Compounds > 6-hydroxymethyl-7,8-dihydropterin
Page last updated: 2024-10-15

6-hydroxymethyl-7,8-dihydropterin

Description

2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one : A dihydropterin that is 7,8-dihydropteridin-4-one substituted at positions 2 and 6 by amino and hydroxymethyl groups respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol : A dihydropterin that is 7,8-dihydropteridin-4-ol substituted at positions 2 and 6 by amino and hydroxymethyl groups respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID135398568
CHEMBL ID1233322
CHEBI ID17083
CHEBI ID44841
SCHEMBL ID230712
MeSH IDM0475106

Synonyms (31)

Synonym
CHEMBL1233322
CHEBI:17083 ,
2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol
2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one
2-amino-4-hydroxy-6-hydroxy-methyl-dihydropteridine
2-amino-7,8-dihydro-4-hydroxy-6-(hydroxymethyl)pteridine
2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine
3672-03-5
4(1h)-pteridinone, 2-amino-7,8-dihydro-6-(hydroxymethyl)-
2-amino-4-hydroxy-6-(hydroxymethyl)-7,8-dihydropteridine
6-pteridinemethanol, 2-amino-7,8-dihydro-4-hydroxy-
7,8-dihydro-6-(hydroxymethyl)pterin
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one
C01300
2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4(3h)-one
6-(hydroxymethyl)-7,8-dihydropterin
6-hydroxymethyl-7,8-dihydropterin
DB02119
2QX0
2-amino-6-(hydroxymethyl)-7,8-dihydro-3h-pteridin-4-one
CHEBI:44841
SCHEMBL230712
DTXSID00274264
2-amino-7,8-dihydro-6-(hydroxymethyl)-4(3h)-pteridinone
Q27093187
2-amino-6-(hydroxymethyl)-1,4,7,8-tetrahydropteridin-4-one
b46l5lr2xm ,
unii-b46l5lr2xm
4(3h)-pteridinone, 2-amino-7,8-dihydro-6-(hydroxymethyl)-
PD008538
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
Saccharomyces cerevisiae metaboliteAny fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dihydropterin
dihydropterin
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (6)

PathwayProteinsCompounds
Folate Biosynthesis1126
GTP Degradation and Molybdenum Cofactor Biosynthesis1020
Tetrahydrofolate Biosynthesis829
superpathway of tetrahydrofolate biosynthesis1029
tetrahydrofolate biosynthesis II1232
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I417

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1682980Binding affinity to Escherichia coli BL21 (DE3) HPPK in presence of ATP and MgCl2 by fluorimetry2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding.
AID1146850Inhibition of Escherichia coli dihydroneopterin aldolase assessed as [14C]glycolaldehyde formation using [14C]neopterin substrate by scintillation counting1977Journal of medicinal chemistry, Sep, Volume: 20, Issue:9
Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.88)18.7374
1990's0 (0.00)18.2507
2000's6 (35.29)29.6817
2010's9 (52.94)24.3611
2020's1 (5.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
piperidine
[no description available]		2.3110azacycloalkane;
piperidines;
saturated organic heteromonocyclic parent;
secondary amine		base;
catalyst;
human metabolite;
non-polar solvent;
plant metabolite;
protic solvent;
reagent
alpha,beta-methyleneadenosine 5'-triphosphate
alpha,beta-methyleneadenosine 5'-triphosphate: do not confuse with beta,gamma-methylene ATP; RN given refers to parent cpd		2.0310nucleoside triphosphate analogue
pyrophosphate
Diphosphates: Inorganic salts of phosphoric acid that contain two phosphate groups.		2.0210diphosphate ion
calcimycin
Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.		2.0610benzoxazole
piperidines
Piperidines: A family of hexahydropyridines.		2.3110
dihydroneopterin triphosphate
[no description available]		2.0710dihydropterin;
neopterins;
pterin phosphate		Escherichia coli metabolite;
mouse metabolite
guanine
[no description available]		7.1102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
sapropterin
sapropterin: RN given refers to parent cpd; co-factor required for catalytic activity of nitric oxide synthases. (6R)-5,6,7,8-tetrahydrobiopterin : A 5,6,7,8-tetrahydrobiopterin in which the stereocentre at position 6 has R-configuration.. sapropterin : A tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer).		2.06105,6,7,8-tetrahydrobiopterincoenzyme;
cofactor;
diagnostic agent;
human metabolite
folic acid
folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.		2.7530folic acids;
N-acyl-amino acid		human metabolite;
mouse metabolite;
nutrient
5,6,7,8-tetrahydromethanopterin
[no description available]		2.0710tetrahydromethanopterin
neopterin
[no description available]		2.0710
5,6,7,8-tetrahydrofolic acid
5,6,7,8-tetrahydrofolic acid: RN given refers to (DL)-isomer		2.0710tetrahydrofolic acid
7,8-dihydropterin
7,8-dihydropterin: RN given refers to parent cpd		1.9510organic molecular entity;
pterins
ConditionIndicatedRelationship StrengthStudiesTrials
Anoxemia
[description not available]		02.0610
Pulmonary Hypertension
[description not available]		02.0610
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		02.0610
Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.		02.0610
Chronic Illness
[description not available]		02.0610
Anterior Cervical Pain
[description not available]		02.0610
Degenerative Disc Disease
[description not available]		02.0610
Acute Post-operative Pain
[description not available]		02.0610
Pseudarthrosis
A pathologic entity characterized by deossification of a weight-bearing long bone, followed by bending and pathologic fracture, with inability to form normal BONY CALLUS leading to existence of the false joint that gives the condition its name. (Dorland, 27th ed)		02.0610
Cervical Spondylosis
[description not available]		02.0610
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		02.0610
Pain, Postoperative
Pain during the period after surgery.		02.0610
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0610
Neck Pain
Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.		02.0610
Spondylosis
A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.		02.0610
Intervertebral Disc Degeneration
Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.		02.0610
Black Death
[description not available]		02.0310
Plague
An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.		07.0310