by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685430	Inhibition of ARK5 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685431	Inhibition of BRAF V600E mutant at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685438	Inhibition of IGF1R at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685446	Inhibition of MST1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365789	AUC (infinity) in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450118	Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450116	Stability in rat liver microsomes assessed as compound remaining at 1 uM measured after 15 mins	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365768	Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685422	Inhibition of MST1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685281	Inhibition of DYRK1A at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685273	Inhibition of human PI3Kgamma by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685271	Inhibition of human PI3Kdelta (p110delta/p85alpha) by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450110	Inhibition of recombinant human N-terminal GST-tagged SGK1 (M1 to L431 residues) expressed in baculovirus infected Sf9 cells at 1 uM using GSK3-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685437	Inhibition of FLT3 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685274	Inhibition of human PI3Kalpha E542K mutant by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450094	Inhibition of recombinant human N-terminal GST/His6-tagged CK1alpha1 (M1 to F365 residues) expressed in Sf9 insect cells at 1 uM using casein as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365738	Selectivity ratio of Ki(app) for recombinant full-length human N-terminal His6-tagged p110gamma expressed in baculovirus infected Sf21 insect cells to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724 res	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450084	Inhibition of PI3K in serum-stimulated human U2OS cells assessed as decrease in AKT1 phosphorylation at S473 by C-ELISA	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685270	Inhibition of human PI3Kbeta (p110beta/p85alpha) by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365790	Half-life in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685276	Inhibition of human PI3Kalpha H1047R mutant by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365766	Stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM after 30 mins by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365787	Tmax in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365736	Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685420	Inhibition of MEK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685424	Inhibition of PDGFR at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685452	Inhibition of SGK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685443	Inhibition of KIT at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685454	Oral bioavailability in BALB-C mouse	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365772	Kinetic solubility of the compound in phosphate buffered saline at pH 7.4 at 1 to 2 mg measured after 24 hrs by HPLC analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365735	Selectivity ratio of Ki(app) for recombinant human full-length N-terminal His6-tagged p110delta/human full-length p85alpha expressed in baculovirus infected Sf21 insect cells to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-f	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365778	AUC (infinity) in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450088	Inhibition of p110delta/p85alpha (unknown origin) using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450106	Inhibition of recombinant human N-terminal GST/His6-tagged MET (K956 to S1390 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450096	Inhibition of recombinant human N-terminal GST/His6-tagged CHK1 (M1 to T476 residues) expressed in baculovirus infected Sf9 cells at 1 uM using S6-peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365788	Cmax in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365740	Selectivity ratio of Ki(app) for recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450107	Inhibition of recombinant human N-terminal GST/His6-tagged PAK1 (M1 to H545 residues) expressed in Sf9 insect cells at 1 uM using LRRWSLG as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450112	Inhibition of recombinant human N-terminal GST-tagged VEGFR2 (D807 to V1356 residues) expressed in Sf9 insect cells at 1 uM using Poly(Glu:Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685421	Inhibition of MET at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685266	Inhibition of CYP2C9 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450082	Inhibition of recombinant human N-terminal GST/His6-tagged IKKbeta (M1 to S756 residues) expressed in baculovirus infected Sf9 cells at 1 uM by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450099	Inhibition of recombinant human N-terminal GST/His6-tagged IGF1R (M954 to C1367 residues) expressed in Sf9 insect cells at 1 uM using poly(Glu,Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685425	Inhibition of PIM1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450120	Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685451	Inhibition of RPS6KA1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685279	Inhibition of BRAF V600E mutant at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365807	Plasma concentration in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685289	Inhibition of JAK2 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450085	Inhibition of recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in Spodoptera frugiperda insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685283	Inhibition of FAK at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685434	Inhibition of EGFR at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685448	Inhibition of PDGFR at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365733	Inhibition of full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724 residues) expressed in baculovirus expression system by ADP Hunter assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685449	Inhibition of PIM1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685458	Antitumor activity in tamoxifen-induced mouse tumor model assessed as reduction in lung metabolic activity at 50 mg/kg/day, po for 3 weeks by [18F]FDG uptake based PET-CT method	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685261	Inhibition of PI3Kalpha in human U2OS cells assessed as inhibition of AKT Ser 473 phosphorylation by Western blot	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450086	Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450117	Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450101	Inhibition of recombinant human N-terminal GST/His6-tagged JAK2 (P717 to G1132 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365767	Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685433	Inhibition of DYRK1A at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685265	Inhibition of CYP1A2 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685272	Inhibition of mTOR	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685263	Stability in human liver microsomes at 1 uM incubated for 15 mins	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685286	Inhibition of IGF1R at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450098	Inhibition of recombinant human N-terminal GST/His6-tagged EGFR (H672 to A1210 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685440	Inhibition of INSR at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (100.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

etp-46321

Description

Cross-References

Synonyms (19)

Protein Targets (6)

Inhibition Measurements

Biological Processes (224)

Molecular Functions (36)

Ceullar Components (30)

Bioassays (139)

Research

Studies (5)

Market Indicators

Research Demand Index: 17.90

Study Types

etp-46321

Description

Cross-References

Synonyms (19)

Protein Targets (6)

Inhibition Measurements

Biological Processes (224)

Molecular Functions (36)

Ceullar Components (30)

Bioassays (139)

Research

Studies (5)

Market Indicators

Research Demand Index: 17.90

Study Types

Related Drugs (1)

Related Conditions (1)