Page last updated: 2024-11-13

etp-46321

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Description

ETP-46321: inhibits PI3K alpha and PI3K delta; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	46927938
CHEMBL ID	2087474
SCHEMBL ID	10100315
MeSH ID	M0576940

Synonyms (19)

Synonym
CHEMBL2087474 ,
bdbm50420714
CS-3350
HY-12340
etp-46321
SCHEMBL10100315
EX-A1284
1252594-99-2
5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine
5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-yl-imidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
BCP19935
etp46321
5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
5-(2-((4-(methyl sulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine
F85058
MS-28782
A926380
CAC59499
AC-36139

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Ki	0.0142	0.0000	0.0081	0.0310	AID1365734; AID1450088; AID685271
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	IC50 (µMol)	0.0023	0.0000	0.6832	10.0000	AID1450083; AID685262
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	Ki	0.0622	0.0001	0.0394	0.1700	AID1365733; AID1365734; AID1365736; AID1450085; AID1450086; AID1450088; AID685262; AID685270; AID685271
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	IC50 (µMol)	0.0043	0.0000	0.7340	10.0000	AID1450083; AID685261; AID685262
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Ki	0.0022	0.0000	0.2539	6.0000	AID1365733; AID1450085; AID685262; AID685274; AID685275; AID685276
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Ki	0.1700	0.0001	0.1168	0.6310	AID1365736; AID1450086; AID685270
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50 (µMol)	4.8800	0.0000	0.8575	10.0000	AID685272
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Ki	4.8800	0.0002	0.4081	4.8800	AID1365739
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Ki	0.1790	0.0001	0.0950	0.5012	AID1365732; AID1450087; AID685273
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (224)

Process	via Protein(s)	Taxonomy
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of cytokine production	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
adaptive immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
respiratory burst involved in defense response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
protein phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
neutrophil chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of neutrophil apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
natural killer cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell degranulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
innate immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
T cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
B cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
mast cell differentiation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
neutrophil extravasation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
positive regulation of epithelial tube formation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
intracellular glucose homeostasis	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of cell-matrix adhesion	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of leukocyte migration	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
transcription by RNA polymerase II	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein import into nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
immune response	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of lamellipodium assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytokine-mediated signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
B cell differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
T cell differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
osteoclast differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cellular response to insulin stimulus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of RNA splicing	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
regulation of toll-like receptor 4 signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cellular response to UV	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
response to endoplasmic reticulum stress	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
interleukin-18-mediated signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of protein import into nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of apoptotic process	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of osteoclast differentiation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of glucose import	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein stabilization	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of filopodium assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
negative regulation of stress fiber assembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
growth hormone receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
myeloid leukocyte migration	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of focal adhesion disassembly	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of endoplasmic reticulum unfolded protein response	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor signaling pathway	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
liver development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of protein phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
vasculature development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
glucose metabolic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phagocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of lamellipodium assembly	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to muscle inactivity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of macroautophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
actin cytoskeleton organization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
platelet activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of actin filament depolymerization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
T cell costimulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of TOR signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to insulin stimulus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to muscle stretch	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of multicellular organism growth	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to L-leucine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
anoikis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of cellular respiration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of neuron apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
T cell receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
relaxation of cardiac muscle	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cardiac muscle contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
adipose tissue development	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to glucose stimulus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cellular response to hydrostatic pressure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to dexamethasone	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cardiac muscle cell contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
energy homeostasis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of actin filament organization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
autosome genomic imprinting	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
response to butyrate	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
positive regulation of protein localization to membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of fibroblast apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
negative regulation of anoikis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
regulation of cell-matrix adhesion	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of gene expression	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
endothelial cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
response to ischemia	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
intracellular calcium ion homeostasis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
autophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
homophilic cell adhesion via plasma membrane adhesion molecules	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of autophagy	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
platelet activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of neutrophil apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
positive regulation of Rac protein signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
embryonic cleavage	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of MAPK cascade	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
angiogenesis involved in wound healing	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
platelet aggregation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of vascular endothelial growth factor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
negative regulation of sprouting angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
regulation of clathrin-dependent endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
protein destabilization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cell growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
T-helper 1 cell lineage commitment	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
heart morphogenesis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
heart valve morphogenesis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
energy reserve metabolic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
'de novo' pyrimidine nucleobase biosynthetic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
inflammatory response	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoskeleton organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosome organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
germ cell development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to nutrient	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cell size	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to heat	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
post-embryonic development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of autophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of lamellipodium assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of gene expression	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of myotube differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
neuronal action potential	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein catabolic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of cell growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of actin filament polymerization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
T cell costimulation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ruffle organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of myelination	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to nutrient levels	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to nutrient levels	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to nutrient	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TOR signaling	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to insulin stimulus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of actin cytoskeleton organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
calcineurin-NFAT signaling cascade	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to amino acid starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
multicellular organism growth	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC1 signaling	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of circadian rhythm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of apoptotic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
response to amino acid	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
anoikis	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of osteoclast differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of translation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of cell size	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of glycolytic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of transcription by RNA polymerase III	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of translational initiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of lipid biosynthetic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
behavioral response to pain	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
rhythmic process	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
oligodendrocyte differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of oligodendrocyte differentiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
voluntary musculoskeletal movement	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of stress fiber assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of keratinocyte migration	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleus localization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cardiac muscle cell development	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cardiac muscle contraction	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to methionine	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of calcineurin-NFAT signaling cascade	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to amino acid stimulus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to L-leucine	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to hypoxia	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to osmotic stress	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of membrane permeability	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of cellular response to heat	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of protein localization to nucleus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of wound healing, spreading of epidermal cells	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of locomotor rhythm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of cytoplasmic translational initiation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of lysosome organization	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
positive regulation of pentose-phosphate shunt	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cellular response to leucine starvation	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
regulation of autophagosome assembly	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
negative regulation of macroautophagy	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphorylation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of cytokine production	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
adaptive immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
dendritic cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of acute inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
respiratory burst involved in defense response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
endocytosis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
inflammatory response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of endothelial cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of triglyceride catabolic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
neutrophil chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
secretory granule localization	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of cell adhesion mediated by integrin	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of Rac protein signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
natural killer cell chemotaxis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell proliferation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
T cell activation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
mast cell degranulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of MAP kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
innate immune response	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of angiogenesis	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of cardiac muscle contraction	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
platelet aggregation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cellular response to cAMP	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
neutrophil extravasation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
hepatocyte apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
regulation of calcium ion transmembrane transport	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
negative regulation of fibroblast apoptotic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cell migration	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol-3-phosphate biosynthetic process	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (36)

Process	via Protein(s)	Taxonomy
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphotyrosine residue binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase adaptor activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin-like growth factor receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
neurotrophin TRKA receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
kinase activator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein phosphatase binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase regulator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase regulatory subunit binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
ErbB-3 class receptor binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein heterodimerization activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol kinase activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
enzyme-substrate adaptor activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase activator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
1-phosphatidylinositol-3-kinase regulator activity	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
protein serine/threonine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein kinase activator activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
insulin receptor substrate binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
RNA polymerase III type 1 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
RNA polymerase III type 2 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
RNA polymerase III type 3 promoter sequence-specific DNA binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TFIIIC-class transcription factor complex binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
ribosome binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phosphoprotein binding	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
protein kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein serine/threonine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
ATP binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
identical protein binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
ephrin receptor binding	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
protein serine kinase activity	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (30)

Process	via Protein(s)	Taxonomy
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)
nucleus	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cis-Golgi network	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytosol	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cell-cell junction	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
perinuclear region of cytoplasm	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
perinuclear endoplasmic reticulum membrane	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
intercalated disc	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
lamellipodium	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
perinuclear region of cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)
nucleus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
nucleoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
nucleolus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
midbody	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
intracellular membrane-bounded organelle	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)
PML body	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosomal membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
Golgi membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
mitochondrial outer membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosome	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
lysosomal membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
endoplasmic reticulum membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
endomembrane system	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
membrane	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
dendrite	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC1 complex	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
TORC2 complex	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
phagocytic vesicle	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nuclear envelope	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase mTOR	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cytosol	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
phosphatidylinositol 3-kinase complex, class IB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
cytoplasm	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (139)

Assay ID	Title	Year	Journal	Article
AID1365771	Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685268	Inhibition of CYP2D6 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685269	Inhibition of CYP3A4 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685441	Inhibition of JAK2 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365773	Permeability of the compound at 300 uL after 5 hrs by PAMPA	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685447	Inhibition of PAK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450119	Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685436	Inhibition of FGFR1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685429	Inhibition of AKT1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450092	Inhibition of human AKT1 at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685288	Inhibition of INSR at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450103	Inhibition of wild-type human MEK1 (M1 to V393 residues) expressed in Sf9 insect cells at 1 uM using ERK2-K54R as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450100	Inhibition of recombinant human N-terminal GST-tagged INSR (G989 to S1382 residues) expressed in baculovirus infected Sf9 cells at 1 uM using Poly(Ala,Glu,Lys,Tyr)6:2:5:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685450	Inhibition of PIM2 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450104	Inhibition of recombinant human N-terminal GST/His6-tagged PLK1 (M1 to S603 residues) expressed in Sf9 insect cells at 1 uM using RBER-CDC25tide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685457	Antitumor activity in tamoxifen-induced mouse tumor model assessed as reduction in lung [18F]FDG uptake at 50 mg/kg/day, po for 3 weeks by PET-CT method	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450097	Inhibition of DYRK1A (unknown origin) at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685278	Inhibition of ARK5 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685275	Inhibition of human PI3Kalpha E545K mutant by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685426	Inhibition of PIM2 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450111	Inhibition of human SRC at 1 uM using poly(Glu,Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685439	Inhibition of IKKbeta at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450114	Stability in human liver microsomes assessed as compound remaining at 1 uM measured after 15 mins	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685427	Inhibition of RPS6KA1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365769	Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365776	Clearance in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365811	Clearance in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis relative to hepatic blood flow	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450080	Inhibition of human FAK at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685290	Inhibition of JNK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450081	Inhibition of recombinant human N-terminal GST/His6-tagged FGFR1 (G400 to R820 residues) expressed in Sf9 insect cells at 1 uM using poly(Glu,Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450087	Inhibition of PI3K p110gamma (unknown origin) using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450105	Inhibition of recombinant human N-terminal His6-tagged PDK1 (M1 to M460 residues) expressed in Sf9 insect cells at 1 uM using LRRWSLG as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685442	Inhibition of JNK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450102	Inhibition of recombinant human N-terminal GST/His6-tagged KIT (T544 to V976 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450109	Inhibition of RPS6KA1 (unknown origin) at 1 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685444	Inhibition of MEK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450093	Inhibition of recombinant human N-terminal GST/His6-tagged B-RAF V600E mutant (Q417 to H766 residues) expressed in baculovirus infected Sf9 cells at 1 uM using MEK1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685282	Inhibition of EGFR at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685453	Clearance in BALB-C mouse	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685291	Inhibition of KIT at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685264	Stability in mouse liver microsomes at 1 uM incubated for 15 mins	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450121	Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365777	Volume of distribution in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685455	In-vivo inhibition of PI3Kalpha-mediated AKT Ser 473 phosphorylation in lung of tamoxifen-induced mouse tumor model at 50 mg/kg, po measured 2 to 4 hrs post dose	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450115	Stability in mouse liver microsomes assessed as compound remaining at 1 uM measured after 15 mins	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685423	Inhibition of PAK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685459	Selectivity ratio of Kiapp for human PI3Kbeta to Kiapp for human PI3Kalpha (p110alpha/p85alpha)	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685277	Inhibition of AKT1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365734	Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human full-length p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685428	Inhibition of SGK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685267	Inhibition of CYP2C19 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450083	Inhibition of full-length human p110alpha (1 to 1068 end residues)/N-terminal GST-tagged p85alpha (1 to 724 end residues) expressed in baculovirus expression system	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365765	Stability in human liver microsomes assessed as parent compound remaining at 0.5 uM after 30 mins by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685456	Antitumor activity in tamoxifen-induced mouse tumor model assessed as tumor growth inhibition at 50 mg/kg/day, po for 3 weeks by computed tomography	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685280	Inhibition of CK1alpha1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365791	Oral bioavailability in BALB-C mouse at 8 mg/kg by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685285	Inhibition of FLT3 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685287	Inhibition of IKKbeta at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685432	Inhibition of CK1alpha1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685284	Inhibition of FGFR1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365775	Half-life in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365741	Inhibition of PI3K in serum-stimulated human U2OS cells assessed as decrease in AKT1 phosphorylation at S473 by C-ELISA	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685445	Inhibition of MET at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365739	Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system by AlexaFluor647-labeled kinase tracer 314 based LanthaScreen assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365770	Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365737	Selectivity ratio of Ki(app) for p110beta/85alpha (unknown origin) to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724 residues) expressed in baculovirus expression system	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685435	Inhibition of FAK at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450095	Inhibition of full length N-terminal GST/His6-tagged human CDK8 (M1 to Y463 residues)/N-terminal His6-tagged Cyc C (M1 to S283 residues) expressed in Sf9 insect cells at 1 uM using RBER-IRStide as substrate by filter binding assay relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365732	Inhibition of recombinant full-length human N-terminal His6-tagged p110gamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450108	Inhibition of recombinant human N-terminal GST/His6-tagged PDGFRalpha (Q551 to L1089 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685262	Inhibition of human PI3Kalpha (p110alpha/p85alpha) by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685430	Inhibition of ARK5 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685431	Inhibition of BRAF V600E mutant at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685438	Inhibition of IGF1R at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685446	Inhibition of MST1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365789	AUC (infinity) in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450118	Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450116	Stability in rat liver microsomes assessed as compound remaining at 1 uM measured after 15 mins	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365768	Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685422	Inhibition of MST1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685281	Inhibition of DYRK1A at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685273	Inhibition of human PI3Kgamma by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685271	Inhibition of human PI3Kdelta (p110delta/p85alpha) by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450110	Inhibition of recombinant human N-terminal GST-tagged SGK1 (M1 to L431 residues) expressed in baculovirus infected Sf9 cells at 1 uM using GSK3-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685437	Inhibition of FLT3 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685274	Inhibition of human PI3Kalpha E542K mutant by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450094	Inhibition of recombinant human N-terminal GST/His6-tagged CK1alpha1 (M1 to F365 residues) expressed in Sf9 insect cells at 1 uM using casein as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365738	Selectivity ratio of Ki(app) for recombinant full-length human N-terminal His6-tagged p110gamma expressed in baculovirus infected Sf21 insect cells to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724 res	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450084	Inhibition of PI3K in serum-stimulated human U2OS cells assessed as decrease in AKT1 phosphorylation at S473 by C-ELISA	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685270	Inhibition of human PI3Kbeta (p110beta/p85alpha) by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365790	Half-life in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685276	Inhibition of human PI3Kalpha H1047R mutant by ADP accumulation based HTRF assay	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365766	Stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM after 30 mins by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365787	Tmax in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365736	Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685420	Inhibition of MEK1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685424	Inhibition of PDGFR at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685452	Inhibition of SGK1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685443	Inhibition of KIT at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685454	Oral bioavailability in BALB-C mouse	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365772	Kinetic solubility of the compound in phosphate buffered saline at pH 7.4 at 1 to 2 mg measured after 24 hrs by HPLC analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365735	Selectivity ratio of Ki(app) for recombinant human full-length N-terminal His6-tagged p110delta/human full-length p85alpha expressed in baculovirus infected Sf21 insect cells to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-f	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365778	AUC (infinity) in BALB-C mouse at 8 mg/kg, iv by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450088	Inhibition of p110delta/p85alpha (unknown origin) using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450106	Inhibition of recombinant human N-terminal GST/His6-tagged MET (K956 to S1390 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450096	Inhibition of recombinant human N-terminal GST/His6-tagged CHK1 (M1 to T476 residues) expressed in baculovirus infected Sf9 cells at 1 uM using S6-peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365788	Cmax in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1365740	Selectivity ratio of Ki(app) for recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system to Ki(app) for full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID1450107	Inhibition of recombinant human N-terminal GST/His6-tagged PAK1 (M1 to H545 residues) expressed in Sf9 insect cells at 1 uM using LRRWSLG as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450112	Inhibition of recombinant human N-terminal GST-tagged VEGFR2 (D807 to V1356 residues) expressed in Sf9 insect cells at 1 uM using Poly(Glu:Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685421	Inhibition of MET at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685266	Inhibition of CYP2C9 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450082	Inhibition of recombinant human N-terminal GST/His6-tagged IKKbeta (M1 to S756 residues) expressed in baculovirus infected Sf9 cells at 1 uM by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450099	Inhibition of recombinant human N-terminal GST/His6-tagged IGF1R (M954 to C1367 residues) expressed in Sf9 insect cells at 1 uM using poly(Glu,Tyr)4:1 as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685425	Inhibition of PIM1 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450120	Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685451	Inhibition of RPS6KA1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685279	Inhibition of BRAF V600E mutant at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365807	Plasma concentration in BALB-C mouse at 8 mg/kg, po by LC-MS/MS analysis	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685289	Inhibition of JAK2 at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450085	Inhibition of recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in Spodoptera frugiperda insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685283	Inhibition of FAK at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685434	Inhibition of EGFR at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685448	Inhibition of PDGFR at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1365733	Inhibition of full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724 residues) expressed in baculovirus expression system by ADP Hunter assay	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685449	Inhibition of PIM1 at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685458	Antitumor activity in tamoxifen-induced mouse tumor model assessed as reduction in lung metabolic activity at 50 mg/kg/day, po for 3 weeks by [18F]FDG uptake based PET-CT method	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685261	Inhibition of PI3Kalpha in human U2OS cells assessed as inhibition of AKT Ser 473 phosphorylation by Western blot	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450086	Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate by HTRF assay	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450117	Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1450101	Inhibition of recombinant human N-terminal GST/His6-tagged JAK2 (P717 to G1132 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID1365767	Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Identification of novel PI3K inhibitors through a scaffold hopping strategy.
AID685433	Inhibition of DYRK1A at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685265	Inhibition of CYP1A2 at 10 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685272	Inhibition of mTOR	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685263	Stability in human liver microsomes at 1 uM incubated for 15 mins	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID685286	Inhibition of IGF1R at 1 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
AID1450098	Inhibition of recombinant human N-terminal GST/His6-tagged EGFR (H672 to A1210 residues) expressed in Sf9 insect cells at 1 uM using TRK-C-derived peptide as substrate by filter binding method relative to control	2017	Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11	Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.
AID685440	Inhibition of INSR at 5 uM	2012	Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10	Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (100.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.90

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.90 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.90)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	3.21	5	0	diazine; pyrazines	Daphnia magna metabolite

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