strontium-radioisotopes and Osteoma

The molecular structure of murine retroviruses expressed in spontaneous and radiation-induced bone tumours was studied. These viruses induce osteomas, lymphomas and osteopetrosis in mice of the NMRI strain. RNase T1 fingerprint analysis indicates the presence of mixed virus populations in the tumours, with major components showing close relationship to Akv MuLV. Cloned viruses, closely related to Akv MuLV, have the same oncogenic properties as the original mixtures. In its nucleotide sequence of the repeat segments of the transcriptional enhancer in the LTR, one cloned virus analysed was distinct from Akv MuLV, but closely related to a spontaneous bone tumour virus isolate, FBJ MuLV.

Topics: Animals; Base Sequence; Bone Neoplasms; Gene Expression Regulation; Mice; Neoplasms, Radiation-Induced; Oligoribonucleotides; Osteoma; Retroviridae; RNA, Neoplasm; RNA, Viral; Strontium Radioisotopes

In primary bone tumors the possibilities of bone scans are discussed. Exact differentiation between malignant and benign disease by this method is impossible. However, scanning provides important information about extent of the disease, metastases, multiplicity of benign lesions and influence of adjoining diseases to the bone. A special indication exists in cases of cerebral meningiomas and an absolute indication for searching osteoplastic metastases, e.g. in carcinomas of the breast and the prostate gland.

Topics: Bone Diseases; Bone Neoplasms; Child; Fluorine; Granuloma; Hemangiosarcoma; Humans; Male; Meningioma; Neoplasm Metastasis; Osteitis Deformans; Osteoma; Radioisotopes; Radionuclide Imaging; Sarcoma, Ewing; Strontium; Strontium Isotopes; Strontium Radioisotopes; Technetium