gallium-ga-68-dotatate and Angiofibroma

gallium-ga-68-dotatate has been researched along with Angiofibroma* in 1 studies

Trials

1 trial(s) available for gallium-ga-68-dotatate and Angiofibroma

ArticleYear
(68)Ga-DOTATATE PET in juvenile angiofibroma.
    Future oncology (London, England), 2016, Volume: 12, Issue:12

    As somatostatin receptors (SSTRs) may be overexpressed in rapidly growing vessels, the aim of this study was the analysis of in vivo and in vitro SSTR2A expression in juvenile angiofibroma (JA).. A group of six male adolescents with a diagnosis of primary, recurrent/residual JA was enrolled in the study. All patients underwent (68)Ga-DOTATATE PET/computed tomography (CT) followed by immunohistochemical staining for SSTR expression.. (68)Ga-DOTATATE PET/CT showed accumulation in areas matching the pathologic tissue in the nasopharynx of all patients studied with SUVmax of 5.1 ± 0.9 (ranging from 3.6 to 6.4). In all cases, the immunohistochemical examination showed a presence of SSTR2A with a high staining index.. In vitro SSTR2A cytoplasm expression was found to be high in all tumor specimens. However, the uptake of (68)Ga-DOTATATE was weak in the PET/CT studies. We postulate that the intracellular localization of the SSTR2A in JA may cause this discrepancy.

    Topics: Adolescent; Angiofibroma; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Receptors, Somatostatin

2016