Page last updated: 2024-10-06
Citrate cycle ( Citrate cycle )
Proteins (21)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | EC 1.3.5.1; Iron-sulfur subunit of complex II; Ip | Homo sapiens (human) |
| Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | PEPCK-M; EC 4.1.1.32 | Homo sapiens (human) |
| ATP-citrate synthase | EC 2.3.3.8; ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzyme | Homo sapiens (human) |
| Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial | EC 6.2.1.5; ATP-specific succinyl-CoA synthetase subunit beta; A-SCS; Succinyl-CoA synthetase beta-A chain; SCS-betaA | Homo sapiens (human) |
| Citrate synthase, mitochondrial | EC 2.3.3.1; Citrate (Si)-synthase | Homo sapiens (human) |
| Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | EC 1.1.1.41; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha | Homo sapiens (human) |
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | EC 1.3.5.1; Flavoprotein subunit of complex II; Fp | Homo sapiens (human) |
| Malate dehydrogenase, mitochondrial | EC 1.1.1.37 | Homo sapiens (human) |
| Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | PEPCK-C; EC 4.1.1.32; Serine-protein kinase PCK1; 2.7.11.- | Homo sapiens (human) |
| 2-oxoglutarate dehydrogenase, mitochondrial | EC 1.2.4.2; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase | Homo sapiens (human) |
| Cytoplasmic aconitate hydratase | Aconitase; EC 4.2.1.3; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1 | Homo sapiens (human) |
| Aconitate hydratase, mitochondrial | Aconitase; EC 4.2.1.3; Citrate hydro-lyase | Homo sapiens (human) |
| Malate dehydrogenase, cytoplasmic | EC 1.1.1.37; Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase; 1.1.1.96 | Homo sapiens (human) |
| Dihydrolipoyl dehydrogenase, mitochondrial | EC 1.8.1.4; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein | Homo sapiens (human) |
| Pyruvate carboxylase, mitochondrial | EC 6.4.1.1; Pyruvic carboxylase; PCB | Homo sapiens (human) |
| Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | EC 6.2.1.4; EC 6.2.1.5; Succinyl-CoA synthetase subunit alpha; SCS-alpha | Homo sapiens (human) |
| Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | EC 2.3.1.61; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K | Homo sapiens (human) |
| Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial | EC 6.2.1.4; GTP-specific succinyl-CoA synthetase subunit beta; G-SCS; GTPSCS; Succinyl-CoA synthetase beta-G chain; SCS-betaG | Homo sapiens (human) |
| Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | Isocitric dehydrogenase subunit beta; NAD(+)-specific ICDH subunit beta | Homo sapiens (human) |
| Fumarate hydratase, mitochondrial | Fumarase; HsFH; EC 4.2.1.2 | Homo sapiens (human) |
| Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial | Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma | Homo sapiens (human) |
Compounds (27)
| Compound | Description |
|---|---|
| phosphoric acid | concise etchant is 37% H3PO4 |
| pyruvic acid | An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) |
| succinic acid | A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) |
| Thiamine Pyrophosphate | The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX. |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| citric acid, anhydrous | |
| NADH | |
| fumaric acid | see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| guanosine diphosphate | A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. |
| guanosine triphosphate | Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. |
| phosphoenolpyruvate | A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways. |
| isocitric acid | RN given refers to unlabeled parent cpd |
| alpha-ketoglutaric acid | |
| ubiquinol-10 | reduced form of coenzyme Q10 |
| ubiquinone q2 | interacts with iron atom to form acceptor quinone complex; RN given refers to cpd with unspecified isomeric designation |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| lipoamide | RN given refers to cpd without isomeric designation |
| succinyl-coenzyme a | |
| oxaloacetic acid | A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE. |
| malic acid | |
| acetyl coenzyme a | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| aconitic acid | A tricarboxylic acid with the formula (COOH)-CH2-C(COOH)=CH-COOH. |
| dihydrolipoamide | RN given refers to cpd without isomeric designation |
| coenzyme a |