Page last updated: 2024-12-11
stannin
Description
stannin: amino acid sequence given in first source; a 10 kDa peptide expressed in trimethyltin-sensitive cells; may play a role in selective toxicity of organotin cpds; homologs have been identified in rabbit, human and Drosophila; from rat brain [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 6335902 |
| MeSH ID | M0203876 |
Synonyms (3)
| Synonym |
|---|
| stannin |
| 289-78-1 |
| DTXSID70894913 |
Research Excerpts
Overview
Stannin (Snn) is a highly conserved, 88-amino acid protein that may mediate the selective toxicity of organotins. Stannin is a protein that has been localized to trimethyltin-sensitive cell populations.
| Excerpt | Reference | Relevance |
|---|
| "Stannin (Snn) is a highly conserved, 88-amino acid protein that may mediate the selective toxicity of organotins. " | ( Stannin, a protein that localizes to the mitochondria and sensitizes NIH-3T3 cells to trimethyltin and dimethyltin toxicity.
Billingsley, ML; Davidson, CE; Reese, BE; Yun, JK, 2004) | 3.21 |
| "Stannin (Snn) is a highly conserved vertebrate protein that has been closely linked to trimethyltin (TMT) toxicity. " | ( Protein kinase C epsilon regulates tumor necrosis factor-alpha-induced stannin gene expression.
Billingsley, ML; Davidson, C; Reese, BE; Yun, J, 2005) | 2 |
| "Stannin (Snn) is a highly conserved, vertebrate protein whose cellular function is unclear. " | ( Elucidation of stannin function using microarray analysis: implications for cell cycle control.
Billingsley, ML; Krissinger, D; Reese, BE; Yun, JK, 2006) | 2.13 |
| "Stannin is a protein that has been localized to trimethyltin-sensitive cell populations, and evidence suggests it plays a role in the toxic effects of organotins. " | ( Chromosomal localization and characterization of the stannin (Snn) gene.
Billingsley, ML; Dejneka, NS; Deng, X; Martin-DeLeon, PA; Polavarapu, R, 1998) | 1.99 |
Effects
| Excerpt | Reference | Relevance |
|---|
| "Stannin has not been previously implicated in virus entry." | ( The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry.
Bradfield, C; Crite, M; DiMaio, D; Erden, A; Iwasaki, A; Kanaya, E; Lipovsky, A; MacMicking, J; Schoggins, JW; Zhang, W, 2017) | 1.46 |
Toxicity
Dosage Studied
Research
Studies (22)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 30.98
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 30.98 (24.57) | | Research Supply Index | 3.14 (2.92) | | Research Growth Index | 4.45 (4.65) | | Search Engine Demand Index | 39.34 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (18.18%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (81.82%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |