Page last updated: 2024-12-06

methyltin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	27864
MeSH ID	M0111282

Synonyms (9)

Synonym
methyltin
monomethyltin ion
methyltin(3+)
stannanetriylium, methyl-
tin(3+), methyl-, ion
u64v227yy6 ,
unii-u64v227yy6
16408-15-4
DTXSID801017141

Research Excerpts

Effects

Excerpt	Reference	Relevance
"Methyltin has been separated from inorganic Sn using anion-exchange chromatography and subjected to Sn isotope ratio measurements via solution nebulization multicollector inductively coupled plasma mass spectrometry (MC-ICPMS)."	( Isotopic fractionation of Sn during methylation and demethylation reactions in aqueous solution. Malinovskiy, D; Moens, L; Vanhaecke, F, 2009)	1.07

Toxicity

Excerpt	Reference	Relevance
" Here, we conducted studies to compare the acute toxicity induced by trimethyltin (TMT) and dimethyltin (DMT), and investigated the cumulative toxic effects of TMT in rats and mice."	( Toxicity of trimethyltin and dimethyltin in rats and mice. Dubois, AM; Gao, H; Gong, Z; Lai, G; Lin, Z; Liu, S; Olson, J; Ren, X; Sui, G; Tang, X; Wu, B; Wu, X; Zhong, Z, 2013)	0.98

Dosage Studied

Excerpt	Relevance	Reference
" The objective of these studies was to replicate the earlier publication and further define the dose-response characteristics of MMT following perinatal exposure."	( Evaluation of developmental neurotoxicity of organotins via drinking water in rats: monomethyltin. Barone, S; Ehman, KD; McDaniel, KL; Moser, VC; Phillips, PM, 2006)	0.56

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (31.82)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (36.36)	29.6817
2010's	6 (27.27)	24.3611
2020's	1 (4.55)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	36.66 (24.57)
Research Supply Index	3.22 (2.92)
Research Growth Index	4.31 (4.65)
Search Engine Demand Index	48.74 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (36.66)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (4.17%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (95.83%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.05	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.06	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.06	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
ethane Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.	2.06	1	alkane; gas molecular entity	plant metabolite; refrigerant
trimethyltin chloride trimethyltin chloride: induces atrophy of thymus, spleen & lymph nodes but causes no change in bone marrow	2.04	1
monotributyltin trichloride [no description available]	1.97	1
mercuric chloride Mercuric Chloride: Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.. mercury dichloride : A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.	1.96	1	mercury coordination entity	sensitiser
stannic chloride [no description available]	7.06	1
dimethyltin [no description available]	9.05	4	organotin compound
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.03	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
mono-n-butyltin [no description available]	2.57	2
tin [no description available]	2.92	4	carbon group element atom; elemental tin; metal atom	micronutrient
trimethyltin trimethyltin : An organotin compound that consists of stannane in which three of the four hydrogens are substituted by methyl groups.	7.47	2
potassium borohydride [no description available]	2.05	1

Condition	Relationship Strength	Studies
Encephalopathy, Toxic [description not available]	2.46	2
Hypokalemia Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)	2.08	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.03	1
Delayed Effects, Prenatal Exposure [description not available]	2.03	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.03	1
Nervous System Disorders [description not available]	1.96	1
Nervous System Diseases Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	1.96	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1

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