RNA sequestering activity

Definition

Target type: molecularfunction

Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:29084823]

RNA sequestering activity involves the binding and sequestration of RNA molecules within a cellular compartment or by a protein complex. This mechanism serves to regulate RNA stability, translation, and transport. RNA sequestering proteins can act as molecular sponges, binding to specific RNA sequences and preventing their interaction with other molecules, such as ribosomes or enzymes. This sequestration can lead to the inhibition of translation, the degradation of the RNA molecule, or its redirection to a different cellular compartment. For example, certain RNA sequestering proteins can bind to mRNAs, preventing their translation into proteins, thereby controlling gene expression. Other proteins can sequester non-coding RNAs, such as microRNAs, influencing their ability to regulate gene expression. RNA sequestration plays a crucial role in various cellular processes, including developmental regulation, immune responses, and stress responses. In many cases, RNA sequestering activity is dynamically regulated in response to cellular signals, allowing cells to fine-tune gene expression and maintain cellular homeostasis.'
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Proteins (1)

Compounds (28)