substance p, sar(9)-met(o2)(11)- has been researched along with substance p in 143 studies
| Studies (substance p, sar(9)-met(o2)(11)-) | Trials (substance p, sar(9)-met(o2)(11)-) | Recent Studies (post-2010) (substance p, sar(9)-met(o2)(11)-) | Studies (substance p) | Trials (substance p) | Recent Studies (post-2010) (substance p) |
|---|---|---|---|---|---|
| 151 | 0 | 6 | 17,289 | 277 | 2,010 |
| 151 | 0 | 6 | 23 | 0 | 0 |
| 151 | 0 | 6 | 85 | 0 | 12 |
| Protein | Taxonomy | substance p, sar(9)-met(o2)(11)- (IC50) | substance p (IC50) |
|---|---|---|---|
| Substance-P receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Substance-K receptor | Rattus norvegicus (Norway rat) | 0.2 | |
| Substance-K receptor | Homo sapiens (human) | 0.2455 | |
| Substance-P receptor | Homo sapiens (human) | 0.0011 | |
| Neuromedin-K receptor | Homo sapiens (human) | 0.125 | |
| Substance-K receptor | Mesocricetus auratus (golden hamster) | 0.148 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.70) | 18.7374 |
| 1990's | 100 (69.93) | 18.2507 |
| 2000's | 39 (27.27) | 29.6817 |
| 2010's | 3 (2.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbier, A; Doutremepuich, JD; Lacheretz, F; Vilain, P | 1 |
| Chrétien, L; Guillemette, G; Regoli, D; Tousignant, C | 1 |
| Hill, RG; Longmore, J | 1 |
| Johnson, CG; Johnson, CL | 2 |
| Seelig, A | 1 |
| Kodner, A; Mayer, EA; Sachs, G; Scott, D; Sun, XP; Wilkes, J | 1 |
| Guillemain, I; Imhoff, V; Rollandy, I; Rossignol, B | 1 |
| Burcher, E; Drapeau, G; Geraghty, DP; Lew, R; Regoli, D | 1 |
| Dam, TV; Martinelli, B; Quirion, R | 1 |
| Dion, S; Drapeau, G; Guillemette, G; Regoli, D; Télémaque, S; Tousignant, C | 1 |
| Kodner, A; Mayer, EA; Regoli, M; Sachs, G; Sun, XP; Supplisson, S | 1 |
| Guillemette, G; Regoli, D; Tousignant, C | 1 |
| Constantine, JW; Lebel, WS; Woody, HA | 1 |
| Couture, R; Drapeau, G; Guimond, C; Laneuville, O; Regoli, D | 1 |
| Beaujouan, JC; Glowinski, J; Saffroy, M; Torrens, Y | 1 |
| Brooks, N; Khan, S; Michael-Titus, AT; Whelpton, R | 1 |
| Longmore, J; Razzaque, Z | 1 |
| Bertrand, C; Daffonchio, L; Geppetti, P; Huber, O; Nadel, JA; Omini, C; Yamawaki, I | 1 |
| Ciccocioppo, R; De Caro, G; Massi, M; Panocka, I; Pompei, P | 1 |
| Bichon, D; Doutremepuich, JD; Ducoux, JP; Emonds-Alt, X; Heaulme, M; Neliat, G; Proietto, V; Santucci, V; Steinberg, R; Vilain, P | 1 |
| Bordey, A; Emonds-Alt, X; Feltz, P; Gauthier, T; Le Fur, G; Lefevre, IA; Oury-Donat, F; Soubrie, P; Thurneyssen, O | 1 |
| Kisara, K; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
| Besson, G; Drazen, JM; Israel, E; Lilly, CM; Rodger, IW | 1 |
| Boni, P; Evangelista, S; Maggi, CA | 1 |
| Bristow, LJ; Young, L | 1 |
| Banasiak, D; Burcher, E | 1 |
| Barnes, PJ; Belvisi, MG; Maggi, CA; Patacchini, R | 1 |
| Maggi, CA; Meini, S; Patacchini, R | 1 |
| Maggi, CA; Santicioli, P; Zagorodnyuk, V | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Meini, S; Patacchini, R; Potier, E; Quartara, L; Sisto, A | 1 |
| Hill, RG; Longmore, J; Razzaque, Z; Shaw, D | 1 |
| Calabrò, F; Chitano, P; Di Blasi, P; Fabbri, LM; Lucchini, RE; Maestrelli, P; Mapp, CE; Saetta, M | 1 |
| Daniel, EE; Fox-Threlkeld, JE; Watson, EG | 1 |
| Barr, AJ; Watson, SP | 1 |
| Burcher, E; Stamatakos, C | 1 |
| Betschart, J; Blanchard, JC; Fardin, V; Flamand, O; Ravard, S | 1 |
| Brugger, F; Evans, RH; Lepre, M; Olpe, HR | 1 |
| Coge, F; Regoli, D | 1 |
| Cenarruzabeitia, E; Del Río, J; Lasheras, B; Ramírez, MJ | 1 |
| Jackson, A; Rupniak, NM | 1 |
| Ciccocioppo, R; de Caro, G; Epstein, AN; Massi, M; Polidori, C | 1 |
| Martini, F; Puizillout, JJ; Reynaud, JC | 1 |
| Ballati, L; Boni, P; Evangelista, S | 1 |
| Cockerham, SL; Silbaugh, SA; Stengel, PW; Yiamouyiannis, CA | 1 |
| Killingsworth, CR; Shore, SA | 1 |
| Giachetti, A; Maggi, CA; Santicioli, P; Zagorodnyuk, V | 1 |
| Aleppo, G; Casabona, G; Di Stefano, M; Genazzani, AA; Nicoletti, F; Scapagnini, U | 1 |
| Mak, JC; Meini, S; Rogers, DF; Rohde, JA | 1 |
| Alberch, J; Arenas, E; Marsal, J; Pérez-Navarro, E | 1 |
| Barnes, PJ; Hirayama, Y; Lei, YH; Rogers, DF | 1 |
| Boucher, S; Couture, R; Gitter, BD; Howbert, JJ; Picard, P; Regoli, D | 1 |
| Mayer, E; Sun, XP; Supplisson, S | 1 |
| Boden, PR; Norris, SK; Woodruff, GN | 1 |
| Håkanson, R; Wang, ZY | 1 |
| Dalforno, G; Gaviraghi, G; Hagan, RM; Palea, S; Pietra, C; Trist, DG | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Patacchini, R | 1 |
| Chahl, LA; Johnston, PA | 1 |
| Bartho, L; Giuliani, S; Maggi, CA; Santicioli, P | 1 |
| Barnickel, G; Greiner, HE; Harting, J; Hölzemann, G; Seelig, A | 1 |
| Bertrand, C; Geppetti, P; Graf, PD; Nadel, JA | 1 |
| Champion, E; Foulon, DM; Jones, TR; Masson, P; Rodger, IW | 1 |
| Humpel, C; Saria, A | 1 |
| McKee, KT; Metters, KM; Millar, L; Rodger, IW | 1 |
| Betschart, J; Blanchard, JC; Garret, C; Grall, I; Piot, O; Ravard, S | 1 |
| Han, Y; Shaikh, MB; Siegel, A | 1 |
| Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Ziche, M | 1 |
| Burcher, E; Gould, DJ; Hill, CE; Strigas, J; Vidovic, M | 1 |
| Chung, FZ; Huang, CC; Pu, Y; Tian, Y; Wu, LH | 1 |
| Burcher, E; Geraghty, DP; Lavielle, S; Strigas, J; Zeng, XP | 1 |
| Akiyama, M; DiMaggio, DA; Hirai, Y; Inoue, A; Krause, JE; Kuroyanagi, N; Nakata, Y; Nishio, H; Ogo, H | 1 |
| Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Zawieja, D; Ziche, M | 1 |
| Claudy, A; Doutremepuich, JD; Gueniche, A; Reichert, U; Schmitt, D; Viac, J | 1 |
| Chrétien, L; Gobeil, F; Jukic, D; Nguyen, QT; Nguyen-Le, XK; Regoli, D | 1 |
| Boucher, S; Couture, R; Gehlert, DR; Helton, DR; Hipskind, PA; Iyengar, S; Kallman, MJ; Li, DL; Lobb, KL; Nixon, JA; Schober, D; Simmons, RM | 1 |
| Field, MJ; Hughes, J; Kuo, BS; Naylor, RJ; Singh, L; Suman-Chauhan, N; Tuladhar, BR; Wright, DS | 1 |
| Fox, AJ; Naeem, S; Patel, IA; Urbán, L; Walpole, C | 1 |
| Bai, T; Knight, D; McKay, K; Schellenberg, RR; Wiggs, B | 1 |
| Beyaert, CA; Hill, JM; Kaufman, MP | 1 |
| Condon, RE; Sarna, SK; Tsukamoto, M | 1 |
| Maggi, CA; Santicioli, P; Turini, D; Zagorodnyuk, V | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Brelière, JC; Emonds-Alt, X; Le Fur, G; Vilain, P | 1 |
| Bunnett, NW; Moore, BA; Sharkey, KA; Vanner, S | 1 |
| Ackley, MA; King, AE; Slack, JR | 1 |
| Ciccocioppo, R; De Caro, G; Massi, M; Panocka, I; Polidori, C; Regoli, D | 1 |
| Kondo, A; Ohmura, M; Saito, M | 1 |
| Evangelista, S; Giachetti, A; Manzini, S; Paoli, S | 1 |
| Bordin, G; Brunelleschi, S; Colangelo, D; Viano, I | 1 |
| Lieberman, DN; Mody, I | 1 |
| Bornstein, JC; Burcher, E; Johnson, PJ | 1 |
| Bell, MI; Lee, K; Richardson, PJ | 1 |
| Ardell, JL; Armour, JA; Hoover, DB; Thompson, GW | 1 |
| Cirillo, R; Conte, B; Lopez, G; Maggi, CA; Manzini, S; Parlani, M | 1 |
| Robledo, RF; Witten, ML | 1 |
| Bianchi, B; Cappugi, P; Danesi, A; Giannotti, B; Ipponi, P; Johansson, O; Matucci, R; Rossi, R | 1 |
| Chen, CF; Chen, LW; Lai, YL | 1 |
| Barbot, L; Cellier, E; Couture, R; Iyengar, S | 1 |
| Chahl, LA; Yip, J | 1 |
| Khawaja, AM; Liu, Y; Rogers, DF | 1 |
| Lappi, DA; Wiley, RG | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Albera, C; Brunelleschi, S; Gagliardi, L; Ghio, P; Lavagno, L; Nicali, R; Pozzi, E; Viano, I | 1 |
| Crane, LH; Hamlin, GP; Nimmo, AJ; Williams, MJ | 1 |
| Bertrand, PP; Bian, XC; Bornstein, JC; Furness, JB | 1 |
| Bobrowski, P; Charbonnet, RM; Lao, J; MacNaughton, WK; Miller, MJ; Sandoval, M; Thompson, JH; Trentacosti, AM; Zhang, XJ | 1 |
| Belmonte, KE; Costello, RW; Evans, CM; Fryer, AD; Gleich, GJ; Jacoby, DB | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Khan, S; Khawaja, AM; Liu, YC; Manzini, S; Rogers, DF | 1 |
| Laferrière, A; Moss, IR; Rodier, ME | 1 |
| Cassone, MC; Collino, M; Dianzani, C; Fantozzi, R; Ferrara, C; Lombardi, G | 1 |
| Ackley, MA; Asghar, AU; King, AE; Worsley, MA | 1 |
| Allouard, N; Bert, L; Bougault, I; Le-Fur, G; Rodier, D; Soubrié, P; Steinberg, R | 1 |
| Gao, C; Gao, N; Hu, HZ; Lin, Z; Liu, S; Ren, J; Wood, JD; Xia, Y | 1 |
| Chan, CC; Jolicoeur, P; Lachance, N; Rasori, R; Robichaud, A; Savoie, C; Stamatiou, PB | 1 |
| Cheunsuang, O; Maxwell, D; Morris, R | 1 |
| Brouillette, J; Couture, R | 1 |
| Bayguinov, O; Hagen, B; Sanders, KM | 1 |
| Bunnett, NW; Roosterman, D; Schmidlin, F | 1 |
| Bornstein, JC; Johnson, PJ | 1 |
| Burcher, E; Holmgren, S; Johansson, A; Liu, L | 1 |
| Baroni, S; Betti, L; Cassano, GB; Giannaccini, G; Giusti, L; Lucacchini, A; Marazziti, D | 1 |
| Bateson, AN; Hilton, KJ; King, AE | 1 |
| Chancellor, MB; de Groat, WC; Erickson, KA; Igawa, Y; Nishizawa, O; Ogawa, T; Seki, M; Seki, S; Yoshimura, N | 1 |
| Couture, R; Deschamps, K | 1 |
| Juszczak, M | 1 |
| Chen, WL; Zhang, YQ; Zhao, ZQ | 1 |
| Huizinga, JD; Nieuwmeyer, F; Ye, J | 1 |
| Brouillette, J; Cloutier, F; Couture, R; Deschamps, K; Neugebauer, W; Ongali, B | 1 |
| Audus, KL; Chappa, AK; Lunte, SM | 1 |
| Fong, AY; Potts, JT | 1 |
| Endoh, T | 1 |
| Amato, A; Mulè, F; Serio, R | 1 |
| Chen, L; Cui, QL; Xue, Y; Yung, WH | 1 |
| Asai, H; Ishii, T; Kiuchi, S; Nagasaki, M; Okamoto, M; Saito, A; Taniguchi, H; Watanabe, Y | 1 |
| Boczek-Leszczyk, E; Juszczak, M; Stempniak, B | 1 |
| Emala, CW; Gallos, G; Goubaeva, F; Mizuta, F; Mizuta, K; Panettieri, RA; Xu, D; Yang, J; Zhu, D | 1 |
| Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T | 1 |
| Boczek-Leszczyk, E; Juszczak, M | 1 |
| Ali, SF; Angulo, JA; Wang, J; Xu, W; Zhu, J | 1 |
| Bae, JH; Jo, HJ; Jung, SJ; Kim, HY; Kim, JS; Kim, YH; Oh, SB; Park, CK | 1 |
| Bassi, GS; Brandão, ML; de Carvalho, MC | 1 |
| Chang, C; Ling, J; Lv, B; Ping, F; Qian, J; Shang, J; Song, H; Wang, L; Wang, Y; Zhou, J | 1 |
143 other study(ies) available for substance p, sar(9)-met(o2)(11)- and substance p
| Article | Year |
|---|---|
Effect of substance P and Sar9Met(O2)11-substance P on cutaneous capillary permeability in guinea pig skin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Atropine; Capillary Permeability; Coloring Agents; Fluoroacetates; Guinea Pigs; Injections, Intradermal; Male; Norepinephrine; Oligopeptides; Organic Chemicals; Promethazine; Skin; Substance P | 1992 |
Characterization of NK-1 receptors in guinea pig and rat brain membranes with NK-1 peptides and a non-peptide antagonist.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; Brain; Guinea Pigs; Membranes; Molecular Sequence Data; Neurokinin A; Neurokinin B; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1992 |
Characterisation of NK receptors in guinea-pig urinary bladder smooth muscle: use of selective antagonists.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1992 |
Characterization of receptors for substance P in human astrocytoma cells: radioligand binding and inositol phosphate formation.
Topics: Astrocytoma; Humans; Inositol Phosphates; Ligands; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tumor Cells, Cultured | 1992 |
Interaction of a substance P agonist and of substance P antagonists with lipid membranes. A thermodynamic analysis.
Topics: Adsorption; Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Electrochemistry; Lipid Bilayers; Membrane Lipids; Membranes, Artificial; Micelles; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylglycerols; Spectrometry, Fluorescence; Substance P; Surface Properties; Thermodynamics | 1992 |
Spatial and temporal patterns of intracellular calcium in colonic smooth muscle.
Topics: Animals; Caffeine; Calcium; Carbachol; Colon; Image Processing, Computer-Assisted; In Vitro Techniques; Muscle, Smooth; Potassium; Rabbits; Sarcoplasmic Reticulum; Signal Transduction; Substance P | 1992 |
The NK-1 receptor and a calcium-phospholipid pathway: inositol trisphosphate production and calcium movements induced by selective agonists of neurokinin receptors in rat parotid glands.
Topics: Animals; Calcium; Inositol 1,4,5-Trisphosphate; Male; Parotid Gland; Peptide Fragments; Phospholipids; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Signal Transduction; Substance P | 1992 |
Binding characteristics of [125I]Bolton-Hunter [Sar9,Met(O2)11]substance P, a new selective radioligand for the NK1 receptor.
Topics: Amino Acid Sequence; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; In Vitro Techniques; Kinetics; Ligands; Male; Molecular Sequence Data; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Submandibular Gland; Substance P; Tachykinins | 1990 |
Autoradiographic distribution of brain neurokinin-1/substance P receptors using a highly selective ligand [3H]-[Sar9,Met(O2)11]-substance P.
Topics: Animals; Autoradiography; Brain; Indicators and Reagents; Iodine Radioisotopes; Male; Neurokinin A; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Succinimides; Tritium | 1990 |
125I-BH[Sar9, Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Cell Membrane; Kinetics; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Structure-Activity Relationship; Substance P; Tachykinins | 1990 |
Neurokinin receptor-mediated regulation of [Ca]i and Ca-sensitive ion channels in mammalian colonic muscle.
Topics: Animals; Calcimycin; Calcium; Calcium Channels; Cells, Cultured; Colon; Membrane Potentials; Muscle, Smooth; Neurokinin A; Peptide Fragments; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1991 |
Binding sites for [3H][Sar9, Met(O2)11]substance P in rat brain and guinea pig ileum.
Topics: Animals; Binding Sites; Brain; Guinea Pigs; Ileum; Iodine Radioisotopes; Kinetics; Membranes; Muscle, Smooth; Rats; Substance P; Succinimides; Tritium | 1991 |
Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Neurokinin A; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Substance P; Tachykinins | 1991 |
Tumor necrosis factor and interleukin-1 down-regulate receptors for substance P in human astrocytoma cells.
Topics: Astrocytoma; Brain Neoplasms; Down-Regulation; Histamine; Humans; Inositol Phosphates; Interleukin-1; Kinetics; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1991 |
Characterization of the peripheral action of neurokinins and neurokinin receptor selective agonists on the rat cardiovascular system.
Topics: Animals; Cardiovascular System; Female; Injections, Intravenous; Male; Neurokinin A; Neurokinin B; Neurons, Afferent; Parasympathetic Nervous System; Peptide Fragments; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Substance P; Sympathetic Nervous System; Tachycardia | 1989 |
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
Topics: Amino Acid Sequence; Animals; Benzamides; Hydrolysis; Indoles; Isoindoles; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Substance P-(1-7) and substance P-(5-11) locally modulate dopamine release in rat striatum.
Topics: Androstanes; Animals; Benzimidazoles; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Potassium; Rats; Rats, Wistar; Substance P | 1995 |
Comparison of the effects of (+/-) CP 96,345 and L-668,169 on neurokinin receptor mediated responses in rat and guinea-pig isolated tissues.
Topics: Animals; Biphenyl Compounds; Eledoisin; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Organ Specificity; Peptide Fragments; Peptides, Cyclic; Portal Vein; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Species Specificity; Substance P; Urinary Bladder | 1993 |
Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.
Topics: Animals; Antitussive Agents; Blood Pressure; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Heart Rate; In Vitro Techniques; Muscle Contraction; Peripheral Nervous System; Platelet Activating Factor; Propylene Glycols; Rats; Rats, Inbred F344; Substance P; Trachea; Urinary Bladder | 1993 |
Selective agonists at NK3 tachykinin receptors inhibit alcohol intake in Sardinian alcohol-preferring rats.
Topics: Alcohol Drinking; Amino Acid Sequence; Animals; Drinking Behavior; Eating; Injections, Intraventricular; Male; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Water Deprivation | 1994 |
In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
Topics: Animals; Brain; Bronchoconstriction; Capillary Permeability; Cell Line; Dogs; Endothelium, Vascular; Guinea Pigs; Humans; Hypotension; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1993 |
SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line.
Topics: Astrocytoma; Binding, Competitive; Calcium; Electric Conductivity; Genes, fos; Humans; Inositol Phosphates; Iodine Radioisotopes; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Succinimides; Taurine; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Behavioral activation of neurokinin-1 agonists in relation to enzymatic degradation in the spinal cord.
Topics: Animals; Behavior, Animal; Drug Stability; Male; Mice; Physalaemin; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1994 |
In vivo evidence for the activation of a septide-sensitive tachykinin receptor in guinea pig bronchoconstriction.
Topics: Animals; Biphenyl Compounds; Bronchial Spasm; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Hypnotics and Sedatives; Male; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Substance P; Sulfones | 1994 |
Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gerbillinae; Harderian Gland; Indoles; Injections, Intravenous; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P | 1994 |
Effect of capsaicin on distribution of binding sites for tachykinins and calcitonin gene-related peptide in rat urinary bladder: a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Calcitonin Gene-Related Peptide; Capsaicin; Male; Neurokinin A; Protein Binding; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Tachykinin; Substance P; Tissue Distribution; Urinary Bladder | 1994 |
Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences.
Topics: Adult; Amino Acid Sequence; Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Parasympathetic Nervous System; Peptide Fragments; Rabbits; Receptors, Tachykinin; Substance P; Sulfones; Synaptic Transmission; Tachykinins | 1994 |
Tachykinin NK1 receptor subtypes in the rat urinary bladder.
Topics: Animals; Benzamides; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Sulfones; Tachykinins; Urinary Bladder | 1994 |
Different Ca2+ influx pathways mediate tachykinin receptor-induced contraction in circular muscle of guinea-pig colon.
Topics: Action Potentials; Animals; Calcium Channels; Colon; Electrophysiology; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Sulfones | 1994 |
Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon.
Topics: Animals; Colon; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones | 1994 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
The effects of toluene diisocyanate and of capsaicin on human bronchial smooth muscle in vitro.
Topics: Acetylcholine; Aged; Bronchi; Capsaicin; Female; Humans; In Vitro Techniques; Isoproterenol; Isotonic Contraction; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Toluene 2,4-Diisocyanate | 1994 |
Tachykinin-mediated increase in motility acts independently of vasoactive intestinal polypeptide release in the canine ileum.
Topics: Animals; Dogs; Female; Gastrointestinal Motility; Ileum; Male; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vasoactive Intestinal Peptide | 1994 |
Protein kinase C mediates delayed inhibitory feedback regulation of human neurokinin type 1 receptor activation of phospholipase C in UC11 astrocytoma cells.
Topics: Enzyme Activation; Ethers, Cyclic; Feedback; Humans; Indoles; Kinetics; Neurokinin-1 Receptor Antagonists; Okadaic Acid; Phosphoprotein Phosphatases; Precipitin Tests; Protein Kinase C; Receptors, Neurokinin-1; Substance P; Substrate Specificity; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1994 |
Septide but not substance P stimulates inhibitory neurons in guinea-pig ileum.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P | 1994 |
Differential ability of tachykinin NK-1 and NK-2 agonists to produce scratching and grooming behaviours in mice.
Topics: Animals; Behavior, Animal; Brain; Grooming; Male; Mice; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1994 |
Physiological and pharmacological characterization of the spinal tachykinin NK2 receptor.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Gerbillinae; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-2; Spinal Cord; Substance P; Tetrodotoxin | 1994 |
NK1 and NK2 receptors are similar in man and rabbit.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Humans; Iodine Radioisotopes; Kinetics; Muscle, Smooth, Vascular; Neurokinin A; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Recombinant Proteins; Substance P; Transfection; Tritium; Venae Cavae | 1994 |
On the nature of the 5-HT receptor subtype inhibiting acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin B; Peptide Fragments; Receptors, Neurokinin-3; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P | 1994 |
Non-specific inhibition of dopamine receptor agonist-induced behaviour by the tachykinin NK1 receptor antagonist CP-99,994 in guinea-pigs.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Dopamine Agonists; Grooming; Guinea Pigs; Haloperidol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oxazines; Piperidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1994 |
Effect of tachykinins on the need-free sodium intake of female rats: a continuous intracerebroventricular infusion study.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eledoisin; Female; Injections, Intraventricular; Peptide Fragments; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Substance P; Tachykinins; Water-Electrolyte Balance | 1994 |
Effects of substance P on cardiovascular regulation in the rabbit.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Electric Stimulation; Heart Rate; Injections, Intra-Arterial; Injections, Intraventricular; Male; Piperidines; Quinuclidines; Rabbits; Substance P; Vertebral Artery | 1995 |
Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs.
Topics: Animals; Biphenyl Compounds; Bronchial Spasm; Capsaicin; Electric Stimulation; Guinea Pigs; Insufflation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vagus Nerve | 1995 |
Pulmonary actions of the neurokinin1-specific agonist [Sar9,Met(O2)11]-substance P.
Topics: Animals; Bronchi; Dose-Response Relationship, Drug; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Male; Pulmonary Gas Exchange; Pulmonary Ventilation; Receptors, Neurokinin-1; Respiratory System; Substance P; Trachea | 1995 |
Tachykinin receptors mediating contraction of guinea pig lung strips.
Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea | 1995 |
Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Apamin; Arginine; Atropine; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Guanethidine; Guinea Pigs; Indomethacin; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Nifedipine; Nitroarginine; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Suramin; Thionucleotides | 1995 |
Amyloid beta protein does not interact with tachykinin receptors coupled to inositol phospholipid hydrolysis in human astrocytoma cells.
Topics: Amyloid beta-Peptides; Astrocytoma; Dimethyl Sulfoxide; Humans; Inositol Phosphates; Peptide Fragments; Phosphatidylinositol Phosphates; Phosphatidylinositols; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tumor Cells, Cultured | 1993 |
Tachykinin control of ferret airways: mucus secretion, bronchoconstriction and receptor mapping.
Topics: Animals; Bronchoconstriction; Capsaicin; Ferrets; Male; Methacholine Chloride; Mucus; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Reproducibility of Results; Stimulation, Chemical; Substance P; Tachykinins; Trachea | 1993 |
Selective resistance of tachykinin-responsive cholinergic neurons in the quinolinic acid lesioned neostriatum.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Microinjections; Neostriatum; Neurokinin A; Neurons; Peptide Fragments; Potassium Chloride; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substance P | 1993 |
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve | 1993 |
Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat.
Topics: Animals; Benzamides; Biphenyl Compounds; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin A; Nociceptors; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Spinal Cord; Substance P | 1993 |
Chloride channels in myocytes from rabbit colon are regulated by a pertussis toxin-sensitive G protein.
Topics: Animals; Bucladesine; Calcimycin; Cell Adhesion; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Colon; Cytosol; Diglycerides; Electric Conductivity; Electrophysiology; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Ion Channels; Ionomycin; Male; Meglumine; Membrane Potentials; Membrane Proteins; Muscle, Smooth; NAD; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Rabbits; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Virulence Factors, Bordetella | 1993 |
Agonists selective for tachykinin NK1 and NK3 receptors excite subpopulations of neurons in the rat medial habenula nucleus in vitro.
Topics: Animals; Electrophysiology; Extracellular Space; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Thalamic Nuclei | 1993 |
The rabbit iris sphincter contains NK1 and NK3 but not NK2 receptors: a study with selective agonists and antagonists.
Topics: Animals; Dactinomycin; Female; Iris; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1993 |
Further studies on the effects of selective neurokinin agonists upon the activation of micturition reflex in rats. Evidence for a dual NK-1 receptor mediated excitatory and inhibitory activity.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intra-Arterial; Injections, Intraventricular; Male; Neurokinin A; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Reflex; Substance P; Urinary Bladder; Urination | 1993 |
In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist.
Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Rats; Receptors, Neurokinin-2; Saliva; Substance P; Sulfones; Urinary Bladder | 1993 |
Neurokinin-1, -2 and -3 receptors are candidates for a role in the opiate withdrawal response in guinea-pigs.
Topics: Animals; Cerebral Ventricles; Guinea Pigs; Injections, Intraventricular; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Substance Withdrawal Syndrome | 1993 |
Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colon.
Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones; Tetrodotoxin | 1993 |
Do substance P agonists insert into the lipid membrane?
Topics: Animals; Cattle; Cell Membrane; Lipid Bilayers; Liposomes; Phosphatidylcholines; Phosphatidylglycerols; Protein Conformation; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1993 |
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
NK1 and NK2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs.
Topics: Animals; Benzamides; Bronchial Spasm; Bronchoconstriction; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 1993 |
Intranigral injection of selective neurokinin-1 and neurokinin-3 but not neurokinin-2 receptor agonists biphasically modulate striatal dopamine metabolism but not striatal preprotachykinin-A mRNA in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Female; Gene Expression Regulation; Injections; Neurokinin A; Neurokinin B; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; RNA, Messenger; Substance P; Substantia Nigra; Tachykinins | 1993 |
Identification of both NK1 and NK2 receptors in guinea-pig airways.
Topics: Animals; Benzamides; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory System; Substance P; Trachea | 1993 |
Comparative behavioural profile of centrally administered tachykinin NK1, NK2 and NK3 receptor agonists in the guinea-pig.
Topics: Animals; Behavior, Animal; Guinea Pigs; Injections, Intraventricular; Male; Motor Activity; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
Medial amygdaloid suppression of predatory attack behavior in the cat: I Role of a substance P pathway from the medial amygdala to the medial hypothalamus.
Topics: Amygdala; Animals; Autoradiography; Biphenyl Compounds; Brain Mapping; Cats; Electric Stimulation; Female; Hypnotics and Sedatives; Hypothalamus, Middle; Male; Microinjections; Neural Pathways; Neurokinin-1 Receptor Antagonists; Predatory Behavior; Receptors, Neurokinin-1; Stereotaxic Techniques; Substance P | 1996 |
The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture.
Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cell Adhesion; Cell Movement; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet-Derived Growth Factor; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Skin; Substance P | 1996 |
Sensory nerves play an efferent role in the function of the arterioles, but not the dilator muscle, of the rat iris.
Topics: Adrenergic Fibers; Animals; Arterioles; Autoradiography; Base Sequence; Binding Sites; Calcitonin Gene-Related Peptide; Efferent Pathways; Electrophysiology; Immunohistochemistry; Iris; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Muscles; Neurons, Afferent; Polymerase Chain Reaction; Rats; Rats, Wistar; Receptors, Tachykinin; RNA, Messenger; Substance P | 1996 |
Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists.
Topics: Amino Acid Sequence; Cloning, Molecular; Exons; Humans; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phosphatidylinositols; Piperidines; Protein Binding; Pyrrolidonecarboxylic Acid; Quinuclidines; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Stereoisomerism; Substance P | 1996 |
Tachykinin receptors in guinea-pig airways: characterization using selective ligands.
Topics: Animals; Biphenyl Compounds; Female; Guinea Pigs; In Vitro Techniques; Lung; Male; Physalaemin; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
Human astrocytoma cells (U-87 MG) exhibit a specific substance P binding site with the characteristics of an NK-1 receptor.
Topics: Astrocytoma; Binding Sites; Binding, Competitive; Cations, Monovalent; Cell Line; Exons; Glioblastoma; Guanine Nucleotides; Guanosine Triphosphate; Humans; Kinetics; Lectins; Receptors, Neurokinin-1; RNA, Antisense; RNA, Complementary; RNA, Messenger; Substance P; Tritium; Tumor Cells, Cultured | 1996 |
Effect of the non-peptide blocker (+/-) CP 96,345 on the cellular mechanism involved in the response to NK1 receptor stimulation in human skin fibroblasts.
Topics: Biphenyl Compounds; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Cytosol; Dipeptides; Fibroblasts; Humans; Hydrolysis; Indoles; Neurokinin-1 Receptor Antagonists; Phosphatidylinositols; Physalaemin; Receptors, Neurokinin-1; Skin; Stimulation, Chemical; Substance P | 1996 |
Substance P and keratinocyte activation markers: an in vitro approach.
Topics: Adolescent; Animals; Biomarkers; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Guinea Pigs; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-8; Keratinocytes; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 1996 |
Neurokinin receptors in the guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
LY303870, a centrally active neurokinin-1 antagonist with a long duration of action.
Topics: Animals; Drug Synergism; Electroshock; Formaldehyde; Guinea Pigs; Humans; Indoles; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex, Startle; Species Specificity; Spinal Cord; Substance P | 1997 |
The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret.
Topics: Animals; Antiemetics; Antineoplastic Agents; Behavior, Animal; Brain; CHO Cells; Cisplatin; Cricetinae; Dogs; Female; Ferrets; Gerbillinae; Guinea Pigs; Humans; Male; Mice; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Sensitivity and Specificity; Sheep; Substance P; Swine; Time Factors; Tryptophan; Vomiting | 1997 |
Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Evoked Potentials; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1996 |
Localization of leukaemia inhibitory factor to airway epithelium and its amplification of contractile responses to tachykinins.
Topics: Animals; Capsaicin; Carbachol; Epithelium; Female; Growth Inhibitors; Guinea Pigs; Humans; Immunohistochemistry; In Vitro Techniques; Interleukin-6; Isoproterenol; Leukemia Inhibitory Factor; Lymphokines; Muscle Contraction; Neurokinin A; Substance P; Trachea | 1997 |
Substance P analogues potentiate the pressor response to microinjection of L-glutamate into laminas I and II of the cat dorsal horn.
Topics: Animals; Blood Pressure; Cats; Chronobiology Phenomena; Drug Synergism; Glutamic Acid; Heart Rate; Microinjections; Phrenic Nerve; Respiration; Spinal Cord; Substance P | 1997 |
A novel motility effect of tachykinins in normal and inflamed colon.
Topics: Animals; Atropine; Colon; Dogs; Female; Hexamethonium; Inflammation; Infusions, Intra-Arterial; Male; Muscle Contraction; Muscle, Smooth; Myoelectric Complex, Migrating; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1997 |
Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum.
Topics: Aged; Aged, 80 and over; Apamin; Electrophysiology; Enzyme Inhibitors; Humans; Ileum; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Nitroarginine; Peptide Fragments; Peptides, Cyclic; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission | 1997 |
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1997 |
Tachykinin-induced contractions of the guinea pig ileum longitudinal smooth muscle: tonic and phasic muscular activities.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Substance P; Tachykinins | 1997 |
Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum.
Topics: Animals; Electric Stimulation; Female; Ganglia, Autonomic; Guinea Pigs; Ileum; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Male; Membrane Potentials; Microscopy, Video; Muscle, Smooth; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurokinin-1; Submucous Plexus; Substance P; Vasodilation | 1997 |
Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro.
Topics: Animals; Biomarkers; Lysine; Membrane Potentials; Neurons; Rats; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tetrodotoxin | 1997 |
Stimulation of tachykinin NK-3 receptors in the nucleus basalis magnocellularis reduces alcohol intake in rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Choice Behavior; Indoles; Male; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Stimulation, Chemical; Substance P; Substantia Innominata | 1997 |
Response of isolated human neurogenic bladders to tachykinins.
Topics: Adolescent; Atropine; Child; Dose-Response Relationship, Drug; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Meningomyelocele; Muscle Contraction; Neurokinin A; Neurokinin B; Sacrococcygeal Region; Substance P; Tachykinins; Urinary Bladder, Neurogenic | 1997 |
Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.
Topics: Animals; Antigens; Blood Proteins; Capsaicin; Dextrans; Dipeptides; Extravasation of Diagnostic and Therapeutic Materials; Fluorescein-5-isothiocyanate; Glycopeptides; Guinea Pigs; Indoles; Male; Nasal Mucosa; Neurokinin A; Neurokinin-1 Receptor Antagonists; Olfactory Receptor Neurons; Peptide Fragments; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rhinitis; Substance P | 1997 |
Tachykinin receptors are present on human monocytes and play a role in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Cell Separation; Female; Humans; Male; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Substance P enhances NMDA channel function in hippocampal dentate gyrus granule cells.
Topics: Animals; Cells, Cultured; Dentate Gyrus; Ion Channel Gating; Male; Neurokinin-1 Receptor Antagonists; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P | 1998 |
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 1998 |
Characterization of the mechanism of action of tachykinins in rat striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Chelating Agents; Corpus Striatum; Diazonium Compounds; Electric Stimulation; Estrenes; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Interneurons; Male; Membrane Potentials; Patch-Clamp Techniques; Phenoxyacetates; Phosphodiesterase Inhibitors; Photochemistry; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 1998 |
Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2, and NK3 receptors.
Topics: Animals; Dogs; Heart; Myocardial Contraction; Neurokinin A; Neurons, Afferent; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1998 |
Inflammatory and motor responses by tachykinins in the guinea-pig oesophageal sphincter.
Topics: Animals; Dipeptides; Diphenhydramine; Dose-Response Relationship, Drug; Esophagogastric Junction; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1998 |
NK1-receptor activation prevents hydrocarbon-induced lung injury in mice.
Topics: Aerosols; Animals; Animals, Congenic; Bronchoalveolar Lavage Fluid; Hydrocarbons; Lung; Lung Diseases; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P | 1999 |
Characterization of [3H]substance P binding sites in human skin.
Topics: Aged; Binding, Competitive; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Neurokinin A; Neurokinin B; Peptide Fragments; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Skin; Substance P; Tritium | 1999 |
Chronic activation of neurokinin-1 receptor induces pulmonary hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atmospheric Pressure; Biphenyl Compounds; Blood Pressure; Cardiac Output; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Neurokinin-1 Receptor Antagonists; Pulmonary Wedge Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Vascular Resistance | 1999 |
Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat.
Topics: Acetamides; Animals; Behavior, Animal; Blood Pressure; Capillary Permeability; Heart Rate; Indoles; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1999 |
Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P.
Topics: Animals; Behavior, Animal; Brain; Cerebral Ventricles; Genes, fos; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Motor Activity; Neurokinin-1 Receptor Antagonists; Organ Specificity; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Receptors, Neurokinin-1; Reference Values; Substance P; Tyrosine 3-Monooxygenase | 1999 |
Effect of non-peptide tachykinin NK(1) receptor antagonists on non-adrenergic, non-cholinergic neurogenic mucus secretion in ferret trachea.
Topics: Acetylcholine; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Ferrets; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; Mucus; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinolines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1999 |
Targeting neurokinin-1 receptor-expressing neurons with [Sar9,Met(O2)11 substance P-saporin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Immunotoxins; Male; N-Glycosyl Hydrolases; Neostriatum; Neurons; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Substance P | 1999 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
Tachykinin activation of human monocytes from patients with interstitial lung disease, healthy smokers or healthy volunteers.
Topics: Adult; Aged; Cells, Cultured; Female; Humans; Lung Diseases, Interstitial; Male; Middle Aged; Monocytes; Neurokinin A; Peptide Fragments; Pulmonary Fibrosis; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Reference Values; Sarcoidosis; Smoking; Substance P; Superoxides; Tachykinins | 2000 |
Hormonal variation of rat uterine contractile responsiveness to selective neurokinin receptor agonists.
Topics: Animals; Diestrus; Estrogens; Estrus; Female; Metestrus; Neurokinin A; Ovariectomy; Peptide Fragments; Piperidines; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Uterine Contraction | 2000 |
Evidence for functional NK1-tachykinin receptors on motor neurones supplying the circular muscle of guinea-pig small and large intestine.
Topics: Animals; Colon; Duodenum; Enzyme Inhibitors; Guinea Pigs; Ileum; Immunohistochemistry; In Vitro Techniques; Indomethacin; Motor Neurons; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P | 2000 |
Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado.
Topics: Animals; Capsaicin; Cyclooxygenase 2; Diarrhea; Diffusion Chambers, Culture; DNA Primers; Dose-Response Relationship, Drug; Electric Stimulation; Gene Expression Regulation, Enzymologic; Guinea Pigs; Ileum; Interleukin-1; Interleukin-6; Intestinal Mucosa; Isoenzymes; Male; Neurons, Afferent; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peru; Phytotherapy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Stomach Ulcer; Substance P; Tumor Necrosis Factor-alpha | 2000 |
Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction.
Topics: Animals; Antibodies; Blood Proteins; Bronchial Hyperreactivity; Cyclophosphamide; Electric Stimulation; Eosinophil Granule Proteins; Female; Guinea Pigs; Heparin; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Ribonucleases; Substance P; Vagus Nerve | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Effect of the long-acting tachykinin NK(1) receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Cyclohexylamines; Electric Stimulation; Ferrets; Histamine; Hypersensitivity; Indoles; Male; Mucus; Neurokinin-1 Receptor Antagonists; Ovalbumin; Receptors, Neurokinin-1; Substance P; Sulfur Radioisotopes; Trachea | 2001 |
Effects of age and clustered hypoxia on [(125)I] substance P binding to neurotachykinin-1 receptors in brainstem of developing swine.
Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain Stem; Down-Regulation; Female; Hypoxia, Brain; Iodine Radioisotopes; Male; Pregnancy; Receptors, Neurokinin-1; Respiration; Substance P; Swine, Miniature; Up-Regulation | 2001 |
Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.
Topics: Adult; Biphenyl Compounds; Calcium; Calcium Channels; Calcium Signaling; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Humans; Interleukin-8; Ion Transport; Neutrophils; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Substance P | 2001 |
Peripheral inflammation reduces the response of spinal dorsal horn neurons to an NK3 receptor agonist.
Topics: Action Potentials; Animals; Carrageenan; Hyperalgesia; Inflammation; Lysine; Neurokinin B; Nociceptors; Pain; Peptide Fragments; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 2001 |
Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiemetics; Dose-Response Relationship, Drug; Guinea Pigs; Locus Coeruleus; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Norepinephrine; Peptide Fragments; Piperidines; Prefrontal Cortex; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tetrazoles | 2002 |
Chemical coding and electrophysiology of enteric neurons expressing neurofilament 145 in guinea pig gastrointestinal tract.
Topics: Action Potentials; Animals; Axons; Calbindin 2; Calbindins; Digestive System; Enteric Nervous System; Excitatory Postsynaptic Potentials; Guinea Pigs; Hexamethonium; Immunohistochemistry; Male; Myenteric Plexus; Neurofilament Proteins; Neurons; Neuropeptide Y; Nitric Oxide Synthase; Receptors, Neurokinin-1; S100 Calcium Binding Protein G; Serotonin; Somatostatin; Submucous Plexus; Substance P; Vasoactive Intestinal Peptide | 2002 |
Assessing the emetic potential of PDE4 inhibitors in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Male; Pentobarbital; Phosphodiesterase Inhibitors; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-3; Substance P; Vomiting | 2002 |
Spinal lamina I neurones that express neurokinin 1 receptors: II. Electrophysiological characteristics, responses to primary afferent stimulation and effects of a selective mu-opioid receptor agonist.
Topics: Action Potentials; Afferent Pathways; Animals; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Neurons; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Opioid, mu; Spinal Cord; Substance P | 2002 |
Evidence for a GABA(B) receptor component in the spinal action of Substance P (SP) on arterial blood pressure in the awake rat.
Topics: Animals; Benzylamines; Bicuculline; Blood Pressure; Depression, Chemical; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intravenous; Injections, Spinal; Male; Phosphinic Acids; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Neurokinin-1; Substance P; Vasoconstrictor Agents; Wakefulness | 2002 |
Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes.
Topics: Animals; Calcium Signaling; Colon; Electric Conductivity; Imidazoles; Indoles; Male; Maleimides; Membrane Potentials; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Myocytes, Smooth Muscle; Neurokinin A; Nicardipine; Patch-Clamp Techniques; Peptide Fragments; Peptides; Physalaemin; Receptors, Tachykinin; Ryanodine; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems; Substance P | 2003 |
The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins.
Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Biological Transport; Calcium; Calcium Signaling; Cell Line; Enzyme Activation; Mitogen-Activated Protein Kinases; Neurokinin B; Protein Structure, Tertiary; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tissue Distribution | 2003 |
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Male; Myenteric Plexus; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Phentolamine; Piperazines; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Substance P; Synaptic Transmission | 2004 |
Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin.
Topics: Animals; Binding Sites; Cardia; Dose-Response Relationship, Drug; Eledoisin; Female; Indoles; Intercellular Signaling Peptides and Proteins; Intestine, Small; Iodine Radioisotopes; Isoindoles; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Physalaemin; Receptors, Tachykinin; Species Specificity; Substance P; Xenopus | 2004 |
Absence of NK1 receptors in human blood lymphocytes and granulocytes.
Topics: Adult; Animals; Antidepressive Agents; Cerebral Cortex; Female; Granulocytes; Humans; Lymphocytes; Male; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Stereoisomerism; Stress, Psychological; Substance P | 2004 |
A model of organotypic rat spinal slice culture and biolistic transfection to elucidate factors that drive the preprotachykinin-A promoter.
Topics: Animals; Animals, Newborn; Biolistics; Biomarkers; Cell Survival; Colforsin; DNA, Recombinant; Female; Green Fluorescent Proteins; Models, Biological; Neuronal Plasticity; Organ Culture Techniques; Posterior Horn Cells; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tachykinins; Transfection; Up-Regulation | 2004 |
Elimination of rat spinal neurons expressing neurokinin 1 receptors reduces bladder overactivity and spinal c-fos expression induced by bladder irritation.
Topics: Animals; Capsaicin; Cell Nucleus; Cystitis; Female; Fluorescent Antibody Technique; Genes, fos; Immunohistochemistry; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Urinary Bladder; Urinary Bladder, Neurogenic | 2005 |
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
Topics: Acetates; Adrenergic beta-Antagonists; Animals; Atenolol; Behavior, Animal; Benzamides; Benzazepines; Blood Pressure; Dopamine D2 Receptor Antagonists; Glutamic Acid; Heart Rate; Indoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 2005 |
Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists.
Topics: Animals; Hypothalamo-Hypophyseal System; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vasopressins | 2005 |
Neurokinin-1 receptor in peripheral nerve terminals mediates thermal hyperalgesia.
Topics: Androstanes; Animals; Behavior, Animal; Benzimidazoles; Cell Degranulation; Edema; Hyperalgesia; Male; Mast Cells; Nerve Endings; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Sural Nerve | 2006 |
Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.
Topics: Action Potentials; Animals; Coiled Bodies; Dilatation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Mice; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Upregulation of tachykinin NK-1 and NK-3 receptor binding sites in the spinal cord of spontaneously hypertensive rat: impact on the autonomic control of blood pressure.
Topics: Acetates; Animals; Autonomic Nervous System; Autoradiography; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Indoles; Injections, Spinal; Male; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Spinal Cord; Substance P; Thoracic Vertebrae; Up-Regulation | 2006 |
Characteristics of substance P transport across the blood-brain barrier.
Topics: Animals; Binding, Competitive; Blood-Brain Barrier; Brain; Capillary Permeability; Cattle; Cells, Cultured; Diffusion Chambers, Culture; Endothelial Cells; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Substance P; Temperature; Tritium | 2006 |
Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea.
Topics: Animals; Diaphragm; Electric Stimulation; Male; Microinjections; Phrenic Nerve; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reflex; Respiratory Center; Respiratory Function Tests; Respiratory Mechanics; Substance P; Vagus Nerve | 2006 |
Dual effects of neurokinin on calcium channel currents and signal pathways in neonatal rat nucleus tractus solitarius.
Topics: Analysis of Variance; Animals; Animals, Newborn; Calcium Channels; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Signal Transduction; Solitary Nucleus; Substance P; Tachykinins | 2006 |
Role for NK(1) and NK(2) receptors in the motor activity in mouse colon.
Topics: Animals; Atropine; Colon; Electric Stimulation; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sodium Channel Blockers; Substance P; Tetrodotoxin | 2007 |
Substance P excites globus pallidus neurons in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Choline O-Acetyltransferase; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Globus Pallidus; Haloperidol; Male; Neurokinin-1 Receptor Antagonists; Neurons; Neurotransmitter Agents; Posture; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tropanes | 2007 |
Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor.
Topics: Animals; Antiemetics; Antineoplastic Agents; Aprepitant; Binding Sites; Brain; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Ferrets; Gerbillinae; Humans; Kinetics; Male; Morpholines; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P; Transfection; Vomiting | 2008 |
Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies.
Topics: Analysis of Variance; Animals; Hypothalamo-Hypophyseal System; In Vitro Techniques; Male; Melatonin; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Peptide Fragments; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vasopressins | 2007 |
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.
Topics: Boron Compounds; Calcium Signaling; Humans; Imidazoles; Inositol 1,4,5-Trisphosphate; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; RNA, Messenger; Substance P; Trachea | 2008 |
Neurokinin receptor modulation of respiratory activity in the rabbit.
Topics: Animals; Exhalation; Inhalation; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phrenic Nerve; Piperidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Vagotomy | 2008 |
Oxytocin release from the rat neurohypophysis into the blood: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists.
Topics: Analysis of Variance; Animals; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2008 |
The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice.
Topics: Analysis of Variance; Androstanes; Animals; Apoptosis; Benzimidazoles; Body Temperature; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Corpus Striatum; Dose-Response Relationship, Drug; Drug Combinations; Electrochemistry; Immunotoxins; In Situ Nick-End Labeling; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Substance P; Tyrosine | 2009 |
Substance P sensitizes P2X3 in nociceptive trigeminal neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium Signaling; Cytophotometry; Immunohistochemistry; Inflammation Mediators; Neurokinin-1 Receptor Antagonists; Neurons; Nociceptors; Patch-Clamp Techniques; Physalaemin; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Trigeminal Nerve | 2010 |
Effects of substance P and Sar-Met-SP, a NK1 agonist, in distinct amygdaloid nuclei on anxiety-like behavior in rats.
Topics: Animals; Anxiety; Central Amygdaloid Nucleus; Corticomedial Nuclear Complex; Male; Maze Learning; Microinjections; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 2014 |
Neurokinin-1 receptor is a novel positive regulator of Wnt/ β-catenin signaling in melanogenesis.
Topics: Animals; beta Catenin; Cells, Cultured; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Humans; Intercellular Signaling Peptides and Proteins; Melanins; Melanocytes; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Phosphorylation; Piperidines; Receptors, Neurokinin-1; Skin; Skin Pigmentation; Substance P; Time Factors; Wnt Signaling Pathway | 2016 |