Bessel-Hagen Disease

Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.

Synonym
Osteochondromas, Multiple
Bessel-Hagen Disease
Exostosis, Multiple Cartilaginous
Exostosis, Hereditary Multiple
Exostoses, Multiple, Type I
Exostosis, Multiple
Exostosis, Familial
Multiple Hereditary Exostoses
Familial Exostoses
Multiple Osteochondromas
Exostoses, Multiple
Diaphyseal Aclasis
Multiple Osteochondromatosis
Chondrodysplasia, Hereditary Deforming
Exostoses, Multiple Cartilaginous
Hereditary Multiple Exostoses
Exostoses, Hereditary Multiple
Hereditary Multiple Exostosis
Exostoses, Multiple Hereditary
Exostoses, Familial
Multiple Cartilaginous Exostoses

Excerpt	Reference
"A case of hereditary multiple exostoses is presented."	( Edeling, CJ, 1988)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	47 (34.81)	23.3326
1990's	19 (14.07)	12.5806
2000's	38 (28.15)	18.1394
2010's	26 (19.26)	28.8240
2020's	5 (3.70)	9.53

Drug	Relationship Strength	Studies	Trials
citric acid, anhydrous	low	1	0
3-hydroxybutyric acid	low	1	0
cytosine	low	1	0
picolinic acid	low	1	0
urea	low	2	0
diatrizoic acid	low	1	0
stallimycin	low	1	0
flumazenil	low	1	0
indomethacin	low	1	0
2-propanol	low	2	0
sodium fluoride	low	1	0
hydroxyproline	low	2	0
aldosterone	low	1	0
tyrosine	low	1	0
histidine	low	1	0
tryptophan	low	1	0
arginine	low	3	0
aminoacetonitrile	low	1	0
technetium	low	2	0
acetylglucosamine	low	2	0
thallium chloride	low	1	0
trolamine salicylate	low	3	0
fluorides	low	1	0
transferrin	low	1	0
paclitaxel	low	1	0
colforsin	low	1	0
aminoquinuride	low	2	0
glucuronic acid	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	low	3	0
methotrexate	low	1	0
proline	low	1	0
carboplatin	low	1	0
glycogen	low	1	0
glucosamine	low	1	0
retinol	low	1	0
keratan sulfate	low	1	0
isomethyleugenol	low	1	0
squalene	low	1	0
stilbenes	low	1	0
tamoxifen	low	1	0
cystine	low	1	0
osteoprotegerin	low	1	0
phenylephrine hydrochloride	low	6	0
thallium	low	1	0
cysteine	low	1	0
phosphorus	low	7	0
small cardioactive peptide a	low	1	0
dolichols	low	1	0
palovarotene	low	1	0
oligonucleotides	low	1	0
ldn 193189	low	1	0
heparitin sulfate	medium	33	1
tetracycline	low	1	0
epidermal growth factor	low	1	0
transforming growth factor beta	low	3	0
cyclin d1	low	2	0
technetium tc 99m medronate	low	8	0
chondroitin sulfates	medium	5	1
guanine	low	1	0

Protein Targets (740)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	11	0	0	11
GLI family zinc finger 3	10	0	0	10
AR protein	11	0	0	11
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	9	0	0	9
estrogen nuclear receptor alpha	13	0	0	13
peroxisome proliferator-activated receptor delta	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
activating transcription factor 6	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	5	0	0	5
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
lamin isoform A-delta10	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	3	0	4
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
glucocorticoid receptor [Homo sapiens]	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
geminin	10	0	0	10
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	3	0	3
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
15-lipoxygenase, partial	3	0	0	3
phosphopantetheinyl transferase	10	0	0	10
USP1 protein, partial	5	0	0	5
nonstructural protein 1	1	0	0	1
Bloom syndrome protein isoform 1	5	0	0	5
DNA polymerase kappa isoform 1	5	0	0	5
peripheral myelin protein 22	8	0	0	8
Eyes absent homolog 2	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Interstitial collagenase	0	1	0	1
Botulinum neurotoxin type A	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Lethal factor	0	2	0	2
Histamine H2 receptor	3	0	0	3
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	0	1	0	1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	6	0	0	6
NFKB1 protein, partial	1	0	0	1
GLS protein	2	0	0	2
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	6	0	0	6
flap endonuclease 1	6	0	0	6
DNA polymerase iota isoform a (long)	7	0	0	7
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
acetylcholinesterase	3	0	0	3
estrogen receptor 2 (ER beta)	6	0	0	6
G	6	0	0	6
cytochrome P450 2D6	2	0	0	2
vitamin D3 receptor isoform VDRA	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Inositol hexakisphosphate kinase 1	6	0	0	6
cytochrome P450 2C9, partial	6	0	0	6
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
farnesoid X nuclear receptor	5	0	0	5
peroxisome proliferator activated receptor gamma	10	0	0	10
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
glp-1 receptor, partial	3	0	0	3
pregnane X receptor	3	0	0	3
TDP1 protein	10	0	0	10
progesterone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
estrogen-related nuclear receptor alpha	11	0	0	11
pregnane X nuclear receptor	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
aryl hydrocarbon receptor	5	0	0	5
thyroid stimulating hormone receptor	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
thyroid hormone receptor beta isoform 2	6	0	0	6
steroidogenic factor 1	0	1	0	1
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	9	0	0	9
ATP-dependent translocase ABCB1	0	5	1	8
5-hydroxytryptamine receptor 1A	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
IDH1	5	0	0	5
Deoxycytidine kinase	0	0	0	1
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	8
Bile salt export pump	0	7	0	7
Canalicular multispecific organic anion transporter 1	0	7	0	7
endonuclease IV	1	0	0	1
regulator of G-protein signaling 4	2	0	0	2
EWS/FLI fusion protein	5	0	0	5
arylsulfatase A	3	0	0	3
cytochrome P450 2D6 isoform 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	4	0	0	4
survival motor neuron protein isoform d	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	4	2	0	6
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Bile salt export pump	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	0	6
5-hydroxytryptamine receptor 1A	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-2	4	2	0	6
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
GABA theta subunit	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	2	0	6
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Carbonic anhydrase 1	0	2	0	6
Carbonic anhydrase 2	0	2	1	7
Carbonic anhydrase 4	0	1	0	4
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase 15	0	1	0	4
Spike glycoprotein	4	0	1	5
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
ATAD5 protein, partial	2	0	0	2
cytochrome P450 3A4 isoform 1	4	0	0	4
Carbonic anhydrase 12	0	0	0	3
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	0	0	3
Adenosine receptor A1	0	1	0	3
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	3
Carbonic anhydrase 5A, mitochondrial	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	1	0	4
Carbonic anhydrase 7	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutamate receptor ionotropic, NMDA 2A	0	0	0	3
Glutamate receptor ionotropic, NMDA 2C	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	3	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	3
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	3
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	0	0	3
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Proton-coupled amino acid transporter 1	0	3	0	3
Amino acid transporter	0	2	0	2
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, Cruzipain	2	0	0	2
Luciferase	3	0	0	3
interleukin 8	2	0	0	2
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
Microtubule-associated protein tau	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
67.9K protein	4	0	0	4
glucocerebrosidase	2	0	0	2
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
M-phase phosphoprotein 8	4	0	0	4
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Phospholipase A2, major isoenzyme	0	1	0	1
Albumin	0	1	1	2
Prostaglandin G/H synthase 1	0	2	0	3
Procathepsin L	0	1	1	2
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Substance-P receptor	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	2	1	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 8	0	1	0	3
Multidrug and toxin extrusion protein 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	4	0	4
GALC protein	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Fumarate hydratase	2	0	0	2
PPM1D protein	2	0	0	2
polyprotein	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Bone morphogenetic protein 4	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Bone morphogenetic protein receptor type-1A	0	1	0	1
Activin receptor type-1B	0	1	0	1
TGF-beta receptor type-1	0	1	0	1
Serine/threonine-protein kinase receptor R3	0	1	0	1
Activin receptor type-1	0	0	1	1
TGF-beta receptor type-2	0	1	0	1
Dual specificity protein kinase CLK2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	1	0	1
Activin receptor type-1	0	1	0	1
Bone morphogenetic protein receptor type-2	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Thymidylate synthase	0	2	0	2
Integrin beta-3	2	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	2	0	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Protein-arginine deiminase type-4	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
Chain A, Beta-lactamase	3	0	0	3
Genome polyprotein	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Tyrosine-protein kinase Fyn	0	2	0	2
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Delta-type opioid receptor	0	4	0	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	1	2
Transmembrane prolyl 4-hydroxylase	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Alpha-synuclein	1	2	0	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Squalene monooxygenase	0	0	0	1
GTPase HRas	0	1	0	1
Estrogen receptor	0	3	1	5
Neutrophil elastase	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Histamine H1 receptor	0	1	0	1
Estrogen receptor beta	0	3	1	4
histone deacetylase 9 isoform 3	1	0	0	1
Tyrosinase	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Chain A, CES1 protein	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Progesterone receptor	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Protein kinase C alpha type	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	2	0	2
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(21)

Research Excerpts

Overview

Research

Studies (135)

Protein Targets (740)

Bessel-Hagen Disease

Synonyms(21)

Research Excerpts

Overview

Research

Studies (135)

Drugs Studied (74)

Protein Targets (740)