Page last updated: 2024-11-12
ochromycinone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
ochromycinone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 11808929 |
| CHEMBL ID | 256705 |
| SCHEMBL ID | 19799341 |
| MeSH ID | M0498937 |
Synonyms (25)
| Synonym |
|---|
| ochromycinone |
| NCGC00180137-01 |
| ACON1_001791 |
| MEGXM0_000296 |
| j655.169f , |
| CHEMBL256705 |
| BRD-K92524032-001-01-3 |
| 28882-53-3 |
| (3s)-8-hydroxy-3-methyl-3,4-dihydro-2h-benzo[a]anthracene-1,7,12-trione |
| benz(a)anthracene-1,7,12(2h)-trione, 3,4-dihydro-8-hydroxy-3-methyl-, (s)- |
| CKZ6P7I25M , |
| (3s)-3.beta.-methyl-8-hydroxy-1,2,3,4,7,12-hexahydrobenzo(a)anthracene-1,7,12-trione |
| (+)-ochromycinone |
| unii-ckz6p7i25m |
| DTXSID40473279 |
| AKOS030254378 |
| J-017311 |
| SCHEMBL19799341 |
| C90290 |
| benz[a]anthracene-1,7,12(2h)-trione, 3,4-dihydro-8-hydroxy-3-methyl-, (3s)- |
| Q27275510 |
| deoxytetrangomycin |
| (s)-ochromycinone |
| CS-0082175 |
| HY-121482 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID315971 | Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | Design, synthesis, and studies of small molecule STAT3 inhibitors. |
| AID315968 | Inhibition of STAT3 binding to DNA | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | Design, synthesis, and studies of small molecule STAT3 inhibitors. |
| AID315970 | Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | Design, synthesis, and studies of small molecule STAT3 inhibitors. |
| AID1252744 | Inhibition of STAT1 (unknown origin) expressed in in IFN-gamma induced human HeLa cells at 50 uM incubated for 1 hr by luciferase reporter gene assay | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors. |
| AID315969 | Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | Design, synthesis, and studies of small molecule STAT3 inhibitors. |
| AID318801 | Antibacterial activity against Bacillus subtilis at 20 to 120 ug/disk | 2008 | Journal of natural products, Jan, Volume: 71, Issue:1 | Angucyclinones from an Indonesian Streptomyces sp. |
| AID318803 | Antibacterial activity against Pseudomonas aeruginosa at 20 to 120 ug/disk | 2008 | Journal of natural products, Jan, Volume: 71, Issue:1 | Angucyclinones from an Indonesian Streptomyces sp. |
| AID1252743 | Inhibition of STAT3 (unknown origin) expressed in Oncostatin M induced human HeLa cells at 50 uM incubated for 1 hr by luciferase reporter gene assay | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors. |
| AID315972 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | Design, synthesis, and studies of small molecule STAT3 inhibitors. |
| AID702275 | Inhibition of STAT3 in human MDA-MB-435 cells at 20 uM after 48 hrs by luciferase reporter gene assay relative to untreated control | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15 | Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 17.49
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.49) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||