Page last updated: 2024-09-27

Angiofibroma

A benign neoplasm of fibrous tissue in which there are numerous small and large, frequently dilated, vascular channels. (Stedman, 25th ed)

Synonyms(1)

Synonym
Angiofibroma

Research Excerpts

Overview

ExcerptReference
"Cellular angiofibroma is a rare tumor."( Colombat, M; De Saint-Maur, P; Gontier, MF; Liard-Meillon, ME; Sevestre, H, 2001)
"Facial angiofibromas are the most visible and unsightly of the cutaneous manifestations of TSC, often resulting in stigmatisation for both the affected individuals and their families."( Bint, LJ; Foster, RS; Halbert, AR, 2012)
"Juvenile angiofibromas are hypervascular tumors that may benefit from preoperative devascularization to reduce intraoperative blood loss."( Chaudhary, N; Gemmete, JJ; Marentette, LJ; McKean, EL; Pandey, AS; Patel, S; Sullivan, SE, 2012)
"Facial angiofibromas are disfiguring facial lesions, present in up to 80% of patients with tuberous sclerosis complex."( Hebert, AA; Koenig, MK; Northrup, H; Roberson, J; Samuels, J; Slopis, J; Woerner, A, 2012)
"Facial angiofibromas are dermatological manifestations of tuberous sclerosis complex, a neurocutaneous disorder characterized by excess cell growth and proliferation."( Almoazen, H; Wheless, JW, 2013)
"Facial angiofibromas are the most troublesome cutaneous manifestations of the tuberous sclerosis complex and are difficult to treat."( Cho, YS; Kim, HU; Park, J; Song, KH; Yun, SK, 2014)
"Facial angiofibromas are present in most of the patients with the tuberous sclerosis complex and may cause severe disfiguration of the face."( De Bernardis, G; Dill, PE; Lösch, U; Weber, P, 2014)
"Angiofibromas are the most recognized cutaneous manifestations of tuberous sclerosis complex."( Krakowski, AC; Nguyen, TA, 2015)
"Facial angiofibromas are most commonly located on the face and have the potential to cause disfigurement."( Gurioli, C; Negosanti, F; Neri, I; Tengattini, V, 2018)
"Facial angiofibroma is the characteristic symptom and also a major diagnostic criterion for Bourneville-Pringle disease."( Bottyán, K; Csoma, ZR; Kemény, L, 2019)
"Cellular angiofibroma is a benign mesenchymal tumor most commonly located in the distal genital tract of both men and women."( Gardeniers, M; Hötte, GJ; Paridaens, D; Verdijk, RM, 2021)
"Facial angiofibromas are benign tumors characteristic of tuberous sclerosis complex."( Boulaguiem, Y; Guerrier, S; Kalia, YN; Lapteva, M; Quartier, J, 2021)
"Multiple angiofibromas are commonly found in patients with tuberous sclerosis complex."( Ma, L; Shi, X; Zhang, B, 2021)
"Cellular angiofibroma is a rare benign tumor and difficult to diagnose."( Li, Y; Neng, YJ; Nong, X; Wu, WJ; Yu, YT; Zhang, M, 2023)

Actions

ExcerptReference
"Angiofibroma affects 70-80% of patients with TSC, typically on the face."( Corsenca, A; French, LE; Hofbauer, GF; Kistler, AD; Marcollo-Pini, A; Serra, AL; Wüthrich, RP, 2008)

Treatment

ExcerptReference
"Recently, treatment of facial angiofibromas with topical rapamycin has been reported to yield promising results."( Cho, YS; Kim, HU; Park, J; Song, KH; Yun, SK, 2014)

Research

Studies (189)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (2.12)23.3326
1990's19 (10.05)12.5806
2000's38 (20.11)18.1394
2010's87 (46.03)28.8240
2020's41 (21.69)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low30
salicylic acid0low30
dimethyl sulfoxide0medium81
glyoxylic acid0low10
amobarbital0low10
cefuroxime0low10
diazepam0low10
pentetic acid0low10
valproic acid0low10
droperidol0low10
fentanyl0low20
flutamide0medium81
lidocaine0low10
isoflurane0low10
propofol0low10
propranolol0low10
vigabatrin0low10
edetic acid0low30
fluoxymesterone0low10
methylprednisolone0low10
pyrroles0low10
diatrizoate meglumine0low10
enbucrilate0low60
trimethaphan0low10
tantalum0low10
technetium0medium11
titanium0low10
argon0low20
gadolinium0low10
acetylglucosamine0low10
tricalcium phosphate0low10
timolol0low10
vecuronium bromide0low10
propiconazole0low150
fomesafen0low10
fluorodeoxyglucose f180low10
n-acetylglucosaminylasparagine0low10
fibrin0low10
elastin0low10
inositol 3-phosphate0low20
tacrolimus0low20
diethylstilbestrol0low10
dactinomycin0low10
bromochloroacetic acid0low10
picibanil0low10
tamoxifen0low10
toremifene0low10
calcitriol0medium21
tranilast0low10
phenylephrine hydrochloride0low280
sirolimus0medium558
semaxinib0low10
everolimus0medium51
gadolinium dtpa0low10
podophyllin0low10
(dtpa-phe(1))-octreotide0low10
technetium tc 99m sestamibi0low10
azd45470low10
vasoactive intestinal peptide0low10
transforming growth factor beta0low60
gallium ga 68 dotatate0medium11
angiogenin0low10
68ga-dotanoc0low30
dacarbazine0low10
eye0low10

Protein Targets (924)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Putative glycosyltransferase WbgO0001
Cytochrome P450 3A40809
Cannabinoid receptor 10101
Killer cell lectin-like receptor subfamily B member 1A0101
Early activation antigen CD690101
Chain A, Beta-lactamase7007
bromodomain adjacent to zinc finger domain 2B4004
geminin180018
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
TDP1 protein180018
AR protein210021
farnesoid X nuclear receptor8008
estrogen nuclear receptor alpha240024
Fumarate hydratase2002
PPM1D protein5005
EWS/FLI fusion protein2002
polyprotein2002
Aurora kinase A0033
Interferon beta110011
Fibroblast growth factor receptor 10224
Fibroblast growth factor receptor 20202
Fibroblast growth factor receptor 40202
Fibroblast growth factor receptor 30202
Vascular endothelial growth factor receptor 20203
Fibroblast growth factor receptor 40101
RAR-related orphan receptor gamma130013
aldehyde dehydrogenase 1 family, member A18008
nuclear receptor subfamily 1, group I, member 3100010
retinoic acid nuclear receptor alpha variant 1120012
thyroid stimulating hormone receptor6006
nuclear factor erythroid 2-related factor 2 isoform 1150015
Cellular tumor antigen p53160016
Nuclear receptor ROR-gamma6006
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Ferritin light chain9009
Vitamin D3 receptor0011
USP1 protein, partial150015
Microtubule-associated protein tau7007
thioredoxin glutathione reductase1001
euchromatic histone-lysine N-methyltransferase 2160016
mitogen-activated protein kinase 17007
nuclear receptor ROR-gamma isoform 1110011
peripheral myelin protein 22110011
ATP-binding cassette sub-family C member 3014014
Multidrug resistance-associated protein 4014014
Bile salt export pump018018
Vitamin D-binding protein0011
Cytochrome P450 1A20102
Androgen receptor0516
Cytochrome P450 2D60303
Vitamin D3 receptor0124
Cytochrome P450 2C9 0304
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0011
Cytochrome P450 2C190303
Kappa-type opioid receptor0213
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Canalicular multispecific organic anion transporter 1013013
Vitamin D3 receptor A0022
Chain A, 2-oxoglutarate Oxygenase6006
interleukin 84004
hypoxia-inducible factor 1 alpha subunit8008
thyroid stimulating hormone receptor5005
glucocorticoid receptor [Homo sapiens]150015
estrogen-related nuclear receptor alpha170017
cytochrome P450 2D66006
peroxisome proliferator activated receptor gamma130013
activating transcription factor 66006
survival motor neuron protein isoform d7007
lamin isoform A-delta10120012
Matrix metalloproteinase-90101
Inositol monophosphatase 12002
Isocitrate lyase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Cruzipain2002
15-lipoxygenase, partial4004
GLI family zinc finger 3130013
caspase 7, apoptosis-related cysteine protease3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
estrogen receptor 2 (ER beta)8008
progesterone receptor120012
cytochrome P450 family 3 subfamily A polypeptide 47007
retinoid X nuclear receptor alpha100010
pregnane X nuclear receptor140014
peroxisome proliferator-activated receptor delta7007
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
caspase-33003
RAD510101
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x6006
Caspase-72002
Bloom syndrome protein isoform 16006
vitamin D3 receptor isoform VDRA5005
thyroid hormone receptor beta isoform a4004
caspase-32002
thyroid hormone receptor beta isoform 2130013
huntingtin isoform 22002
histone-lysine N-methyltransferase 2A isoform 2 precursor4004
cytochrome P450 3A4 isoform 19009
caspase-1 isoform alpha precursor1001
Gamma-aminobutyric acid receptor subunit pi95418
Voltage-dependent calcium channel gamma-2 subunit8008
ATP-dependent translocase ABCB10619
Gamma-aminobutyric acid receptor subunit beta-195418
Gamma-aminobutyric acid receptor subunit delta95418
Gamma-aminobutyric acid receptor subunit gamma-295418
Glutamate receptor 28008
Gamma-aminobutyric acid receptor subunit alpha-595418
Gamma-aminobutyric acid receptor subunit alpha-395418
Gamma-aminobutyric acid receptor subunit gamma-195418
Gamma-aminobutyric acid receptor subunit alpha-295418
Gamma-aminobutyric acid receptor subunit alpha-495418
Gamma-aminobutyric acid receptor subunit gamma-395418
Gamma-aminobutyric acid receptor subunit alpha-695418
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-71001
Spike glycoprotein90211
Gamma-aminobutyric acid receptor subunit alpha-195418
Growth factor receptor-bound protein 20101
Gamma-aminobutyric acid receptor subunit beta-395418
Gamma-aminobutyric acid receptor subunit beta-295418
Pantothenate synthetase0101
Discoidin domain-containing receptor 20123
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
GABA theta subunit95418
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
ATPase family AAA domain-containing protein 5110011
Ataxin-2120012
Gamma-aminobutyric acid receptor subunit epsilon95418
thioredoxin reductase8008
Hsf1 protein0011
chromobox protein homolog 1120012
Gamma-aminobutyric acid 0101
glp-1 receptor, partial6006
G6006
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Voltage-dependent L-type calcium channel subunit alpha-1F0202
HLA class I histocompatibility antigen, B alpha chain 6006
Fatty acid-binding protein, liver0101
Alpha-1-acid glycoprotein 10001
Albumin0124
Albumin0011
Gamma-aminobutyric acid receptor subunit alpha-10204
Gamma-aminobutyric acid receptor subunit beta-10204
Neuronal acetylcholine receptor subunit alpha-41203
Gamma-aminobutyric acid receptor subunit alpha-20204
Gamma-aminobutyric acid receptor subunit alpha-30204
Neuronal acetylcholine receptor subunit beta-21203
Gamma-aminobutyric acid receptor subunit alpha-10336
Translocator protein0113
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20325
5-hydroxytryptamine receptor 1A010314
Gamma-aminobutyric acid receptor subunit alpha-40204
Gamma-aminobutyric acid receptor subunit gamma-20204
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30325
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50235
Gamma-aminobutyric acid receptor subunit alpha-30224
Gamma-aminobutyric acid receptor subunit alpha-20224
Gamma-aminobutyric acid receptor subunit beta-20224
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Gamma-aminobutyric acid receptor subunit alpha-60213
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
Inositol hexakisphosphate kinase 16006
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0202
cytochrome P450 2C9, partial6006
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Luciferase7007
acetylcholinesterase5005
ATAD5 protein, partial4004
GLS protein4004
Smad34004
regulator of G-protein signaling 44004
67.9K protein4004
IDH15005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
cellular tumor antigen p53 isoform a3003
potassium voltage-gated channel subfamily H member 2 isoform d6006
heat shock protein beta-13003
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
serine/threonine-protein kinase PLK12002
high affinity choline transporter 1 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
lethal factor (plasmid)3003
neuropeptide S receptor isoform A3003
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
5-hydroxytryptamine receptor 4010010
Nuclear receptor subfamily 1 group I member 20145
Carbonic anhydrase 10404
Carbonic anhydrase 20404
Estrogen receptor0427
Glucocorticoid receptor0404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Integrin beta-33003
Tyrosine-protein kinase Fyn0224
Glycine receptor subunit alpha-10404
Aldo-keto reductase family 1 member B10707
Integrin alpha-IIb3003
Beta-1 adrenergic receptor0819
Alpha-2A adrenergic receptor07210
Polyunsaturated fatty acid 5-lipoxygenase0202
Adenosine receptor A30516
Muscarinic acetylcholine receptor M10516
Polyunsaturated fatty acid lipoxygenase ALOX150202
D(2) dopamine receptor0819
Androgen receptor0707
Alpha-1B adrenergic receptor0516
Alpha-2B adrenergic receptor0618
Alpha-2C adrenergic receptor0528
Muscarinic acetylcholine receptor M30516
Glycine receptor subunit beta0404
Substance-K receptor0404
D(1A) dopamine receptor0718
Acetylcholinesterase0202
Glycine receptor subunit alpha-20404
Prostaglandin G/H synthase 10404
Sodium-dependent noradrenaline transporter 0617
Glycine receptor subunit alpha-30404
Thromboxane-A synthase 0202
Alpha-1D adrenergic receptor0618
5-hydroxytryptamine receptor 2A0819
5-hydroxytryptamine receptor 2C010111
Adenosine receptor A2a0516
Adenosine receptor A10404
Sodium-dependent serotonin transporter0606
Mu-type opioid receptor0729
D(3) dopamine receptor0707
Vasopressin V1a receptor0314
Alpha-synuclein4004
Delta-type opioid receptor0718
Kappa-type opioid receptor0718
5-hydroxytryptamine receptor 2B010111
Alpha-1A adrenergic receptor0516
Histamine H2 receptor7007
5-hydroxytryptamine receptor 609110
Estrogen-related receptor gamma0112
Disintegrin and metalloproteinase domain-containing protein 171001
Sodium-dependent dopamine transporter 0404
Aldehyde oxidase0101
TAR DNA-binding protein 433003
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140123
Estrogen receptor beta0426
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Cysteinyl leukotriene receptor 10202
Cereblon isoform 40202
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0202
SMAD family member 24004
SMAD family member 34004
cytochrome P450 2D6 isoform 13003
cytochrome P450 2C9 precursor2002
DNA polymerase beta1001
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50404
Angiotensin-converting enzyme0404
5-hydroxytryptamine receptor 1B0808
Histamine H1 receptor0303
N-acetyltransferase Eis0101
Potassium voltage-gated channel subfamily H member 20808
Nuclear receptor subfamily 3 group C member 3 0404
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Eyes absent homolog 20101
Amyloid-beta precursor protein0101
Angiotensin-converting enzyme 0101
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
Bone morphogenetic protein receptor type-1B0022
Cell division cycle 7-related protein kinase0022
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50022
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30123
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10123
Epidermal growth factor receptor0224
High affinity nerve growth factor receptor0022
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20022
Protein kinase C beta type0123
Insulin receptor0022
Tyrosine-protein kinase Lck0123
Cyclin-dependent kinase 10123
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0123
Insulin-like growth factor 1 receptor0123
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Platelet-derived growth factor receptor beta0123
Tyrosine-protein kinase Fgr0022
Serine/threonine-protein kinase A-Raf0022
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
DNA topoisomerase 2-alpha0022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0123
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0022
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0022
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0123
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10022
Cyclin-dependent kinase 20022
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Mitogen-activated protein kinase 10022
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0022
RAC-beta serine/threonine-protein kinase0022
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40022
Myosin-100022
Dual specificity mitogen-activated protein kinase kinase 20022
Receptor-type tyrosine-protein kinase FLT30123
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0022
Glycine--tRNA ligase0022
Protein kinase C iota type0123
Exosome RNA helicase MTR40022
Serine/threonine-protein kinase mTOR0325
Tyrosine-protein kinase Tec0022
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20022
Elongation factor Tu, mitochondrial0022
Choline-phosphate cytidylyltransferase A0022
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Dual specificity protein kinase CLK30022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10022
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10023
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0022
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10022
DNA topoisomerase 2-beta0022
Protein kinase C theta type0123
Activin receptor type-10022
Macrophage-stimulating protein receptor0123
Focal adhesion kinase 10022
Protein kinase C delta type0123
Tyrosine-protein kinase BTK0022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10023
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Sodium channel protein type 5 subunit alpha0303
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110022
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Putative heat shock protein HSP 90-beta 20022
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase N30022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30022
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Regulatory-associated protein of mTOR0202
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
Serine/threonine-protein kinase Nek70011
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Dual specificity testis-specific protein kinase 20022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Target of rapamycin complex subunit LST80202
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Obg-like ATPase 10022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20023
Serine/threonine-protein kinase TBK10022
Septin-90022
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Long-chain-fatty-acid--CoA ligase 50011
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
Solute carrier family 22 member 1 0202
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0303
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0303
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10606
Sigma non-opioid intracellular receptor 10101
pregnane X receptor4004
transcriptional regulator ERG isoform 33003
endonuclease IV3003
nonstructural protein 16006
alpha-galactosidase1001
peripheral myelin protein 22 isoform 14004
cytochrome P450 2C19 precursor2002
D(1A) dopamine receptor6006
nuclear factor erythroid 2-related factor 2 isoform 23003
DNA polymerase iota isoform a (long)4004
M-phase phosphoprotein 85005
muscleblind-like protein 1 isoform 13003
muscarinic acetylcholine receptor M15005
Cocaine esterase0203
Bile salt export pump0404
Arylacetamide deacetylase0001
Arylacetamide deacetylase0001
Arylacetamide deacetylase0001
4-hydroxy-tetrahydrodipicolinate synthase0101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
flap endonuclease 12002
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Multidrug and toxin extrusion protein 10202
Sodium channel protein type 3 subunit alpha0101
nuclear receptor subfamily 1, group I, member 21001
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent phosphofructokinase5005
GALC protein2002
arylsulfatase A6006
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
phosphopantetheinyl transferase3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
heat shock protein HSP 90-alpha isoform 20001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90002
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0202
Fatty-acid amide hydrolase 10202
UDP-glucuronosyltransferase 1A80001
Beta-1 adrenergic receptor 0124
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Beta-2 adrenergic receptor0415
Muscarinic acetylcholine receptor M20314
5-hydroxytryptamine receptor 1A0101
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Beta-3 adrenergic receptor0617
Beta-1 adrenergic receptor0315
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0124
Nuclear receptor subfamily 2 group E member 10022
chaperonin-containing TCP-1 beta subunit homolog1001
histone acetyltransferase KAT2A isoform 12002
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET0101
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET0101
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET0101
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
thyrotropin-releasing hormone receptor2002
NPC intracellular cholesterol transporter 1 precursor3003
vasopressin V1a receptor0011
oxytocin receptor0011
histone deacetylase 9 isoform 31001
importin subunit beta-1 isoform 11001
serine/threonine-protein kinase mTOR isoform 12002
eyes absent homolog 2 isoform a1001
tyrosine-protein kinase Yes1001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
transient receptor potential cation channel subfamily V member 11001
glycogen synthase kinase-3 alpha0001
POsterior Segregation0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Rap guanine nucleotide exchange factor 31001
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Tubulin alpha-1A chain0101
Tubulin beta chain0101
Receptor tyrosine-protein kinase erbB-20202
Platelet-derived growth factor receptor beta0101
Macrophage colony-stimulating factor 1 receptor0101
Mast/stem cell growth factor receptor Kit0101
Dihydrofolate reductase0101
Platelet-derived growth factor receptor alpha0101
Vascular endothelial growth factor receptor 1 0101
Platelet-derived growth factor receptor alpha 0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Vascular endothelial growth factor receptor 10101
Tyrosine-protein kinase ZAP-700101
Angiopoietin-1 receptor0101
Vascular endothelial growth factor receptor 20101
1,25-dihydroxyvitamin D-3 receptor 0101
Rap guanine nucleotide exchange factor 41001
Dihydrofolate reductase0101
ALK tyrosine kinase receptor0101
Zinc finger protein mex-50011
Tyrosine-protein kinase JAK20011
Cyclin-dependent kinase-like 50011
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Serine/threonine-protein kinase receptor R30011
Peptidyl-prolyl cis-trans isomerase FKBP1A0426
Peptidyl-prolyl cis-trans isomerase FKBP1B0022
Protein kinase C zeta type0112
Cyclin-dependent kinase 180011
Tyrosine-protein kinase Mer0011
Peptidyl-prolyl cis-trans isomerase FKBP50202
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
MAP kinase-activated protein kinase 50011
Misshapen-like kinase 10011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase mTOR 0101
Isoleucine--tRNA ligase, mitochondrial0011
Serine/threonine-protein kinase ICK0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Serine/threonine-protein kinase 240011
Solute carrier organic anion transporter family member 1B10202
DNA polymerase kappa isoform 11001
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40002
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0202
Splicing factor 3B subunit 30101
Chain A, CES1 protein0101
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
glucocerebrosidase1001
Spike glycoprotein0022
Replicase polyprotein 1ab0022
interferon gamma precursor0001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A2002
streptokinase A precursor0011
Transmembrane protease serine 20022
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Estrogen receptor0012
Progesterone receptor0101
Procathepsin L0022
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0123
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Cytochrome P450 2B60101
Protein kinase C eta type0101
Histamine H2 receptor0202
Substance-P receptor0202
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Melanocortin receptor 30202
D(1A) dopamine receptor1001
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0022
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
NFKB1 protein, partial2002
Envelope glycoprotein0022
dopamine D1 receptor1001
MSH0001
Thrombopoietin1001
Parkin1001
pyruvate kinase1001
polyunsaturated fatty acid lipoxygenase ALOX121001
atrial natriuretic peptide receptor 1 precursor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
atrial natriuretic peptide receptor 2 precursor1001
pyruvate kinase PKM isoform b1001
Hematopoietic prostaglandin D synthase0101
Transient receptor potential cation channel subfamily A member 10101
Ornithine decarboxylase1001
NACHT, LRR and PYD domains-containing protein 3 0101
Transient receptor potential cation channel subfamily V member 20101
Histone deacetylase 30202
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Solute carrier family 22 member 20101
Multidrug and toxin extrusion protein 20101
Gamma-aminobutyric acid type B receptor subunit 20101
4-aminobutyrate aminotransferase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
Gamma-aminobutyric acid type B receptor subunit 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]