thiourea and Osteoma

thiourea has been researched along with Osteoma* in 1 studies

Other Studies

1 other study(ies) available for thiourea and Osteoma

Article	Year
Effect of thiourea on intracranial bone tumour formation in AkR mice. Hormone research, 1979, Volume: 10, Issue:2-3 The effect of administration of thiourea (5 g/kg in diet) alone or simultaneously with thyroxine (1 mg/l in drinking water) on the frequency of hyperplastic benign osteoma of the skull was studied in AkR mice. Animals treated with both thiourea and thyroxine were in hyperthyroidism: the thyroxine dose received was higher that that required to prevent thiourea-induced thyroid gland hypertrophy. A significant increase of the intracranial bone tumour (IBT) frequency was observed both in mice treated with thiourea alone and those which received thiourea and thyroxine simultaneously. Increase of IBT frequency was not due to the antithyroid effect of thiourea but seems due to a direct toxic action of thiourea on the pituitary. Topics: Animals; Body Weight; Female; Male; Mice; Mice, Inbred AKR; Neoplasms, Experimental; Osteoma; Pituitary Gland; Skull Neoplasms; Thiourea; Thyroid Gland; Thyroxine	1979

Article

Year

Effect of thiourea on intracranial bone tumour formation in AkR mice.

Hormone research, 1979, Volume: 10, Issue:2-3

The effect of administration of thiourea (5 g/kg in diet) alone or simultaneously with thyroxine (1 mg/l in drinking water) on the frequency of hyperplastic benign osteoma of the skull was studied in AkR mice. Animals treated with both thiourea and thyroxine were in hyperthyroidism: the thyroxine dose received was higher that that required to prevent thiourea-induced thyroid gland hypertrophy. A significant increase of the intracranial bone tumour (IBT) frequency was observed both in mice treated with thiourea alone and those which received thiourea and thyroxine simultaneously. Increase of IBT frequency was not due to the antithyroid effect of thiourea but seems due to a direct toxic action of thiourea on the pituitary.

Topics: Animals; Body Weight; Female; Male; Mice; Mice, Inbred AKR; Neoplasms, Experimental; Osteoma; Pituitary Gland; Skull Neoplasms; Thiourea; Thyroid Gland; Thyroxine

1979