salvianolic-acid-a and Weight-Gain

Salvianolic acids possess anti-inflammatory properties. This study investigated the therapeutic effect of salvianolic acids on chronic mild stress (CMS)-induced depressive-like behaviors in rats and the involvement of toll-like receptor 4 (. Eighty male Sprague-Dawley rats were randomly subjected to CMS or non-CMS protocol for 6 weeks. Starting 3 weeks after CMS exposure, the rats in each group were administered saline, fluoxetine (positive control), salvianolic acids, or salvianolic acids + fluoxetine daily for 3 weeks. The body weight change, sucrose preference, and immobility duration in forced swimming were examined before and after drug treatment. The rats were sacrificed at 3 weeks after drug treatment. Quantitative real-time PCR was performed to measure the mRNA levels of. Compared with non-CMS rats, CMS rats had significantly reduced weight gains and sucrose preference, along with significantly increased immobility durations and elevated mRNA levels of. Thus, salvianolic acids alleviate depressive-like behaviors, possibly by suppressing

Topics: Animals; Disease Models, Animal; Fluoxetine; Hippocampus; Male; Myeloid Differentiation Factor 88; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Psychological; Sucrose; Toll-Like Receptor 4; Weight Gain