stannin: amino acid sequence given in first source; a 10 kDa peptide expressed in trimethyltin-sensitive cells; may play a role in selective toxicity of organotin cpds; homologs have been identified in rabbit, human and Drosophila; from rat brain [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6335902 |
| MeSH ID | M0203876 |
| Synonym |
|---|
| stannin |
| 289-78-1 |
| DTXSID70894913 |
Stannin (Snn) is a highly conserved, 88-amino acid protein that may mediate the selective toxicity of organotins. Stannin is a protein that has been localized to trimethyltin-sensitive cell populations.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Stannin has not been previously implicated in virus entry." | ( The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry. Bradfield, C; Crite, M; DiMaio, D; Erden, A; Iwasaki, A; Kanaya, E; Lipovsky, A; MacMicking, J; Schoggins, JW; Zhang, W, 2017) | 1.46 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Of primary interest is understanding how this highly-conserved peptide with an interesting structure and cellular localization transmits both normal and potentially toxic signals within the cell." | ( Functional and structural properties of stannin: roles in cellular growth, selective toxicity, and mitochondrial responses to injury. Billingsley, ML; Buck-Koehntop, BA; Davidson, CE; Reese, BE; Veglia, G; Yun, J, 2006) | 0.6 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " TMT administration causes selective neuronal death involving either the granular neurons of the dentate gyrus or the pyramidal cells of the Cornu Ammonis, with a different pattern of localization depending on the different species studied or the dosage schedule." | ( Gene expression profiling as a tool to investigate the molecular machinery activated during hippocampal neurodegeneration induced by trimethyltin (TMT) administration. Corvino, V; Di Maria, V; Geloso, MC; Lattanzi, W; Michetti, F, 2013) | 0.39 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (30.98) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (18.18%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (81.82%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||