valproic acid has been researched along with Glycine Encephalopathy in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nonketotic hyperglycinemia (NKH), or glycine encephalopathy, is an autosomal recessive disorder caused by a defect in the glycine cleavage enzyme system." | 1.38 | Paradoxical increase in seizure frequency with valproate in nonketotic hyperglycinemia. ( Aida, N; Iai, M; Kure, S; Osaka, H; Shimbo, H; Tsuji, M; Tsuyusaki, Y; Wada, T; Yamashita, S, 2012) |
| "Hyperglycinemia was induced in healthy vervet monkeys when treated with a single oral dose of 50 mg/kg valproate." | 1.38 | Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate. ( Bergh, JJ; Kotze, HF; Mienie, LJ; Terre'Blanche, G; Viljoen, J, 2012) |
| "An important subset of children with nonketotic hyperglycinemia are atypical variants who present in a heterogeneous manner." | 1.33 | Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia. ( Morrison, PF; Sankar, R; Shields, WD, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsuyusaki, Y | 1 |
| Shimbo, H | 1 |
| Wada, T | 1 |
| Iai, M | 1 |
| Tsuji, M | 1 |
| Yamashita, S | 1 |
| Aida, N | 1 |
| Kure, S | 1 |
| Osaka, H | 1 |
| Viljoen, J | 1 |
| Bergh, JJ | 1 |
| Mienie, LJ | 1 |
| Kotze, HF | 1 |
| Terre'Blanche, G | 1 |
| Chen, PS | 1 |
| Yang, YK | 1 |
| Yeh, TL | 1 |
| Lo, YC | 1 |
| Wang, YT | 1 |
| Morrison, PF | 1 |
| Sankar, R | 1 |
| Shields, WD | 1 |
| Korman, SH | 1 |
5 other studies available for valproic acid and Glycine Encephalopathy
| Article | Year |
|---|---|
Paradoxical increase in seizure frequency with valproate in nonketotic hyperglycinemia.
Topics: Anticonvulsants; Brain; Child; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Humans; | 2012 |
Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Chlorocebus aethiops; Disease Mod | 2012 |
Nonketotic hyperosmolar syndrome from olanzapine, lithium, and valproic acid cotreatment.
Topics: Adult; Benzodiazepines; Drug Therapy, Combination; Humans; Hyperglycinemia, Nonketotic; Lithium Chlo | 2003 |
Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia.
Topics: Anticonvulsants; Brain Diseases; Child; Chorea; Female; Humans; Hyperglycinemia, Nonketotic; Valproi | 2006 |
Diagnosis of nonketotic hyperglycinemia in patients treated with valproic acid.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Female; Humans; Hyperglycinemia, Nonketotic; Infant | 2007 |