Page last updated: 2024-09-27

Macrocephaly

A congenital abnormality in which the occipitofrontal circumference is greater than two standard deviations above the mean for a given age. It is associated with HYDROCEPHALUS; SUBDURAL EFFUSION; ARACHNOID CYSTS; or is part of a genetic condition (e.g., ALEXANDER DISEASE; SOTOS SYNDROME).

Synonyms(4)

Synonym
Megacephaly
Macrocephaly
Megalencephaly
Megalocephaly

Research Excerpts

Research

Studies (38)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (2.63)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's30 (78.95)28.8240
2020's7 (18.42)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
carnitine0low20
salicylic acid0low20
glutaric acid0low10
taurine0low10
sk&f 812970low10
cefuroxime0low10
amphetamine0low10
eflornithine0low10
valproic acid0low10
sevoflurane0low10
prednisolone0low10
thyroxine0low10
aspartic acid0low20
apomorphine0low10
bromodeoxyuridine0low20
histidine0low10
arginine0low10
phencyclidine0low10
quinazolines0low10
thiazoles0low20
enbucrilate0low10
tantalum0low10
propiconazole0low10
quinpirole0low10
aripiprazole0low10
thiazolyl blue0low10
oxytocin0low10
inositol 3-phosphate0low10
riboflavin0low10
cystine0low10
levetiracetam0low10
sirolimus0low30
casein kinase ii0low10
ic 871140low10
acid phosphatase0low10
ro13-99040low10
diphthamide0low10
byl7190low10
eye0low10

Protein Targets (942)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma110011
TDP1 protein130013
AR protein110011
nuclear receptor subfamily 1, group I, member 3110011
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]100010
estrogen-related nuclear receptor alpha120012
pregnane X nuclear receptor9009
estrogen nuclear receptor alpha150015
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
nuclear factor erythroid 2-related factor 2 isoform 25005
heat shock protein beta-13003
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta10100010
Voltage-dependent calcium channel gamma-2 subunit8008
Bile salt export pump011011
Cyclin-dependent kinase 10123
Heat shock protein HSP 90-beta0101
Glutamate receptor 28008
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 432002
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 57007
Ataxin-28008
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 46006
retinoid X nuclear receptor alpha7007
NPYLR7B0022
arylsulfatase A7007
IDH14004
Histone H2A.x3003
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 14004
flap endonuclease 15005
nuclear receptor ROR-gamma isoform 16006
peripheral myelin protein 224004
survival motor neuron protein isoform d4004
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Rap guanine nucleotide exchange factor 32002
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0224
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20101
Insulin receptor0023
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0023
Adenosine receptor A30225
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10023
Inosine-5'-monophosphate dehydrogenase 20123
Endoplasmin0112
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenosine receptor A10113
Adenosine receptor A30101
Adenosine receptor A2a0135
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10225
Adenosine receptor A2a0214
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine receptor A10011
Adenosine kinase0023
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
Solute carrier family 22 member 30101
5-hydroxytryptamine receptor 2C0415
Phenylethanolamine N-methyltransferase0202
Cytochrome P450 2A60202
Substance-P receptor0101
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 1A0415
Cytochrome P450 2A50101
Sodium-dependent dopamine transporter0213
5-hydroxytryptamine receptor 1B0314
5-hydroxytryptamine receptor 1D0314
5-hydroxytryptamine receptor 1F0314
5-hydroxytryptamine receptor 2B0314
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 7 0415
5-hydroxytryptamine receptor 5A0213
5-hydroxytryptamine receptor 5B0213
5-hydroxytryptamine receptor 3A0213
Sigma non-opioid intracellular receptor 10202
5-hydroxytryptamine receptor 4 0213
Beta-2 adrenergic receptor0101
5-hydroxytryptamine receptor 3B0213
Sigma non-opioid intracellular receptor 10303
thioredoxin reductase7007
ATAD5 protein, partial5005
Microtubule-associated protein tau4004
euchromatic histone-lysine N-methyltransferase 2140014
Bloom syndrome protein isoform 14004
D(1A) dopamine receptor2002
neuropeptide S receptor isoform A2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
Luciferase3003
acetylcholinesterase4004
phosphopantetheinyl transferase5005
hypoxia-inducible factor 1 alpha subunit4004
GLS protein3003
GLI family zinc finger 36006
aldehyde dehydrogenase 1 family, member A15005
estrogen receptor 2 (ER beta)6006
progesterone receptor7007
retinoic acid nuclear receptor alpha variant 1100010
farnesoid X nuclear receptor6006
cytochrome P450 2D64004
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma7007
aryl hydrocarbon receptor6006
thyroid stimulating hormone receptor5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)7007
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C19 precursor5005
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
vitamin D3 receptor isoform VDRA3003
potassium voltage-gated channel subfamily H member 2 isoform d4004
thyroid hormone receptor beta isoform 28008
nuclear factor erythroid 2-related factor 2 isoform 18008
geminin7007
cytochrome P450 3A4 isoform 14004
lethal factor (plasmid)5005
Gamma-aminobutyric acid receptor subunit pi4004
Solute carrier family 22 member 1 0101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Cellular tumor antigen p5391010
Integrin beta-32002
Integrin alpha-IIb2002
5-hydroxytryptamine receptor 1A0224
Tryptophan 5-hydroxylase 10101
D(2) dopamine receptor05411
Gamma-aminobutyric acid receptor subunit beta-14004
Alpha-1B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
D0405
D(3) dopamine receptor0215
Alpha-2B adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
D(2) dopamine receptor0303
D(1A) dopamine receptor05310
D(4) dopamine receptor0428
D(1B) dopamine receptor0315
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0404
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
D(4) dopamine receptor0213
D(3) dopamine receptor0438
Alpha-1A adrenergic receptor0202
Histamine H2 receptor2002
5-hydroxytryptamine receptor 70101
Spike glycoprotein5005
D(2) dopamine receptor05411
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
E3 ubiquitin-protein ligase Mdm20101
D0101
GABA theta subunit4004
Canalicular multispecific organic anion transporter 10404
D0303
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit epsilon4004
ATP-dependent phosphofructokinase4004
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
NFKB1 protein, partial2002
thyroid stimulating hormone receptor2002
alpha-galactosidase2002
chromobox protein homolog 15005
DNA polymerase iota isoform a (long)3003
muscarinic acetylcholine receptor M13003
Cytochrome P450 3A40506
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
5-hydroxytryptamine receptor 3E0101
SMAD family member 24004
Fumarate hydratase2002
USP1 protein, partial3003
PPM1D protein3003
SMAD family member 34004
EWS/FLI fusion protein6006
G3003
polyprotein2002
67.9K protein3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
transcriptional regulator ERG isoform 31001
histone acetyltransferase KAT2A isoform 13003
5-hydroxytryptamine receptor 2A0011
Solute carrier family 22 member 20101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 3B0101
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 3003
ATP-dependent translocase ABCB10304
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Alpha-2C adrenergic receptor0101
Muscarinic acetylcholine receptor M30101
Alpha-1D adrenergic receptor0101
5-hydroxytryptamine receptor 2C0202
Histamine H1 receptor0112
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Inositol monophosphatase 12002
Potassium voltage-gated channel subfamily H member 20404
5-hydroxytryptamine receptor 3D0101
Multidrug and toxin extrusion protein 20101
5-hydroxytryptamine receptor 3C0101
Inositol hexakisphosphate kinase 13003
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0101
cytochrome P450 2C9, partial3003
Chain A, Ferritin light chain3003
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
Carbonic anhydrase 10205
Carbonic anhydrase 20205
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 0304
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0304
Glutamate receptor ionotropic, NMDA 2B0304
Glutamate receptor ionotropic, NMDA 2C0305
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0304
Glutamate receptor ionotropic, NMDA 3B0304
Carbonic anhydrase 40002
Glutamate receptor ionotropic, NMDA 3A0304
interleukin 82002
pregnane X receptor4004
bromodomain adjacent to zinc finger domain 2B1001
nuclear receptor subfamily 1, group I, member 22002
Nuclear hormone receptor family member daf-120011
serine/threonine-protein kinase mTOR isoform 13003
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Thymidine kinase, cytosolic0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Nuclear receptor ROR-gamma3115
Thymidine kinase0001
Thymidylate kinase0101
Bone morphogenetic protein receptor type-1B0022
Membrane-associated progesterone receptor component 10011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0303
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10022
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Dynamin-like 120 kDa protein, mitochondrial0022
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50022
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30022
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10022
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20022
Protein kinase C beta type0022
Tyrosine-protein kinase Lck0022
Tyrosine-protein kinase Fyn0022
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0022
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Serine/threonine-protein kinase A-Raf0022
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
DNA topoisomerase 2-alpha0022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Proto-oncogene tyrosine-protein kinase Src0022
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0022
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0134
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0022
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0224
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10022
Cyclin-dependent kinase 20123
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Phosphatidylinositol 3-kinase regulatory subunit alpha0303
Mitogen-activated protein kinase 10022
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0022
RAC-beta serine/threonine-protein kinase0022
Delta-type opioid receptor0102
DNA replication licensing factor MCM40022
Dual specificity mitogen-activated protein kinase kinase 20022
Receptor-type tyrosine-protein kinase FLT30022
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0022
Glycine--tRNA ligase0022
Protein kinase C iota type0022
Exosome RNA helicase MTR40022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0202
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0202
Serine/threonine-protein kinase mTOR0213
Tyrosine-protein kinase Tec0022
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30022
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0202
MAP kinase-activated protein kinase 20022
Elongation factor Tu, mitochondrial0022
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Interleukin-1 receptor-associated kinase 10022
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10023
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
DNA-dependent protein kinase catalytic subunit0101
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0022
Cyclin-dependent kinase 160022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10123
DNA topoisomerase 2-beta0022
Protein kinase C theta type0022
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0022
Tyrosine-protein kinase BTK0022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10023
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Serine-protein kinase ATM0101
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Serine/threonine-protein kinase ATR0112
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0123
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10123
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0022
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140022
Mitogen-activated protein kinase kinase kinase 110022
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Putative heat shock protein HSP 90-beta 20022
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
Mitogen-activated protein kinase kinase kinase kinase 30022
MAP kinase-activated protein kinase 50022
Misshapen-like kinase 10022
Phosphatidylinositol 3-kinase catalytic subunit type 30101
Atypical kinase COQ8A, mitochondrial0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
ATP-dependent RNA helicase DDX10022
Aurora kinase B0022
Serine/threonine-protein kinase Nek10022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Phenylalanine--tRNA ligase beta subunit0022
Isoleucine--tRNA ligase, mitochondrial0022
BMP-2-inducible protein kinase0022
Obg-like ATPase 10022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
5'-AMP-activated protein kinase subunit gamma-20023
Serine/threonine-protein kinase TBK10022
Septin-90022
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Serine/threonine-protein kinase ICK0022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0101
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Chain A, Protein kinase CK2, alpha Subunit0101
Chain A, PROTEIN KINASE CK2, alpha SUBUNIT0101
Chain A, Protein Kinase Ck2, Alpha Subunit0101
endonuclease IV1001
dopamine D1 receptor3003
Thrombopoietin1001
Parkin1001
NPC intracellular cholesterol transporter 1 precursor2002
peripheral myelin protein 22 isoform 11001
ras-related protein Rab-9A2002
Serine/threonine-protein kinase Sgk10101
Casein kinase II subunit alpha 0101
Cyclin-A20101
D(1A) dopamine receptor1102
Casein kinase II subunit beta0202
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0202
Cyclin-A10101
Casein kinase II subunit alpha 30202
Single-stranded DNA cytosine deaminase1001
Chain A, Beta-lactamase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Cruzipain2002
PAX80001
STAT3, partial0101
thioredoxin glutathione reductase1001
Smad32002
activating transcription factor 63003
tumor necrosis factor2002
thyroid hormone receptor beta isoform a5005
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Solute carrier organic anion transporter family member 1A40103
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10102
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B10203
Ornithine decarboxylase0101
60 kDa heat shock protein, mitochondrial0202
10 kDa heat shock protein, mitochondrial0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Mitochondrial 2-oxodicarboxylate carrier0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Cytochrome P450 2C9 0303
Potassium voltage-gated channel subfamily A member 50101
Cytochrome P450 2J20202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Potassium voltage-gated channel subfamily A member 10101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Chain A, Protein (aspartate Aminotransferase)0011
Chain A, Aspartate Aminotransferase0011
Solute carrier family 22 member 60203
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Solute carrier family 22 member 70001
Chain A, HISTIDINE-BINDING PROTEIN0011
Carbonic anhydrase 120102
Plasma kallikrein0001
Carbonic anhydrase 30102
Histidine-binding periplasmic protein0011
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase0001
Carbonic anhydrase 70102
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90102
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Carbonic anhydrase 150102
Carbonic anhydrase 130102
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Chain A, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM0101
Cytochrome P450 2C190202
Aldehyde oxidase0101
chaperonin-containing TCP-1 beta subunit homolog2002
Synaptic vesicle glycoprotein 2A0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Sodium-dependent serotonin transporter0101
Muscarinic acetylcholine receptor M40012
Kappa-type opioid receptor0001
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 3A0101
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
glp-1 receptor, partial2002
nonstructural protein 11001
heat shock protein HSP 90-alpha isoform 20001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
15-lipoxygenase, partial2002
interferon gamma precursor0001
Beta-2 adrenergic receptor0101
Dipeptidyl peptidase 40011
Dipeptidyl peptidase 40011
Metabotropic glutamate receptor 50011
5-hydroxytryptamine receptor 2A0112
Mu-type opioid receptor0011
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
thyrotropin-releasing hormone receptor1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
caspase-1 isoform alpha precursor1001
Riboflavin-binding protein0112
60 kDa chaperonin0101
Caspase-71001
Thiosulfate sulfurtransferase0101
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0202
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit beta-10001
Cell division cycle 7-related protein kinase0011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Tyrosine-protein kinase JAK20011
Nuclear receptor subfamily 1 group I member 20022
Cyclin-dependent kinase-like 50011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0011
Eukaryotic translation initiation factor 4E0011
Tyrosine-protein kinase Fgr0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Dual specificity protein kinase TTK0011
Myosin-100011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Alpha-synuclein1001
G protein-coupled receptor kinase 60011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Choline-phosphate cytidylyltransferase A0011
Dual specificity protein kinase CLK30011
Ras-related protein Rab-27A0011
Serine/threonine-protein kinase PLK10011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 170011
Protein kinase C zeta type0011
Cyclin-dependent kinase 180011
Tyrosine-protein kinase Mer0011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Activin receptor type-2B0011
Mitogen-activated protein kinase 110011
Calcium/calmodulin-dependent protein kinase type IV0011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Serine/threonine-protein kinase N30011
ATP-dependent RNA helicase DHX300011
Regulatory-associated protein of mTOR0101
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase kinase kinase kinase 10011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
PAS domain-containing serine/threonine-protein kinase0011
Dual specificity testis-specific protein kinase 20011
Target of rapamycin complex subunit LST80101
Serine/threonine-protein kinase mTOR 0101
Serine/threonine-protein kinase NLK0011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Serine/threonine-protein kinase 240011
DNA polymerase III, partial1001
hypothetical protein, conserved1001
GALC protein1001
glucocerebrosidase1001
DNA polymerase kappa isoform 12002
Sodium- and chloride-dependent taurine transporter0101
Proton-coupled amino acid transporter 10101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Aldo-keto reductase family 1 member B10101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]