salvianolic-acid-a and Kidney-Failure--Chronic

To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF).. The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sham-operated group (group S), in which only the capsules of both kidneys were removed. The rats in group CRF+SAA were intragastrically administrated with 10 mg/kg SAA for 8 weeks. The blood urine nitrogen (BUN), urine creatinine (Ucr), creatinine clearance rate (Ccr), and serum uperoxide dismutase (SOD) and malondialdehyde (MDA) were tested. The expressions of transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 7 (BMP-7) and Smad6 protein in renal tissue were determined.. After treatment, compared with group CRF, in group CRF+SAA the BUN, Scr, serum MDA and kidney/body weight ratio were decreased, the Ccr and serum SOD were increased, the TGF-β1 protein expression level in renal tissue was decreased, and the BMP-7 and Smad6 protein levels were increased (all P < 0.05).. SAA can alleviate the renal damage in CRF rats through anti-oxidant stress, down-regulation of TGF-β1 signaling pathway and up-regulation of BMP-7/Smad6 signaling pathway.

Topics: Animals; Bone Morphogenetic Protein 7; Caffeic Acids; Disease Models, Animal; Down-Regulation; Kidney Failure, Chronic; Kidney Function Tests; Lactates; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Smad6 Protein; Transforming Growth Factor beta1; Up-Regulation